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Very-nearly-closed-circuit anaesthesia. A computer analysis.

A simple analogue study of inspired oxygen concentrations in a circle absorber system was made. Good agreement with clinical observations and figures reported by others was obtained. The suggested low-flow regime was nitrous oxide 1 litre/min and oxygen 0.6 litre/min, which provides inspired oxygen concentrations between 35-25%, over a range of oxygen consumption from 150-300 ml/min. The use of such low flows is economical and reduces atmospheric pollution in the operating theatre.

Air Pollution↗

A compartmental analysis of circulatory lymphocytes in the spleen.

A tentative model describing the passage of circulatory lymphocytes through the spleen is formulated in accord with known anatomical features. In order to preserve isomorphism between the model and the splenic system, the model is formulated in compartmental form and its design allows alternative routes and modes of lymphocyte transit to be considered. The simultaneous differential equations arising from the model are solved using an analogue computer which also provides the means whereby the performance of the model may be compared with suitable dynamic data drawn from literature. This not only allows the selection of a particular configuration of the model in preference to its alternatives, but also allows the numerical determination of certain unknown parameters. In the case of the rat spleen, best agreement between model and experimental data is obtained when between 10 and 25% of the total lymphocyte flux in the model spleen passes through the marginal zone where the average dwell time of the lymphocytes is about 50 min. The white pulp receives a lymphocyte flux from the marginal zone amounting to about 10% of the total splenic flux and the white pulp lymphocytes are sequestered for a period of 4-6 hr before release to the venous circulation. The red pulp receives 90% of the total splenic flux but the majority of lymphocytes find transit through the red pulp in less than 5 min. The remaining flux of lymphocytes, amounting to 10% of the splenic input, is delayed in transit through the red pulp by 2-3 hr before release to the venous circulation.

Animals↗

Computerized study of the velocity of the rapid eye movements.

The average velocity-amplitude characteristics of rapid eye movements (voluntary saccades, and fast phases of caloric and optokinetic [OKN] nystagmus) in normal humans were analyzed with an analogue-digital computer and compared among them. For the same amplitude of movement the velocity of the saccades is considerably greater than that of the fast phases of the OKN, and these in turn are greater than those of their vestibular counterparts. The complexity in oculomotor neurophysiology makes this observation difficult to explain.

Adult↗

The energy requirement of the dental cutting process.

The results are presented of research into the efficiency of various forms of dental burs. This research was carried out at the Delft University of Technology in collaboration with the Subfaculty of Dentistry of the Free University of Amsterdam. The process efficiency was measured during burring of both human teeth and amalgam plugs, with diamond burs and tungsten carbide burs at different speeds and diameters of the bur. Only the efficiency of the cutting process was evaluated, disregarding a number of other essential aspects of the burring process, such as the remaining surface quality after burring and the vibrations generated during burring.

Air↗