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Contingency contrast effects in discrimination conditioning.

Three experiments observed differential electrodermal responding to signal stimuli (CSs) by contrasting positive, random, and negative contingencies between the signals and strong stimuli (UCSs). Experimentation began as a test of the proposition that electrodermal response to a random signal (or CSR) would lie between the response to a reinforced or excitatory stimulus (CS+) and that to a nonreinforced or inhibitory stimulus (CS- or CSI). A clear intermediate position for CSR did not result. Instead it appeared that CSR was operating as a mildly excitatory signal. This led to a second experiment where response to pairs of stimuli with different contingent relations could be compared in independent samples. The pairs were CS+ and CS-, CS+ and CSR, and CSR and CS-. Differential responding was observed in all pairs and response to CSR was significantly larger in the group receiving CSR with CS- than it was in the group receiving CSR with CS+. A contingency contrast effect was suggested. A third experiment explored the implications of a contingency contrast effect by varying overall UCS density, the duration of "safety intervals," and the presence or absence of instructions about contingencies. The UCS density and instruction variables influenced the differential performance to CSR and CS-, a result that was interpreted as further evidence for a perceptual contingency-contrast effect. Some theoretical implications of such a contrast phenomenon are examined, as they apply to autonomic learning. The CS is interpreted as a signal supplying contingency information that is dependent upon a complex of factors in the stimulation environment.

Association Learning↗

The memory representation of motor skills: a test of schema theory.

Currently, a popular model for the central representation of motor skills is embodied in Schmidt's schema theory of discrete motor skill learning (Schmidt, 1975). Two experiments are reported here that contrast predictions from a schema abstraction model that is the basis for schema theory with those from an exemplar-based model of motor skill memory representation. In both experiments, subjects performed 300 trials per day of three variations of a three-segment timing task over 4 days of acquisition. The subjects then either immediately transferred to four novel variations of the same task (Experiment 1) that varied in degree of similarity to the exemplars experienced during acquisition; or performed two novel and two previously produced exemplars, following 24-h and 1-week retention intervals (Experiment 2). The results indicated that novel task transfer was not affected by the degree of similarity between the acquisition and transfer exemplars, and that there was no advantage for a previously produced exemplar over a novel exemplar after either a 24-hr or 1 week retention interval. Also, in both experiments, a consistent pattern of bias in responding was noted for novel task transfer and retention. These results are indicative of a schema abstraction model of memory representation for motor skills.

Journal Article↗

The independence of response structure and element production in timing sequences.

In three experiments, participants were asked to produce a prescribed temporal sequence of key presses. The number of elements in a key press sequence, the movement time of the elements, and uniformity of the timing elements comprising the sequence were manipulated. If the processing of the sequence structure was independent of the processing of elements comprising the sequence, increasing the number of the elements in the sequence should affect the production of the sequence but not the proficiency with which the individual elements are, produced. Increasing the movement time of the elements, however, should affect the production of the elements but have little, if any, effect on the integrity of the sequence. The findings indicated that increasing the number of elements negatively affected sequence production when the elements were nonuniform but had little or no effect when elements were uniform. Alternatively, element production was affected by movement time but not number of elements. The results of these experiments appear to confirm the independence of sequence and element production. However, Experiment 3, in which the uniformity of the elements was directly contrasted, found strong evidence for coarticulatory influences in the learning processes, whereby the longer and shorter than average elements in the sequence negatively affected the sequence integrity and the production of the individual elements. When faced with a nonuniformn timing pattern, participants appear to elongate or shrink individual elements of a uniform timing pattern to fit the desired sequence requirements. The result is that the longer or shorter than average elements require more practice to produce correctly, tend to regress across retention intervals, and are generally less stable than the elements nearer the average.

Adult↗

Powered, air-purifying particulate respirator filter penetration by a DOP aerosol.

In 1995, new certification requirements for all nonpowered, air-purifying particulate filter respirators were put in place when 42 CFR 84 replaced 30 CFR 11. However, the certification requirements for all other classes of respirators, including powered air-purifying respirators (PAPRs), were transferred to 42 CFR 84 from 30 CFR 11 without major changes. Since the inception of 42 CFR 84, researchers have learned that the efficiency of electrostatic filter media, in contrast with mechanical filter media, can be rapidly degraded by oil aerosols. Further, confusion may exist among respirator users, since electrostatic PAPR filters have the same magenta color assigned to high-efficiency filters for nonpowered particulate respirators that have been tested and certified for use against oil aerosols (i.e., P100 filters). Users may expect that the magenta color of certified PAPR filters indicates suitability for use against oil aerosols. This may not be the case. To illustrate the potential degradation of electrostatic PAPR filters, new filters certified under 42 CFR 84 were tested using a TSI model 8122 Automated Respirator Tester against charged and neutralized DOP aerosols with intermittent loading schedules. The performance of a magenta-colored electrostatic PAPR filter--one for which the manufacturer's user instructions appropriately indicates is not suitable for use in oily environments--was compared with the performance of several mechanical PAPR filters. In tests against both DOP aerosols, the electrostatic PAPR filter showed a significant decrease in performance at DOP loadings exceeding 400 mg, whereas mechanical filters showed no significant change in the performance except at extremely high loadings. The decreased performance of the electrostatic PAPR filter was found to be significantly greater when tested against a neutralized DOP aerosol when compared with a charged DOP aerosol. While laboratory tests show that the filtration efficiency of this electrostatic PAPR filter degrades with exposure to DOP aerosol, the observed laboratory degradation may or may not affect workplace performance, as similar degradation has not been verified in workplace studies. Based on these laboratory results, a proposed method for evaluating high-efficiency PAPR filters is presented. This proposed method would ensure that high-efficiency PAPR filters (> or = 99.97% efficient and magenta in color) meet critical performance criteria when loaded.

Aerosols↗

An individual patient comparison of response to a memory training program--psychogenic V organic amnesia: brief report.

Psychogenic amnesia ("dissociative amnesia" in DSM-IV) has received relatively little attention in the literature. We compared neuropsychological and behavioral findings between a patient with psychogenic amnesia and one with organic amnesia from their early stages in a rehabilitation program. A 52-yr-old man developed anterograde and retrograde amnesia and short-term memory disturbance 1 mo after an operation for esophageal carcinoma, with no loss of personal identity and information. No apparent organic causes were identified, but because the patient and his wife rejected psychiatric treatment and memory deficit characteristics were compatible with that of an organic origin, the patient was referred to a physiatrist. A 46-yr-old man with anterograde amnesia was diagnosed with limbic encephalitis based on findings of magnetic resonance imaging and single-photon emission computed tomography, which showed lesions in both medial temporal lobes. Both patients underwent "memory book" training because they showed preserved performance in motor learning tasks. The first patient's responses to training contrasted with the other's and were indicative of psychogenic amnesia, with cancer representing a precipitating stress. Counseled by the physiatrist, the patient and his wife accepted suggestions to undergo psychiatric treatment. We propose that it is important to consider behavioral responses to memory rehabilitation as well as neuropsychological findings in differentiating psychogenic amnesia from an organic one and that physiatrists may be pivotal in diagnosing and initiating treatment in such psychiatric disorders.

Amnesia↗

Adjuvant chemotherapy in elderly patients with breast cancer: where are we?

PURPOSE OF REVIEW: Breast cancer in elderly patients is a major health concern that will only increase in the future. For early-stage breast cancer, adjuvant chemotherapy may be indicated in this patient group following adequate local treatment and before possible hormone therapy. This review summarizes the current knowledge and provides guidelines for the use of adjuvant chemotherapy in elderly patients with breast cancer. RECENT FINDINGS: Most data are extracted from large multicenter trials with upper age limits of 65 or 70 years. Only one multicenter randomized study investigated the potential benefit of an adjuvant anthracycline-based chemotherapy regimen added to endocrine treatment after the age of 65 years. Retrospective analyses from international group databases show the same potential absolute benefit derived from adjuvant chemotherapy in elderly compared with younger patients, however. This benefit must be weighed against life expectancy and tolerability of chemotherapy. SUMMARY: Limited confidence of medical oncologists with cytotoxic chemotherapy administration to the elderly and a lack of both prospective studies and shared guidelines for decision making in this subpopulation are the main factors responsible for the limited use of adjuvant chemotherapy in elderly patients with breast cancer. Fortunately this contrasts with an increasing awareness among clinicians, who should learn to integrate absolute benefit, life expectancy, and tolerance of chemotherapy in their clinical decisions. Discrimination on the basis of older age alone is no longer acceptable.

Aged↗

Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor.

We investigated the effects of a novel melanocortin-4 (MC4) receptor antagonist,1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine (MCL0129) on anxiety and depression in various rodent models. MCL0129 inhibited [(125)I][Nle(4)-D-Phe(7)]-alpha-melanocyte-stimulating hormone (alpha-MSH) binding to MC4 receptor with a K(i) value of 7.9 nM, without showing affinity for MC1 and MC3 receptors. MCL0129 at 1 microM had no apparent affinity for other receptors, transporters, and ion channels related to anxiety and depression except for a moderate affinity for the sigma(1) receptor, serotonin transporter, and alpha(1)-adrenoceptor, which means that MCL0129 is selective for the MC4 receptor. MCL0129 attenuated the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4 receptor, whereas MCL0129 did not affect basal cAMP levels, thereby indicating that MCL0129 acts as an antagonist at the MC4 receptor. Swim stress markedly induced anxiogenic-like effects in both the light/dark exploration task in mice and the elevated plus-maze task in rats, and MCL0129 reversed the stress-induced anxiogenic-like effects. Under nonstress conditions, MCL0129 prolonged time spent in the light area in the light/dark exploration task and suppressed marble-burying behavior. MCL0129 shortened immobility time in the forced swim test and reduced the number of escape failures in inescapable shocks in the learned helplessness test, thus indicating an antidepressant potential. In contrast, MCL0129 had negligible effects on spontaneous locomotor activity, Rotarod performance, and hexobarbital-induced anesthesia. These observations indicate that MCL0129 is a potent and selective MC4 antagonist with anxiolytic- and antidepressant-like activities in various rodent models. MC4 receptor antagonists may prove effective for treating subjects with stress-related disorders such as depression and/or anxiety.

Animals↗

Early reading for low-SES minority language children: an attempt to 'catch them before they fall'.

Minority language and low socioeconomic status (SES) students are at high risk for language and learning disabilities. In an attempt to 'catch them before they fall', an early reading project was initiated in four kindergarten classes, in a low-SES bilingual school (English/French as a second language), where minority language children form a majority. The project included: (1) teaching reading and writing to kindergarten students, and outcome research: individual pre- and post-treatment assessment using a computer software to measure phonological processing and decoding skills; (2) reading testing of grade 1 students, graduates of traditional kindergartens with no explicit reading instruction programs. Statistical analyses of the pre- and post-tests showed that in only 9 weeks the kindergarten students were able to learn phonological skills critical to the reading process. By contrast, a significant number of the grade 1 students, all graduates of a traditional kindergarten, showed serious reading lags on a group reading test, indicating that early reading instruction is justifiable for this high-risk student population.

Age Factors↗

Temporal memory over the adult lifespan.

Performances of noncollege student young adults, middle-aged adults, and elderly adults were contrasted on word temporal memory and paired-associate learning tasks. A comparison group of college-student subjects was also evaluated on each task. Significant effects for age variation were found for each task. The age sensitivity for temporal memory conflicts with one of the criteria commonly established for determining the automaticity of a memory task. In addition, moderately high positive correlations were found for each age group between word temporal memory scores and paired-associate learning scores, implying the involvement of effortful processes over the adult lifespan in word temporal memory.

Adult↗

Explicit knowledge of stimulus-outcome contingencies and stimulus control of selective attention and instrumental action in human smoking behaviour.

RATIONALE: External stimuli (S+) that reliably signal that addictive drugs are available command the focus of selective attention and control instrumental action that procures the drug. According to incentive salience theory, as the contingency between the S+ and the drug is learned the magnitude of attentional orienting towards the S+ increases. By contrast, alternative theories propose that processing of the S+ becomes more efficient with training such that the measured attentional orienting response elicited by the S+ decreases. OBJECTIVES: The aim of the present study was to prompt half of participants to acquire explicit knowledge of the stimulus-reinforcer contingencies arranged in training, to examine the impact of this manipulation on the magnitude of attentional orienting towards the S+. METHODS: Smokers (n=32) completed an instrumental discrimination training procedure in which a set of stimuli were established as differential predictors that an instrumental response would yield tobacco-smoke reinforcement. During training, attention for the stimuli and performance of the instrumental tobacco-seeking response were measured in parallel. One group (n=16) was prompted to develop explicit knowledge of the discriminative contingencies in training whereas another group (n=16) underwent discrimination training without prompting. RESULTS: The prompted group reported accurate knowledge of the contingencies and showed no attentional orienting response towards the S+. By contrast, the unprompted group reported inaccurate knowledge of the contingencies and showed an attentional orienting response towards the S+. The S+ appeared to control the instrumental tobacco-seeking response in both groups equally. CONCLUSIONS: The results suggest that attention for drug paired S+ is associated with the process of learning about the relationship between those cues and the drug.

Attention↗

Early signs of cognitive deficits among human immunodeficiency virus-positive hemophiliacs.

A total of 181 human immunodeficiency virus (HIV)-seropositive hemophiliacs and 28 hemophilic controls were evaluated by psychometric tests and by electroencephalogram (EEG). Patients were classified from stages 1-6 according to the immunological criteria of the Walter Reed staging system. Statistical analysis of psychometric data showed an effect of the stage of the disease on test performances, indicating a decline in attention, accumulation of perceptual interferences, decline in visuoperceptual speed and visuomotor response speed and reduced verbal memory performance, especially in stage 6 patients. Comparison of performance levels with normative test data already revealed cognitive deficits in about 20-30% of the patients in stages 2-5. As regards verbal memory, especially learning and recognition of new verbal information were impaired. In contrast, there was no significant deficit for nonverbal memory processing. Compared with the controls, patients exhibited an increasing number of abnormal EEG findings in stages 2-6. As a conclusion, in the stages before acquired immunodeficiency syndrome (AIDS) develops, EEG findings as well as psychometric findings indicate central nervous system involvement of AIDS in about 20-30% of cases, whereas in full-blown AIDS there is a marked increase to 80%. Besides a more general deficit of attention and psychomotor speed as is seen in subcortical dementia, there is evidence for a particular verbal learning disorder, suggesting additional selective impairment of the brain.

AIDS Dementia Complex↗

Achievement strategies at school: types and correlates.

In this study we made an effort to identify the kinds of strategies adolescents deploy in achievement context in an unselected sample of Swedish adolescents. The participants were 880 14-15-year-old comprehensive school students (399 boys and 481 girls) from a middle-sized town in central Sweden. Six groups of adolescents were identified according to the strategies they deployed. Four of them, i.e. optimistic, defensive pessimistic, self-handicapping and learned helplessness strategies, were similar to those described previously in the literature. The results showed that membership in the functional strategy groups, such as in mastery-oriented and defensive pessimist groups, was associated with well-being, school adjustment and achievement, and low levels of norm-breaking behaviour. By contrast, membership in the dysfunctional, for example self-handicapping and learned helplessness strategy groups, was associated with low levels of well-being, and of school adjustment, and a higher level of norm-breaking behaviour.

Achievement↗

Functional magnetic resonance imaging evidence for a lack of striatal dysfunction during implicit sequence learning in individuals with animal phobia.

OBJECTIVE: This study investigated the neural substrates of implicit sequence learning in subjects with and without small animal phobia, in a follow-up to analogous studies of obsessive-compulsive disorder (OCD). METHOD: Ten subjects with specific phobia and 10 healthy comparison subjects were studied by using a serial reaction time task paradigm and functional magnetic resonance imaging. RESULTS: A main effect of condition (implicit sequence learning versus random sequence) was observed across diagnostic groups in the right striatum, as well as in other regions. In the striatum, the a priori region of interest, there were no significant effects of diagnosis or the interaction of diagnosis and condition. CONCLUSIONS: Brain activation in the striatum of subjects with specific phobia does not significantly differ from that of normal comparison subjects during implicit sequence learning. This suggests different pathophysiological mechanisms for specific phobia in contrast to OCD, in which deficient striatal recruitment has been reproducibly found with this paradigm. This approach offers promise for demonstrating diagnostic specificity across different neuropsychiatric disorders based on the presence or absence of deficient striatal activation.

Adult↗

Symbols are not uniquely human.

Modern semiotics is a branch of logics that formally defines symbol-based communication. In recent years, the semiotic classification of signs has been invoked to support the notion that symbols are uniquely human. Here we show that alarm-calls such as those used by African vervet monkeys (Cercopithecus aethiops), logically satisfy the semiotic definition of symbol. We also show that the acquisition of vocal symbols in vervet monkeys can be successfully simulated by a computer program based on minimal semiotic and neurobiological constraints. The simulations indicate that learning depends on the tutor-predator ratio, and that apprentice-generated auditory mistakes in vocal symbol interpretation have little effect on the learning rates of apprentices (up to 80% of mistakes are tolerated). In contrast, just 10% of apprentice-generated visual mistakes in predator identification will prevent any vocal symbol to be correctly associated with a predator call in a stable manner. Tutor unreliability was also deleterious to vocal symbol learning: a mere 5% of "lying" tutors were able to completely disrupt symbol learning, invariably leading to the acquisition of incorrect associations by apprentices. Our investigation corroborates the existence of vocal symbols in a non-human species, and indicates that symbolic competence emerges spontaneously from classical associative learning mechanisms when the conditioned stimuli are self-generated, arbitrary and socially efficacious. We propose that more exclusive properties of human language, such as syntax, may derive from the evolution of higher-order domains for neural association, more removed from both the sensory input and the motor output, able to support the gradual complexification of grammatical categories into syntax.

Animals↗

Social categorizations, social comparisons and stigma: presentations of self in people with learning difficulties.

Self-categorization theory stresses the importance of the context in which the meta-contrast principle is proposed to operate. This study is concerned with how 'the pool of psychologically relevant stimuli' (Turner, Hogg, Oakes, Reicher & Wetherell, 1987, p. 47) comprising the context is determined. Data from interviews with 33 people with learning difficulties were used to show how a positive sense of self might be constructed by members of a stigmatized social category through the social worlds that they describe, and therefore the social comparisons and categorizations that are made possible. Participants made downward comparisons which focused on people with learning difficulties who were less able or who displayed challenging behaviour, and with people who did not have learning difficulties but who, according to the participants, behaved badly, such as beggars, drunks and thieves. By selection of dimensions and comparison others, a positive sense of self and a particular set of social categorizations were presented. It is suggested that when using self-categorization theory to study real-world social categories, more attention needs to be paid to the involvement of the perceiver in determining which stimuli are psychologically relevant since this is a crucial determinant of category salience.

Adolescent↗

S-Allylcysteine prevents amyloid-beta peptide-induced oxidative stress in rat hippocampus and ameliorates learning deficits.

The effects of S-allylcysteine on oxidative damage and spatial learning and memory deficits produced by an intrahippocampal injection of amyloid-beta peptide 25-35 (Abeta(25-35)) in rats were investigated. The formation of reactive oxygen species, lipid peroxidation and the activities of the antioxidant enzymes superoxide dismutase and glutathione peroxidase were all measured in hippocampus 120 min after Abeta(25-35) injection (1 microl of 100 microM solution), while learning and memory skills were evaluated 2 and 35 days after the infusion of Abeta(25-35) to rats, respectively. Abeta(25-35) increased both reactive oxygen species and lipid peroxidation, whereas pretreatment with S-allylcysteine (300 mg/kg, i.p.) 30 min before peptide injection decreased both of these markers. In addition, Abeta(25-35)-induced incorrect learning responses were prevented in most of trials by S-allylcysteine. In contrast, enzyme activities were found unchanged in all groups tested. Findings of this work: (i) support the participation of reactive oxygen species in Abeta(25-35)-induced hippocampal toxicity and learning deficits; and (ii) suggest that the protective effects of S-allylcysteine were related to its ability to scavenge reactive oxygen species.

Amyloid beta-Peptides↗

Transfer of learning to compensate for impairment by alcohol and visual degradation.

RATIONALE: Past research on social drinkers shows that prior experience performing a task in a visually degraded environment results in the reduction of alcohol-induced impairment. It is possible that task experience under alcohol might similarly carry over to reduce impairment from visual degradation. OBJECTIVES: The purpose of this study was to test the symmetry of the transfer of learning between two distinct sources of impairment, visual degradation and alcohol. MATERIALS AND METHODS: Psychomotor impairment was measured by a pursuit rotor tracking task. Forty two participants were randomly assigned to one of six treatment groups. Two groups were tested under alcohol after having prior task experience performing with or without visual degradation. Two groups were tested under visual degradation after having prior task experience performing under active (0.65 g/kg) or inactive (placebo) doses of alcohol. The remaining two groups served as controls that tested the learning effects of repeating each active treatment. RESULTS: Clear evidence for asymmetrical transfer of learning was observed. Prior task experience with visual degradation reduced the impairing effects of alcohol. By contrast, prior task experience under alcohol had no effect on impairment produced by visual degradation. CONCLUSIONS: Evidence for differential transfer of learning to compensate for alcohol- and visual-degradation-induced impairment is of practical interest, given that the two disturbances commonly co-occur outside the laboratory. Reasons for the asymmetry are unclear, and likely involve differences in mechanisms by which each treatment impairs psychomotor function.

Adult↗

5-HT6 receptor antagonists enhance retention of a water maze task in the rat.

RATIONALE: 5-HT(6) receptors are predominantly located in the brain and may be involved in cognitive processes. The aim of this study was to assess the effects of two potent and selective 5-HT(6) receptor antagonists, SB-271046-A and SB-357134-A, on learning and memory in the rat. METHODS: Spatial learning and memory was assessed by testing the effects of SB-271046-A and SB-357134-A on acquisition and retention of a water maze task. RESULTS: In the water maze, administration of SB-271046-A or SB-357134-A (3 or 10 mg/kg) had no effect on learning per se. At 10 mg/kg, however, both compounds produced a significant improvement in retention of a previously learned platform position when tested 7 days after training. By contrast, the acetylcholinesterase inhibitor, Aricept (donepezil, 0.1, 0.3 mg/kg PO) had no effect in this task. CONCLUSIONS: This study demonstrates that systemic administration of SB-271046-A and SB-357134-A produces improvements in retention of a water maze task in the rat. These data indicate that 5-HT(6) receptor antagonism may be involved in cognitive function.

Animals↗