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[Content of hypophysiotropic, adrenotropic and thyrotropic hormones in the blood in Duchenne's progressive muscular dystrophy].

Content of hypophysis-, adrenal gland- and thyroid gland-tropic hormones was studied in blood plasma of children with primary X-linked Dushenne's myopathy at various periods of the disease, as compared with the patterns observed in healthy children of the same age. Increase in the functional activity of hypophysis and decrease -- in functions of adrenal cortex glands were observed in the muscular dystrophy; these alterations correlated with the disease steps. Relationship between the hormonal alterations and the dystrophy steps suggests the importance of the hormones in pathogenesis of the myodystrophic impairment.

11-Hydroxycorticosteroids↗

[Estimation of the probability of heterozygosity in Duchenne-type progressive muscular dystrophy].

The severe Duchenne type of muscular dystrophy is inherited as an X-linked recessive trait. Approximately two thirds of healthy female heterozygous carriers have a high serum creatine kinase (SCK). A suspected carrier with a normal SCK level therefore, presents an important problem in genetic counselling. Based on Bayesian methods, Emery and Hollyway derived a formula which is applicable when the sporadic case is either the son or brother of a consultant and which also includes information on SCK levels in the consultant and in normal daughters and sisters. The present paper describes the results obtained with use of this formula in 27 families with at least a propositus with Duchenne muscular dystrophy.

Adolescent↗