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At least 1,099 records · Page 61Linked to original sources
PubMed1995

Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats.

Under the condition of obvious iron-overload, there is a zonal hemosiderin (iron) deposition in hepatic lobules. The deposition is heaviest in the periportal (zone 1) and lightest in the perivenous (zone 3) hepatocytes. However, the mechanism for this pattern of iron deposition is obscure. Hepatic tissues from control, iron-deficient or iron-overloaded Wistar rats were used to study its pathogenesis. Iron-deficiency was induced by a low iron regimen. Iron-overload was produced by repeated intraperitoneal injections of ferric nitrilotriacetate (Fe(3+)-NTA) for 1-4 months. Liver tissues of the rats were immunohistochemically and histochemically stained for transferrin receptor (TfR), transferrin (Tf), ferritin (Ft), and iron. The staining intensity of TfR, Tf and Ft increased in hepatocytes of iron-deficient rats and decreased in that of the iron-overloaded in comparison with the control rats. TfR staining was strong in zone 1, with gradual transition into weak staining in zone 3 hepatocytes of the rat liver. TfR located primarily on the hepatocyte membrane. Tf had both membranous and cytoplasmic distribution. Many hepatocytes in group B had strong cytoplasmic Tf staining. Conversely, only a few hepatocytes had weakly stained cytoplasmic Tf in group C. Hepatocytes and Kupffer cells were Ft positive in control rats. Ft was distributed only in the cytoplasm. The staining intensity of Ft was stronger in zone 3 than in zone 1 hepatocytes of iron-deficient rats. In iron-overloaded rats, the iron deposition was severe in zone 1 and mild in zone 3 hepatocytes.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed2005

Presentation of intraocular foreign body 25 years after the event.

Delayed presentation of retained intraocular foreign body is a diagnostic and therapeutic challenge to the ophthalmologist. Herein a case of a man presenting 25 five years after initial injury with a retained metallic foreign body adjacent to the optic disc is described.

Accidents, Occupational↗
PubMed1997

How clean is a mini-pig?--Impressions and suggestions of a pathologist working in the field of toxicology.

Gross and histopathological investigations of more than 100 minipigs revealed: 1. Findings due to repeated blood sampling. For anatomical reasons the thyroid gland of pigs can be injured during blood sampling. Histopathological investigation of thyroid glands often revealed inflammatory and reparative fibrotic changes of this organ. Depending on the grade of damage, thyroid hormone levels may vary. To avoid misinterpretation of results, most careful blood sampling by experienced personnel is recommended. 2. Findings due to viral, bacterial and parasitic infections. These concerned mainly the lungs which often showed pneumonic alterations. In case of parasitic invasion, the skeletal muscles may reveal degenerative changes due to sarcosporidia (re-) infection. Therefore, optimal hygienic conditions, e.g. during blood sampling, and continuing health monitoring are recommended. 3. Findings due to preventive iron administration. Months after preventive iron-dextran administration at the breeding station, histopathological examination revealed siderin accumulation in a number of organs, namely in the cells of the mononuclear phagocytic system in liver and kidneys. As a unique finding an intraglomerular siderin deposition in the mesangial cells with subsequent glomerulosclerosis in certain glomeruli was observed.

Animals↗
PubMedDate not supplied

Nuclear resonance scattering measurement of human iron stores.

Hepatic iron stores were measured noninvasively in 31 patients (thalassemia, hemodialysis, hemosiderosis, refractory anemia) with suspected iron overload, employing a nuclear resonance scattering (NRS) technique. The thalassemia patients were undergoing desferrioxamine chelation therapy during the NRS measurements. The hemodialysis patients were measured before chelation therapy. Iron levels measured by NRS were in general agreement with those determined in liver biopsies by atomic absorption spectroscopy. In addition, NRS measurements from the thorax of some of these patients suggest that this method may also prove useful for clinical assessment of cardiac iron.

Adolescent↗
PubMed1976

Role of chronic hepatitis in development of thalassaemic liver disease.

Liver function and the presence of HBsAg and anti-HBsAg were studied in 90 hypertransfused thalassaemic children. Increased serum transaminases were found in 62 patients, and persisted from more than 6 months in 45 cases. Liver biopsy in this latter group led to a diagnosis of 14 cases of chronic persistent hepatitis, 9 cases of aggressive hepatitis, and 3 cases of hepatic fibrosis. In Italy thalassaemic children undergoing hypertransfusion therapy frequently encounter SH virus infection, with a consequent hepatitis that is generally anicteric and unrecognized unless systematically sought. In a liver already stressed by the concomitant iron overload, hepatitis infection might thus play a key role in the evolution of cirrhosis which frequently affects thalassaemics.

Adolescent↗