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PubMed2004

Covariation bias for ambiguous social stimuli in generalized social phobia.

The authors investigated whether the negative interpretation bias in generalized social phobia (GSP) reflects and is maintained by illusory correlations. Participants were exposed to descriptions of ambiguous social events, situations involving fear-relevant animals and nature scenes that were randomly paired with negative, positive, or neutral emotional facial expressions. Prior to the experiment, the GSP participants overestimated the contingency social situations-negative outcome, whereas the controls judged negative outcomes as least likely. A posteriori, the GSP participants exhibited an illusory correlation specifically between social cues and negative outcomes. During the experiment, only the controls showed distorted outcome predictions for social situations. Hence, illusory correlations--possibly resulting from acquired associations between social cues and negative consequences--may contribute to a negative interpretation bias in GSP.

Adult↗

PubMed2005

A holistic approach to the promotion of older hospital patients' health.

PURPOSE: To describe how nurses interpreted health promotion related to older patients in a medical hospital ward and the presuppositions for this work. METHODS: The study had a descriptive and explorative design. Data were created through participant observation of five nurses and informal dialogues with four nurses working in an infection unit in a small hospital in Norway. The nurses where followed during a period of 6 months. The observations and dialogues were interpreted and transformed into text. This text was analysed with qualitative content analysis and interpreted hermeneutically on three levels: (1) reading the text to get an overview of the themes; (2) systematically separating central patterns; and (3) highlighting the patterns with examples. FINDINGS: The nurses' interpretation of health promotion was closely connected to their interpretation of health and holistic nursing. Two main aspects were uncovered in the informal dialogues: a biomedically oriented nursing view and a holistically oriented nursing view. The observations showed that presuppositions, such as waiting for something or somebody, constantly changing situations, complexity and diversity in patient cases, influenced the nurses' work in general and also their focus on health promotion. The nurses balanced between the biomedical and the holistic approach. It seemed to be important for the nurses to be the masters of walking on a tightrope and to have professional clinical competence. CONCLUSION: It was difficult to find a clear focus on health promotion. The most visible focus was on diagnosis and treatment, while the more complex and comprehensive situations related to health promotion of older patients seemed to be underprioritized. The phenomenon of 'waiting' may be an important issue for further research.

Aged↗

PubMed1989

Interpretation of England and Wales cancer mortality data: the effect of enquiries to certifiers for further information.

For some death certificates in England and Wales the cause information coded and published in national data is not that initially submitted by the certifier, but instead derives from a subsequent enquiry to the certifier for further information. These enquiries can lead to substantial artefacts in secular mortality data, and also to substantial non-comparability between mortality data for special study groups, such as subjects in cohort studies, and published mortality data. A description of current enquiry policy relevant to cancers, and changes in this policy over recent years is given to aid interpretation of mortality data. The effects on secular data of changes in enquiry policy are illustrated. At 4-digit level of the ICD, changes in enquiry policy can alter published mortality rates by several hundred per cent. At 3-digit level the greatest effects of enquiries at present are to increase the number of deaths coded to cancer of the eye by 35% and cancer of the body of the uterus by 31%; cancers of the thymus, heart and mediastinum are increased by 18%, and pleural cancer by 17%, while decreases of more than 10% are caused for several 'other' and 'unspecified' rubrics, and a decrease of 6% for deaths coded to melanoma.

Data Interpretation, Statistical↗

PubMed1999

Charge distribution as a tool to investigate structural details: meaning and application to pyroxenes.

The charge distribution (CD) method, previously introduced as a development of the bond-valence (BV) approach, is applied for the first time to mineral structures, and specifically to pyroxenes. CD essentially involves the distribution of the Effective Coordination Number (ECoN) of a cation among all the neighboring anions. This distribution is then interpreted in terms of distribution of 'charges', where 'charge' represents the formal oxidation state. Differently from BV, the CD description depends upon the geometry of each coordination polyhedron, which is characterized through ECoN (a non-integer number). The contribution of each cation-oxygen bond to ECoN, labelled 'bond weight', corresponds to the bond strength in the BV method, but it is defined in terms of bond-length ratio in each polyhedron and not as a function of the cation-oxygen pair. The ratio q/Q of the formal oxidation number to the computed charge can be interpreted as a measure of the correctness of the structure (cation ratio) and of the degree of over- or under-bonding (anion ratio). A similar interpretation is not possible for the analogous quantities obtained through the BV approach. The analysis in terms of CD of the pyroxene chains (from 101 structures) shows different trends as a function of composition, temperature and pressure; in particular it shows a different behaviour of the two crystallographically independent chains of orthopyroxenes and of P2(1)/c clinopyroxenes.

Journal Article↗

PubMed2005

Pride and confidence at work: potential predictors of occupational health in a hospital setting.

BACKGROUND: This study focuses on determinants of a healthy work environment in two departments in a Swedish university hospital. The study is based on previously conducted longitudinal studies at the hospital (1994-2001), concerning working conditions and health outcomes among health care personnel in conjunction with downsizing processes. Overall, there was a general negative trend in relation to mental health, as well as long-term sick leave during the study period. The two departments chosen for the current study differed from the general hospital trend in that they showed stable health development. The aim of the study was to identify and analyse experiential determinants of healthy working conditions. METHODS: Thematic open-ended interviews were carried out with seventeen managers and key informants, representing different groups of co-workers in the two departments. The interviews were transcribed verbatim and an inductive content analysis was made. RESULTS: In the two studied departments the respondents perceived that it was advantageous to belong to a small department, and to work in cooperation-oriented care. The management approaches described by both managers and co-workers could be interpreted as transformational, due to a strain of visionary, delegating, motivating, confirmative, supportive attitudes and a strongly expressed solution-oriented attitude. The daily work included integrated learning activities. The existing organisational conditions, approaches and attitudes promoted tendencies towards a work climate characterised by trust, team spirit and professionalism. In the description of the themes organisational conditions, approaches and climate, two core determinants, work-pride and confidence, for healthy working conditions were interpreted. Our core determinants augment the well-established concepts: manageability, comprehensiveness and meaningfulness. These favourable conditions seem to function as a buffer against the general negative effects of downsizing observed elsewhere in the hospital, and in the literature. CONCLUSION: Research illuminating health-promoting aspects is rather unusual. This study could be seen as explorative. The themes and core dimensions we found could be used as a basis for further intervention studies in similar health-care settings. The result could also be used in future health promotion studies in larger populations. One of the first steps in such a strategy is to formulate relevant questions, and we consider that this study contributes to this.

Adult↗

PubMed2006

A classification based framework for quantitative description of large-scale microarray data.

Genome-wide surveys of transcription depend on gene classifications for the purpose of data interpretation. We propose a new information-theoretical-based method to: assess significance of co-expression within any gene group; quantitatively describe condition-specific gene-class activity; and systematically evaluate conditions in terms of gene-class activity. We applied this technique to describe microarray data tracking Escherichia coli transcriptional responses to more than 30 chemical and physiological perturbations. We correlated the nature and breadth of the responses with the nature of perturbation, identified gene group proxies for the perturbation classes and quantitatively compared closely related physiological conditions.

Cell Proliferation↗

PubMedDate not supplied

[Highest level of division in classification of organisms. 3. Monodermata and Didermata].

The deepening our knowledge and embrassing the larger array of the investigated organisms leads to replacement of typological classifications with phylogenetic ones. This process seems to be the main stream of modern systematics. But typological classifications have not lost the value, remaining the important tool of the description of phylogeny. It is especially obvious today when molecular reconstructions are using so widely. However resulted phylogenetic classifications are difficult for understandable interpretation. Therefore phylogeneticist is interested in elaboration of typological classifications that can help to explain the results. As an example the phylogenetic classifications of organisms proposed recently by Cavalier-Smith (1998, 2002) and Gupta (1998, 2000) are considered. The modified system of Gupta is the most adequate description of organism phylogeny. Basal clostridia and togobacteria have to the greatest degree kept features of a common ancestor of organisms. From this common ancestor evolution spread by two phyletic lines. One of them included Gram-negative bacteria. The main groups of them have branched of from a common ancestor in the following order: (Deinococci, Chloroflexi) --> (Cyanobacteria) --> (Chlamydia, CFB, Fibrobacteria, Chlorobia) --> (Aquificae) --> --> (Epsilonproteobacteria, Deltaproteobacteria) --> (Alfaproteobacteria) --> (Betaproteobacteria) --> --> (Gammaproteobacteria). In other phyletic line the main groups were separated in the following order: (Thermotogae) --> (Clostridia, Fusobacteria) --> (Bacillae) --> (Actinobacteria). Exact position of archaebacteria and eukaryotes related to this line remains unclear. Typological division of organisms into Didermata and Monodermata (Gupta, 1998) corresponds to these two branches of a cladogram. The cell of the diderm organisms is covered with two membranes, plasmatic and outer. The cell of the monoderm organisms has only one plasmatic membrane. Development of the cellular organization at the earliest stages of evolution of a life went through use of non-lamellar (non-bilayer) lipids which could give a cell with one membrane (not two membranes as in the scenario of Cavalier-Smith (2001)). Membranes appeared at the earliest stages of the evolution of life. Therefore their distinction is quite logical to take as a principle the first typological division of organisms. At the same time the typological classifications considered beyond the framework of phylogenetics, have no independent value. Typological classifications do not give monothetic division into groups. Always there are exceptions. So, among Monodermata there are Gram-negative forms (Acidaminococcaceae, Syntrophomonadaceae, some Thermoanaerobacteriaceae), which are didermic.

Bacteria↗

PubMed1990

Computer diagnosis of skin disease.

A transferable computer program for the differential diagnosis of diseases of the skin, CLINDERM, has been produced for use by physicians on standard IBM and compatible personal microcomputers. This program lists the differential diagnosis and definitive diagnosis of any presented disease of the skin, except single tumors. The physician operator indicates the distribution and detailed description of lesions, which the interactive system integrates with a comprehensive knowledge base. The computer diagnosis in 129 cases was compared with independent interpretation of the same information by an academic dermatologist. Results were synonymous in 66.7% of all diseases and similar in an additional 4.7%. A common differential diagnosis was obtained in 24%, for a 95.3% rate of synonymous, similar, or common differential diagnoses. Diagnosis was different in 3.9% and description was inadequate for diagnosis in 0.8%. The variation in diagnosis showed that some descriptive terms are prejudicial of certain diagnoses; that diagnostic terms are not all completely standardized; that some diagnoses are variants of another disease; and that drug-induced eruptions simulate many other diseases. A skin disease can usually be diagnosed by specific description. Most lesions that are not diagnostic from inspection are nodular. A computer can be programmed to list diagnoses according to morphologic description.

Dermatology↗

PubMed2004

Statisticodynamical approach of state distributions in the products of four-atom planar unimolecular reactions. I. Formal developments for conserved vibrations.

Traditional statistical approaches, entirely based on transition state theory (TST), do not allow the description of rotational state distributions in the products of indirect reactions governed by short-range forces. Owing to the interpretative power of TST, this limitation has long been acting as a brake upon a deep understanding of determining attributes of indirect reaction dynamics. Recently, however, we developed a statisticodynamical approach (SDA) of final state distributions for triatomic unimolecular reactions [P. Larregaray, L. Bonnet, and J. C. Rayez, J. Chem. Phys. 114, 3349 (2001); Phys. Chem. Chem. Phys. 4, 1577 (2002); 4, 1781 (2002)]. The approach combines TST for the description of state distributions at the transition state (TS) and the linear transformation model for the description of their alteration on the way from the TS to the products. The whole description is mostly analytical, thus keeping the rationalizing spirit of TST. The goal of the present series is to extend SDA to the case of four-atom planar unimolecular reactions, assuming that internal vibrations of the nascent products are conserved from the TS on. This first part is concerned with formal developments while the remaining parts deal with their validation and application, in particular to the fragmentation of isocyanic acid.

Journal Article↗

PubMed2003

Evaluation of a novel electronic fetal monitor simulator.

The purpose of this study was to evaluate the content validity and construct validity of a novel electronic fetal monitor (EFM) simulator. Fourteen residents in Gynecology and Obstetrics (OB/GYN) and 7 medical students in their OB/GYN clerkship interpreted 10 fetal heart rate (FHR) tracings and 4 clinical scenarios generated by the EFM simulator. Their responses were scored by experts in maternal-fetal medicine. Construct validity was determined by comparing subjects' scores to their level of experience. Subjects assessed content validity of the EFM simulator by rating the realism of its various elements on a 4-point Likert scale. Residents achieved statistically significant higher mean scores in the description of FHR tracings generated by the simulator than medical students and statistically significant higher mean scores in the correct interpretation of and interventions in 2 of 4 clinical scenarios. Two-thirds of the residents rated the simulator-generated FHR tracings and clinical scenarios as "real" or "very real." The EFM simulator exhibited both content and construct validity, supporting its use in an educational setting.

Adult↗

PubMed2000

[What is burnout?].

BACKGROUND: Burnout is most often described as a concept with three separate dimensions: emotional exhaustion, depersonalization (lack of empathy), and reduced accomplishments at work. We wanted to study the descriptive validity of the concept, which may be measured by the Maslach Burnout Inventory. MATERIAL AND METHODS: The Maslach Burnout Inventory was mailed to 1,476 members of the Norwegian Medical Association. The response rate was 73%. The dimensional structure of the instrument was examined by principal component analysis, and the identified factors correlated with validated measures of job satisfaction and depression. The dichotomized factors were combined in eight different ways, and the specificity of the resulting types was studied. RESULTS: The three original dimensions were reproduced, and the internal consistency of the factors was good (Cronbach's alpha ranging from 0.91 to 0.69). There were high correlations between emotional exhaustion and both job satisfaction (r = -0.54) and depression (r = 0.72). INTERPRETATION: Emotional exhaustion seems to be the least specific of the burnout dimensions. For the purpose of reasonable descriptive validity, the burnout notion should be based on both emotional exhaustion and depersonalization. With the applied dichotomization thresholds, this implies that 3% of Norwegian physicians are "burned out".

Adult↗

PubMed1975

Evidence for diaphragms in the pores of annulate lamellae and the nuclear membrane.

Interpretation of cross and tangential sections of the annulate lamellae and nuclear membrane of Rana pipiens oocytes provides evidence in these structures for the existence of disphragms spanning the pores. The evidence appears to rule out explanations ascribing such diaphragms to an optical artifact. More detailed description is given of a component of the pore complex only briefly described heretofore and now called the "intracisternal ring." The varied results and interpretations of studies of the pore complex in various cells are discussed.

Animals↗

PubMed1995

Spatial statistical methods in environmental epidemiology: a critique.

Despite recent advances in the available statistical methods for geographical analysis, there are many constraints to their application in environmental epidemiology. These include problems of data availability and quality, especially the lack in most situations of environmental exposure measurements. Methods for disease 'cluster' investigation, point source exposures, small-area disease mapping and ecological correlation studies are critically reviewed, with the emphasis on practical applications and epidemiological interpretation. It is shown that, unless dealing with rare diseases, high specificity exposures and high relative risks, cluster investigation is unlikely to be fruitful, and is often complicated by the post hoc nature of such studies. However, it is recognized that in these circumstances proper assessment of the available data is often required as part of the public health response. Newly available methods, particularly in Bayesian statistics, offer an appropriate framework for geographical analysis and disease mapping. Again, it is uncertain whether they will give important clues as to aetiology, although they do give valuable description. Perhaps the most satisfactory approach is to test a priori hypotheses using a geographical database, although problems of interpretation remain.

Adult↗

PubMed2002

Opinion: Interpretation of the complexity of innate immune responses by functional genomics.

Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.

Animals↗

PubMedDate not supplied

Does considering severity of illness improve interpretation of patient satisfaction data?

With the emergence of new, relatively low-cost code-based severity indexes, this question arises: Do complex descriptions of patient population in terms of severity yield a clearer picture of patients' opinions about hospital care and service? Consumers and third-party payers of healthcare are using patient satisfaction data with increasing frequency to evaluate the quality of care that hospitals provide. Insurers also use satisfaction data, when they are available, for contracting and ensuring provider accountability. The study described here examines whether the all patient refined-diagnosis related groups (APR-DRG) severity-of-illness rating system, in particular, can explain the variability in inpatient satisfaction ratings independently of patient demographics and clinical events. Multiple logistic regression was used on a data set of 3,720 patient records from one tertiary care facility, and model terms were fitted on the basis of reason for admission, year, gender, length of stay, age, and severity. The findings were that age and reason for admission were consistent predictors of high satisfaction on 14 survey items. APR-DRG severity was not a significant factor. Length of stay made a small but significant contribution on three items related to clinical quality.

Data Interpretation, Statistical↗

PubMed2007

Computer algorithm for automated work group classification from free text: the DREAM technique.

OBJECTIVE: This study developed and tested a computer method to automatically assign subjects to aggregate work groups based on their free text work descriptions. METHODS: The Double Root Extended Automated Matcher (DREAM) algorithm classifies individuals based on pairs of subjects' free text word roots in common with those of standard classification systems and several explicitly defined linkages between term roots and aggregates. RESULTS: DREAM effectively analyzed free text from 5887 participants in a multisite chronic obstructive pulmonary disease prevention study (Lung Health Study). For a test set of 533 cases, DREAMs classifications compared favorably with those of a four-human panel. The humans rated the accuracy of DREAM as good or better in 80% of the test cases. CONCLUSIONS: Automated text interpretation is a promising tool for analyzing large data sets for applications in data mining, research, and surveillance. Work descriptive information is most useful when it can link an individual to aggregate entities that have occupational health relevance. Determining the appropriate group requires considerable expertise. This article describes a new method for making such assignments using a computer algorithm to reduce dependence on the limited number of occupational health experts. In addition, computer algorithms foster consistency of assignments.

Algorithms↗

PubMed1984

The courtship disorders: a further investigation.

The senior author had put forward the hypothesis that voyeurism , exhibitionism, obscene telephone calling, toucheurism - frotteurism , and at least some cases of the preferential rape pattern all distort normal courtship behavior in basically the same manner. An earlier study (Freund et al., 1983) tested part of this hypothesis, namely that voyeurism , exhibitionism, and frotteurism - toucheurism , are closely related. However, the outcome of one of the experiments by which this test was performed could be interpreted as indicating that the relationship between these anomalous erotic inclinations consists simply in that they may be expressions of a disinclination toward intercourse. The present study was conducted to test this interpretation. It compared 16 exhibitionists with 16 sexually normal controls on penile responses to auditorily presented descriptions of the four phases of normal sexual interaction (location of a suitable partner; pretactile erotic interaction; tactile interaction short of intercourse; the situation of intercourse) and sexually neutral situations. These descriptions were narratives about the examined subject's involvement in such interaction. No differences in responding between exhibitionists and normal controls were observed. Both groups responded most to descriptions of intercourse. The second largest response was to tactile interaction (short of intercourse). The third was to situations of partner location and pretactile interaction, which were not differentiated from each other. Responses to sexually neutral situations were smaller than those to descriptions of any category of sexual interaction. This result refutes the hypothesis that exhibitionism develops on the basis of a disinclination toward intercourse. The close relationship between exhibitionism, and voyeurism and toucheurism (or frotteurism ), had been demonstrated earlier.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed2001

Novel technique to average breathing loops for infant respiratory function testing.

Breathing loops can be obtained by plotting two respiratory signals on an x-y diagram: the resulting loops represent a non-parametric description of the respiratory system. In infancy, loops are commonly measured during tidal breathing and their interpretation is hampered by high within-subject variability. Therefore a two-dimensional averaging technique for loops has been developed. The algorithm is based on segmentation of the loops and required two steps. First, the total length of the loop of every breathing cycle was divided into a specified number of equidistant intervals and the co-ordinates calculated by stepwise linear approximation of the curve. Second, averaged loops were calculated using the arithmetical mean (or the median if there were artifacts) of the x and y co-ordinates of the loops for all calculated points. To compare the new technique with averaging in the time domain a simulation study was performed using respiratory signals with a coefficient of variation (CV) of 5%, 10%, 15% and 20%. In contrast to the new technique, with increasing CV, averaging in the time domain led to increasing contortions in the averaged flow-volume loops. Mean errors of peak tidal expiratory flow were -3.3%, -13.9%, -21.3% and -34.2%, whereas errors with the new technique were considerably lower (0.5%, 0.4%, 0.5% and -0.1%) and independent of the level of CV.

Algorithms↗