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Results for “spatiotemporal coupling”

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At least 109 records · Page 6Linked to original sources
PubMed2003

Pallidotomy in Parkinson's disease improves single-joint, repetitive, ballistic movements, but fails to modify multijoint, repetitive, gestural movements.

We studied 12 non-demented PD patients in on state before and 3 months after posteroventral pallidotomy (PVP), in order to evaluate the effects of surgery upon an unconstrained, multijoint skilled movement as well as a single joint, repetitive, ballistic movement. A Selspot II System was used for three-dimensional data acquisition, processing and reconstruction of limb trajectories. Specific wrist kinematic features of spatial accuracy (linearity and planarity), temporal attributes (acceleration and velocity), spatiotemporal relationships (velocity-curvature coupling), and joint kinematic variables (relationships between wrist and elbow velocities and relative arm angle amplitudes) for each cycle of movement were graphically and numerically analysed. QMC was applied to single joint, repetitive, ballistic movements. QMC significantly improved after PVP (P < 0.0006). However, wrist as well as joint kinematic variables of the gestural movements failed to change significantly after PVP. The lack of improvement of the kinematic abnormalities of the gestural movement in PD patients would indicate that they are unrelated to the basic motor deficit; most likely they are the result of a disruption of a complex of sensorimotor integration processes due to abnormal parieto-frontal basal ganglia interaction.

Dyskinesias↗
PubMed2003

Head movements destabilize cyclical in-phase but not anti-phase homologous limb coordination in humans.

The present study addressed the role of head movements in the coordination of the homologous upper or lower limbs in supine normal subjects. Consistent with previous research, in-phase mirror symmetrical movements were performed more accurately and consistently than anti-phase movements. However, inclusion of head movements destabilized in-phase but not anti-phase homologous limb coordination, in contrast to previous work demonstrating a higher vulnerability of anti-phase than in-phase coordination to various experimental perturbations. It was observed that the head moved in the same direction as the limbs during anti- but not during in-phase coordination. Furthermore, the interlimb patterns also affected the head rotations that were lower in spatiotemporal consistency and less consistently coupled with the limbs during in-phase than during anti-phase coordination. These findings provide new insights into the coalition of egocentric and allocentric constraints during interlimb coordination.

Adult↗
PubMed2000

The coordination of bimanual prehension movements in a centrally deafferented patient.

Many everyday tasks require that we use our hands co-operatively, for example, when unscrewing a jar. For tasks where both hands are required to perform the same action, a common motor programme can be used. However, where each hand needs to perform a different action, some degree of independent control of each hand is required. We examined the coordination of bimanual movement kinematics in a female patient recovering from a cerebrovascular accident involving anterior regions of the parietal lobe of the right hemisphere, which resulted in a dense hemianaesthesia of her left arm. Our results indicate that unimanual movements executed by our patient using her non-sensate hand are relatively unimpaired. In contrast, during bimanual movements, reaches executed by our patient using her non-sensate hand show gross directional errors and spatiotemporal irregularities, including the inappropriate coupling of movement velocities. These data are discussed with reference to the role played by limb proprioception in the planning and control of prehension movements.

Aged↗
PubMed1990

Neurotrophic factors, their receptors, and the signal transduction pathways they activate.

Our studies of the spatiotemporal availability of neurotrophic factors, coupled with tagged ligand binding assays that identify cell bearing receptors for these factors, should lead toward defining the physiological roles of these molecules in the animal. The use of the tagged ligands to identify factor-responsive cell lines has also provided new model systems for the examination of ligand-receptor interactions, as well as for the study of the subsequent induction of intracellular response pathways. To obtain insights into such intracellular pathways, we have molecularly cloned genes encoding a family of serine-threonine protein kinases, most closely related to kinases involved in the yeast response to pheromones. These kinases may be crucial regulators of early steps in the response of mammalian cells to neurotrophic factors as well as other extracellular signals.

Amino Acid Sequence↗
PubMed2003

Propagating wave and irregular dynamics: spatiotemporal patterns of cholinergic theta oscillations in neocortex in vitro.

Neocortical "theta" oscillation (5-12 Hz) has been observed in animals and human subjects but little is known about how the oscillation is organized in the cortical intrinsic networks. Here we use voltage-sensitive dye and optical imaging to study a carbachol/bicuculline induced theta ( approximately 8 Hz) oscillation in rat neocortical slices. The imaging has large signal-to-noise ratio, allowing us to map the phase distribution over the neocortical tissue during the oscillation. The oscillation was organized as spontaneous epochs and each epoch was composed of a "first spike," a "regular" period (with relatively stable frequency and amplitude), and an "irregular" period (with variable frequency and amplitude) of oscillations. During each cycle of the regular oscillation, one wave of activation propagated horizontally (parallel to the cortical lamina) across the cortical section at a velocity of approximately 50 mm/s. Vertically the activity was synchronized through all cortical layers. This pattern of one propagating wave associated with one oscillation cycle was seen during all the regular cycles. The oscillation frequency varied noticeably at two neighboring horizontal locations (330 microm apart), suggesting that the oscillation is locally organized and each local oscillator is about </=300 microm wide horizontally. During irregular oscillations, the spatiotemporal patterns were complex and sometimes the vertical synchronization decomposed, suggesting a de-coupling among local oscillators. Our data suggested that neocortical theta oscillation is sustained by multiple local oscillators. The coupling regime among the oscillators may determine the spatiotemporal pattern and switching between propagating waves and irregular patterns.

Animals↗
PubMed2003

Hole-defect chaos in the one-dimensional complex Ginzburg-Landau equation.

We study the spatiotemporally chaotic dynamics of holes and defects in the one-dimensional (1D) complex Ginzburg-Landau equation (CGLE). We focus particularly on the self-disordering dynamics of holes and on the variation in defect profiles. By enforcing identical defect profiles and/or smooth plane wave backgrounds, we are able to sensitively probe the causes of the spatiotemporal chaos. We show that the coupling of the holes to a self-disordered background is the dominant mechanism. We analyze a lattice model for the 1D CGLE, incorporating this self-disordering. Despite its simplicity, we show that the model retains the essential spatiotemporally chaotic behavior of the full CGLE.

Journal Article↗
PubMed2003

Emergence of patterns in driven and in autonomous spatiotemporal systems.

The relationship between a driven extended system and an autonomous spatiotemporal system is investigated in the context of coupled map lattice models. Specifically, a locally coupled map lattice subjected to an external drive is compared to a coupled map system with similar local couplings plus a global interaction. It is shown that, under some conditions, the emergent patterns in both systems are analogous. Based on the knowledge of the dynamical responses of the driven lattice, we present a method that allows the prediction of parameter values for the emergence of ordered spatiotemporal patterns in a class of coupled map systems having local coupling and general forms of global interactions.

Journal Article↗
PubMed2004

Chimera states for coupled oscillators.

Arrays of identical oscillators can display a remarkable spatiotemporal pattern in which phase-locked oscillators coexist with drifting ones. Discovered two years ago, such "chimera states" are believed to be impossible for locally or globally coupled systems; they are peculiar to the intermediate case of nonlocal coupling. Here we present an exact solution for this state, for a ring of phase oscillators coupled by a cosine kernel. We show that the stable chimera state bifurcates from a spatially modulated drift state, and dies in a saddle-node bifurcation with an unstable chimera state.

Journal Article↗
PubMed2002

Turbulence in small-world networks.

The transition to turbulence via spatiotemporal intermittency is investigated in the context of coupled maps defined on small-world networks. The local dynamics is given by the Chaté-Manneville minimal map previously used in studies of spatiotemporal intermittency in ordered lattice. The critical boundary separating laminar and turbulent regimes is calculated on the parameter space of the system, given by the coupling strength and the rewiring probability of the network. Windows of relaminarization are present in some regions of the parameter space. New features arise in small-world networks; for instance, the character of the transition to turbulence changes from second-order to a first-order phase transition at some critical value of the rewiring probability. A linear relation characterizing the change in the order of the phase transition is found. The global quantity used as order parameter for the transition also exhibits nontrivial collective behavior for some values of the parameters. These models may describe several processes occurring in nonuniform media where the degree of disorder can be continuously varied through a parameter.

Journal Article↗
PubMed1999

Myotube heterogeneity in developing chick craniofacial skeletal muscles.

Avian skeletal muscles consist of myotubes that can be categorized according to contraction and fatigue properties, which are based largely on the types of myosins and metabolic enzymes present in the cells. Most mature muscles in the head are mixed, but they display a variety of ratios and distributions of fast and slow muscle cells. We examine the development of all head muscles in chick and quail embryos, using immunohistochemical assays that distinguish between fast and slow myosin heavy chain (MyHC) isoforms. Some muscles exhibit the mature spatial organization from the onset of primary myotube differentiation (e.g., jaw adductor complex). Many other muscles undergo substantial transformation during the transition from primary to secondary myogenesis, becoming mixed after having started as exclusively slow (e.g., oculorotatory, neck muscles) or fast (e.g., mandibular depressor) myotube populations. A few muscles are comprised exclusively of fast myotubes throughout their development and in the adult (e.g., the quail quadratus and pyramidalis muscles, chick stylohyoideus muscles). Most developing quail and chick head muscles exhibit identical fiber type composition; exceptions include the genioglossal (chick: initially slow, quail: mixed), quadratus and pyramidalis (chick: mixed, quail: fast), and stylohyoid (chick: fast, quail: mixed). The great diversity of spatial and temporal scenarios during myogenesis of head muscles exceeds that observed in the limbs and trunk, and these observations, coupled with the results of precursor mapping studies, make it unlikely that a lineage based model, in which individual myoblasts are restricted to fast or slow fates, is in operation. More likely, spatiotemporal patterning of muscle fiber types is coupled with the interactions that direct the movements of muscle precursors and subsequent segregation of individual muscles from common myogenic condensations. In the head, most of these events are facilitated by connective tissue precursors derived from the neural crest. Whether these influences act upon uncommitted, or biased but not restricted, myogenic mesenchymal cells remains to be tested.

Animals↗
PubMed2002

Technical aspects and utility of fMRI using BOLD and ASL.

Functional magnetic resonance imaging (fMRI) is an emerging methodology which provides various approaches to visualizing regional brain activity non-invasively. Although the exact mechanisms underlying the coupling between neural function and fMRI signal changes remain unclear, fMRI studies have been successful in confirming task-specific activation in a variety of brain regions, providing converging evidence for functional localization. In particular, fMRI methods based on blood oxygenation level dependent (BOLD) contrast and arterial spin labeling (ASL) perfusion contrast have enabled imaging of changes in blood oxygenation and cerebral blood flow (CBF). While BOLD contrast has been widely used as the surrogate marker for neural activation and can provide reliable information on the neuroanatomy underlying transient sensorimotor and cognitive functions, recent evidence suggests perfusion contrast is suitable for studying relatively long term effects on CBF both at rest or during activation. New developments in combining or simultaneously measuring the electrophysiological and fMRI signals allow a new class of studies that capitalize on dynamic imaging with high spatiotemporal resolution. This article reviews the biophysical bases and methodologies of fMRI and its applications to the clinical neurosciences, with emphasis on the spatiotemporal resolution of fMRI and its coupling with neurophysiology under both normal and pathophysiological conditions.

Brain Diseases↗
PubMed2000

Stochastic resonance and noise-enhanced order with spatiotemporal periodic signal

Stochastic resonance is investigated in a chain of coupled threshold elements driven by independent noises and a plane traveling wave. Both stochastic resonance in an individual element embedded in the chain, characterized by a maximum of the signal-to-noise ratio for nonzero noise intensity, and stochastic resonance with spatiotemporal signal, characterized by a maximum of the spatiotemporal input-output correlation function, are observed. For a wide range of wavelengths of the plane wave an optimum value of coupling exists for which both kinds of stochastic resonance are most pronounced, i.e., the phenomenon of array enhanced stochastic resonance is observed. For large wavelengths the enhancement of stochastic resonance coincides with a maximum of spatiotemporal synchronization among elements with the same phase of the periodic signal at inputs. This synchronization is a manifestation of spatiotemporal order induced in the system by the cooperative influence of noise and periodic signal.

Journal Article↗
PubMed2007

Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation.

The cortical hemodynamic response to somatosensory stimulus is investigated at the level of individual vascular compartments using both depth-resolved optical imaging and in-vivo two-photon microscopy. We utilize a new imaging and spatiotemporal analysis approach that exploits the different characteristic dynamics of responding arteries, arterioles, capillaries and veins to isolate their three-dimensional spatial extent within the cortex. This spatial delineation is validated using vascular casts. Temporal delineation is supported by in-vivo two-photon microscopy of the temporal dynamics and vascular mechanisms of the arteriolar and venous responses. Using these techniques we have been able to characterize the roles of the different vascular compartments in generating and controlling the hemodynamic response to somatosensory stimulus. We find that changes in arteriolar total hemoglobin concentration agree well with arteriolar dilation dynamics, which in turn correspond closely with changes in venous blood flow. For 4-s stimuli, we see only small changes in venous hemoglobin concentration, and do not detect measurable dilation or ballooning in the veins. Instead, we see significant evidence of capillary hyperemia. We compare our findings to historical observations of the composite hemodynamic response from other modalities including functional magnetic resonance imaging. Implications of our results are discussed with respect to mathematical models of cortical hemodynamics, and to current theories on the mechanisms underlying neurovascular coupling. We also conclude that our spatiotemporal analysis approach is capable of isolating and localizing signals from the capillary bed local to neuronal activation, and holds promise for improving the specificity of other hemodynamic imaging modalities.

Animals↗
PubMed2001

Phase-locked spatial domains and Bloch domain walls in type-II optical parametric oscillators.

We study the role of transverse spatial degrees of freedom in the dynamics of signal-idler phase locked states in type-II optical parametric oscillators. Phase locking stems from signal-idler polarization coupling which arises if the cavity birefringence and/or dichroism is not matched to the nonlinear crystal birefringence. Spontaneous Bloch domain wall formation is observed numerically and the dynamics and chiral properties of the fronts are investigated. Bloch walls connect homogeneous regions of self-phase-locked solutions by means of a polarization transformation. The parameter range for phase locking is found analytically. The polarization properties and the dynamics of walls in one and two transverse spatial dimensions are explained. The transition from Bloch to Ising walls is characterized, the control parameter being the linear coupling strength. The wall dynamics governs spatiotemporal dynamical states of the system, which include transient curvature driven domain growth, persistent dynamics dominated by spiraling defects for Bloch walls, and labyrinthine pattern formation for Ising walls.

Journal Article↗
PubMed2004

Simulations of ion transport in a collisional radio-frequency plasma sheath.

A hybrid theoretical model, capable of describing the characteristics of a collisional sheath driven by a sinusoidal current source and determining the energy and angular distributions of ions incident onto the substrate, is proposed. The model consists of one-dimensional time-dependent fluid equations coupled with the Poisson equation determining spatiotemporal evolution of the sheath and the Monte Carlo simulation predicting the energy and angular distributions of ions striking the electrode, in which charge-exchange collisions between ions and neutrals are included. Additionally, an equivalent circuit model in conjunction with the fluid equations is adopted to self-consistently determine the relationship between the instantaneous potential at a rf-biased electrode and the sheath thickness. It is found that the collisional effects would influence the height of the energy peaks in the ion energy distributions and the ion angular distributions.

Journal Article↗
PubMed2005

Generalized synchronization in coupled Ginzburg-Landau equations and mechanisms of its arising.

Generalized chaotic synchronization regime is observed in the unidirectionally coupled one-dimensional Ginzburg-Landau equations. The mechanism resulting in the generalized synchronization regime arising in the coupled spatially extended chaotic systems demonstrating spatiotemporal chaotic oscillations has been described. The cause of the generalized synchronization occurrence is studied with the help of the modified Ginzburg-Landau equation with additional dissipation.

Journal Article↗
PubMed2006

Synchronization and symmetry breaking in mutually coupled fiber lasers.

We experimentally study the synchronization and the emergence of leader-follower dynamics in two time-delayed mutually coupled fiber ring lasers. We utilize spatiotemporal representations of time series to establish the roles of leader and follower in the synchronized dynamics.

Journal Article↗