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PubMed1980

The family meets the hospital. A laboratory forecast of the encounter.

Families, like persons, can be considered as unitary cases. Like persons, families can be classified before treatment begins in an effort to predict their responses and thus, to formulate the best treatment program. Although many classification schemes have been proposed in the past, evidence is presented on the first successful use to our knowledge of a family classification scheme to predict a family's response to a family-oriented treatment program. The classification scheme grouped families according to their typical style of adapting to new situations. A family's classification was based on its performance in a standard laboratory problem-solving situation in which its interaction patterns could be measured precisely and objectively. This approach to classification successfully predicted the family's engagement in a family-oriented, inpatient treatment program for adolescents.

Adolescent↗
PubMed2004

Transcatheter patent foramen ovale closure for secondary prevention of paradoxical embolic events: acute results from the FORECAST registry.

Patients with patent foramen ovale (PFO) and paradoxical embolism are at increased risk for recurrent events. Percutaneous PFO closure is a new treatment modality aimed at secondary prevention. We report the multicenter experience of interventional closure of PFO using two different devices in 272 patients. The mean age was 51 +/- 14.2 years and 52.9% were males. The implantation procedure resulted in an initial complete shunt closure rate of 74.3% with a periprocedural complication rate of 6.6%. There were no deaths or pericardial tamponade. The mean procedure time was less than 44 min under either conscious sedation, local or general anesthesia. This is the largest report to date demonstrating the procedural safety, reliability, and feasibility of the transcatheter PFO closure technique with the STARFlex and CardioSEAL septal implants. Randomized clinical trials are currently in progress to identify patients most likely to benefit from this intervention.

Adult↗
PubMedDate not supplied

Concentration of glutathione and expression of glutathione peroxidases 1 and 4 in fresh sperm provide a forecast of the outcome of cryopreservation of human spermatozoa.

Oxidative stress imbalance potentially leads to damage of the structure of the cell and macromolecules such as plasma membrane components, proteins, and DNA. The plasma membrane of the sperm cell, which has high levels of polyunsaturated fatty acids, renders it particularly sensitive to free radical-mediated attacks. The freezing and subsequent thawing of sperm is a physically stressful process carried out during routine procedures in assisted reproduction techniques, which results in a highly variable and unpredictable reduction in the number of motile sperm cells. Subsequently, oxidative status can positively or negatively affect the motility, viability, and fertilizing capacity of thawed sperm. These effects are counteracted by various oxidative defense enzymes and anti-oxidants such as glutathione peroxidase isoforms GPx1 and GPx4, glutathione reductase (GR), and cellular glutathione (reduced) (GSH). In this way, oxidative status could represent a predictive marker of sperm quality following the freeze-thaw process. This study was based on 56 human sperm samples. We observed direct positive and negative relationships between the postthaw motile sperm recovery rate and GPx1 and GPx4 expression and activity, on the one hand, and GSH concentrations, on the other. No correlation was found between this recovery rate and GR or basic semen parameters. Predictive values clearly demonstrate that, among the molecules analyzed, the most accurate diagnoses result when analyses are conducted for GPx1 and GPx1 messenger RNA expression, GPx1 and GPx4 enzymatic activity, and GSH concentration. In conclusion, a reserve of glutathione, together with GPx expression, is necessary to eliminate free radicals using GSH or a like structural protein and seems to be essential for a good postthaw recovery. These molecules can be employed as indicators of postthaw sperm quality.

Cryopreservation↗
PubMed1993

A simple method to forecast good promoters of Escherichia coli by means of doublet frequencies.

A training sample (taken offhand) of 14 promoter sequences, 70 or 69 base pairs in length each, with their (relative) promoter strengths given by Deuschle et al. (1986), is used to find a relation between some sequence characteristics and the promoter strength. The analysis is based on the doublet frequencies of purines and pyrimidines in the promoter sequence under study.

Escherichia coli↗