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Results for “Pattern Recognition, Physiological”

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PubMedDate not supplied

EEG coherence analysis and field dependence.

The sensitivity of EEG coherence analysis was examined by comparing two groups of subjects that differed on a measure of information processing style. The psychological theory of field-dependence was combined with a physiological model for interpreting the EEG and led to the prediction that field-dependent subjects would have lower alpha band coherence than field-independent subjects. This was empirically supported. The results also demonstrated a negative linear correlation between field-dependence and EEG coherence during an eyes-closed 'resting' condition. Under this condition the more field-dependent a subject was, the lower their coherence tended to be. These results supported the hypothesis that EEG coherence analysis may be a sensitive measure of the EEG correlates of cortical functioning.

Adult↗

PubMed2026

Transcriptomic changes in the gut mucosa of fasting northern elephant seal pups reveal immune modulation during early microbiome establishment.

Fasting is an integral component of the life-history of many species. Following abrupt weaning, northern elephant seal pups (Mirounga angustirostris) undergo an extended post-weaning fast of approximately 60 days. During this period, enteric bacterial diversity increases, suggesting that host immune regulation may facilitate the establishment of microbial communities. However, the molecular processes occurring within the intestinal mucosa during this transition remain poorly understood. To investigate these mechanisms, we characterized transcriptional changes in the enteric mucosa of male and female northern elephant seal pups sampled at weaning and after one month of fasting. Total RNA isolated from rectal swabs was sequenced and aligned to the Mirounga angustirostris reference genome. Differential gene expression and gene set enrichment analyses were used to identify genes and pathways associated with fasting and sex-specific responses. Fasting was accompanied primarily by transcriptional downregulation, including genes involved in antimicrobial defense, inflammation, protein turnover, and epithelial remodeling. In contrast, several genes associated with B-cell activity and immune recognition were upregulated. Gene Set Enrichment Analysis revealed coordinated activation of immune-regulatory pathways indicating dynamic modulation of intestinal immunity rather than generalized immune suppression. Pronounced sex-specific differences were also observed. Male pups exhibited transcriptional patterns consistent with enhanced immune tolerance, whereas females showed broader immune-pathway activation, including enrichment of pro-inflammatory and stress-response pathways. Several non-coding RNAs also displayed sex-specific changes in expression. Together, these findings suggest that fasting induces transcriptional remodeling of the gut and may contribute to immune regulation during a critical period of microbiome establishment in northern elephant seal pups.

Animals↗

PubMedDate not supplied

Cortical connections and early visual function: intra- and inter-columnar processing.

While it is widely assumed that the long-range horizontal connections in V1 are present to support contour integration, there has been only limited consideration of other possible relationships between anatomy and physiology (the horizontal connections) and visual function beyond contour integration. We introduce the possibility of other relationships directly from the perspective of computation and differential geometry by identifying orientation columns in visual physiology with the (unit) tangent bundle in differential geometry. This suggests abstracting early vision in a space that incorporates both position and orientation, from which we show that the physiology is capable of supporting a number of functional computations beyond contour integration, including texture-flow and shading-flow integration, as well as certain relationships between them. The geometric abstraction emphasizes the role of curvature, which necessitates a coupled investigation into how it might be estimated. The result is an elaboration of layer-to-layer interactions within an orientation column, with non-linearities possibly implemented by shunting inhibition. Finally, we show how the same computational framework naturally lends itself to solving stereo correspondence, with binocular tangents abstracting curves in space.

Animals↗

PubMed1998

Multicenter study of noninvasive monitoring systems as alternatives to invasive monitoring of acutely ill emergency patients.

BACKGROUND: Recent reports showed lack of effectiveness of pulmonary artery catheterization in critically ill medical patients and relatively late-stage surgical patients with organ failure. Since invasive monitoring requires critical care environments, the early hemodynamic patterns may have been missed. Ideally, early noninvasive hemodynamic monitoring systems, if reliable, could be used as the "front end" of invasive monitoring to supply more complete descriptions of circulatory pathophysiology. OBJECTIVES: To evaluate the accuracy and reliability of noninvasive hemodynamic monitoring consisting of a new bioimpedance method for estimating cardiac output combined with arterial BP, pulse oximetry, and transcutaneous PO2 and PCO2; we compared this system of noninvasive monitoring with simultaneous invasive measurements to evaluate circulatory deficiencies in acutely ill patients shortly after hospital admission where invasive monitoring was not readily available. We also preliminarily explored early differences in temporal hemodynamic patterns of survivors and nonsurvivors. DESIGN AND SETTING: Prospective comparison of simultaneous invasive and noninvasive measurements of circulatory function with retrospective analysis of data in university-run county hospitals, university hospitals and affiliated teaching hospitals, and a community private hospital. PATIENTS: We studied 680 patients, including 139 severely injured or hemorrhaging patients in the emergency department (ED), 129 medical (nontrauma) patients on admission to the ED, 274 high-risk surgical patients intraoperatively, and 138 patients recently admitted to the ICU. RESULTS: A new noninvasive impedance device provided cardiac output estimations under conditions in which invasive thermodilution measurements were not usually applied. There were 2,192 simultaneous bioimpedance and thermodilution cardiac index measurements; the correlation coefficient, r = 0.85, r2 = 0.73, p < 0.001. The precision and bias was -0.124+/-0.75 L/min/m2. Both invasive and noninvasive monitoring systems provide similar information and identified episodes of hypotension, low cardiac index, arterial hemoglobin desaturation, low transcutaneous O2, high transcutaneous CO2, and low oxygen consumption before and during initial resuscitation. The limitations of noninvasive systems were described. CONCLUSIONS: Noninvasive monitoring systems gave continuous displays of physiologic data that provided information allowing early recognition of low flow and poor tissue perfusion that were more pronounced in the nonsurvivors. Noninvasive systems may be acceptable alternatives where invasive monitoring is not available.

Adult↗

PubMed2002

MAP kinase signalling cascade in Arabidopsis innate immunity.

There is remarkable conservation in the recognition of pathogen-associated molecular patterns (PAMPs) by innate immune responses of plants, insects and mammals. We developed an Arabidopsis thaliana leaf cell system based on the induction of early-defence gene transcription by flagellin, a highly conserved component of bacterial flagella that functions as a PAMP in plants and mammals. Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a leucine-rich-repeat (LRR) receptor kinase. Activation of this MAPK cascade confers resistance to both bacterial and fungal pathogens, suggesting that signalling events initiated by diverse pathogens converge into a conserved MAPK cascade.

Arabidopsis↗

PubMed2003

A model using MT-like motion-opponent operators explains an illusory transformation in the optic flow field.

Previous studies have shown that a physiologically based model using motion-opponent operators to compute heading performs accurately for simulated observer translations. Here we show how this model can explain an illusory shift in the perceived focus of expansion of a radial flow field that occurs when a field of laterally moving dots is superimposed on a field of radially moving dots. Furthermore, we can use the model to predict the perceptual shift of the focus of expansion for novel visual stimuli. These results support the hypothesis that this illusion results from motion subtraction during the processing of optic flow fields.

Computer Simulation↗

PubMed1986

Sequential state generation by model neural networks.

Sequential patterns of neural output activity form the basis of many biological processes, such as the cyclic pattern of outputs that control locomotion. I show how such sequences can be generated by a class of model neural networks that make defined sets of transitions between selected memory states. Sequence-generating networks depend upon the interplay between two sets of synaptic connections. One set acts to stabilize the network in its current memory state, while the second set, whose action is delayed in time, causes the network to make specified transitions between the memories. The dynamic properties of these networks are described in terms of motion along an energy surface. The performance of the networks, both with intact connections and with noisy or missing connections, is illustrated by numerical examples. In addition, I present a scheme for the recognition of externally generated sequences by these networks.

Artificial Intelligence↗

PubMed2003

Obstructed labour.

Obstructed labour is an important cause of maternal deaths in communities in which undernutrition in childhood is common resulting in small pelves in women, and in which there is no easy access to functioning health facilities with the capability of carrying out operative deliveries. Obstructed labour also causes significant maternal morbidity in the short term (notably infection) and long term (notably obstetric fistulas). Fetal death from asphyxia is also common. There are differences in the behaviour of the uterus during obstructed labour, depending on whether the woman has delivered previously. The pattern in primigravid women (typically diminishing contractility with risk of infection and fistula) may result from tissue acidosis, whereas in parous women, contractility may be maintained with the risk of uterine rupture. Ultimately, tackling the problem of obstructed labour will require universal adequate nutritional intake from childhood and the ability to access adequately equipped and staffed clinical facilities when problems arise in labour. These seem still rather distant aspirations. In the meantime, strategies should be implemented to encourage early recognition of prolonged labour and appropriate clinical responses. The sequelae of obstructed labour can be an enormous source of human misery and the prevention of obstetric fistulas, and skilled treatment if they do occur, are important priorities in regions where obstructed labour is still common.

Cervical Ripening↗

PubMed1992

[A personal computer-based system for online monitoring of neurologic intensive care patients].

In the management of neurological intensive care patients with an intracranial space-consuming process the measurement and recording of intracranial pressure together with arterial blood pressure is of special interest. These parameters can be used to monitor the treatment of brain edema and hypertension. Intracranial pressure measurement is also important in the diagnosis of the various subtypes of hydrocephalus. Not only the absolute figures, but also the recognition of specific pressure-patterns is of particular clinical and scientific interest. This new, easily installed and inexpensive system comprises a PC and a conventional monitor, which are connected by an AD-conversion card. Our software, specially developed for this system demonstrates, stores and prints the online-course and the trend of the measurements. In addition it is also possible to view the online-course of conspicuous parts of the trend curve retrospectively and to use these values for statistical analyses. Object-orientated software development techniques were used for flexible graphic output on the screen, printer or to a file. Though developed for this specific purpose, this system is also suitable for recording continuous, longer-term measurements in general.

Cerebral Hemorrhage↗

PubMed2004

Boosting bit rates in noninvasive EEG single-trial classifications by feature combination and multiclass paradigms.

Noninvasive electroencephalogram (EEG) recordings provide for easy and safe access to human neocortical processes which can be exploited for a brain-computer interface (BCI). At present, however, the use of BCIs is severely limited by low bit-transfer rates. We systematically analyze and develop two recent concepts, both capable of enhancing the information gain from multichannel scalp EEG recordings: 1) the combination of classifiers, each specifically tailored for different physiological phenomena, e.g., slow cortical potential shifts, such as the pre-movement Bereitschaftspotential or differences in spatio-spectral distributions of brain activity (i.e., focal event-related desynchronizations) and 2) behavioral paradigms inducing the subjects to generate one out of several brain states (multiclass approach) which all bare a distinctive spatio-temporal signature well discriminable in the standard scalp EEG. We derive information-theoretic predictions and demonstrate their relevance in experimental data. We will show that a suitably arranged interaction between these concepts can significantly boost BCI performances.

Algorithms↗

PubMed1990

Structural and functional characterization of the CD2 immunoadhesion domain. Evidence for inclusion of CD2 in an alpha-beta protein folding class.

The T-lymphocyte transmembrane glycoprotein CD2 plays an important physiological role in facilitating adhesion between T-lymphocytes and their cognate cellular partners. This interaction is mediated by binding of CD2 to the broadly distributed surface polypeptide LFA-3 and augments the recognition function of the CD3-Ti antigen-major histocompatibility complex receptor via stabilization of conjugate formation between cells. To define better the structural components of the CD2 extracellular region which are important in contact-mediated cellular adhesion, a single-domain CD2 immunoadhesion protein has been prepared from papain digestion of a soluble two-domain CD2 molecule. This amino-terminal domain fragment binds to LFA-3 on human B-cells with a dissociation constant of 0.4 microM, possesses functional immunoadhesion epitopes as defined by the binding of monoclonal antibodies raised to native CD2, and retains the ability to inhibit sheep erythrocyte rosette formation with human T-cells. Thus, all of the immunoadhesion functions ascribed to CD2 reside within the amino-terminal domain. Circular dichroism analysis of the isolated CD2 adhesion domain suggests the presence of substantial alpha-helical character (22%), consistent with earlier computer modeling analyses that predicted a pattern of alternating alpha-helices and beta-sheets within the extracellular region of CD2. Despite the existence of short stretches of sequence homology between CD2 and immunoglobulin superfamily members, the circular dichroism data provide supporting biophysical evidence for classification of CD2 in an alpha-beta (either alpha/beta or alpha + beta) protein folding class.

Amino Acid Sequence↗

PubMed2002

Digital and biological computing in organizations.

Michael Conrad unveiled many of the fundamental characteristics of biological computing. Underlying the behavioral variability and the adaptability of biological systems are these characteristics, including the ability of biological information processing to exploit quantum features at the atomic level, the powerful 3-D pattern recognition capabilities of macromolecules, the computational efficiency, and the ability to support biological function. Among many other things, Conrad formalized and explicated the underlying principles of biological adaptability, characterized the differences between biological and digital computing in terms of a fundamental tradeoff between adaptability and programmability of information processing, and discussed the challenges of interfacing digital computers and human society. This paper is about the encounter of biological and digital computing. The focus is on the nature of the biological information processing infrastructure of organizations and how it can be extended effectively with digital computing. In order to achieve this goal effectively, however, we need to embed properly digital computing into the information processing aspects of human and social behavior and intelligence, which are fundamentally biological. Conrad's legacy provides a firm, strong, and inspiring foundation for this endeavor.

Adaptation, Physiological↗

PubMed1995

A.R.P. Walker Lecture. Food and the gut.

A.R.P. Walker pioneered the research into the association between food, gut function and disease patterns in southern Africa. His attention to ways in which dietary differences can explain geographical differences in disease patterns has led to the realisation that civilisation and modern food technology can exert a strong influence on dietary practices, gut function and disease tendencies. Recognition that South African blacks have a very low incidence of colonic problems such as diverticulitis, adenomatous polyps and carcinoma drew attention to the possibility that the traditional African diet, with a high fibre content, may maintain colonic health and prevent disease in old age. This review explores some of the mechanisms that may account for these differences and also examines ways in which malnutrition alters gut function. To quote Walker's conclusions: 'There is a need, indeed a duty, for writers on nutrition to devote a portion of their space to the nutritional lessons to be learned from the past, from war-time experiences and from present day Third-World populations.'

Adaptation, Physiological↗

PubMed2000

tRNA-guanine transglycosylase from Escherichia coli: recognition of noncognate-cognate chimeric tRNA and discovery of a novel recognition site within the TpsiC arm of tRNA(Phe).

tRNA-guanine transglycosylase (TGT) is a key enzyme involved in the posttranscriptional modification of tRNA across the three kingdoms of life. In eukaryotes and eubacteria, TGT is involved in the introduction of queuine into the anticodon of the cognate tRNAs. In archaebacteria, TGT is responsible for the introduction of archaeosine into the D-loop of the appropriate tRNAs. The tRNA recognition patterns for the eubacterial (Escherichia coli) TGT have been studied. These studies are all consistent with a restricted recognition motif involving a U-G-U sequence in a seven-base loop at the end of a helix. While attempting to investigate the potential of negative recognition elements in noncognate tRNAs via the use of chimeric tRNAs, we have discovered a second recognition site for the E. coli TGT in the TpsiC arm of in vitro-transcribed yeast tRNA(Phe). Kinetic analyses of synthetic mutant oligoribonucleotides corresponding to the TpsiC arm of the yeast tRNA(Phe) indicate that the specific site of TGT action is G53 (within a U-G-U sequence at the transition of the TpsiC stem into the loop). Posttranscriptional base modifications in tRNA(Phe) block recognition by TGT, most likely due to a stabilization of the tRNA structure such that G53 is inaccessible to TGT. These results demonstrate that TGT can recognize the U-G-U sequence within a structural context that is different than the canonical U-G-U in the anticodon loop of tRNA(Asp). Although it is unclear if this second recognition site is physiologically relevant, this does suggest that other RNA species could serve as substrates for TGT in vivo.

Base Sequence↗

PubMed1997

Lectin binding patterns of porcine oviduct mucosa and endometrium during the oestrous cycle.

Important functions of the oviduct during reproduction include the provision of an optimal environment for gametes and zygotes and nutrition of the early embryo. These functions are ensured by the secretion of an oviductal fluid which is known to contain organ-specific glycoproteins. Glycoconjugates of the apical glycocalyx are considered to play a major role in cell recognition and interaction processes. In the present investigation, binding patterns of Con A, HPA, LTA, RCA I, UEA I, and WGA were studied in defined segments of the oviduct (infundibulum, ampulla, isthmus) and in the uterus during the oestrous cycle. The carbohydrate distribution showed regional as well as time dependent differences. LTA, HPA and WGA reacted strongly with Golgi regions and secretory granules in the oviduct epithelium during the follicular phase, indicating high secretory activity. LTA, HPA, and UEA I also revealed a varying carbohydrate composition of the glycocalyx during the oestrous cycle. Prominent regional differences in glycoconjugate expression were shown in oviductal segments by LTA and HPA binding: during the follicular phase, LTA binding sites were only present on epithelial cells of the isthmic segment, the ampulla and infundibulum being unreactive. D-N-acetyl-galactosamine residues were demonstrated on ciliated epithelial cells of the ampulla and infundibulum exclusively during oestrus. The glycocalyx of uterine epithelial cells was clearly defined by HPA, WGA, LTA, RCA I and UEA I; LTA binding was restricted to the secretory phase. The observation of regional and time dependent variability in glycoconjugate distribution strongly indicates their specific physiological functions in reproductive processes.

Animals↗

PubMed2006

Monitoring cardiac output using the femoral and radial arterial pressure waveform.

This study was performed to determine the interchangeability of femoral artery pressure and radial artery pressure measurements as the input for the PiCCO system (Pulsion Medical Systems, Munich, Germany). We studied 15 intensive care patients following cardiac surgery. Five-second averages of the cardiac output derived from the femoral artery pressure (COfem) were compared to 5-s averages derived from the radial artery pressure (COrad). One patient was excluded due to problems in the pattern recognition of the arterial pressure signal. In the remaining 14 patients, 14 734 comparative cardiac output values were analysed. The mean sample time was 88 min, range [30-119 min]. Mean (SD) COfem was 6.24 (1.1) l.min(-1) and mean COrad 6.23 (1.1) l.min(-1). Bland-Altman analysis showed an excellent agreement with a bias of - 0.01 l.min(-1), and limits of agreement from 0.60 to - 0.62 l.min(-1). If changes in CO were > 0.5 l.min(-1), the direction of changes in COfem and COrad were equal in 97% of instances. We conclude that femoral artery pressure and radial artery pressure are interchangeable as inputs for the PiCCO device.

Aged↗

PubMed1991

The shift effect can be elicited with both foveal and peripheral masks.

Foveal target detection thresholds are elevated by presenting a counterphasing, vertical squarewave grating in the peripheral retina. This psychophysical "shift effect" has been considered to be an analogue of the neurophysiological "periphery effect" first described by McIlwain (1964; Journal of Neurophysiology, 27, 1154-1173). Physiological response properties of cells from the retina and lateral geniculate nucleus of cat and primate visual systems predict that sensitivity thresholds should also be elevated for peripheral targets in the presence of a foveal counterphasing mask. In these experiments, contrast sensitivities for human observers were obtained using a two-interval forced-choice procedure for peripheral target sinusoids in the presence of a foveal counterphasing mask. A suppressive shift effect was elicited by the foveal counterphasing squarewave mask, but only for counterphasing peripheral sinusoids. Masking was only obtained at the lowest spatial frequencies for both the peripheral and foveal shift effects.

Contrast Sensitivity↗

PubMed2001

Does the Wisconsin Card Sorting Test measure prefontral function?

This review describes a research program aimed at evaluating the validity and specificity of the Wisconsin Card Sorting Test (WCST), one of the most widely used tests of prefrontal function in clinical and experimental neuropsychology. In spite of its extensive use, voices of caution have arisen against the use of WCST scores as direct markers of prefrontal damage or dysfunction. Adopting a cognitive neuroscience approach, the present research program integrates behavioral, physiological, and anatomical information to investigate the cognitive and neural mechanisms behind WCST performance. The results show that WCST performance evokes conspicuous physiological changes over frontal as well as posterior brain regions. Moreover, WCST scores confound very heterogeneous cognitive and neural processes. This confounding effect may have led many authors to overlook the relative importance of certain dysfunctional states such as those indexed by random errors. These findings strongly suggest that WCST scores cannot be regarded as valid nor specific markers of prefrontal lobe function. However, they do provide some relevant clues to update our current knowledge about prefrontal function. In the long run, the integrative approach of cognitive neuroscience may help us design and develop more valid and sensitive tools for neuropsychological assessment.

Brain Mapping↗