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PubMed1984

[Bacteriological and architectural studies of infected stones].

The stones associated with urinary tract infection were cultured using a method to distinguish between surface contamination and bacteria within the stone. Twenty three of 30 stones (77%) were infected mainly by Proteus mirabilis or Pseudomonas aeruginosa and most were composed of struvite and/or apatite. Most oxalate and uric acid stones were sterile; occasionally the stones with positive culture had a non-urea-splitting bacteria and these were thought to have been infected secondarily. Some infected stones were studied by light microscopy scanning election microscopy and transmission electron microscopy. We found many rods in the interstices of crystals of struvite and apatite extensively from the nucleus to peripheral layers. These findings are important in the prevention and treatment of infection stones.

Adolescent↗
PubMed1984

Evaluation of a calculolytic diet in female dogs with induced struvite urolithiasis.

The calculolytic effect of a diet designed to reduce the urine concentration of urea, P, and Mg was evaluated in female Beagles with induced urease-positive urinary tract infections and struvite urolithiasis and in female Beagles with induced sterile struvite urolithiasis. The reduced-protein calculolytic diet induced urolith dissolution in 5 of 6 infected dogs with struvite urolithiasis in 2 to 5 months (means = 14.4 weeks). At the end of 6 months, uroliths in comparable control dogs fed a maintenance diet were 5 times larger and 14 times heavier than at the beginning of the study. The calculolytic diet induced urolith dissolution in 6 of 6 noninfected dogs with struvite uroliths in 2 to 4 weeks (means = 3.3 weeks). Four uroliths in noninfected dogs fed the maintenance diet dissolved over a period of 2 to 5 months (means = 14 weeks). Urolith dissolution in dogs fed the calculolytic diet was associated with diet-induced diuresis, reduction in urine pH, reduction in urine concentration of urea ammonia, P, and Mg, and increase in urine titratable acidity. Consumption of the calculolytic diet was also associated with significant (P = less than 0.01) reduction in the serum concentration of urea and albumin and a significant (P = less than 0.01) increase in serum hepatic alkaline phosphatase activity. Concomitant occurrence of hydropic degeneration of hepatocytes indicated that these biochemical and morphologic changes were associated with dietary protein restriction.

Animals↗
PubMed1984

Infrared spectroscopic studies of renal stones.

The chemical composition of 125 urinary stones was determined by means of an infrared spectrophotometric method using the potassium bromide pellet technique. Statistical combinations regarding the chemical composition of the stones are discussed and compared with the findings of other workers. Calcium oxalate was the commonest component of pure as well as mixed stones.

Apatites↗
PubMed1984

Qualitative and quantitative analysis of uroliths in dogs: definitive determination of chemical type.

Effective treatment and prevention of urolithiasis depends on accurate determination of the chemical nature of the uroliths. A widely used qualitative chemical procedure was compared with quantitative crystallographic analysis of 272 canine uroliths. Agreement between the 2 methods was 78%. Qualitative analysis failed to detect 62% of calcium-containing uroliths and 83% of carbonate apatite uroliths. Qualitative analysis gave false-positive results for urates in 55% of cystine uroliths. Mixed uroliths comprising 6% of the total could not be classified without quantitative analysis. Silicate, cystine, and urate uroliths generally were of pure composition. Crystallographic analysis indicated the following distribution of major types: struvite, 69%; calcium oxalate, 10%; urate, 7%; silicate, 3.5%; cystine, 3.2%; calcium phosphate, 1%; and mixed, 6%. Among dogs with struvite uroliths, 66% had positive results of bacterial culturing from the urinary bladder. Six breeds (Miniature Schnauzer, Welsh Corgi, Lhasa Apso, Yorkshire Terrier, Pekingese, and Pug) had a significantly higher risk for urolithiasis, compared with other breeds. The German Shepherd Dog had a significantly lowered risk, compared with other breeds. Two breeds had significant relationship to a specific type of urolith: Miniature Schnauzer for oxalate, and Dalmatian for urate (P less than 0.001). It was concluded that quantitative analysis, using crystallography, was superior for the detection of calcium oxalate, carbonate apatite, cystine, urate, and mixed uroliths.

Animals↗
PubMed1984

[Structural studies of infection stones: structure of the nuclei].

The composition and structure of nuclei of infection stones were investigated. Twenty seven out of 40 renal stones were found to contain struvite and/or carbonate apatite in the nuclei as well as peripheral layers, and 13 contained calcium oxalate. Some bladder stones also contained different substances in the nuclei. In some infection stones whose architecture was studied in thin section and with scanning electron microscopy, we found large numbers of bacteria in the nuclei composed of struvite and/or apatite. Though we could find no bacteria within the nuclear parts composed of oxalate, we found them in apatite layers outside the nuclei. Urea-splitting bacteria are suggested to participate both in the initial formation of struvite stones and in the diversion of oxalate stones into phosphate stones. Such bacteria may play important roles in stone formation, not only as promotors of crystallization of struvite and apatite but also as a component such as of an organic matrix.

Calcium Oxalate↗
PubMed1984

Stone composition and metabolic study in urinary calculous disease.

A series of 178 urinary stones is analysed qualitatively during a three year period from 1980 to 1982. The majority (96%) of stones orginate from the upper tract. Calcium oxalate stones are the commonest entity seen in the western countries but less than 20% of such stones occur locally. A large proportion consists of mixed stones and one third are infective as triple phosphate is present. 20% contain urate as a constituent whereas relatively pure urate stones constitute 4%. The true incidence of pure urate stones is higher (about 10%) as we have been dissolving them with alkalinisation of urine without surgery. Idiopathic hypercalciura occurs in 11.8% and none has persistent hypercalcaemia. Hyperuricosuria which is commoner, occurs in 24% of patients. It is important to identify this group as it results in the formation of metabolically active stones, and they can be treated with allopurinol to prevent recurrence of stones.

Adult↗
PubMed1984

[Experimental magnesium ammonium phosphate lithiasis induced by Ureaplasma in the rat].

Struvite urinary stones are commonly associated with infections by urease possessing bacteria (Proteus). Ureaplasma urealyticum, a genital mycoplasma, is predominantly located in the human genito-urinary tract and produces urease. Its possible role in the formation of infection stones was studied in the rat model described by Friedlander and Braude. Struvite bladder stones were produced in 60% of Sprague-Dawley male rats after infection of ureaplasmas (serotype 1, 2, 3, 7) into the renal medulla. Mycoplasma hominis, another genital mycoplasma, produced bladder stones in only 10% of animals. A kinetic study showed that pure struvite stones appeared into the bladder 4 to 5 days after inoculation and that U. urealyticum did not usually remain viable more than 6 days. Acetohydroxamic acid and doxycycline prevented the formation of the stones.

Animals↗
PubMed1984

[Comparative bacteriological and chemical analysis of kidney calculi. Apropos of 135 cases].

The formation of some urinary tract stones (struvite stones) is known to be related to infection by urease-possessing microorganisms, such as Proteus sp. and some other bacteria. Ureaplasma urealyticum, a genital mycoplasma, contains also urease and is predominantly located in the urogenital tract. Its significance in the production of human urinary stones has not yet been elucidated. In this study, 135 human calculi obtained by surgery were analysed chemically and were cultured for the presence of conventional bacteria and U. urealyticum, 51 were ammonium magnesium phosphate stones and contained Proteus (27), E. coli (4), Staphylococcus epidermidis (3), Streptococcus D (2), Pseudomonas aeruginosa (1), Staphylococcus aureus (1), Corynebacterium (1), Candida albicans (1). U. urealyticum was isolated in one patient, from two different calculi (left and right) taken after an interval of fifteen days. Different bacteria were isolated from other calculi (oxalate, uric acid). This findings suggest that Ureaplasma urealyticum should be looked for in struvite calculi.

Bacteria↗