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Microsurgical procedures in the peripheral nerves and the dorsal root entry zone for the treatment of spasticity.

When spasticity becomes severe and harmful, in spite of physical and medical therapy, neurosurgery can give functional improvement. This paper deals with the long term results of Selective Peripheral Neurotomies of the Tibial Nerve and Selective Posterior Rhizotomies in the Dorsal Root Entry Zone, in 123 patients with spastic disorders localized to the limbs. The micro-techniques and intra-operative electro-stimulation for identification of the nervous structures responsible for the spastic components, can give a substantial reduction of the harmful spasticity, without suppressing the useful muscle tone and impairing the residual motor and sensory functions. The results were effective, with a 1 to 13 year follow-up (5 on average), in 89% of 47 Selective Peripheral Neurotomies of the tibial nerve for spastic foot, in 92% of 53 Selective Posterior Rhizotomies for paraplegia and in 87% of 23 Selective Posterior Rhizotomies for hemiplegia. In the most severe situations ("comfort" indications), correction of the abnormal postures and relief of pain facilitated nursing and physiotherapy. Sometimes there was reappearance of some useful voluntary movements. In the less affected patients ("functional" indications), the suppression of the harmful spastic components made the persistant capacities more effective.

Adolescent↗

Quantitative vibration perception testing in elderly people: an assessment of variability.

The variability of vibration perception threshold measured by the Biothesiometer for three consecutive readings on a single occasion and 18 sequential readings over 7 days was assessed in 20 elderly convalescent subjects. The coefficient of variation for three consecutive readings at the great toe was high [right great toe: median (range) 15 (6-260%]. The median coefficients of variation for sequential readings were higher than those for consecutive readings at both toes [right great toe: median (range) 26 (5-71)% versus 15 (6-26)%, p = 0.0001]. Thus quantitative tests of sensory function are not reliable in elderly people, even when the subjects have no acute medical problem. Screening for neuropathy in elderly patients should probably rely on clinical examination or electrophysiological tests.

Aged↗

Shigella endotoxin-induced ocular inflammation in the normal and sensory denervated rabbit eye.

Injection of Shigella endotoxin (2 mug) into the vitreous chamber of a normal rabbit eye induces on infiltration of polymorphonuclear leucocytes, miosis, a moderately intense dilation of iris, conjunctival and limbal vessels, and a breakdown in the blood-aqueous and blood-vitreal barriers. Significant amounts of soluble blood protein and prostaglandin-like (PG) material are found in the aqueous and vitreous humours withdrawn at 24 h. Endotoxin injected into the sensory denervated eye elicits similar vascular changes which appear to occur less rapidly than in normal eyes. conversely, the levels of aqueous and vireal PG-like material, as well as the capacity of excised irides to form PG from exogenous precursors, seems greater in the denervated eyes. If PG is an important mediator of ocular changes in the early phases, the results suggest that the action of this inflammatory autacoid in facilitating the ocular changes is less effective in eyes deprived of functional sensory nerves.

Animals↗

Esophageal sensation in spinal cord-injured patients: balloon distension and cerebral evoked potential recording.

We sought to determine the esophageal sensory function in patients with a C6 or C7 spinal cord injury. A balloon was repetitively distended 10 cm above the lower esophageal sphincter in five patients and nine normal control subjects. Sensation was reported on a scale from 0 to 2 with progressive distension to pain threshold (level 2). Cortical responses were recorded from midline scalp electrodes. Blinded determinations of quality and reproducibility of the potentials were performed. All subjects experienced sensation with esophageal balloon distension. Volumes to sensation showed a trend toward a higher sensory threshold in patients but were significant only for first sensation, not pain. In all subjects, a triphasic evoked potential response consisting of a negative-positive-negative complex was noted with distension but not with sham distension. Characteristics (amplitude, latency, reproducibility, and quality) of the evoked potentials were not different in patient and control groups. These data suggest sensory pathways from the distal esophagus are intact in patients with a C6 or C7 spinal cord injury.

Adult↗

Pediatric autonomic disorders.

The scope of pediatric autonomic disorders is not well recognized. The goal of this review is to increase awareness of the expanding spectrum of pediatric autonomic disorders by providing an overview of the autonomic nervous system, including the roles of its various components and its pervasive influence, as well as its intimate relationship with sensory function. To illustrate further the breadth and complexities of autonomic dysfunction, some pediatric disorders are described, concentrating on those that present at birth or appear in early childhood.

Adrenal Insufficiency↗

[Event-related cerebral potentials. Classification and clinical use].

Event-related potentials (ERP) constitute an heterogeneous group of brain electrical signals time-locked to sensory stimulation, motor responses, and associative processes, recorded using computer averaging. Several kinds of brain electric activity are encompassed by the generic term "event related potentials": sensory evoked potentials, time-coherent cerebral events related to motor acta, long-latency potentials associated with psychological variables, slow potential shifts linked to psychological constructs, and "emitted" cerebral events of endogenous origin. Shortcomings of this classification are pointed out and a simpler one is proposed, distinguishing between sensory, motor, and associative time-locked potentials. Their clinical use is illustrated under six major headings: testing of sensory function, localization of lesions, maturation of the central nervous system, genetic markers, evaluation of pharmacologic agents, and indicators of cognitive processes. Some methodological issues relevant to the clinical use of ERP are discussed.

Association↗

Effect of graded hypothermia (27 degrees to 34 degrees C) on behavioral function, histopathology, and spinal blood flow after spinal ischemia in rat.

BACKGROUND AND PURPOSE: We used a rat model of reversible spinal ischemia to assess the effect of spinal cord temperature on the development of neurological and histopathologic changes after 20 minutes of reversible aortic occlusion. Spinal cord blood flow and CO2 reactivity was tested by using laser Doppler before and 60 minutes after ischemia. METHODS: In halothane (1%)-anesthetized rats, the spinal cord temperature as assessed by using thermocouple in the paraspinal muscles was lowered to 34 degrees, 31 degrees, or 27 degrees C. After ischemia, spinal cord temperature was raised to 37 degrees C for the next 30 minutes. Animals were maintained in this normothermic condition for 8 hours, after which motor and sensory function were assessed. All animals were then anesthetized and perfused with 10% formalin for light microscopic analysis of spinal cords. RESULTS: In normothermic animals, 20 minutes of ischemia resulted in a loss of CO2 reactivity and hind limb paraplegia with an attendant allodynia that persisted for the 8 hours of reperfusion. Even mild (34 degrees C) hypothermia resulted in significant improvement of neurological function compared with the normothermic group. In paraplegic animals, lumbosacral interneuronal pools localized primarily in laminae III through VII displayed heavy argyrophilic neurons and areas of localized necrosis. In moderate and deep hypothermic animals preservation of CO2 responsivity and complete recovery of neurological function were seen with no detectable histopathologic changes. CONCLUSIONS: These results show that a slight decrease in spinal cord temperature in the peri-ischemic period provides significant protection as measured by histopathology and neurological function.

Animals↗

Rehabilitative optometric services for survivors of acquired brain injury.

In a retrospective study of clinical management practices, we assessed the impact of offering rehabilitative optometric services to a group of severely head-injured residents of a long-term rehabilitation facility. Each testable patient admitted (n = 55) was screened for visual function, and more than half were identified as having visual problems in need of treatment. A few were sent to local practitioners, but most (n = 26) were referred to a rehabilitative optometrist (with a specialty in low vision). For all but two patients, optometric treatment recommendations were implemented. All of those who received treatment benefited; indeed, in most cases the impact on participation in the overall rehabilitation program was significant. For the severely brain-injured, the study emphasized the need for (1) careful screening of visual-sensory function, (2) referral for rehabilitative optometric evaluation and treatment, (3) taking the necessary time for evaluations, and (4) the value of having a cognitive rehabilitation therapist assist the rehabilitative optometrist.

Adult↗

The opticogravic nerve: eye-level anatomic relationships within the central nervous system.

The anatomic relationships between arterial blood supply and key structures within the central nervous system (CNS) are important in comprehending the neurophysiological effects of acceleration (+Gz) stress, including +Gz-induced loss of consciousness (G-LOC). An accurate understanding of the location of the vascular and neurologic structures at eye-level is vital, since it is possible to determine precisely when visual symptoms occur. Cerebral perfusion is supported by the pressure-equalizing effects provided by the cerebrospinal fluid. While brain and brain stem are protected by this pressure compensation, the eye is not. Decreased visual function results when retinal perfusion is compromised. G-LOC generally occurs following loss of visual function. The exact location(s) of altered perfusion within the CNS that results in G-LOC is currently unknown. To thoroughly understand G-LOC, it will be necessary to understand which CNS structures must be affected by +Gz-induced ischemia to cause G-LOC. Based on previous theoretical considerations of loss of consciousness as a protective mechanism, it is possible to consider the eye (visual system) as a dual sensor for both vision and gravitational (acceleration) stress. Due to this expanded definition of the sensory functions of the second cranial nerve, it would therefore be more appropriate to describe it as the "opticogravic" nerve. This manuscript discusses some of these considerations and the eye-level neuroanatomic relationships of vital importance for the acceleration medical subspecialist.

Acceleration↗

Relationship between catecholamine neurons and cerebral blood vessels studied by their simultaneous fluorescent revelation in the rat brainstem.

In order to study the relationship between catecholamine neurons and cerebral blood vessels, a technique was developed which permitted the simultaneous visualization of blue-green fluorescent catecholamine neurons and red fluorescent stained blood vessels in the brain of the normal rat. Sympathetic nerve fibers were found on the major arteries and in the pia-arachnoid at the base of the brainstem and also along paramedia and lateral perforating arteries as small as 10-12 microns within the brain. Running within the parenchyma, central catecholamine nerve fibers occasionally approached and intersected smaller blood vessels, either arterioles or venules of 8-12 microns, and infrequently climbed along or encircled these vessels for a limited distance, particularly within the lateral tegmentum. Across the nuclei of the brainstem, no overall contiguity of catecholamine terminals with capillaries was apparent, and no correlation between the density of catecholamine varicosities and that of capillaries existed. Only in regions with a high density of both catecholamine varicosities and capillaries, such as in the principal olivary nucleus, did a significant overlap of the two occur. But in most cases of moderately to densely innervated and vascularized regions, such as the solitary tract nuclei, the greatest concentration of terminals appeared over the parenchyma. Regarding the blood supply to the catecholamine neurons, their perikarya did not receive a particularly dense capillary supply relative to other nuclei. However, a special relationship of catecholamine cells to blood vessels was suggested, particularly in the case of dopamine neurons in the substantia nigra by the close apposition of cellular processes to adjacent small vessels. This morphological study was undertaken to determine whether central catecholamine neurons may significantly innervate cerebral blood vessels and accordingly, may function analogously to the peripheral sympathetic adrenergic neurons in the regulation of the vascular system. Although a limited number of associations between central catecholamine nerve terminals and small blood vessels suggested the possibility of an innervation in a few regions, the lack of an overall correspondence and correlation between the two across brainstem nuclei indicated that the analogy of central catecholamine neurons to the sympathetic nervous system was inappropriate. On the other hand, evidence of contact with vessels by presumed dendrites of the catecholamine neurons suggested a possible vascular sensory function.

Adrenergic Fibers↗

Electrical stimulation of tooth pulp in humans. II. Qualities of sensations.

Individual premolar teeth of 22 normal volunteers were stimulated via intradentinal electrodes using brief electrical pulses. Questionnaires were used to determine the qualities of sensations produced by this stimulation. Operationally defined 'innocuous' sensations predominated between 1 and 10 dB SL, and were absent above 30 dB SL. Similarly defined 'painful' sensations were observed throughout the range of suprathreshold intensities but were most common above 20 dB SL. These findings demonstrate that non-painful sensations can arise from electrical tooth pulp excitation in circumstances in which spread of the stimulating current to periodontal and gingival structures is most unlikely. Two interpretations of these results are considered: (1) that tooth pulp afferents may have some unspecified sensory function besides mediation of painful sensations and (2) that they may be specialized in the mediation of nociceptive impulses but may give rise to innocuous sensations under special circumstances.

Adolescent↗

Functional constipation with impaired rectal sensation improved by electrical stimulation therapy: report of a case.

Patients with intractable constipation often complain of social, physical, and psychologic stress. Recently, biofeedback therapy has been widely used for the management of intractable constipation, particularly in cases of constipation associated with pelvic floor dyssynergia. However, some constipated patients often complain of absent or diminished sense of wanting to defecate. It is unclear whether impaired rectal sensation is a cause or outcome of constipation and what specific treatment is available for these patients. We treated a 25-year-old female patient who complained of intractable constipation for ten years. Colon transit time study and defecography showed nonspecific findings. Her anorectal manometric findings were within normal ranges with the exception of impaired rectal sensation. Rectal sensory threshold volumes for desire and urge to defecate and maximal tolerated volume were greatly increased. She was treated by electric stimulation therapy for the purpose of improving impaired rectal sensory function. After 14 sessions of electric stimulation therapy, her constipated symptoms improved dramatically. Furthermore, the desire and urge threshold volumes were remarkably decreased. We report this case of constipation with impaired rectal sensation possibly treated by electric stimulation therapy.

Adult↗

Results of suture of the sciatic nerve after missile injury.

OBJECTIVE: To evaluate functional recovery after suture of the sciatic nerve after missile injury. METHODS: We reviewed the outcome of 23 adults and four children who had the sciatic nerve sutured above the knee 3 to 14 weeks after missile injury and who were followed for 14 to 36 months. RESULTS: In adults, useful motor recovery was significantly better after suture of tibial (83%) than peroneal (39%) nerves, after suture of nerves at the thigh (71%) than at the buttock (31%) level, and after end-to-end anastomosis (74%) than grafting (39%). Useful sensory function was recovered in 78% of tibial nerves. Fifty-seven percent of adults walked wearing special shoes or pads. Significantly better recovery occurred in children, who all walked with normal footwear. CONCLUSION: We advocate exploration of the sciatic nerve at any level within 3 months if no spontaneous recovery occurs after a missile injury. We do not advocate exploration of the sciatic nerve at the buttock level if only peroneal function is lost except in children.

Activities of Daily Living↗

Effects of an alpha(2)-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans.

To characterize alpha(2)-adrenergic control of motor and sensory functions of gastrointestinal tract and colon, we studied dose-related effects of clonidine (placebo or up to 0.3 mg po) by random assignment in 55 healthy humans. Gastrointestinal transit was measured in all subjects; in 35, we assessed colonic compliance, tone, and sensations of gas and pain during phasic distensions. Clonidine did not significantly alter gastrointestinal or colonic transit, but it increased colonic compliance and reduced fasting tone without altering colonic response to a meal. Clonidine significantly reduced aggregate sensation to distensions overall and had significant linear dose-related sensory effects at 8- and 24-mmHg distensions. Effect on pain (including dose-response relationship) was due to 0.3-mg dose for distensions at 24 mmHg. We confirmed that clonidine relaxes fasting colonic tone and reduces sensation of pain. In this study, gut transit was not altered by clonidine, and novel dose-response characteristics and clonidine's effect on gas sensation are provided. Doses as low as 0.05 mg may be effective and potentially useful in reducing colonic tone and gas sensation.

Adrenergic alpha-Agonists↗

Effect of self-activating phthalocyanine gel on palatal donor site healing, inflammatory biomarkers, somatosensory and patient-centered outcomes: a randomized split-mouth clinical trial.

OBJECTIVES: To evaluate effects of self-activating phthalocyanine (PHY) gel on palatal donor site after subepithelial connective tissue graft (SCTG) harvesting, considering clinical outcomes, inflammatory biomarkers, patient-centered outcomes, and quantitative somatosensory changes. MATERIALS AND METHODS: Twenty participants were included in this randomized, crossover, split-mouth clinical trial. Donor sites received topical PHY gel (PHY group-PHYG) and placebo gel (control group-CG). Clinical parameters (residual wound area-RWA, wound epithelialization-WE, residual remodeling area-RRA and tissue thickness-TM) were assessed at baseline, 7, 14, 30, and 60 days. Patient-centered outcomes were recorded during 14 postoperative days and inflammatory biomarkers at 3 and 7 days postoperatively. Mechanical detection threshold (MDT) and mechanical pain threshold (MPT) were evaluated at baseline, 2 months, and 6 months. RESULTS: PHYG and CG exhibited similar clinical outcomes, but PHYG demonstrated superior performance in reducing RRA. Both groups presented positive postoperative progression of patient-centered outcomes. IL-10 levels showed a significant increase in PHYG, suggesting a more favorable anti-inflammatory response. MDT remained stable but, donor sites exhibited transient hypersensitivity (MPT) at 2 months. CONCLUSIONS: PHYG and CG protocols promoted satisfactory healing of palatal donor sites. Most clinical parameters and patient-centered outcomes were similar between groups. The PHYG presented reduced RRA and increased IL-10 levels. Donor sites exhibited transient hypersensitivity, which tended to resolve over time. CLINICAL RELEVANCE: Both postoperative protocols resulted in favorable healing of palatal donor sites following SCTG harvesting, with comparable clinical and patient-centered outcomes. Quantitative sensory testing indicates that hypersensitivity may occur during healing, but sensory function tends to recover progressively.

Humans↗

Effect of graft bed on long-term functional results of extremity skin grafts.

The purpose of the current study was to determine whether the long-term functional results of extremity burns grafted on fat were different from those grafted on fascia. Twelve patients (mean burn size, 38% TBSA) who had fascial excision of the majority of one or more extremities were examined a minimum of one year postinjury. Range of motion, motor strength, and sensation of the fascially excised extremities were measured. Twelve comparable patients with extremity burns (mean burn size, 35% TBSA) who had grafts placed on fat were used as positive controls. Patients whose burns were excised to fat had better joint mobility (P = 0.001) and sensory function (P = 0.001) than did patients whose burns were excised to fascia. Both groups had comparable muscle strength. These results indicate that patients with full-thickness burns of the extremities who have grafts placed on fat have significantly better long-term extremity function than do patients who have their skin grafts placed on fascia.

Adipose Tissue↗

Neural engineering to produce in vitro nerve constructs and neurointerface.

OBJECTIVE: Recently, our laboratory recapitulated a natural form of axon growth that occurs between late embryogenesis and early adulthood. In this article, we describe how this novel neural engineering approach may be used to produce a nervous tissue interface to integrate disconnected motor and sensory functions for external control. METHODS: For nervous system repair, we recently developed a unique method to engineer nervous tissue constructs in vitro consisting of bundles of axons spanning two populations of neuronal somata. To integrate electronics and nervous tissue to transform electrophysiological signals into electronic signals, we have designed a nervous tissue interface. RESULTS: Our nervous tissue interface consists of stretch-grown nervous tissue with one end interfaced with a multiple electrode array, enabling us to detect and record real-time efferent signals conducted down the nerve and stimulate afferent sensory signaling. CONCLUSION: Our ultimate goal is to develop a neurally controlled prosthesis and a nervous system interface that could be linked to the patient's thoughts, providing two-way signaling for motor control and feedback from multiple external stimuli.

Axons↗

Common dimensions of visual and auditory agnosia and an explanation of the auditory recognition deficit in aphasia.

An experimental analysis of auditory recognition disturbances was performed; 81 patients with localized cerebral lesions were examined with a recognition test for meaningful sounds and with a nonverbal intelligence test (Block Design). Sensory stimulation was 5 or 15 sec for each sound. Nonverbal intelligence accounted for a considerable and significant amount of variance in recognition performance. The aphasic group was more impaired in auditory recognition than were both the other groups, i.e., patients with right or left hemispheric lesions without aphasia. The auditory recognition disturbance in the aphasic group depended to a significant extent on stimulus duration, which means a slowing down of the recognition process in aphasia. The analogies to studies on visual agnosia are striking. In both modalities, recognition depends on intellectual functioning, sensory disturbances or reduced sensory input, and the presence of aphasia.

Adult↗