PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Loss of function”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,117 records · Page 62Linked to original sources

Principles of modern low vision rehabilitation.

Low vision rehabilitation is a new emerging subspecialty drawing from the traditional fields of ophthalmology, optometry, occupational therapy, and sociology, with an ever-increasing impact on our customary concepts of research, education, and services for the visually impaired patient. A multidisciplinary approach and coordinated effort are necessary to take advantage of new scientific advances and achieve optimal results for the patient. Accordingly, the intent of this paper is to outline the principles and details of a modern low vision rehabilitation service. All rehabilitation attempts must start with a first hand interview (the intake) for assessing functionality and priority tasks for rehabilitation, as well as assessing the patient's all-important cognitive skills. The assessment of residual visual functions follows the intake and offers a unique opportunity to measure, evaluate, and document accurately the extent of functional loss sustained by the patient from disease. An accurate assessment of residual visual functions includes assessment of visual acuity, contrast sensitivity, binocularity, refractive errors, perimetry, oculomotor functions, cortical visual integration, and light characteristics affecting visual functions. Functional vision assessment in low vision rehabilitation measures how well one uses residual visual functions to perform routine tasks, using different items under various conditions, throughout the day. Of the many functional vision skills known, reading skills is an obligatory item for all low vision rehabilitation assessments. Results of assessment guide rehabilitation professionals in developing rehabilitation plans for the individual and recommending appropriate low vision devices. The outcome from assessing residual visual functions is detection of visual functions that can be improved with the use of optical devices. Methods for prescribing devices such as image relocation with prisms to a preferred retinal locus, field displacement to primary gaze position, field expansion, and manipulation of light are practiced today in addition to, or instead of, magnification. Correction of refractive errors, occlusion therapy, enhancement of oculomotor skills, and field restitution are additional methods now available for prescribing devices leading to rehabilitation of visual functions. The outcome from assessing residual functional vision is detection of functional vision that can be improved with the use of vision therapy training. After restoration of optimal residual visual functions is achieved with optical devices, one can follow with training programs for restoration of lost vision-related skills. If an optical dispensary is available where prescribing of low vision devices routinely take place, this will help ensure familiarity and specialization of the dispensary and staff with low vision devices and their special dispensing requirements. The dispensing of low vision devices is an opportunity to introduce the device to the patient, train the patient in the correct use of the device for the task selected, and create a direct and continuous connection with the patient until the next encounter. Following assessment, prescribing, and dispensing of devices, a low vision practitioner, ophthalmologist or optometrist, is responsible for recommending and prescribing vision therapy training to improve residual functional vision. An attempt to present a template for a comprehensive modern low vision rehabilitation practice is made here by summarizing scientific developments in the field and stressing the multidisciplinary involvement required for this kind of practice. It is hoped that this paper and other initiatives from colleagues, the public, and government will promote and raise awareness of modern low vision rehabilitation for the benefit of all.

Humans↗

A low-tech alternative to static progressive wrist extension splinting: the wrist extension strap.

The authors have found that for best results, a wearing time of 1 hour 3 to 4 times a day is desired. Similar to many splints designed to increase range of motion, there is some functional loss during wearing time. Application of the splint should be scheduled appropriately around functional activities. Based on clinical experience, the authors have found this splint is easy to fabricate, cost-effective, and relatively comfortable.

Equipment Design↗

[Successful decompression of the acoustic nerve after postarachnitic hearing damage (author's transl)].

Arachnitic adhesions of the pontine angle can damage the VIIIth cranial nerve to complete hearing loss. If there exists only a circumscript damage of the myeline sheet, this functional loss is reversible after decompression of the nerve. Preoperatively, the electrocochleography and the cisternoscopy discover this type of nerve damage and so, the probability of the postoperative hearing recovery is quite predictable.

Aged↗

[Occlusive retinal vasculopathy with subsequent secondary glaucoma. Demonstration of typical findings and therapeutic references].

The etiology of occlusive vascular retinopathy with subsequent neovascular glaucoma has not been clarified even today. If not diagnosed in the early stage therapy is often unsuccessful. Men and women aged between 35 and 65 years are affected with equal frequency. In a group of nine patients presenting at our clinic within three years four had irreversible functional loss by the time of the initial examination. In eyes with better visual function at the time of diagnosis only minimal vision and visual field can be preserved. Even this is only possible with intensive therapeutic efforts. Besides a rapid diagnosis to exclude prior vascular processes that can be treated areas of the retina with reduced perfusion always need to be treated by means of cryo- or lasercoagulation. Adjacently inhibitors of thrombocyte-aggregation to improve perfusion should be administered. Any delay of coagulation should be avoided since resulting secondary glaucoma is very difficult to treat.

Adult↗

[Lipids and primary prevention of coronary disease].

In this paper the data concerning the relationship between presence of lipid disorders and development of atherosclerosis are presented. The epidemiological studies showed that lipid disorders in young persons are of prognostic significance concerning future development of cardiovascular disease. Large, placebo controlled clinical trials demonstrated that reduction of serum cholesterol was associated with reduction in incidence of cardiovascular disease, however the decrease in total mortality (by 22%, p < 0.051) was observed only with statin treatment in WOSCOPS. Hyperlipidemia is associated with impairment of endothelial function, loss of endothelium dependent vasodilatation, development of inflammatory responses and impairment of anticoagulant function. Hypolipidemic therapy leads to improvement of endothelial function and stabilisation of atherosclerotic changes. Modification of all existing risk factors is of importance in prevention of cardiovascular diseases.

Cardiovascular Diseases↗

A role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanes.

Loss of p53 function has been linked to increased responsiveness to taxane treatment of ovarian carcinoma in clinical studies. We recently reported that the acquisition of cisplatin resistance in an ovarian carcinoma cell line (IGROV-1) was associated with mutation of p53 and collateral sensitivity to paclitaxel. The increased sensitivity to paclitaxel of the cisplatin-resistant subline appeared to be pharmacologically relevant since it was reflected in an in vivo sensitization to taxanes. To investigate the cellular and molecular basis of this phenomenon, we performed a comparative study of cellular response to taxanes (paclitaxel and the novel analog IDN 5109) in the parental cell line, containing wild-type p53 and its cisplatin-resistant p53 mutant subline (IGROV-1/Pt1). IDN 5109 was included in this study because of its higher potency and efficacy compared with paclitaxel on both tumor systems. The pattern of cellular response of the two ovarian cell lines was different. In IGROV-1 cells, apoptosis was an early event consequent to a transient mitotic arrest. The cell death of IGROV-1/Pt1 cells was a somewhat slow and delayed event, following mitotic arrest and appearance of hyperploid cells. The increased cytotoxic effect of IDN 5109, compared with paclitaxel, was associated with more marked p34(cdc2) dephosphorylation in IGROV-1 cells and higher Bcl-2 phosphorylation in IGROV-1/Pt1 cells after 24 hr of treatment. In each cell line, these biochemical events were not correlated with parallel levels of mitotic cells. Attempts to reintroduce wild-type p53 in IGROV-1/Pt1 were unsuccessful. However, in other p53-deficient cells (osteosarcoma SAOS), taxane treatment was associated with hyperploid progression and the introduction of wild-type p53 resulted in a reduced sensivity. Although our approach does not allow definitive conclusions, these results suggest that loss of p53-dependent post-mitotic checkpoint results in a different time-course of taxane-induced cell death following DNA reduplication. These events, more evident after exposure to the potent analog IDN 5109, support the notion that the enhanced sensitivity of p53 mutant cells is closely related to the different mode of cell death.

Antineoplastic Agents, Phytogenic↗

[Equilibrium function in patients with acute sensorineural hearing loss].

Equilibrium function was investigated with computer-assisted stabilography (CS) in patients with acute neurosensory hypoacusis. This new diagnostic tool was employed in combination with extended vestibulometric and audiologic examinations. Correlations were found between stabilographic and vestibulometric findings. CS is recommended as a method of screening diagnosis in examination of patients with imbalanced equilibrium.

Acute Disease↗

Anxiety disorders and disability secondary to urinary incontinence among adults over age 50.

OBJECTIVE: No previous research has investigated whether there is an association between anxiety disorders and urinary incontinence. We hypothesized that anxiety disorders would be associated with increased urinary incontinence related disability. METHOD: Continuing participants who were aged 50 years and older in a longitudinal study of community-dwelling adults who were initially living in East Baltimore in 1981 (n = 787). Participants were classified as incontinent if any uncontrolled urine loss within the 12 months prior to the interview was reported. Urinary incontinence related functional loss was further assessed based on a series of questions relating directly to participants' inability to engage in certain activities due to their urinary incontinence. Anxiety disorders were assessed with standardized interviews. RESULTS: Persons meeting criteria for an anxiety disorder were no more likely to have urinary incontinence than were persons without anxiety disorders (unadjusted odds ratio (OR) = 1.36,95 percent confidence interval (CI) [0.96, 1.93]). Among people with urinary incontinence (n = 159), persons meeting criteria for anxiety disorders in 1981 and in 1994 were much more likely to report urinary incontinence relatedfunctional impairment in 1994(adjusted OR = 6.51, 95 percent CI [1.42, 29.86]). CONCLUSIONS: Individuals with changes in day-to-day routines or activities secondary to urinary incontinence were more likely to meet criteria for an anxiety disorder than were other older adults. Further studies must tease out the temporal relationship and whether early detection of urinary incontinence and associated anxiety improves quality of life and functioning.

Aged↗

Preconditioning prevents loss in mitochondrial function and release of cytochrome c during prolonged cardiac ischemia/reperfusion.

Loss in mitochondrial function and induction of mitochondrial-mediated apoptosis occur as a result of cardiac ischemia/reperfusion. Brief and repeated cycles of ischemia/reperfusion, termed ischemic preconditioning, prevent or minimize contractile dysfunction and apoptosis associated with prolonged episodes of cardiac ischemia and reperfusion. The effects of preconditioning on various indices of ischemia/reperfusion-induced alterations in mitochondrial function and structure were therefore explored. Utilizing an in vivo rat model data is provided indicating that preconditioning completely prevents cardiac ischemia/reperfusion-induced: (1) loss in the activity of the redox sensitive Krebs cycle enzyme alpha-ketoglutarate dehydrogenase; (2) declines in NADH-linked ADP-dependent mitochondrial respiration; (3) insertion of the pro-apoptotic Bcl-2 protein Bax into the mitochondrial membrane; and (4) release of cytochrome c into the cytosol. The results of the current study indicate that preconditioning prevents specific alterations in mitochondrial structure and function that are known to impact cellular viability and provide insight into the collective benefits of preconditioning.

Animals↗

Loss of lung function associated with exposure to silica dust and with smoking and its relation to disability and mortality in South African gold miners.

The data from a lung function study on 2209 white 45-54 year old South African gold miners in 1968-71 and at a five year follow up examination, were analysed to establish the actual loss of lung function associated with exposure to silica dust and with smoking. Ex-smokers were excluded from the analysis. Of the remaining 1625 subjects, 1249 had the five year follow up test of lung function. The estimated excess loss of lung function for a 50 year old gold miner, associated with 24 years of underground dust exposure of an average respirable dust concentration of 0.30 mg m-3 (14.4 ghm-3) was 236 ml of FEV1 (95% confidence interval (95% CI 134-337) and 217 ml of FVC (95% CI 110-324). By comparison, the effect of smoking one packet of cigarettes a day over 30 years was associated with an estimated loss of 552 ml of FEV1 (95% CI 461-644) and 335 ml of FVC (95% CI 170-500). The cumulative dust exposure was not associated with the longitudinal loss of FEV1 or FVC when the initial FEV1 and FVC were adjusted in the models. According to the predicted values, however, gold miners appear to have a greater loss of lung function from 50 to 55 years of age than that predicted for a general population.

Aged↗

Selective alterations in guanine nucleotide regulation of opiate receptor binding and coupling with adenylate cyclase.

Pretreatment of rat brain membranes at pH 4.5 increased GTP and Gpp(NH)p regulation of [3H]-D-ala2-met5-enkephalinamide (D-ala-enk) binding with no change in absolute binding itself. Pretreatment at pH 4.5 did not alter basal adenylate cyclase activity but did cause a loss (50-90%) in NaF- and Gpp(NH)p-stimulated activity, indicating a functional loss of GTP-coupling proteins. The addition of cis-vaccenic acid partially restored NaF- and Gpp(NH)p-stimulated cyclase after low pH pretreatment but, in the same membranes, did not reverse the increase in GTP regulation of agonist binding. These results suggest that GTP regulation of binding and stimulation of adenylate cyclase occur by fundamentally different mechanisms.

Adenylyl Cyclases↗

In utero surgery rescues neurological function at birth in sheep with spina bifida.

We hypothesize that the neurologic deficit associated with open spina bifida is not directly caused by the primary defect but rather is due to chronic mechanical and chemical trauma since the unprotected neural tissue is exposed to the intrauterine environment. We report here that exposure of the normal spinal cord to the amniotic cavity in midgestational sheep fetuses leads to a human-like open spina bifida with paraplegia at birth, indicating that the exposed neural tissue is progressively destroyed during pregnancy. When open spina bifida was repaired in utero at an intermediate stage, the animals had near-normal neurologic function. The spinal cord was deformed but largely preserved. These findings suggest that secondary neural tissue destruction during pregnancy is primarily responsible for the functional loss and that timely in utero repair of open spina bifida might rescue neurologic function.

Animals↗

Development and validation of a model for estimating premorbid verbal intelligence in the elderly.

In a preliminary effort to improve the early diagnosis of dementia, we developed a regression-based method for estimating premorbid intelligence measured by the ability to read irregular words from the American version of the Nelson Adult Reading Test (AMNART). Using errors on the AMNART and years of education, a model for predicting current verbal intelligence (VIQ) was developed in a sample of nondemented elderly. Double cross validation showed that the model had high accuracy and stability in estimating current VIQ in nondemented subjects. The model was then used to estimate premorbid VIQ in mildly demented subjects. Estimated premorbid IQ exceeded current IQ by at least 10 points and did not differ from that of nondemented subjects. Less than 10% of nondemented elderly had discrepancies that were as large. If intellectual decline predicts future functional loss and can be reliably measured using cross-sectional data, the requirement of functional impairment may be an unnecessary barrier to the early diagnosis of dementia.

Actuarial Analysis↗

A naturally occurring rat model of X-linked cone dysfunction.

PURPOSE: To describe the electrophysiological, histologic, and hereditary features of a naturally occurring rat model of cone function loss. METHODS: Dark- and light-adapted electroretinograms (ERGs) were used to evaluate retinal function. The thickness and architecture of the retina were observed by light microscopy. The cone density was investigated by wholemount immunocytochemistry. The inheritance pattern was defined by mating with control female rats. RESULTS: In affected rats, light-adapted ERGs were nearly absent, whereas dark-adapted responses were of normal amplitude with delays in b-wave implicit time. Overall retinal structure was normal at the light microscopic level. There was no difference in cone density between control and affected rats. The cone function abnormality is inherited as an X-linked trait. CONCLUSIONS: A spontaneous rat mutant was identified that has markedly affected cone function, whereas rod-mediated function is largely spared. The presence of the normal number of cone outer segments indicates that the defect does not involve cone photoreceptor degeneration. This rat model provides a model of X-linked cone dysfunction, and may also be used to examine aspects of rod-mediated visual function in the rat. Further studies are needed to identify the gene that is involved.

Animals↗

Relation of dieting and voluntary weight loss to psychological functioning and binge eating.

Voluntary weight loss in obese patients consistently reduces negative emotions such as depression and anxiety in the short term. Dieting by persons of normal weight is associated with low self-esteem and depressive symptoms. Dieting is linked to the development and maintenance of eating disorders such as anorexia nervosa and bulimia nervosa, although the precise nature of this association is unclear. Dieting cannot be a sufficient causal condition and must combine with other still undetermined vulnerabilities to cause eating disorders. Identification of these risk factors must precede the development of effective programs to prevent eating disorders.

Diet, Reducing↗

The rheumatoid thumb.

The thumb frequently is involved in rheumatoid arthritis and often is a source of significant functional loss, pain, and deformity. Fortunately, much can be done to provide pain relief, improve function, enhance appearance, and slow the progression of disease. Specific surgical interventions should be based on the nature and stage of deformity as well as the status of tendons, ligaments, and adjacent joints. Treatment options, in isolation or in combination, include synovectomy, arthrodesis, arthroplasty, and tendon repair or transfer. Although most thumb deformities can be classified as one of six common types, other patterns of deformity also are seen. It therefore is imperative not to operate on pattern recognition alone, but to examine each patient carefully and individualize treatment.

Arthritis, Rheumatoid↗

Accelerated (malignant) hypertension: a study of 121 cases between 1974 and 1996.

A series of 121 consecutive cases with accelerated hypertension is presented. Forty-seven patients had essential hypertension. This diagnosis was confirmed during the follow-up, which lasted from 3 to 255 months (mean 63.1 +/- 58.1). The relationship between the effects of pharmacological treatment on high blood pressure (BP) and disease course were analyzed in accelerated essential hypertensive patients only, to avoid the imponderable influence of basic disease in secondary hypertension. In most cases, therapeutical effect on BP was monitored by multiple daily BP self-measurements. Since 1974, when this study was initiated, plasma creatinine concentration at admission showed a clear-cut decrease, especially after the introduction in the eighties of new hypotensive drugs. A sustained BP decrease assured a long-lasting preservation of renal function, if the initial functional loss was limited (plasma creatinine concentration of 2 mg/dl (176.8 mumol/l) or less). Renal function was preserved even if the BP decrease was not optimal and signs of relapsing malignant retinopathy were observed in the course of disease. Although the whole series showed a 12-year survival rate of about 69%, patients enrolled after 1980 had a 100% survival rate.

Administration, Oral↗

Relative blue-light extinction in lens nucleus related to age and cataract.

The extent of visual function loss from nuclear cataractous change can be estimated by observing the extinction of blue light compared to white light as a function of sagittal lens depth in standard slit lamps. Apparent extinction (loss of transmissivity) of 50% or more of the depth of the lens in blue light of maximal intensity compared to white light at minimal intensity is associated with marked visual loss. However, this transmissivity ratio of 0.5 or less also applies if light intensity remains constant and the blue filter is simply moved in and out of the light beam. Therefore, if 50% or more of the lens appears dark to blue-filtered light, nuclear changes have significantly decreased effective visual acuity. Relative blue-light extinction associated with nuclear change that may be amenable to surgical correction can thus be distinguished from the extinction effect caused by age alone.

Adolescent↗