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PubMed2006

Predicting compulsive Internet use: it's all about sex!

The objective of this research was to assess the predictive power of various Internet applications on the development of compulsive Internet use (CIU). The study has a two-wave longitudinal design with an interval of 1 year. The first measurement contained 447 adult heavy Internet users who used the Internet at least 16 h per week and had Internet access at home for at least 1 year. For the second measurement, all participants were invited again, of whom 229 responded. By means of an online questionnaire, the respondents were asked about the time spent on various Internet applications and CIU. On a cross-sectional basis, gaming and erotica seem the most important Internet applications related to CIU. On a longitudinal basis, spending a lot of time on erotica predicted an increase in CIU 1 year later. The addictive potential of the different applications varies; erotica appears to have the highest potential.

Adolescent↗
PubMed2001

How does stress increase risk of drug abuse and relapse?

RATIONALE: The notion that stress leads to drug abuse in vulnerable individuals and relapse in addicts is not new. Most major theories of addiction postulate that stress plays an important role in increasing drug use and relapse. Several animal studies and some human laboratory studies have shown that stress exposure enhances drug self-administration. Although clinical observations suggest that exposure to stress increases drug use, and are associated with craving and relapse in addicts, human research in this area is largely correlational and at times contradictory. OBJECTIVE: Given the growing preclinical evidence that supports the key role of stress in substance abuse, careful examination of this research area in humans is warranted. This paper examines empirical evidence on how stress may increase the vulnerability to drug abuse, and explores whether chronic drug abuse alters the stress response and coping in addicts, thereby increasing the likelihood of drug seeking and relapse. Unanswered questions on the association between stress and substance abuse in humans are identified. CONCLUSION: Preclinical research has shown that stress, in addition to drug itself, plays a key role in perpetuating drug abuse and relapse. However, the mechanisms underlying this association in humans remain unclear. A greater understanding of how stress may perpetuate drug abuse will likely have a significant impact on both prevention and treatment development in the field of addiction.

Adaptation, Biological↗
PubMed2004

Impulsiveness, locus of control, motivation and problem gambling.

A questionnaire consisting of demographic items, questions about gambling behavior, the South Oaks Gambling Screen (SOGS), a depression inventory, the Eysenck Impulsiveness Questionnaire, Levenson's Internality, Powerful Others and Chance Scales of locus of control and the Gambling Motivation Scale, was completed by a non-random sample of 147 New Zealand university students who gambled for money, median age 24 years. Approximately 17 of the sample was classified as problem gamblers, the rest as non-problem gamblers. Multivariate analysis of variance showed that there were significant differences between problem and non-problem gamblers on gambling frequency, number of activities, parents' gambling, depression, impulsiveness and motivation, but not on locus of control. Amotivation (apathy) and motivation towards stimulation correlated with powerful others and chance locus of control, and motivation to impress others with powerful others locus of control. Hierarchical regression analysis showed that: (1) beyond gambling frequency, number of activities and parents' gambling, motivation explained a substantial proportion of variance in SOGS scores, with impulsiveness accounting for a lesser amount, and (2) predictors of problem gambling included impulsiveness, amotivation and the motivations for accomplishment and tension release. It was concluded that gambling motivation is a more useful construct than locus of control in explaining problem gambling. Suggestions were made for future research, and aspects of gambling motivation were discussed in terms of a treatment program with groups of problem gamblers.

Adaptation, Psychological↗
PubMed2007

Temperament and character in pathological gambling.

OBJECTIVE: We have studied temperament and character in pathological gambling (PG). METHODS: Thirty-eight DSM-IV verified pathological gamblers (31 males and 7 females; mean age 35.4 +/- 10.4 years) were tested with Cloninger's Temperament and Character Inventory (TCI). Matched controls were chosen from the normal population. RESULTS: Pathological gamblers scored higher on the temperament factors novelty seeking (NS) and harm avoidance (HA). The most pronounced difference was found in the character factor self-directedness (SD). The pathological gamblers differed from controls in cooperativeness and self-transcendence. A personality disorder was found in 29% of the pathological gamblers 84% of whom scored either low on SD and high on impulsivity or had a more dishonest behaviour. Two-thirds of pathological gamblers showed immature character with or without high HA in temperament. The other third showed normal-character extravagant behaviour (86%), high impulsivity (36%) and less responsibility (50%) being the most common personality traits. CONCLUSION: HA and NS might be trait-like characteristics in PG.

Adult↗
PubMedDate not supplied

Is there a general tendency to become addicted?

The tendency to become addicted across a number of different substances or activities was determined for a sample of 573 subjects, including college students and their parents. Four components of addiction were defined: craving, tolerance, withdrawal and lack of control. Subjects rated the extent to which each of these components characterized their relationships to each of ten substance/activities: coffee, tea, cola beverages, favorite alcoholic beverage, chocolate, nonchocolate sweets, hot chili pepper on food, cigarettes, gambling and video games. An "addiction score" was computed for each subject and each substance/activity, by summing the scores on the four components. Correlations in addiction scores for almost all activities were positive, but low (between 0 and .30), with the exception of chocolate and nonchocolate sweets, where the correlation was higher. The results suggest, at best, a weak tendency to become addicted, across a wide range of substances or activities. Other explanations for the low positive correlations are available, besides the notion of a general tendency to become addicted. There were a few significant mother-father correlations in various addiction scores, but none between mid-parent and child values. Three of the four components of addiction (craving, lack of control and withdrawal), were highly correlated. We conclude that there is little basis for the assumption of a general tendency to become addicted, a conclusion which casts doubt on the derivative notion of an addictive personality.

Adolescent↗
PubMedDate not supplied

The effect of type A personality on physiological arousal while playing computer games.

Despite the widespread use of computer games, there is a lack of systematic research in the area--particularly on their "addictiveness" potential. Anecdotal evidence suggests that computer game addiction may be due to arousal properties of computer games, although other factors may be important. This study examined the relationship between Type A personality and arousal in computer-game play. It was hypothesised that, during computer-game play, Type A and Type B subjects would have significantly higher heart rates as compared with baseline levels and that Type A subjects would experience a significantly greater increase in arousal when playing a computer game than Type B subjects. These hypotheses were both supported and the results are discussed in relation to arousal, personality, and addiction.

Adult↗
PubMed2006

The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats.

We recently reported that systemic injections of the mGluR(2/3) agonist LY379268, which decreases evoked glutamate release, attenuate context- and discrete cue-induced reinstatement of heroin seeking, but not heroin self-administration. Here, we report that systemic injections of LY379268 attenuate context- and discrete cue-induced reinstatement of sucrose seeking, but not sucrose self-administration. These results suggest that similar neuronal mechanisms mediate cue-induced relapse to opiate- and palatable food seeking.

Amino Acids↗
PubMed2006

Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behavior.

It has been proposed that some neuroadaptations that underlie behavioral sensitization may play a role in the development and persistence of addiction. However, whether or not sensitization facilitates the development of symptoms specific to addiction, such as the escalation of drug intake, is not known. We examined, therefore, the effect of pretreatment with a sensitizing regimen of amphetamine on the escalation of subsequent drug intake in rats given the opportunity to self-administer cocaine. Amphetamine pretreatment produced psychomotor sensitization and also accelerated the subsequent escalation of cocaine intake. This suggests that the neural circuits that are altered as a consequence of repeated amphetamine treatment, and the induction of sensitization, may overlap with those responsible for the development of some addiction-like behaviors.

Amphetamine↗
PubMed2004

Saturation of tobacco smoking models and risk of alcohol and tobacco use among adolescents.

PURPOSE: To examine how saturation of an adolescent's environment with models of cigarette smoking (e.g., parents, siblings, friends) affects the probability of tobacco and alcohol use among junior high and high school students. METHODS: The Health and Smoking Questionnaire was administered to 806 adolescents (182 smokers and 624 nonsmokers; 57.2% female) average age of 15.1 years (SD = 1.6) in a mid-size Midwestern town. The questionnaire contains standardized items in five domains: demographics, smoking status and history, perceptions of risk and risk reduction, risk factors for tobacco use, and parenting style. RESULTS: Risk for smoking or using alcohol increased dramatically as the number of models who smoke increased in an adolescent's environment. For instance, adolescents with one significant other who smoked were nearly four times (OR = 3.76, p <.001) more likely to smoke than someone with no significant others who smoked. However, if an adolescent had four significant others who smoked, they were over 160 times more likely to smoke (OR = 161.25, p <.001). Similar results were found for alcohol use; adolescents who had one significant other who smoked were more than 2.5 (OR = 2.66, p <.001) times more likely to drink than those without smoking models. Adolescents who had four significant other smoking models were 13 times (OR = 13.08, p <.001) more likely to drink. CONCLUSIONS: As the number of cigarette smokers in an adolescent's environment increases, risk of tobacco and alcohol use increases substantially. These data suggest that multiple models of tobacco use will substantially increase risk for substance use in adolescents.

Adolescent↗
PubMed2005

Addiction and the treatment of pain.

Persons experiencing pain, whether acute or chronic, seek and deserve relief from their discomfort and loss of function. However, opioid analgesics have the capacity to induce tolerance, physical dependence, and addiction. Furthermore, persons with a history of opioid use disorders or other substance misuse problems are at "high risk" when they acquire painful conditions requiring aggressive treatment. Prescription of opioids could trigger a relapse to the original drug of choice or could initiate a new bout of addiction with the prescribed drug. This article explores the relationship between addiction and pain, including signs of developing addiction and approaches to managing pain in those with addiction.

Acute Disease↗
PubMed2002

The California Tobacco Control Program and potential harm reduction through reduced cigarette consumption in continuing smokers.

Harm reduction for continuing smokers has been suggested as a public health priority. We evaluated whether tobacco control programs might reduce cigarette consumption among current smokers through strategies aimed primarily at protecting nonsmokers from secondhand smoke (SHS). Data were from adult (18+ years) respondents to multiple (1990, 1992, 1996, 1999), large, cross-sectional, population-based surveys of smoking behavior, conducted to evaluate the California Tobacco Control Program. Adult daily smoking prevalence decreased from 15.9 +/-0.4%(+/-95% confidence interval) of the California adult population in 1990 to 13.0 +/-0.3% in 1999. Concurrently, moderate-to-heavy daily smoking (>or= 15 cigarettes/day) decreased from 10.3 +/-0.4% in 1990 to 7.4 +/-0.3% in 1999, and heavy daily smoking (>or= 25 cigarettes/day) from 3.4 +/- 0.2% in 1990 to 1.9 +/- 0.1% in 1999. Decreased daily smoking was observed in all demographic subgroups except young adults. Among college graduates, the daily smoking prevalence in 1999 was 6.4 +/- 0.4%, a level previously observed only among U.S. physicians. In 1999, nearly 30% of current smokers did not smoke daily, and more than 60% said they now smoked less than previously. In 1999, self-reported cigarette consumption was inversely related to believing SHS is harmful to nonsmokers, having a smoke-free workplace, and living in a smoke-free home. In California, tobacco control strategies that educated the population about SHS and resulted in smoking restrictions may have led continuing smokers to smoke less, which should reduce the harm from smoking to the public health in the long term.

Adolescent↗
PubMed2004

Internet addiction: characteristics of a questionnaire and prevalence in Norwegian youth (12-18 years).

The use of the Internet has increased considerably during the last few years, and there are also some clinical observations that some people 'get hooked', and develop an Internet addiction. An epidemiological study was performed in a representative sample of the Norwegian youth population (N= 3,237; response rate 45.2%). The proportion not using Internet was only 4.9%, while 35.8% were non-frequent users, and 49.6% (1,591) were frequent (weekly) users. They used the Internet on the mean 4.3 hours a week. A mean of 1.98% (boys 2.42%, girls 1.51%) could be described as having an 'Internet addiction' according to the criteria in the Diagnostic Questionnaire of Young (1998), and an additional 8.68% (in sum 10.66) were considered to have an at-risk Internet use (boys 9.21%, girls 8.13%). If these proportions were calculated on individuals who used the Internet frequently, 4.02% fulfilled 5 criteria, and an additional 17.66% 3-4 criteria, giving quite high figures of problematic Internet use (in sum 21.68). The different diagnostic criteria gave a broad range of affirmative answers (from 0.4% to 27.9%). The results have important implications for further studies of prevalence, implementation of preventive measures, and the development of treatment approaches for Internet addiction.

Adolescent↗
PubMed1998

Transition from moderate to excessive drug intake: change in hedonic set point.

Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour of access per session, drug intake remained low and stable. In contrast, with 6 hours of access, drug intake gradually escalated over days. After escalation, drug consumption was characterized by an increased early drug loading and an upward shift in the cocaine dose-response function, suggesting an increase in hedonic set point. After 1 month of abstinence, escalation of cocaine intake was reinstated to a higher level than before. These findings may provide an animal model for studying the development of excessive drug intake and the basis of addiction.

Animals↗