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[Management and storage of radioactive waste].

Management of radioactive waste is a matter of public concern. Such management, however, is today handled industrially in France, and when these techniques are well applied, it is possible to create storage centres. Waste having a short half-life is now stored in the Centre de l'Aube, which replaces the one begun in 1969 in the Department de la Manche. For waste with a long half-life, following the law passed in 1991, ANDRA is pursuing its programme of site prospection to establish two underground laboratories for studying geological storage.

Drug Storage↗

Safe handling of antineoplastic drugs. Results of a survey.

As research continues to highlight the risks involved in handling antineoplastic drugs, the health services are giving increased attention to safety measures. In order to establish what protective measures nursing staff employ and what they know about antineoplastic drugs, a survey was carried out in The Netherlands. The questions were based on the self-study modules by Dunne and the (American) Oncology Nursing Society. A total of 1,373 questionnaires were distributed in 10 hospitals. Of these, 824 were returned, which represents a response rate of 60%. Over two-thirds (68%) of the nursing staff reported that they were involved, on a daily or weekly basis, in caring for patients being treated with antineoplastic drugs. In the view of 94% of the nurses, protective measures are effective. While administering antineoplastic drugs, 91% of the respondents said that they wore gloves, 21% said that they wore a gown, 18% wore a mask, and 3% used goggles. While handling excreta, fewer nurses applied safety measures. Thirty-nine percent of the respondents knew that latex gloves offer a greater degree of protection than PVC gloves. It appeared that there was not one Dutch hospital whose guidelines for the safe handling of antineoplastic material were completely up-to-date and that nurses do not always follow the guidelines established.

Antineoplastic Agents↗

Food for thought.

Explore the source record for details and available documents.

Ethics, Medical↗

A process for selecting a safety needle system in a community teaching hospital.

Healthcare workers, especially intravenous nurses, are wary of the threat of bloodborne pathogens. In light of the Bloodborne Pathogen Standard issued by the Occupational Safety and Health Administration (OSHA), healthcare institutions must examine occupational exposures to blood and other infectious materials and investigate ways to minimize risks. The author describes the experiences of a community teaching hospital and the progressive steps involved in selecting a safety needle system.

Hospitals, Community↗

[Ecological awareness and health services wastes].

Environmental clean-up involves a series of factors, among them the question of solid wastes, which are not always properly managed. The problem is more serious with respect to medical waste. The awareness of people and the attention of administrators are of fundamental importance for an equilibrated coexistence with the physical environment.

Ecology↗

Degradation and inactivation of antitumor drugs.

Chemical methods for the degradation of 11 antineoplastic drugs [etoposide, teniposide, bleomycin, mitomycin C, cisplatin, cis-dichloro-trans-dihydroxy-bis(isopropylamine) platinum IV (CHIP), cyclophosphamide, ifosfamide, carmustine, lomustine, and methotrexate] were investigated. The success of the degradation procedures was assessed by HPLC and degree of biological inactivation by mutagenicity assays. The most widely applicable procedure was oxidation with potassium permanganate or 5.25% sodium hypochlorite solution (bleach). Oxidation completely degraded and inactivated etoposide, teniposide, bleomycin, mitomycin C, and methotrexate. In addition, oxidation followed by nucleophilic substitution resulted in the complete degradation and inactivation of cyclophosphamide and ifosfamide. Although carmustine and lomustine were chemically degraded by treatment with acidic potassium permanganate, the resulting reaction mixtures remained mutagenic. Therefore, this procedure cannot be recommended. The platinum-containing compounds, cisplatin and CHIP, were rendered nonmutagenic by reaction with sodium diethyldithiocarbamate. These easily performed, relatively safe procedures can be used to prevent exposure to mutagenic wastes and spills in the hospital setting.

Antineoplastic Agents↗

Fighting the needlestick battle without needles.

Institutions may face heavy fines by 1997 for not providing employees with safe sharps devices to prevent the spread of bloodborne pathogens to health care workers. One hospital decided to eliminate IVPB needles, which are responsible for the majority of needlestick injuries nationwide. To achieve this goal, medical-surgical nurses evaluated safe IVPB systems and chose one that decreased their needlestick injury rate by 68.6%.

Accidents, Occupational↗