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At least 1,099 records · Page 61Linked to original sources
PubMed1976

The histopathologic basis for functional decrements in late radiation injury in diverse organs.

As more and more patients respond favorably to combined cancer therapies, the time of survival from radiotherapy will become the most important single factor in the incidence and progression of late radiation changes. The late sequelae of irradiation are the sum of the following: 1) residua of the direct and indirect early changes in responsive cell populations; 2) progressive vascular sclerosis with its associated effect upon connective tissue and the parenchymal cells; and 3) the reactive or replacement connective tissue proliferation which is responding to 1) and 2). From this it may be seen that further investigative efforts need direction toward: 1) reducing the magnitude and permanence of the early principal parenchymal cell injury; 2) diminishing the severity of the early microvascular change which adds significantly to the early parenchymal cell damage; 3) determining the mechanics of the progressive vascular sclerosis with a view to retarding this effect; and 4) lessening the reactive fibrosis.

Blood Vessels↗
PubMed1989

Histopathology of severe renal vascular damage in blacks.

During the 1970s renal biopsies were obtained after blood pressure had been controlled in 41 black patients in Memphis who had severe hypertension plus excretory renal failure. An additional 13 binephrectomy specimens were also studied. This material yielded significant information on the state of the renal arteries--arterioles under these circumstances. Fibrinoid necrosis of the afferent glomerular arteriole and proliferative glomerulitis were not noted. Rather, the vascular lesion characterized by the accumulation of smooth muscle cells and mucopolysaccharide in the intima attended by a marked narrowing of the lumen was dominant. This lesion caused pronounced ischemia associated with obsolescence of glomeruli, atrophy, and fibrosis (end-stage kidney). This lesion has been renamed musculomucoid intimal hyperplasia as a result of changes revealed by electron microscopic and histochemical studies. Since this study the incidence of this severe vascular disease of the kidney in the same geographic area has been markedly reduced. There are a number of possible reasons for this change in incidence, but a major one appears to be improved treatment of hypertension and better compliance with antihypertensive therapy. Why such extreme changes occur in a subset of hypertensive blacks is not known. It is apparent that without improved antihypertensive treatment, this type of end-stage renal disease due to severe vascular damage will continue to be encountered.

Adult↗
PubMed1993

Congestive heart failure in a patient with systemic hypertension.

A 70-year-old man developed hypertension many years previously and had a bout with severe congestive heart failure 4 to 5 years before his death. Autopsy showed congestion and edema characteristic of heart failure, and enlarged heart, and slight focal interstitial left ventricular fibrosis, but only slight to moderate coronary atherosclerosis.

Aged↗