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Results for “Cognitive Reflection”

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PubMed2001

Olfactory-evoked regional cerebral blood flow in Alzheimer's disease.

Olfaction is impaired in Alzheimer's disease (AD). It was hypothesized that AD would reduce olfactory-evoked perfusion in mesial temporal olfactory (piriform) cortex, where neuropathology begins. Seven AD patients and 8 elderly controls (ECs) underwent olfactory threshold and identification tests and olfactory stimulation during positron emission tomography. Odor identification was impaired in AD, but threshold was not. Olfactory stimulation in ECs activated right and left piriform areas and right anterior ventral temporal cortex. AD patients had less activation in right piriform and anterior ventral temporal cortex but not in the left piriform area. Although orbital cortex did not activate in ECs, there was a significant between-groups difference in this area. Right piriform activation correlated with odor identification. Impaired odor identification likely reflects sensory cortex dysfunction rather than cognitive impairment. Given olfactory bulb projections to the mesial temporal lobe, olfactory stimulation during functional imaging might detect early dysfunction in this region.

Aged↗

PubMed2004

Cognitive vulnerability to depression: a taxometric analysis.

Although there is increasing support for the hypothesis that negative cognitive styles contribute vulnerability to depression, it remains unclear how best to conceptualize the heterogeneity in cognitive vulnerability to depression. Specifically, does this heterogeneity reflect quantitative or qualitative differences among individuals? The goal of this study was to address this question by examining whether the underlying structure of cognitive vulnerability to depression is best conceptualized as dimensional or categorical. Taxometric analyses provided consistent support for the dimensional nature of negative cognitive styles. It appears, therefore, that cognitive vulnerability to depression is best conceptualized as a dimensional construct, present to a greater or lesser extent in all individuals. Despite this, the strength of the relationship between negative cognitive styles and depressive symptoms does appear to vary as a function of where along the cognitive style continuum one falls.

Adult↗

PubMed1989

Evidence from aphasia for the role of proper names as pure referring expressions.

Here we describe a patient who, as a result of brain damage, had a dramatic inability to retrieve proper names, and who thus offered the opportunity of observing the distinction made in the brain between proper and common names. Although category specific aphasic disturbances are relatively common, this patient's anomia for proper names is very rare: only two other cases have been described so far. The opposite phenomenon, a selective sparing of proper names, has also been recently observed. It is widely assumed that double dissociations such as this reflect the premorbid organization of the cognitive system: the categories of proper and common nouns, therefore, would be separately represented or, at least, separately accessed in the intact brain. The only other such deficits, including the inability to learn arbitrary links between words and to guess the titles of pieces of music, are believed to be indicative of a problem in dealing with purely referential relations. This, in turn, would indirectly confirm the role of proper names as pure referring expressions.

Adult↗

PubMed2003

X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome.

Polyamines (putrescine, spermidine, spermine) are ubiquitous, simple molecules that interact with a variety of other molecules in the cell, including nucleic acids, phospholipids and proteins. Various studies indicate that polyamines are essential for normal cell growth and differentiation. Furthermore, these molecules, especially spermine, have been shown to modulate ion channel activities of certain cells. Nonetheless, little is known about the specific cellular functions of these compounds, and extensive laboratory investigations have failed to identify a heritable condition in humans in which polyamine synthesis is perturbed. We report the first polyamine deficiency syndrome caused by a defect in spermine synthase (SMS). The defect results from a splice mutation, and is associated with the Snyder-Robinson syndrome (SRS, OMIM_309583), an X-linked mental retardation disorder. The affected males have mild-to-moderate mental retardation (MR), hypotonia, cerebellar circuitry dysfunction, facial asymmetry, thin habitus, osteoporosis, kyphoscoliosis, decreased activity of SMS, correspondingly low levels of intracellular spermine in lymphocytes and fibroblasts, and elevated spermidine/spermine ratios. The clinical features observed in SRS are consistent with cerebellar dysfunction and a defective functioning of red nucleus neurons, which, at least in rats, contain high levels of spermine. Additionally, the presence of MR reflects a role for spermine in cognitive function, possibly by spermine's ability to function as an 'intrinsic gateway' molecule for inward rectifier K(+) channels.

Base Sequence↗

PubMed2006

The genetics of developmental dyslexia.

Reading reflects the complex integration of several cognitive processes and proves more difficult to achieve for a significant proportion of the population. Developmental dyslexia (DD), or specific reading disability, is influenced by genes, a fact that has led several research groups to attempt to identify susceptibility genes through the sequential analysis of genetic linkage and association. Strong evidence has now emerged for the presence of genes influencing DD at several chromosomal loci and for at least one of these, there is evidence implicating specific genes. In this review, we present the evidence for a genetic contribution to DD and its component processes and review the current status of molecular genetic research aimed at identifying susceptibility genes for this common, complex disorder.

Chromosomes, Human↗

PubMed1998

Motives for social decision-making strategies among Finnish and Estonian adolescents [corrected].

Justifications for aggression and withdrawal were compared between Finnish and Estonian adolescents. The former had grown up in a pluralistic Western culture; the latter, in a communist Soviet culture. After receiving a questionnaire with descriptions of 2 everyday social problems, teasing and backbiting, and a list of problem-solving strategies, the participants were asked how they would justify the use of each strategy. The Estonian participants more frequently chose instrumental justifications for aggression, whereas the Finnish participants tended to report that aggressive behavior was "fun." Aggression may be perceived as more deviant in Finland than in Estonia. Among the Finnish participants, withdrawal was motivated by a desire to avoid harm; among the Estonian participants, withdrawal reflected helplessness. The Estonian participants experienced cognitive dissonance between official education and the informal information learned in families; there was also dissonance between inner speech (banned history) and the official history taught in the schools.

Adolescent↗

PubMed2002

Self-regulatory learning and generalization for people with brain injury.

PRIMARY OBJECTIVE: brain injury can result in the loss of previous learnt behaviours that affect an individual's daily functioning. The use of self-regulation helps the individual to relearn the lost behaviours by bringing him/her to self-conscious level through independent and reflective learning derived using a social cognitive perspective. The purpose of this paper is to report on clinical observations made with the use of self-regulation in people with brain injury during the relearning of lost functions. METHODS AND PROCEDURES: daily tasks were used to assess the relearning ability of the subjects pre- and post-programme. EXPERIMENTAL INTERVENTION: one-week self-regulatory training on five selected daily tasks. MAIN OUTCOMES AND RESULTS: these provisory observations would suggest that, with specific guidance for people with different needs, such as with impaired cognitive function and depression, self-regulation is effective in enhancing their relearning. CONCLUSION: Self-regulatory training is effective in enhancing the relearning of lost functions.

Aged↗

PubMed2005

Not all false memories are created equal: the neural basis of false recognition.

False recognition, a type of memory distortion where one claims to remember something that never happened, can occur in response to items that are similar but not identical to previously seen items (i.e., related false recognition) or in response to novel items (i.e., unrelated false recognition). It is unknown whether these 2 types of memory errors arise from the same or distinct neural substrates. Using functional magnetic resonance imaging, we compared the neural activity associated with true recognition, related false recognition, and unrelated false recognition for abstract shapes. True recognition and related false recognition were associated with similar patterns of neural activity, including activity in the prefrontal cortex, the parietal cortex, and the medial temporal lobe. By contrast, unrelated false recognition was associated with activity in language-processing regions. These results indicate that false recognition is not a unitary phenomenon, but rather can reflect the operation of 2 distinct cognitive and neural processes.

Adolescent↗

PubMed2002

Educational theory and medical education practice: a cautionary note for medical school faculty.

Educational theory is routinely cited as justification for practice in medical education, even though the justification for the theory itself is unclear. Problem-based learning (PBL), for example, is said to be based on powerful educational principles that should result in strong effects on learning and performance. But research over the past 20 years has produced little convincing evidence for the educational effectiveness of PBL, which naturally raises doubts about the underlying theory. This essay reflects on educational theory, in particular cognitive theory, and concludes that the theory is little more than metaphor, not rigorous, tested, confirmed scientific theory. This metaphor/theory may lead to ideas for basic and applied research, which in turn may facilitate the development of theory. In the meantime, however, the theory cannot be trusted to determine practice in medical education. Despite the intuitive appeal of educational theory, medical educators have a responsibility to set aside their enthusiasm and make it clear to medical school faculty and administrators that educational innovations and practice claims are, at best, founded on conjecture, not on evidence-based science.

Education, Medical↗

PubMed1997

Pain and patienthood.

OBJECTIVE: The objective of this study was to identify possible differences between chronic pain patients (consumers) and persons with chronic pain lasting > 1 year who had not consulted a doctor because of the pain during the last year (nonconsumers). Group differences were studied from the perspective of a stress-response model and a taxometric approach to chronic pain. METHODS: Both samples were compared on data acquired through questionnaires. Data-reduction techniques were applied. RESULTS: Nonconsumers differ from patients who are still seeking a medical solution for their pain problem. These differences are reflected in lower levels of distorted cognition, less pain-related distress, higher activity levels, and higher levels of internal orientation. Furthermore, nonconsumers used fewer analgesics. CONCLUSIONS: Nonconsumers appear to lead a "better life" with pain than do chronic pain patients who still wish to lead a life without pain. The idea of having learned to live with pain can be very meaningful and could cause a change in quality of life (QOL). We suggest that this may be a very legitimate goal for interventions.

Adaptation, Psychological↗

PubMed2001

Learning related modulation of functional retrieval networks in man.

The medial temporal lobe has been implicated in studies of episodic memory tasks involving spatio-temporal context and object-location conjunctions. We have previously demonstrated that an increased level of practice in a free-recall task parallels a decrease in the functional activity of several brain regions, including the medial temporal lobe, the prefrontal, the anterior cingulate, the anterior insular, and the posterior parietal cortices, that in concert demonstrate a move from elaborate controlled processing towards a higher degree of automaticity. Here we report data from two experiments that extend these initial observations. We used a similar experimental approach but probed for effects of retrieval paradigms and stimulus material. In the first experiment we investigated practice related changes during recognition of object-location conjunctions and in the second during free-recall of pseudo-words. Learning in a neural network is a dynamic consequence of information processing and network plasticity. The present and previous PET results indicate that practice can induce a learning related functional restructuring of information processing. Different adaptive processes likely subserve the functional re-organisation observed. These may in part be related to different demands for attentional and working memory processing. It appears that the role(s) of the prefrontal cortex and the medial temporal lobe in memory retrieval are complex, perhaps reflecting several different interacting processes or cognitive components. We suggest that an integrative interactive perspective on the role of the prefrontal and medial temporal lobe is necessary for an understanding of the processing significance of these regions in learning and memory. It appears necessary to develop elaborated and explicit computational models for prefrontal and medial temporal functions in order to derive detailed empirical predictions, and in combination with an efficient use and development of functional neuroimaging approaches, to further the understanding of the processing significance of these regions in memory.

Adult↗

PubMed2006

Serum calcium is an independent predictor of quality of life in multiple myeloma.

Bone disease is an important feature of multiple myeloma, and hypercalcaemia is a frequent complication of this disease. We examined the association between serum calcium and quality of life (QOL) scores of 686 multiple myeloma patients at the time of diagnosis. Data from two Nordic studies using the EORTC QLQ-C30 questionnaire were analysed by means of linear regression analysis and a curve fitting program. Serum calcium was independently related to appetite loss, nausea/vomiting and physical functioning (P < 0.001) and to cognitive functioning (P = 0.001), i.e. scores reflecting symptoms that are well known in non-malignant hypercalcaemia. In addition, we found a highly significant independent relationship between serum calcium and the scores for fatigue and pain (P < 0.001). Serum calcium appeared to be as strong a predictor for fatigue as the concentration of haemoglobin. A cubic model (y = a + bx3) fitted the data slightly better than the simple linear model (y = a + bx) and suggested worsening QOL scores at levels of serum calcium above 2.5-3.0 mmol/L. Hypercalcaemia in patients with multiple myeloma seems to be associated with the same symptoms as in non-malignant hypercalcaemia. In addition, an increased level of serum calcium may aggravate the pain and fatigue caused by the skeletal disease itself.

Adult↗

PubMed1985

Red blood cell abnormalities in Alzheimer disease.

In a prospective, double-blind study of 84 unselected persons in a dementia clinic, the red blood cell/plasma choline ratios were found to be significantly higher in 47 subjects with clinically defined Alzheimer disease (DAT) than in 37 non-DAT, nondepressed subjects (3.54 +/- 0.48 versus 2.04 +/- 0.34, p less than 0.02). The latter group included intellectually intact subjects as well as patients with other dementias who were comparable to the Alzheimer patients in age, sex, and degree of cognitive impairment. The elevated mean ratio reflected the greater proportion of Alzheimer patients with high red blood cell plasma choline ratios. These elevated ratios appeared to be related to both increases in red cell content and decreases in plasma choline. The authors conclude that the results confirm and extend those previously reported in short series of patients and agree with other evidence that Alzheimer disease has systemic manifestations in nonneural cells, which may be useful in further investigations of the disease's cellular pathophysiology.

Aged↗

PubMed1989

Mental health in Dutch adolescents: self-reported competencies and problems for ages 11-18.

Beside parents and teachers, adolescents themselvess may be valuable informants about their own psychological functioning. The present study, which provides prevalence data on behavioral/emotional problems and competencies reported by adolescents aged 11-18 from the general population, was preceded by two studies providing such data for parent and teacher reported problems. The instrument used in the present study is the Youth Self Report (YSR) developed by Achenbach and Edelbrock to obtain adolescents' self-reports on their problems and competencies in a standardized way. YSRs completed by 52 adolescents on two occasions with a time-interval of 3-4 weeks revealed test-retest reliability expressed as intraclass correlation coefficients of 0.87 for total problem scores and 0.69 for total competence scores. The YSR was completed by 941 adolescents aged 11-18 from the general population. For each of the 103 problem items and 17 competence items, the prevalence rates were presented graphically for both genders in two-year age-groups. To identify differences related to sex, age and socio-economic status (SES), ANCOVAs were performed on the scores for each problem and competence item as well as on total problem and total competence scores. Whereas the level of problem scores was the same across the 11-18 years age-span, girls obtained higher total problem scores with increasing age. Younger girls scored lower and older girls scored somewhat higher than boys. Implications of these findings with respect to sex differences in referral rates for children and adults are discussed. The increase with increasing age in self-reports of problems concerning inner feelings and thoughts may reflect the adolescent's change in cognitive, socio-emotional and physical functioning. We could not demonstrate significant SES differences in problem scores. Comparisons of problem scores obtained for referred and nonreferred adolescents revealed a correct classification rate of 73.6%, which seems satisfactory given the fact that parents rather than the adolescent usually initiate referrals. Comparisons of problem item scores in ANCOVAs of referred and nonreferred samples revealed significant referral status effects for 68 of the 103 problem items, with referred adolescents scoring higher than nonreferred adolescents. The largest effect of referral status was found for the item "Nervous". The third largest effect was obtained for the item "Unhappy, sad, depressed", which also showed strong discrimination between parent scores for referred and nonreferred samples. Competence scores showed much weaker discrimination between referred and nonreferred groups.

Adolescent↗

PubMed1982

Brief marital therapy outcome: personality correlates.

The purpose of the study was to investigate with regression analyses the relationship between personality and background variables and outcome of brief marital therapy. Twenty personality dimensions from the Personality Research Form and data on age, education, number of previous unions, number of children and number of sessions were used as independent variables. The dependent variable was provided by ratings of over-all improvement in affective communication: sexual, verbal, and social, provided by clinical records of 30 couples. The main result was that only the husband's traits were found to be important correlates of improvement in affective communication of both husbands and wives. The important traits involved husband's cognitive efficiency in the area of reflection and accurate judgement of situations, submissiveness, and sensitivity to social approval of his behaviour. The number of individual therapy sessions given to wives was also a notable predictor of improvement. Other personality and background variables were not significantly related to outcome.

Adult↗

PubMed1991

Psychogenic voice disorders: literature review and case report.

This paper explores some of the similarities and differences between hysteria and hypochondriasis and suggests that voice disorders are a prototype of disorders which reflect the intricate interplay of emotional, cognitive and physiological functions. Speech production requires the involvement of various systems of the body, including the central nervous system, respiratory and vocal systems. Voice disorders can take many different forms and can be caused by a variety of factors. A review of the relevant literature is presented along with a clinical case record of a woman with hysterical dysarthria.

Dysarthria↗

PubMed1992

Emotional adjustment of children with hydrocephalus and of their parents.

Emotional and behavioral adjustment after infantile hydrocephalus were investigated. Children's and parents' adjustments were assessed by means of questionnaires (PIC-R, SCL-90-R) in a sample of 48 children with shunted hydrocephalus. The PIC-R patterns of the children were mostly reflective of their anomalous physical and cognitive development, but there was no evidence for a specific "hydrocephalic personality" pattern. Discriminant analyses revealed that there were no strong relationships between distress of the parents (as assessed by the SCL-90-R) and a variety of physical and psychosocial variables, despite the fact that many parents were significantly distressed. It was concluded that the majority of children with hydrocephalus do not present with a specific psychiatric profile, that clinically significant levels of distress are quite common in their parents, and that such distress is typically not related to the hydrocephalus per se.

Child↗

PubMed2003

A reflection and evaluation model of comparative thinking.

This article reviews research on counterfactual, social, and temporal comparisons and proposes a Reflection and Evaluation Model (REM) as an organizing framework. At the heart of the model is the assertion that 2 psychologically distinct modes of mental simulation operate during comparative thinking: reflection, an experiential ("as if") mode of thinking characterized by vividly simulating that information about the comparison standard is true of, or part of, the self; and evaluation, an evaluative mode of thinking characterized by the use of information about the standard as a reference point against which to evaluate one's present standing. Reflection occurs when information about the standard is included in one's self-construal, and evaluation occurs when such information is excluded. The result of reflection is that standard-consistent cognitions about the self become highly accessible, thereby yielding affective assimilation; whereas the result of evaluation is that comparison information is used as a standard against which one's present standing is evaluated, thereby yielding affective contrast. The resulting affect leads to either an increase or decrease in behavioral persistence as a function of the type of task with which one is engaged, and a combination of comparison-derived causal inferences and regulatory focus strategies direct one toward adopting specific future action plans.

Affect↗