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At least 1,099 records · Page 61Linked to original sources
PubMed2002

The transition to marriage and changes in alcohol involvement among black couples and white couples.

OBJECTIVE: The purpose of this study was to assess whether the reduction in alcohol involvement typically associated with the transition to marriage differs for blacks, compared with whites. METHOD: Couples (n = 248, white; n = 100, black) in which both partners were entering into their first marriage were assessed at the time of marriage, their first anniversary and their second anniversary. At each wave, husbands and wives were each given an identical questionnaire packet to complete independently at home and a postage-paid envelope for packet return. A broad range of constructs was assessed, including personality characteristics, relationship functioning, drinking behaviors and social network characteristics. Alcohol involvement measures included average daily volume of consumption, frequency of heavy drinking, alcohol-related problems and alcohol dependence. RESULTS: Whites decreased their frequency of heavy drinking and alcohol dependence over the early marital years, whereas blacks remained relatively stable. Alcohol problem trajectories were similar for wives of both races. White men reported a decline in alcohol problems, whereas black men reported an increase in problems over the first 2 years of marriage. Racial differences in the alcohol involvement trajectories could not be attributable to racial differences in family formation or demographic factors. CONCLUSIONS: Findings suggest limited generalizability of previous research, indicating a reduction in alcohol involvement associated with the transition to marriage. Individuals who continue to drink heavily after this transition may be at an especially high risk for the subsequent development of serious alcohol and marital problems.

Adolescent↗
PubMed1984

Critical period for the entrainment of the circadian rhythm in blinded pups by dams.

The critical period for the entrainment of circadian rhythm in blinded pups by a foster mother with a rhythm inverted to that of the natural mother was determined by a convenient method for the analysis of the circadian rhythm of drinking behavior. The pups, optically enucleated on day 1, were transferred to the foster mother at various ages, measured in days from birth, and raised until weaning. When the pups were transferred before 4 days of age, the drinking rhythm of the adopted pups was in phase with that of the blinded natural pups born of and raised by the foster mother. On the other hand, when the mother was exchanged after 10 days of age, the rhythm of the adopted pups was out of phase with that of the natural pups of the foster mother. Pups exchanged on 5 or 7 days of age showed inconsistent phase of rhythm, either being entrained by the foster or the natural mothers, or affected by both mothers. These results indicate that blinded pups must be adopted by the foster mothers earlier than day 4 for the foster mothers to fully entrain the circadian rhythm of blinded pups.

Animals↗
PubMedDate not supplied

The effectiveness of an inpatient group cognitive behavioral therapy program for alcohol dependence.

The present study evaluated the effectiveness of attendance at a clinically based, short-term, in-patient group CBT program largely based on Monti, Abrams, Kadden, and Cooney to treat problem drinking. Participants were 37 males and 34 females diagnosed with alcohol dependence. Patients attended 42 CBT sessions over three weeks, with each session being one hour in duration. Measures included the Khavari Alcohol Test (KAT), the Short Alcohol Dependence Data Questionnaire (SADD), the Beck Anxiety Index (BAI), the Symptom Checklist-90-Revised (SCL-90), a General Self-Efficacy scale (GSE), and the Drinking Expectancy Profile (DEP). Group attendance rates were monitored daily. Two structured phone calls were conducted at one month and three months post-discharge. Results showed that attendance rates at CBT group sessions were not associated with improvements found at the end of therapy or in drinking behaviors at three-month follow-up. Full support could not be found for the effectiveness of group CBT and cognitive models of problem drinking.

Adolescent↗
PubMed1993

Reducing the desire to drink. Pharmacology and neurobiology.

The past decade has witnessed major advances in understanding of neural functioning and neurobiological bases of alcohol consumption. Concurrent with this, a range of exciting investigations have been conducted on pharmacologic agents that may curb drinking behavior. Research is reviewed on several promising medications influencing neurotransmitter and endocrine systems with particular attention to the serotonergic and opioid systems. Following this overview, recommendations are offered regarding research methodology to support future pharmacotherapy trials.

Alcohol Deterrents↗
PubMedDate not supplied

Behavioral toxicological assessment of oral pralidoxime methanesulfonate in the rat.

The behavioral toxicity of pralidoxime methanesulfonate (P2S) was examined in the rat by comparing standard measures such as conditioned taste aversion (CTA), drinking behavior and acute oral toxicity. P2S produced a weak CTA at doses of 0.4 and 0.8 g/kg (PO) and a profound CTA at the highest dose (1.6 g/kg) using a single sucrose-flavored conditioning trial with a one bottle test. The CTA produced by the highest dose of P2S was blocked by a specific, and exclusively peripheral, histamine-H2blocker, cimetidine (30 mg/kg, IP), which also has a cytoprotecting effect on gastric mucosal lesions. These data suggest that the H2 receptors may be involved in inducing the aversive effects of P2S through the inherent local irritating property of P2S on the rat gastric mucosa. There was no disruption of water drinking in thirsty rats with P2S at doses ranging from 0.2 to 1.6 g/kg. The survival time after an acute oral lethal dose of P2S (8-15 g/kg) was prolonged in non-fasted rats (16.5-38.5 min) compared to fasted ones (3.5-14.5 min), however the LD50's were identical (8.7 +/- 1.0 and 7.5 +/- 0.5 g/kg; respectively); indicating that P2S taken with food delays the lethal effects, but does not affect its lethal potency.

Administration, Oral↗
PubMed1992

Familial transmission of alcohol use: V. Drinking patterns among spouses, Tecumseh, Michigan.

This study examined concordance and discordance of self-reported alcohol consumption in 184 spouse pairs drawn from a representative sample of the Tecumseh, MI community. A significant association (tau B = .57, p less than .001) between self-reported alcohol consumption of husbands and that of wives was observed. Drinking daily and high maximum drinking were also significantly correlated between spouses, as were church attendance, smoking, impulsivity, and sociability. A significant association between the drinking of wives and that of their mothers-in-law was noted. The relationship between husbands' drinking and that of their fathers-in-law was marginally significant. However, three-quarters of daughters of heavy-drinking fathers (21 of 28) married abstemious men (never drank or drank lightly), while only 7% married heavy-drinking husbands. These findings lend support to the idea that a network of familial influences--both primary and secondary assortative mating--contributes to regulating adult drinking behavior.

Adult↗
PubMedDate not supplied

Ethanol self-administration in ALKO rats: II. Effects of selection and fixed-ratio size.

The ethanol-reinforced behavior of ALKO Alcohol Accepting (AA) rats was studied as a function of fixed-ratio (FR) size (1, 2, 4, 8 and 16) across several ethanol concentrations (8, 16 and 32% w/v). A comparison was also made with ethanol-reinforced behavior of Sprague-Dawley (SD) rats. Ethanol, previously shown to serve as a reinforcer in AA and SD rats, maintained responding in these animals under conditions of intermittent reinforcement. SD rats exhibited higher response rates than AA rats to obtain 8% ethanol concentrations as fixed-ratio size was varied in these experiments. These results confirm that, for AA rats, the selection for preference in a two-bottle choice situation did not include the selection for those biological factors which maximize ethanol-reinforced behavior under conditions of intermittent reinforcement. These experiments suggest the existence of distinct, biologically influenced components of ethanol drinking behavior, and have demonstrated several similarities as well as differences between two-bottle choice preference tests and operant studies of ethanol-reinforced behavior.

Animals↗
PubMed2003

Effect of morphine, naloxone and histamine system on water intake in adult male rats.

The present study investigated the interaction between histamine and opioid systems on water intake in adult male rats. Intracerebroventricular (i.c.v.) injections were carried out in all experiments. Water intake was measured 1 h after drug injections. Administration of histamine (40-80 microg/rat) and naloxone (0.5-1 microg/rat) increased, while morphine (2.5 microg/rat), pyrilamine (25-50 microg/rat), the histamine H1 receptor antagonist, and ranitidine (10-20 microg/rat), the histamine H2 receptor antagonist, decreased water intake in isolated rats. Blockade of histamine H1 and H2 receptors attenuated the histamine-induced response. Pyrilamine, but not ranitidine, increased the inhibitory effect induced by morphine. Also, pharmacological blockade of histamine H1 and H2 receptors decreased the naloxone-induced effect on water intake. It is concluded that the histaminergic system may have a close interaction with morphine and naloxone on drinking behavior.

Analgesics, Opioid↗
PubMed1996

Identification of hazardous/harmful drinking among subcritically injured patients.

OBJECTIVES: To examine the relationship between a saliva alcohol test (SAT) and hazardous/harmful drinking, as measured by the Alcohol Use Disorders Identification Test (AUDIT), among a sample of subcritically injured patients. METHODS: Patients (n = 78) seeking treatment for a subcritical injury were saliva-tested for alcohol and interviewed regarding their drinking behaviors and related difficulties. Associations of SAT values with AUDIT results were determined. RESULTS: SAT results and hazardous/harmful drinking were not independent events (p < 0.001). Estimates of sensitivity and specificity (using a dichotomous SAT result [> or = 4 mmol/L] to identify positive AUDIT patients) were 65.2% and 83.6%, respectively. SAT-positive people had significantly higher AUDIT scores than did SAT-negative individuals (p < 0.0001). Patients experiencing assault-type injuries were much more likely to be SAT-positive than were patients incurring other types of injury. Discriminant function analysis suggests that AUDIT scores can successfully identify SAT-positive and SAT-negative patients; the analysis accounted for 42.5% of the variance and correctly classified 84.6% of the sample. CONCLUSIONS: The use of an easy-to-administer, noninvasive, routine SAT, among patients presenting for a subcritical injury in a hospital ED, provides a mechanism for the identification of individuals with a history of hazardous/harmful drinking. However, since discrimination of hazardous/harmful drinking is imperfect, some caution is warranted when conducting such screening activities.

Accident Proneness↗
PubMed1980

Reversibility of cognitive deficit in alcoholics.

Testing of alcoholics and matched controls on a series of psychological measures and retesting approximately 14 months later showed improvement in alcoholics' problem-solving abilities, but not to the level of controls. Improvement was not related to posttreatment drinking behavior.

Alcohol Drinking↗
PubMed2001

Social influence processes and college student drinking: the mediational role of alcohol outcome expectancies.

OBJECTIVE: Social influences are among the most robust predictors of adolescent substance use and misuse. Studies with early adolescent samples have supported the need to distinguish among various types of social influences to better delineate relations between social factors and alcohol use and problems. METHOD: The first major goal of the present study (N = 399, 263 women) was to examine unique relations between particular facets of social influence and alcohol use and problems in a relatively heavy-drinking population (i.e., college students). We hypothesized that active social influences (offers to drink alcohol) and passive social influences (social modeling and perceived norms) would demonstrate positive associations with measures of alcohol use and problems. We also tested the hypothesis that alcohol outcome expectancies would mediate associations between social influences and drinking behaviors. RESULTS: Structural equation modeling analyses provided strong support for the first hypothesis. Social modeling demonstrated the strongest association with alcohol use and problems, and active social influences demonstrated significant associations with both use and problems. Perceived norms were related to alcohol use, but not directly with alcohol problems. Support for the second hypothesis was positive but limited to one type of social influence. Strong evidence for a mediational role of outcome expectancies was found for relations between social modeling and alcohol use and problems. CONCLUSIONS: Together, these findings demonstrate the unique and relative contribution of active and passive social influences and provide limited support for a hypothesized process by which social factors influence cognitions and alcohol-related behaviors.

Adolescent↗
PubMed1983

Alcoholism among women: a comparison of Black and White problem drinkers.

This study examines alcohol-related behavior of Black and White female problem drinkers. Subjects included 163 Whites and 38 Blacks currently in treatment. Findings indicate some similarities and important differences between Black and White women in terms of selected factors. When social background factors are held constant, race continues to be a significant predictor of selected drinking behavior factors. In addition, White problem-drinking women are more likely than their Black counterparts to perceive difficulties in male-female relations as a major cause of their alcohol problems. Implications for improving prevention and treatment services to women are discussed.

Age Factors↗
PubMed2006

Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats.

A genome scan of the F2 generation from an inbred alcohol-preferring (iP) and inbred alcohol-nonpreferring (iNP) rat cross identified a significant quantitative trait locus (QTL) on chromosome 4 with a lod score of 9.2. To confirm this QTL and to create animals for fine mapping of the QTL region, chromosome 4 reciprocal congenic strains were developed by transferring the chromosome 4 QTL interval into the respective iP or iNP backgrounds. The iP strain was crossed with the iNP strain to create iPiNP F1 animals, which were backcrossed to either iNP or iP animals to produce the N2 generation. Using marker-assisted selection, 10 generations of backcrossing were performed. The selection was followed by an intercross between the N10 animals to produce homozygous animals (N10F1), resulting in the finished congenic strains. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) and the iNP chromosome 4 QTL was transferred to the iP (P.NP) exhibited the expected effect on alcohol consumption of the donor strain. Development of these congenic strains further indicates that the chromosome 4 QTL region is, in part, responsible for the disparate alcohol consumption observed between the iP and iNP rats. These congenic animals will be an invaluable resource for fine mapping the QTL region and for the identification of the gene(s) that influences the drinking behavior of the iP and iNP rats.

Alcohol Drinking↗
PubMed1996

Effects of tryptophan depletion in drug-free adults with autistic disorder.

BACKGROUND: The primary objective of this study was to investigate the behavioral and biochemical responses to acute tryptophan depletion in drug-free adult patients with autistic disorder. METHODS: Twenty drug-free adults with autistic disorder (16 men and 4 women) (mean [+/- SD] age, 30.5 +/- 8.5 years) underwent short-term tryptophan depletion in a double-blind, placebo-controlled, randomized crossover design. Patients received a 24-hour, low-tryptophan diet followed the next morning by an amino acid drink. Behavioral ratings were obtained on the morning of the amino acid drink (baseline) and 180, 300, and 420 minutes after the drink. Plasma free and total tryptophan levels were obtained at baseline and 5 hours after the drink. The active and sham testing sessions were separated by 7 days. RESULTS: Eleven (65%) of the 17 patients who completed both test days showed a significant global worsening of behavioral symptoms with short-term tryptophan depletion, but none of the 17 patients showed any significant change in clinical status from baseline after sham depletion (P = .001). Tryptophan depletion led to a significant increase in behaviors such as whirling, flapping, pacing, banging and hitting self, rocking, and toe walking (P < .05). In addition, patients were significantly less calm and happy and more anxious. No significant change was observed in social relatedness or repetitive thoughts and behavior. Plasma total and free tryptophan levels were reduced 86% and 69%, respectively, 5 hours after the tryptophan-deficient amino acid drink. Patients who had a significant global exacerbation of symptoms had significantly higher baseline plasma total tryptophan levels (P < .001) and Autism Behavior Checklist scores (P = .005) than did patients who showed no significant change in symptoms after tryptophan depletion. CONCLUSIONS: The results of this study are consistent with previous research that has implicated a dysregulation in serotonin function in some patients with autism. These data suggest that the short-term reduction of serotonin precursor availability may exacerbate some symptoms characteristic of autism in some patients. Continued investigation into the role of serotonin in the pathogenesis and treatment of autistic disorder is warranted.

Adult↗
PubMed2000

Craving: what can be done to bring the insights of neuroscience, behavioral science and clinical science into synchrony.

Alcohol self-administration behavior is the common thread that is necessary to bring the insights of neuroscience, behavioral science and clinical science into synchrony around the concept of craving. Animal models should address the molecular and cellular changes that take place in behaviorally relevant brain regions of rats consequent to chronic self-administration of ethanol. Animal models can focus on the biology of the anticipatory state in alcohol preferring/consuming rats, as well as studies of the effects of possible medications on this state in the animal model, on actual alcohol consuming behavior, and on the residual effects of chronic alcohol on the non-human mammalian brain. In human studies of craving, cue-reactivity in the absence of the opportunity to drink alcohol does not have the same salience as cue-reactivity in which drinking is possible. Moreover, actual drinking behavior serves to validate self-reports of craving. Studies of limited alcohol self-administration in the laboratory are an essential element in screening new medications for the treatment of alcoholism. Studies to date suggest no adverse reaction to the participation of alcoholic subjects in limited alcohol self-administration studies, but the research community should continue to monitor carefully the outcomes of alcohol-dependent subjects who participate in this type of research, and efforts should always be made to encourage these subjects to enter active treatment. In outpatient clinical trials of new treatments for alcoholism, the assessment of craving should include queries regarding symptoms and signs of protracted abstinence such as sleep disturbances, as well as questions regarding situational craving. Field observations of alcoholics in their favorite drinking environments would contribute greatly to our understanding of the real-world phenomenology of craving.

Alcohol Drinking↗
PubMed2006

Automated telephone screening for problem drinking.

OBJECTIVE: This study assessed test-retest reliability and criterion validity for an automated version of the Alcohol Use Disorders Identification Test (AUDIT), a screening tool for alcohol-related problems. Participants' willingness to use such a system to learn about and change their drinking behavior was also assessed. METHOD: Participants were 202 callers recruited through newspaper ads and flyers asking for volunteers concerned about their drinking and willing to help test a new method of screening and referral for alcohol problems. Participants were divided into two groups. The first group of subjects recruited received the Telephone-Linked Communications (TLC)-AUDIT twice, administered a week apart. The second group received the TLC-AUDIT once and a human-administered AUDIT once, also a week apart. RESULTS: Test-retest reliability was assessed in 102 participants; the intraclass correlation of AUDIT scores between both administrations was .87; kappa for nonproblem versus problem drinking (AUDIT score of 8 or above) was .89. The validity study compared the TLC-AUDIT scores of the next 100 participants to AUDIT questions administered by a human interviewer. The intraclass correlation was .94; kappa was .75. Seventy-five percent of all participants who screened positive for problem drinking agreed they would "talk to a computer again to learn more about your drinking pattern and how to deal with it". CONCLUSIONS: Automated telephone technology can be used to administer the AUDIT instrument with high levels of reliability and validity. This technology could be used to deliver behavioral change interventions.

Adult↗
PubMed1984

Family structure, race, and adolescents' alcohol use: a research note.

Family structure is related to adolescents' drinking behavior differently for Blacks than Whites. Black adolescents were more likely to be heavy alcohol users when both natural parents were present, but the opposite was true for the whites. Only when non-White adolescents were in families with both parents, and the father had at least a high school education, did they drink near the rate of White adolescents. There was support of social learning theory.

Adolescent↗