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Results for “PASTEURELLA INFECTIONS”

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PubMedDate not supplied

Serologic associations between fowl cholera and other diseases.

As part of a case-control study designed to identify fowl cholera risk factors, 2087 blood samples were collected from 71 California meat-turkey flocks. Samples were tested for antibodies to three mycoplasmas and four viruses pathogenic for turkeys. Flocks that had antibodies to Newcastle disease virus and/or Mycoplasma meleagridis had an increased risk of having an outbreak of fowl cholera. This information should prove useful for fowl cholera control programs in meat turkeys.

Animals↗
PubMed1986

Assessment of immunity to Pasteurella haemolytica in sheep by in vitro methods.

The sera of conventionally-reared sheep which had been experimentally infected with Pasteurella haemolytica serotype A2 and Mycoplasma ovipneumoniae were compared with those of animals from the same source which had been vaccinated 3 times with an alhydrogel-adsorbed mixture of cell-wall extract and heat-killed cells of P. haemolytica A2 emulsified in Freund's incomplete adjuvant. Both groups of animals had high titres of anti-P. haemolytica A2 IgG by ELISA, high opsonic indices in a phagocytic assay involving ovine lung macrophages, and reacted with a large number of cell-wall antigens in an immunoblot test. Both types of sera also protected mice against challenge with P. haemolytica A2 in mucin. In contrast, sera from animals injected twice with a vaccine similar to the first but lacking oil adjuvant yielded much lower values in the ELISA, opsonic index and immunoblotting assays, and failed to protect mice against challenge. The correlations between the 3 in vitro tests and the passive protection test in mice suggest that evaluation of the efficacy of P. haemolytica vaccines may be possible by in vitro methods alone.

Animals↗
PubMed1981

Effects of nitric oxide on resistance to bacterial infection in mice.

Continuous exposure to 2 ppm nitric oxide (NO) for as long as 4 wk did not reduce the resistance of male mice to infection by aerosol inoculation with Pasteurella multocida. In contrast, mortality was slightly enhanced and survival shortened in NO-exposed compared to control female mice; however, the importance of these small differences is uncertain. These results suggest only that male and female mice did not react similarly to the infectious challenge after exposure to NO.

Animals↗
PubMed1999

Detection of low-virulent classical swine fever virus in blood of experimentally infected animals: comparison of different methods.

The effectiveness of virus isolation, commercial antigen enzyme-linked immunosorbent assay (ELISA), reverse transcriptase-polymerase chain reaction (RT-PCR), and flow cytometry in detection of a low-virulent classical swine fever virus (CSFV) in blood in the early period of infection was evaluated. Domestic pigs at the age of 6-8 weeks and young wild boars were inoculated with a low-virulent field isolate of CSFV originating from a wild boar. This virus induced serious clinical reaction in only one pig which was naturally infected with Pasteurella multocida. Nine of 13 infected domestic pigs showed viremia. All infected weanling pigs were found viraemic by virus isolation on day 6 post infection (p.i.) but virus-free by RT-PCR. The flow cytometry was apparently not as sensitive as the virus isolation. Two young wild boars infected with the virus were viremic only for the first 2 days p.i. Virus isolation and RT-PCR were of similar sensitivity. Three different commercial antigen ELISAs used were not able to detect viral antigen in any animal.

Animals↗
PubMed1997

[LPS receptor expression and lps binding capacity of monocytes and macrophages in swine].

The expression of the lipopolysaccharide (LPS) receptor CD14, being of importance for an effective immune response, and the direct measurable binding of LPS molecules by alveolar macrophages (AM), peritoneal macrophages (PM) and peripheral blood mononuclear cells (PBMC) of swine were determined. Additionally, the influence of an experimental intrabronchial infection with Pasteurella multocida on these parameters was investigated. Whereas the AM and the PM differed only negligibly regarding their share of CD14 bearing and LPS binding cells, in contrast to AM the intensity of the LPS-binding of PM was significantly higher. Among the PBMC, two populations could be detected which expressed the CD14 with different intensity, whereas the LPS-binding of both populations was similarly pronounced. Following infection of the animals, AM showed an unchanged percentage of CD14 positive cells and simultaneously an increased CD14 receptor expression. On the other hand, the percentage of the LPS-binding cells rose, while no changes of the intensity of LPS-binding were observable. The studies revealed that intrabronchial infection results in local and systemic alterations of CD14 expression and LPS-binding capacity of different cell populations. However, a direct correlation between the appearance of CD14- and LPS-binding does not seem to inevitably exist, indicating probably CD14-independent LPS-binding.

Animals↗
PubMed2005

Enzootic pneumonia of pigs--a diagnostic dilemma.

In an enzootic pneumonia-free Australian pig herd, an outbreak of a severe respiratory disease in the grow-out herd was initially diagnosed as acute tracheitis and pneumonia precipitated by the dusty environment, with a superimposed mixed infection of Pasteurella multocida and Arcanobacterium pyogenes. Culture for Mycoplasma hyopneumoniae, Salmonella sp and fungi was negative. The outbreak persisted. Subsequently, gross lesions consistent with enzootic pneumonia occurred, but histological lesions were equivocal and definitive tests for M hyopneumoniae remained negative. Eighteen months after the initial outbreak, gross and histological lesions were consistent with enzootic pneumonia but serological tests were still negative. Almost 2 years later, one of four nasal swabs was positive by the polymerase chain reaction test for M hyopneumoniae, and then lung samples were sporadically positive. The pneumonic disease became endemic in the herd. Gross lesions consistent with enzootic pneumonia occurred in another herd belonging to the same company nearly 2 years after the initial outbreak. Again, results of laboratory tests were inconsistent. Despite sporadic positive polymerase chain reaction tests for M hyopneumoniae, the respiratory disease resolved within 4 months and there has been no clinical evidence of enzootic pneumonia during the subsequent 4 years. These cases raise important questions about the role of the diagnostic tests and their interpretation, and the ecology of M hyopneumoniae and its role in enzootic pneumonia.

Actinomycetaceae↗
PubMed1989

[A case of chronic bronchitis with Pasteurella multocida possibly resulting from infection from a bird].

A 60-year-old woman was admitted to our division for further evaluation of fever and purulent sputa. In sputum cultures performed when the patient had complained of an increase in symptoms on three occasions during the previous 6 months, Pasteurella multicoida was usually detected. Based on the fact that the bacteria had been detected from the patient's sputa after feeding a macaw, but was not detected after treatment of the bird with OFLX, a diagnosis of respiratory tract infection by P. multocida was made. Clinical symptoms and laboratory data of the patient were markedly improved after treatment with cefaclor (750 mg/d). The bacteria in this case were sensitive toward many antibiotics. This case was considered to be the first case of bird-mediated Pasteurella infection.

Animals↗
PubMed2000

Bacteriological warfare amongst cats: what have we learned about cat bite infections?

Cat bite infections are one of the most common infectious diseases presenting to veterinary practices and to emergency rooms at human hospitals. This review describes the disease in humans and cats, the origin of organisms involved in cat bite abscesses and the importance of selected organisms such as members of the genus Porphyromonas in the disease. It also discusses future directions, the importance of identifying significant organisms and why an understanding of antimicrobial susceptibility patterns is of consequence to the outcome of the disease in humans and cats.

Abscess↗
PubMed1984

Development of a combined clostridial and Pasteurella haemolytica vaccine for sheep.

The efficacy of a multicomponent clostridial vaccine containing Pasteurella haemolytica antigens was tested in specific pathogen free or conventionally reared lambs exposed to experimental infection with P haemolytica serotypes A1, A2 or A6. In four experiments assessment was based upon the findings of clinical, pathological and bacteriological examinations. Three experiments carried out in conventionally reared lambs demonstrated protection against challenge infection with P haemolytica serotypes A1, A2 and A6 in vaccinated lambs. However, the inconsistency of the disease induced in these experiments emphasised the need to perform definitive studies in specific pathogen free conditions. The final experiment was carried out with specific pathogen free lambs and confirmed the efficacy of the multicomponent clostridial vaccine containing P haemolytica antigen in protecting against the effects of infection with P haemolytica serotype A6. In addition, this experiment indicated that the inclusion of several components in a vaccine did not affect the efficacy of an individual antigenic component.

Animals↗