PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Extrachromosomal Inheritance”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,099 records · Page 61Linked to original sources
PubMed1976

Transposable genetic elements and plasmid evolution.

Transposable elements of DNA that are structurally defined and genetically discrete units seem to have an important role in the evolution of bacterial plasmids. Recombination occurring at the termini of such elements can result in the joining together of unrelated DNA segments that lack extensive nucleotide sequence homology. In addition, transposable elements serve as novel biological switches capable of turning on and off the expression of nearby genes as a consequence of their insertion into or excision from plasmid genomes.

Alleles↗
PubMed1980

Excision sequences in the mitochondrial genome of yeast.

It is well established that spontaneous cytoplasmic 'petite' mutants of Saccharomyces cerevisiae have mitochondrial genome units in which an excised segment of the parental wild-type genome has been tandemly amplified (Fig. 1), so that the excised segment becomes the repeat unit of the petite genome; the latter may in turn undergo further deletions leading to secondary petite genomes having shorter repeat units (see ref. 1 for a brief review). Recent investigations on the mitochondrial genomes of several spontaneous petite mutants have shown that frequently the ends of the excised segment correspond to short sequences of the wild-type genome which are extremely rich in GC, the GC clusters; alternatively, they seem to be located in the long AT-rich stretches, the AT spacers, which form at least half of the genome. As sequence repetitions have been demonstrated in both GC clusters and AT spacers, it is very likely that excision takes place by a mechanism involving illegitimate site-specific recombination events between homologous sequences, as previously postulated. We show here that the sequences involved in the excision of a particular spontaneous petite genome are direct nucleotide repeats located in the AT spacers.

Base Sequence↗