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At least 1,081 records · Page 60Linked to original sources
PubMed1991

Management of oral mucositis during local radiation and systemic chemotherapy: a study of 98 patients.

Oral mucositis is among the complications of head and neck irradiation and systemic chemotherapy. To determine whether or not mucositis could be prevented or reduced in intensity by using Kamillosan Liquidum as an oral rinse, 98 patients were placed on study protocols. Twenty patients who were treated with radiation therapy and 46 patients who received systemic chemotherapy participated in prophylactic oral care with Kamillosan oral rinse. Thirty-two patients were treated therapeutically after mucositis had developed. Sixteen patients receiving chemotherapy were treated therapeutically and prophylactically with Kamillosan oral rinse during repeated cycles of chemotherapy. Only one of the 20 patients who had had radiation therapy developed grade 3 mucositis in the final week of treatment. Thirty-six of the 46 patients undergoing chemotherapy did not develop clinically noticeable mucositis. It appears that resolution of mucositis is accelerated by Kamillosan rinse. Prophylactic oral care appeared to modify the oral environment favorably and maintain tissue integrity.

Adult↗
PubMed1991

Gingival enhancement in fixed prosthodontics. Part III: Anamnestic findings.

This study obtained anamnestic data from a questionnaire given at the conclusion of a 7-week chlorhexidine gingival enhancement study regarding patients' oral hygiene practices, perception of change in gingival health, and side effects. In the patient population using the 7-week chlorhexidine treatment regimen, most patients noticed an improvement in gingival health, were willing to continue usage after the study, and would recommend the rinse to others. Of the patients who reported side effects, taste alteration was more objectionable than staining. The patients' observed gingival health benefits were more important than the patients' perception of the side effects such as staining and taste alteration.

Adult↗
PubMed1991

In vivo antifungal efficacy of salivary histidine-rich polypeptides: preliminary findings in a denture stomatitis model system.

Six denture stomatitis patients, all found to have Candida albicans on their maxillary denture and palatal tissue surfaces, volunteered in this preliminary study to test the in vivo efficacy of human salivary antifungal histidine-rich polypeptides (HRPs) in treating their oral disease. The patients were equally divided among the Newton types classification and, as expected, the severity of the inflammation was greatest in the Newton type III patients and least in the Newton type I patients. Patients received sterile solutions of either HRP-3 or HRP-4, which they used both as a mouthrinse and as a denture soak for a period of 1 week. Agar replicas of the tissue-fitting surface of the maxillary dentures revealed HRP reduction and/or elimination of C. albicans from the denture; in one Newton type II individual, this finding directly correlated with a site-specific reduction in palatal inflammation. In the Newton type II and type III individuals alike, there was a significant generalized decrease in inflammation suggesting the therapeutic efficacy of the HRPs. Killing of this yeast species by the HRPs, as determined by scanning electron microscopy (SEM), was probably responsible for the observed clinical benefits noted in this investigation. In the SEM, HRP-treated blastospores appeared severely deflated, as if they had been emptied of significant quantities of intracellular material.

Candida albicans↗
PubMed1992

Assessment of antimicrobial treatment of denture stomatitis using an in vivo replica model system: therapeutic efficacy of an oral rinse.

Five denture stomatitis patients demonstrating Candida albicans on both maxillary dentures and palates volunteered to test the effects of Peridex oral rinse in treating their oral disease. They used Peridex rinse both as a mouthrinse and as a denture soak for a period of 24 days. Agar replicas of the tissue-fitting surfaces of the maxillary dentures revealed elimination of C. albicans. Significant decreases in palatal inflammation were also noted, although some inflammation was still evident. Several weeks after the termination of Peridex oral rinses, inflammation increased as concentrations of C. albicans on the denture surface returned to pretreatment levels. A marked similarity in the site-specific localization of this yeast species on the denture was noted before and after Peridex rinse treatment.

Acrylic Resins↗
PubMed1975

Migratory glossitis. A clinical-histologic review of seventy cases.

The observations on seventy patients with migratory glossitis and follow-up experiences over a period of 10 years are recorded. Women represented 65.7 per cent of the total, and most cases occurred in patients over 40 years of age. In 20 per cent of the patients other anomalies of the tongue were associated, and in 20 per cent subjective complaints were associated with psychic stress. Histologic investigations showed an inflammatory reaction of the epithelium and of the underlying connective tissue. The patient must be reassured of the benign nature of the tongue lesion. At follow-up examination, the lesions were present but no malignant change was observed.

Acridines↗
PubMed1977

Rationalization of electric pulp-testing methods.

A new electric pulp-testing system, the Testark, was developed in order to assess the potential of a different way of testing pulp sensitivity, thus making this electric pulp test more dependable than the conventional electric pulp-testing method. A study was conducted to evaluate the potential of the Testark system in comparison with a commercially available pulp tester. This pilot study consisted of application of three different desensitizing agents (sodium fluoride, test product. 'A', and test product 'B') to the cervical areas of hypersensitive teeth. The results were recorded with both the Testark and the conventional pulp tester simultaneously, and the sodium fluoride and test product 'B' proved to yield a beneficial effect by desensitizing the teeth after a single application. The level of desensitization with these agents was higher than the level obtained with the test product 'A' paste, which was utilized daily for 14 days. The results obtained with the conventional pulp tester differed by way of interpretation from those obtained with the Testark system. The Testark system proved to be easy to use and highly accurate in the data readings because of its high resolution. The Testark systemwas found to be more dependable than the commerical pulp tester, since it reduced the subjective errors which are inevitable when a commerical pulp tester is used. The Testark system is being developed further, and more studies are being conducted at the present time, in order to assess the full potential of the instrument.

Adult↗
PubMed1977

The effect of chlorhexidine mouth rinses on oral Candida in a group of leukemic patients.

Eighteen leukemic patients were examined for the presence of Candida albicans in the oral cavity. Fifteen patients were found to be Candida "carriers." Nine of the patients were put on a chlorhexidine mouth rinse regimen. Although chlorhexidine was clearly fungicidal in vitro, no decrease in Candida titer was obtained with the mouth rinse. The ineffectiveness of the drug in vivo might be due to the specific location of Candida organisms in the oral mucosa.

Biguanides↗