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PubMed1988

[Infectious complications, delayed wound healing and inflammatory syndromes as late complications of cardiovascular surgery].

Four-hundred and three patients were admitted to an internal medicine unit for late complications of cardiac or vascular surgery; 321 of these patients (80 per cent) had a total of 379 complications or intercurrent disease, 147 (40 per cent) of which were infections (71 cases), delayed healing of the operative wound (39 cases) or inflammatory syndromes (37 cases). Such complications are notable for their immediate or secondary severity, the diagnostic problems sometimes raised by their latency, their repercussions on the length of hospitalization and cost of surgery, and the thoughts they inspire concerning the minimal stay in hospital required after this type of surgery.

Cardiovascular Diseases↗

PubMed1994

Microvascular and acute complications in IDDM patients: the EURODIAB IDDM Complications Study.

The prevalence of microvascular and acute diabetic complications, and their relation to duration of diabetes and glycaemic control were examined in a cross-sectional study of 3250 IDDM patients in Europe (EURODIAB IDDM Complications Study). Mean (SD) duration of diabetes was 14.7 (9.3) years. HbA1c and AER were measured centrally. Retinopathy was assessed by centrally graded retinal photography. Autonomic neuropathy was measured by heart rate and blood pressure responses to standing up. Sensory neuropathy was measured by biothesiometry. Normal HbA1c was found in 16% of patients. An AER of 20 micrograms/min or higher was found in 30.6% (95% CI 29.0%, 32.2%) of all patients, and 19.3% (15.6%, 23.0%) of those with diabetes for 1 to 5 years. The prevalence of retinopathy (46% in all patients; 82% after 20 or more years) was substantially lower than in comparable studies. Of all patients 5.9% (5.1%, 6.7%) had postural hypotension, 19.3% (17.9%, 20.7%) had abnormal heart rate variability, 32.2% (30.6%, 33.8%) reported one or more severe hypoglycaemic attacks during the last 12 months and 8.6% (7.6%, 9.6%) reported hospital admission for ketosis over the same period. Microvascular and acute complications were clearly related to duration of diabetes and to glycaemic control. However, the relation of glycaemic control to raised albuminuria differed qualitatively from its relation to retinopathy.

Adolescent↗

PubMed2005

[List of complications--reduction of errors and complications by elimination of unsafe actions and conditions].

The "Komplikationenliste " (list of complications) of the association of the heads of departments of the Swiss society of internal medicine is a clinical tool for the registration and reduction of complications/errors of medical treatment. It is the aim to improve patient safety in hospital medicine. By the systematic and prospective analysis of interventions and complications in the participating medical departments it is possible to collect also rare incidents. All the complications and errors are communicated to all the departments of internal medicine in Switzerland in order to reduce them. The principle for the reduction of such events is the elimination of unsafe actions and conditions and apparently harmless errors in daily diagnostic and therapeutic interventions in order to avoid the potentially serious consequences.

Decision Support Systems, Clinical↗

PubMed2004

Liver abscess complicating transcatheter arterial embolization: a rare but serious complication. A retrospective study after 3878 procedures.

OBJECTIVES: Liver abscess is one of the complications of transcatheter arterial embolization (TAE) for hepatocellular carcinoma. We studied the clinical features and analysed the incidence, risk factors, helpful clinical clues, culture profiles and predictive factors of post-TAE liver abscess. The influence of abscess development on the evolution of the tumour process was also studied. METHODS: We retrospectively reviewed records of 3878 TAE procedures performed over a 6 year period. RESULTS: Ten cases of liver abscess developed in nine patients (eight males and one female). The incidence was 0.26% (10 episodes/3878 procedures). The main clinical presentations included fever (91.7%), chills (50%) and abdominal pain (33.3%). All but one febrile patient presented fever in a recurrent form. The positive culture rates were 41.7% for blood and 83.3% for pus. Gram negative bacteria were found in 80% of blood cultures and 68% of pus cultures. Polymicrobial infections were encountered in 60% of the blood cultures and 70% of pus cultures. Management included antibiotics, drainage and operation. Four patients died due to the direct complications of liver abscess. One patient experienced total tumour resolution after successful treatment for liver abscess. Patients with larger liver abscesses and patients with greater age carried higher mortality rates. CONCLUSIONS: Liver abscess is a rare complication after TAE for hepatocellular carcinoma. Recurrent fevers after an initial symptom free interval should arouse suspicion of an abscess. The mortality is high and a large abscess and higher age predict an unfavourable outcome. Abscess formation can lead to complete tumour resolution.

Adult↗

PubMed2004

Transblepharoplasty lower eyelid and midface rejuvenation: part I. Avoiding complications by utilizing lessons learned from the treatment of complications.

Transblepharoplasty midface elevation has become a common aesthetic procedure in recent years. As new techniques have been utilized, complications have arisen. Management of these referred complications has resulted in the development of a technique that elevates the midface and restores the normal position and shape to the lower eyelid with minimal postoperative problems. Four principles must be followed to achieve satisfactory results. The orbicularis oculi/orbital septum bond must not be altered in midface surgery. The lateral canthus must be reattached to its normal anatomic location at the lateral orbital rim if there is lateral canthal tendon laxity. The orbital fat should be addressed via a transconjunctival approach, when necessary, to prevent middle lamella inflammation and orbital septum retraction. A suture at the inferior lateral orbital rim simulating the orbitomalar ligament, as well as orbicularis oculi muscle sutures, elevates the midface. Utilizing these steps, the midface and lower eyelid can be satisfactorily repositioned with minimal complications. This surgical approach can be utilized in all appropriate candidates but is especially useful in reoperative cosmetic surgery patients and the older patient population.

Adipose Tissue↗

PubMed2003

Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose?

Glycemic control is the primary mediator of diabetic microvascular complications and also contributes to macrovascular complications. A new study (see related article beginning on page 1049) reveals a previously unrecognized association between oxidant activation of poly(ADP ribose) polymerase (PARP) and upregulation of known mediators of glycemic injury. Inhibitors of PARP may have potential therapeutic roles in the prevention of diabetic complications.

Animals↗

PubMed1995

[A case report of aldosterone-producing adrenocortical adenoma complicated with chronic renal failure associated with nephrocalcinosis: review of APAs complicated with chronic renal failure].

A 57-year-old man was admitted to our hospital because of dyspnea due to congestive heart failure caused by hypertensive heart disease in September, 1992. Twenty years ago, he was diagnosed to be hypertensive, and in 1980, he was diagnosed to at our hospital to have primary aldosteronism (PA) due to a right aldosterone-producing adrenocortical adenoma (APA). There were no hypertensive vascular complications at that time. He refused surgical removal, and anti-hypertensive drugs including spironolactone were administered. However, his drug compliance was very inaccurate. On this recent admission, left ventricular hypertrophy associated with impaired contractivity, hypertensive retinal change and mild protein uria were noted, but no hematuria was detected. His renal function was impaired (Ccr: 15.2ml/min). An abdominal CT scan showed a typical right APA, bilateral renal atrophy and fine granular calcification at renal medulla, even though he had no hypercalcemia and hypercalciuria. In addition, multiple cerebral infarction was demonstrated by a brain CT scan, along with coronary artery stenoses at the right coronary artery and left circumflex branch by coronary angiography and bilateral multiple renal artery stenoses by renal angiography. Right adrenalectomy and renal biopsy were performed. Histological examinations revealed a yellow tan-colored APA, many sclerotic glomerulus, and severely hyarinized renal arterioles. After adrenalectomy, blood pressure was not normalized but was controlled easily by hypotensive agents. Impaired renal function was not improved and deteriorated slightly but did not get worse there after. Since 1959, including ours, 22 cases of APAs complicated with chronic renal failure were reported in Japan. In conclusion, surgical removal should be recommended for APA, even if the patient's condition is complicated with chronic renal failure.

Adrenal Gland Neoplasms↗

PubMed2002

Influence of health care providers on the development of diabetes complications: long-term follow-up from the Pittsburgh Epidemiology of Diabetes Complications Study.

OBJECTIVE: To quantify total diabetes care received (generalist or specialist) from diagnosis onward and its association with the incidence of diabetes complications in a representative cohort of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: A total of 429 subjects from the Pittsburgh Epidemiology of Diabetes Complications Study, a prospective follow-up study of childhood-onset type 1 diabetic subjects first seen between 1986 and 1988 (mean age 28 years, mean duration 19 years), followed biennially for up to 10 years were studied. Specialist care was defined as care received from a board-certified endocrinologist, diabetologist, or diabetes clinic and quantified as the percent of diabetes duration spent in specialist care. RESULTS: There was a significant trend for a higher incidence of neuropathy, overt nephropathy, and coronary artery disease with lower use of specialist care. Multivariate analyses controlling for diabetes duration, demographic characteristics, health care practices, and physiological risk factors demonstrated that higher past use of specialist care was found to be significantly protective against the development of overt nephropathy (risk ratio 0.43, 95% CI 0.21-0.88) and neuropathy (0.54, 0.35-0.83) and weakly protective against coronary artery disease (0.65, 0.37-1.1). CONCLUSIONS: A higher proportion of diabetes duration spent in specialist care may result in delayed development of certain diabetes complications independent of other risk factors. This study thus supports the concept that the benefits of specialist care should be available to all patients with type 1 diabetes.

Adult↗

PubMed1998

Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. The Diabetes Control and Complications Trial Research Group.

BACKGROUND: Although insulin secretion is severely decreased in most patients with type 1 diabetes, levels of residual insulin secretion often vary early in the disease. The significance of residual insulin secretion with regard to metabolic control and to long-term complications and ways to preserve such secretion are not well understood. OBJECTIVE: To compare the effects of intensive and conventional therapy on residual insulin secretion in Diabetes Control and Complications Trial (DCCT) participants. DESIGN: Multicenter, randomized, controlled clinical trial. SETTING: 29 DCCT clinical centers. PATIENTS: 855 of the 1441 DCCT participants had had type 1 diabetes for 1 to 5 years at baseline. Of these 855 patients, 303 were C-peptide responders (C-peptide level, 0.20 to 0.50 pmol/mL after ingestion of a standardized, mixed meal); 138 of these patients were randomly assigned to intensive therapy, and 165 were assigned to conventional therapy. Five hundred fifty-two patients were nonresponders (stimulated C-peptide level < 0.2 pmol/mL); 274 of these patients were assigned to intensive therapy, and 278 were assigned to conventional therapy. INTERVENTIONS: 1) Intensive therapy with 3 or more insulin injections daily or continuous subcutaneous infusion of insulin, guided by 4 or more glucose tests per day or 2) conventional therapy with 1 or 2 insulin injections daily. MEASUREMENTS: Stimulated C-peptide level was measured annually in responders. Development of retinopathy and microalbuminuria was assessed annually, hemoglobin A1c levels were measured quarterly, and episodes of hypoglycemia were ascertained quarterly. RESULTS: Responders receiving intensive therapy maintained a higher stimulated C-peptide level and a lower likelihood of becoming nonresponders than did responders receiving conventional therapy (risk reduction, 57% [95% CI, 39% to 71%]; P < 0.001). As in the entire DCCT cohort, intensively treated responders had a reduced risk for retinopathy progression and development of microalbuminuria and a higher risk for severe hypoglycemia compared with conventionally treated responders. Among intensively treated patients, responders had a lower hemoglobin A1c value (P < 0.01), a 50% (95% CI, 12% to 72%) reduced risk for retinopathy progression, and a lower risk for severe hypoglycemia (risk reduction, 65% [CI, 53% to 74%]; P < 0.001) compared with nonresponders. CONCLUSIONS: Intensive therapy for type 1 diabetes helps sustain endogenous insulin secretion, which, in turn, is associated with better metabolic control and lower risk for hypoglycemia and chronic complications. These observations underscore the importance of initiating intensive diabetic management as early as safely possible after type 1 diabetes is diagnosed.

Adolescent↗

PubMed1991

Complications of foot surgery. Complications of anesthesia.

Anesthesia is a necessity when performing surgery. As with any component of the surgical task, there are complications associated with any of the various anesthetic agents and techniques. The most effective way to diminish a complication is through prevention. A detailed medical history and examination of the patient will alert the physician to possible hazards along the surgical path. Dialogue with the anesthesiologist to promote teamwork is always in the patient's best interest and can lower the complication rate.

Aged↗

PubMed1990

Oral complications of cancer therapies. Oral complications in the pediatric population.

A number of acute oral complications may be associated with cancer therapy in children, but the extent and duration of these complications, and the most effective management techniques. have not been well described. The few studies differ in design, making comparisons difficult. Well-controlled, prospective clinical studies are needed to define the most effective strategies for the management of acute oral complications in children. However, it is clear that dental intervention prior to cancer therapy is an important factor in the optimal preparation of the patient. During cancer therapy, intensive supervised oral preventive protocols appear to be of benefit to the child's oral health, overall comfort, and well-being. Furthermore, the prevention of oral infection may significantly reduce the morbidity associated with cancer therapy. Long-term preventive oral care may help prevent dental disease and infection in medically compromised children and contribute to improving the quality of life.

Antineoplastic Agents↗

PubMed1990

Oral complications of cancer therapies. Chronic dental complications.

Radiation therapy (RT) and chemotherapy have increased long-term survival with certain cancers. The use of dental investigation and treatment of chronic or delayed oral complications is developing. Altered dental root development, enamel opacities, hypocalcifications, periodontal problems, and a higher caries rate are seen in children treated with chemotherapy. The psychosocial implications of long-term survival on routine dental care are important. Prevention and treatment of long-term oral complications of radiation therapy are changing. Osteoradionecrosis remains complicated and devastating. Strategies that avoid post-RT extractions include caries prevention, oral hygiene measures, meticulous restorative dentistry, overdentures, and improved posts for endodontically treated teeth. Guidelines for post-RT extractions vary greatly. Pediatric patients who receive head and neck irradiation may have total arrest of tooth and jaw development within the portal. The dentist must be able to diagnose and treat the variety of alterations already identified and should engage in scholarly research to answer the questions that remain.

Antineoplastic Agents↗

PubMed1989

[Cesarean section and postoperative infectious-inflammatory complications. I. A new method for assessing the degree of risk of infectious-inflammatory complications].

After analysing the present practice and describing their experience in 111 caesarean sections, the authors present a new scoring test for evaluation of the degree of the risk from infectious inflammatory complications after caesarean section and implementation of selective antibiotic prophylaxis in accordance with the evaluation. An attempt is made to classify separate factors according to their significance for development of inflammatory complications during the post partial period. The results, schematized on table 1 and figure 1 in the article, illustrate the practical benefit from the test in the prophylaxis of infectious inflammatory complications after caesarean section.

Anti-Bacterial Agents↗

PubMed1995

[Complications in the intraperitoneal chemotherapy with the implantable intraperitoneal port and the strategy for the prevention of the complication].

Fifty-four patients with gastrointestinal carcinomas were treated with intraperitoneal chemotherapy through devices, and an implantable port system which had been used subcutaneously. The complications of the implantable ports were analysed in this study. There were 1 bowel perforation, 2 cases of retention of ascites, 2 infections, 2 inflow obstructions and 8 cases of pain, especially in the perineal or lower abdominal area. The number of patients requiring removal of the device due to complications were 7; 1 perforation, 2 ascites, 2 infections and 2 for pain. The strategy for reducing the complications due to the device were analysed as follows. A soft catheter should be selected. The catheter in the abdominal cavity should not be long, not as long as the tip of catheter touch the bottom of pelvic organs. Due care for kinking of the catheter should be taken in the implanting procedure. Antibiotics should be applied in and around the port. Steroids should be added to the solution for intraperitoneal chemotherapy.

Aged↗

PubMed2003

Risk factors influencing the outcome after surgical treatment of complicated deep sternal wound complications.

BACKGROUND: Median sternotomy is the most frequently used incision for cardiac procedures but carries a substantial risk for deep sternal wound infections and/or sternal dehiscence. In contrast to previous studies that examined risk factors for sternal infections this study evaluates factors that lead to poor outcome after surgical revision of the non healing sternum. METHODS: Between 1985 and 1999, 193 adults (mean age 64 +/- 9 years, m/f = 3/1) necessitated sternal revisions (incidence 1.93%). Pre-, intra- and post-operative risk factors were evaluated for their influence on the outcome after sternal revision. RESULTS: 65 of the 193 patients had a complicated course: ten (5.2%) died due to sepsis/multi organ failure (n = 6) or cardiac causes (n = 4). 32 patients (16.6%) needed several revisions, 17 (9%) were discharged with sternal instability, 5 (3%) with chronic fistula and one with persistent osteomyelitis. Univariate and multivariate analysis identified cardiopulmonary resuscitation (odds ratio (OR) = 11.188, p = 0.010), corticoid treatment (OR = 7.043, p = 0.0055), diabetes (OR = 4.130, p = 0.0128), smoking history (OR = 2.996, p = 0.0041), renal insufficiency (hazard ratio (HR) = 1.884), old age (OR = 1.108, p = 0.0266), high body mass (HR = 1.06), ECC time (p = 0.023), cross clamp time (p = 0.028), systemic hypothermia (p = 0.016), non-use of IMA (p = 0.042) or prolonged ventilation as risk factors for mortality or poor outcome. No correlation between sternal closure technique, mediastinal irrigation or antibiotic therapy and outcome after mediastinal revision could be found. CONCLUSIONS: To avoid disappointing results after sternal revision one should aim to preoperatively identify high-risk patients and aggressively address risk factors. This rather than modifications of the surgical and medical approach might improve the outcome of patients with mediastinal complications.

Age Factors↗

PubMed2001

[Major vascular and neural complications in varicose vein surgery. Prospective documentation of complication rate in surgery of the V. saphena magna and V. saphena parva].

The complication rate in varicose vein surgery has not been viewed separately for the sapheno-femoral and the saphenopopliteal junction. From 1.10.1988 to 31.12.99 we prospectively registered the major vascular and neural complication rate. A total of 31,838 ligations of the saphenofemoral junction and 6,152 ligations of the saphenopopliteal junction were performed. There were seven major vascular injuries (0.017%) and three major neural injuries (0.0074%). The specific risk at the saphenofemoral junction amounts to: major venous injury n = 4 (0.013%) without development of a postthrombotic syndrome (PTS); no arterial injury and no major neural injury. At the saphenopopliteal junction we found three major venous injuries (0.049%) with development of PTS in all cases. There were three major neural injuries (0.049%) with complete regeneration in two cases and one permanent paresis of digit V. Since operations on the saphenopopliteal junction show a higher risk of major vascular und major neural injury, flush ligation of the saphenopopliteal junction should not be forced in every case.

Adult↗

PubMed1983

Complications of vitreous surgery for diabetic retinopathy. II. Postoperative complications.

One hundred seventy-nine eyes were analyzed to determine the incidence of postoperative complications after vitrectomy for proliferative diabetic retinopathy. One hundred twenty-nine (72%) of the 179 eyes achieved improved vision, and 117 (65%) were considered visual successes with final vision in the functional range of 5/200 or better. Corneal epithelial defects occurred in 51 eyes (28%), but severe corneal complications were rare, and no eye developed corneal clouding as the sole cause of later visual loss. The lens was retained in 128 eyes (75%), and visually significant lens opacities occurred later in 17% of the phakic eyes. Postoperative iris neovascularization was reduced by not removing the lens, and rubeosis iridis occurred in 15 (13%) of 114 phakic eyes and in 21 (32%) of 65 aphakic eyes (P = 0.012). Vitreous hemorrhage was present in 75% of eyes immediately after surgery and cleared in an average of 6.2 weeks in phakic eyes and 5.4 weeks in aphakic eyes. Fifty-two eyes (29%) had recurrent vitreous hemorrhage after the initial postoperative period. New retinal detachment occurred after surgery in 16% of eyes and was treated successfully in 38%. Reoperations were done in 45 eyes (25%), and 32 (71%) of these were for repair of retinal detachment or removal of nonclearing vitreous hemorrhage. Six eyes (3%) developed phthisis bulbi, and one other eye was enucleated.

Adult↗

PubMed2006

Gender and elevated albumin excretion in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) cohort: role of central obesity.

BACKGROUND: Microalbuminuria (MA), a predictor of cardiovascular disease in subjects without diabetes and with type 2 diabetes, is more common in men than women in some studies. MA has been linked to central obesity-related traits, including increased waist-hip ratio (WHR), suggesting visceral adiposity might contribute to elevated albumin excretion rate (AER). These relationships have been examined less thoroughly in patients with type 1 diabetes. METHODS: We examined the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications database obtained 4 years after the end of the DCCT to determine whether sex was related to AER in patients with type 1 diabetes and how WHR, a surrogate for visceral adiposity, affected the sex-MA relationship. We fitted models with ln(AER) as the response, adjusted for age, hemoglobin A1c level, smoking status, diabetes duration, and blood pressure, plus WHR, body mass index (BMI), or sex, alone or in combination. RESULTS: Men had greater AERs. WHR was associated with AER, whereas neither sex nor BMI alone was associated with AER when adjusted for WHR. For women, but not men, AER was associated with waist circumference. CONCLUSION: Sex is associated with AER in patients with type 1 diabetes, a relationship accounted for by WHR, consistent with a role for visceral adiposity in this process. Whether this observation is caused by a direct effect of sex hormones on the kidney and WHR or the effect of sex hormones on body fat distribution leading to differences in AER remains to be determined.

Adult↗