SEARCH · PubMed Health

Results for “PERIODONTAL DISEASE”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,117 records · Page 62Linked to original sources

PubMed1993

Periodontal disease experience in adult long-duration insulin-dependent diabetics.

The aim of this study was to analyse periodontal disease experience in 40- to 70-year-old, sex-matched insulin-dependent diabetics and non-diabetics. The study involved 83 diabetics and 99 non-diabetics. The clinical and radiographic examination comprised recordings of number of teeth, presence of plaque, gingival conditions, probing pocket depth and alveolar bone level (main variable). Diabetics aged 40 to 49 years had more periodontal pockets > or = 6 mm and more extensive alveolar bone loss than non-diabetics in the same age-group. There was also a significantly higher number of subjects belonging to classification groups with severe periodontal disease experience among diabetics in that age-group. In the age-groups 50-59 and 60-69 years, no major differences were found. The disease duration in these 3 age groups was 25.6 years, 20.5 years and 18.6 years, respectively, and the age of onset thus appears to be an important risk factor for future periodontal destruction.

Adult↗

PubMed1989

Radiographic and clinical assessments of destructive periodontal disease.

191 subjects, aged 35-80 years, were examined for periodontal disease using radiographic and clinical means. At all approximal tooth surfaces, assessments were made of (i) the distance on radiographs between the cementoenamel junction and the most coronal level of the alveolar bone, and (ii) probing attachment loss. The results revealed that (i) a strong correlation existed between the radiographic and the clinical assessments (r = 0.80, p = 0.0001), (ii) the difference between the 2 types of assessments was within 2 mm in 92% of the tooth sites examined, (iii) the degree of agreement between the 2 methods was similar, irrespective of tooth type and tooth surface, but (iv) the agreement was poor at sites with severe periodontal tissue breakdown.

Adult↗

PubMed1977

Periodontal disease associated with Down's syndrome: an orthopantomographic evaluation.

The occurrence of advanced periodontal disease with bone loss in patients with Down's syndrome was studied by orthopantomographic technique to obtain objective and quantitative data. The results were compared to a material of pairs matched according to age, sex, and the severity of mental retardation. Both groups of patients were institutionalized and subject to the same hospital conditions and dental care. Eighty-four percent of the young adults (19 to 39 years of age) with Down's syndrome showed advanced alveolar bone loss of 2.5 mm or more as compared with 27% in the matched pair contorls. The mean bone loss of the mandibular first molars in the study group was detected in 17.8%, and in 3.0% in their controls. No difference in radiographically detectable calculus, decay and/or fillings were observed between the two groups. It is concluded that Down's syndrome is associated with an increased prevalence and severity of periodontal disease, and that this is due to the basic congenital disorder rather than to institutionalization or inadequate oral hygiene.¿

Adolescent↗

PubMed1993

Glycosulfatase activity of Porphyromonas gingivalis a bacterium associated with periodontal disease.

Porphyromonas gingivalis, a bacterium implicated in the pathogenesis of periodontal disease, was found to elaborate an extracellular glycosulfatase enzyme. Upon purification by low temperature acetone fractionation, an active enzyme at 60% acetone was obtained which on SDS-PAGE gave a protein band of 37kDa. The glycosulfatase effectively caused desulfation of galactosyl- and lactosylceramide sulfates (pH 5.0) which contain the sulfate ester groups at C-3 of galactose, a well as proteoglycans (pH 5.7-6.2) of gingival tissue which are rich in N-acetylgalactosamine-4-sulfate, but not the sulfated salivary mucin with the sulfate groups at C-6 of galactose and C-6 of N-acetylglucosamine. The results demonstrate for the first time that P. gingivalis displays glycosulfatase activity and that the disruptive action of this enzyme may be a major factor in the etiology of periodontal disease.

Culture Media↗

PubMed1990

[Oral findings in severely handicapped patients participating in the periodic dental check-up system for five years--dental caries, gingival recessions and hyperplasias, periodontal diseases].

In March 1987, we investigated the quality of oral hygiene, and the incidence of dental caries and periodontal diseases in 140 severely handicapped patients who had been hospitalized in two national sanatorium. All of the patients had participated under the Matsumoto Dental College Hospital Periodic Dental Check-up System for five years. The results were as follows: 1. The teeth of all the subjects had been brushed by the sanatorium nursing staff twice per day. The prevailing brushing technique was the horizontal method. 2. 37.5% of the subjects showed complete adaptability to the tooth brushing by the nursing staff. However, 2.1% showed no adaptability whatsoever. 3. The mean value of the OHI-S was 1.53. The labial surfaces of the maxillary anterior teeth showed the lowest OHI-S value, while the mandibular left posterior teeth showed the highest. 4. The DMF-T was estimated to be 12.51 (DMFT ratio = 48.2%). The average D-T was 2.07 +/- 4.03, and the average F-T was 8.43 +/- 7.22. 5. 19.3% of the patients were diagnosed with gingival hyperplasia, and 10.7% had local gingival recessions. 1) Of the patients who had taken Phenytoin daily, 35.5% were diagnosed with hyperplasia. 2) Most local gingival recessions were found on the labial gingiva of the mandibular anterior teeth. A relationship was determined to exist the local recession and the horizontal brushing method. 6. 89.2% of the patients suffered from periodontal diseases.(ABSTRACT TRUNCATED AT 250 WORDS)

DMF Index↗

PubMed1988

Bacterial invasion in root cementum and radicular dentin of periodontally diseased teeth in humans. A reservoir of periodontopathic bacteria.

In this study the viability and the distribution of bacteria within the radicular dentin and pulp of periodontally diseased caries-free teeth were studied. Healthy teeth served as controls. Samples were obtained from the pulp tissue and from the radicular dentin. Dentin samples were taken from the interdental surfaces in the subgingival area. Starting from the pulpal side, three to five successive dentin layers of approximately 1 mm thickness were sampled. The samples were processed and cultured using an anaerobic technique. Bacterial growth was detected in 87% of the periodontally diseased teeth. In 83% of the teeth, bacteria were present in at least one of the dentin layers. Fifty-nine percent of the diseased teeth, from which the pulp tissue was cultured, contained bacteria in the pulp samples. The mean bacterial concentrations in the pulp and dentin layers ranged from 1,399 to 16,537 colony-forming units (CFU) per mg of tissue. These concentrations were 259 to 7,190 times greater than concentrations found in healthy teeth. It is suggested that the roots of periodontally diseased teeth could act as bacterial reservoirs from which recolonization of mechanically treated root surfaces can occur, as well as infection of the dental pulp. These findings might change current concepts concerning root surface debridement in periodontal therapy.

Actinomyces↗

PubMed2002

Postnatal lipopolysaccharide-induced illness predisposes to periodontal disease in adulthood.

The long-term consequences of neonatal lipopolysaccharide (LPS) exposure on adult behavioral and neuroendocrine stress responsiveness as well as on the clinical course of periodontal disease were assessed in male Lewis rats. At 3 and 5 days of age, pups were administered either saline (SHAM) or LPS or were left undisturbed. After postnatal treatment, mothers licked LPS-treated pups significantly more. In adult LPS rats of 3-5 months of age, home cage activity indicated changes of the diurnal rhythmicity. Furthermore, SHAM- and LPS-treated animals displayed treatment-specific signs of increased anxiety in social interaction, elevated plus maze, holeboard, and open field tests. At 7 months of age, a dramatic increase of periodontal fiber loss in LPS rats was associated with increased plasma interleukin-6 levels. In contrast, SHAM treatment caused high plasma interferon-gamma cytokine levels and protective effects in periodontal disease. Parameters of the response to novelty were significantly correlated with later disease susceptibility. Thus, LPS-induced early postnatal illness modulates the adult behavioral responsiveness to stress and predisposes to periodontal disease.

Age Factors↗

PubMed1997

Periodontal disease diagnosis: current status and future developments.

OBJECTIVES: This manuscript attempts to critically review traditional and currently employed methods of periodontal diagnosis, in the light of current knowledge about individual patients and sites at risk of progressive periodontal attachment loss. DATA SOURCES: Articles published over the last decade from international research journals, have demonstrated that existing methods of periodontal disease diagnosis are seriously deficient with respect to accuracy, their ability to predict ongoing or future disease activity and their ability to determine the current activity status of historically diseased sites. STUDY SELECTION: Longitudinal studies have questioned the rationale behind traditional treatment regimes and underlined the importance of site-directed therapy to avoid potentially damaging instrumentation of quiescent or healthy sites. The recent explosion in local, less invasive chemotherapies for periodontal disease management has aimed at addressing the site-specific nature of this group of diseases, but the true benefits of such novel therapies cannot be realised until more accurate and specific diagnostic techniques become available. CONCLUSIONS: The manuscript concludes that the range of clinical information collected by experienced periodontists using currently available technology is probably sufficient to manage mild-to-moderate chronic adult periodontitis. However, those patients at risk from more aggressive attachment loss, and those individuals that appear refractory to traditional therapies, require the development of more accurate diagnostic tests to compliment the revolution in site-specific therapies. A diagnostic model is presented, which attempts to draw together current and future diagnostic methods for managing the majority of periodontal disease types, and it is suggested that current diagnoses should include some assessment of "risk'.

Adult↗

PubMed1993

A socio-ecologic model for periodontal diseases.

A socio-ecologic conceptual model for periodontal diseases has been proposed. The model, which includes 4 items: health-care organization, human biology, behavioral factors, and environment, has been tested on a random-sample of 50-year-old Oslo citizens. The investigation is based on a clinical examination as well as a questionnaire and structured interview. A logistic regression model was used to study associations between risk factors and the probability of deep periodontal pockets (> 5.5 mm). The risk of periodontal pockets was positively associated with: short duration of education, being of male gender, previous periodontal treatment, poor oral hygiene and infrequent toothbrushing. Variables describing behavioral factors and human biology were the items found to be most closely associated with periodontal pocketing.

Biology↗

PubMed1986

Attachment level changes in destructive periodontal diseases.

The present communication attempts to summarize some of the features of attachment loss which are of interest to the clinician and the statistician analyzing data from clinical trials. These include the measurements employed to detect changes in attachment level, the nature of the destructive disease process and the effects of therapy on the attachment level measurements. Although there are several difficulties associated with the attachment level measurement, at the present time it appears to be the best estimator of periodontal attachment available. The overall standard deviation of this measurement in greater than 46,000 replicate measurements at periodontal sites in 58 subjects was 0.78 mm (range 0.4 to 1.2 mm). In the periodontally healthy subject, the length of the attachment measured around 28 teeth is approximately 700 mm. Therefore, there are approximately 1400 adjacent points along the periodontal attachment where a measurement could be made using a periodontal probe with a 0.5 mm diameter tip. If 6 measurements were recorded per tooth, then approximately 12% of the possible probable points would be evaluated. Recent data indicate that destructive periodontal diseases progress with acute bursts of activity rather than as slowly progressive, continual processes. Such findings suggest new models of attachment loss progression. In one likely model, destructive periodontal diseases would progress by asynchronous bursts of activity at individual sites which occur with greater frequency during a finite period of time in an individual's life. 3 major patterns of attachment loss could be distinguished when frequency distributions of attachment level measurements were constructed for 61 destructive periodontal disease subjects. Pattern I (30 subjects) exhibited a bimodal distribution with localized destruction occurring at less than 34% of sites. Pattern II (14 subjects) exhibited more widespread disease (greater than 33% of sites affected) with a trimodal frequency distribution. Pattern III (17 subjects) exhibited a unimodal distribution in which virtually all sites were affected. The proportions of Fusobacterium nucleatum, Streptococcus intermedius and Eikenella corrodens in subgingival plaque samples were significantly elevated in sites of subjects with patterns II and III (the widespread disease groups). Bacteroides intermedius, Streptococcus uberis and Actinobacillus actinomycetemcomitans were elevated in sampled sites of localized disease subjects (pattern I). The effects of therapy by Widman flap surgery and systemic tetracycline were examined by several statistical analyses.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗

PubMed1995

The use of radiographic techniques in the diagnosis and management of periodontal diseases.

Radiographs continue to play an important role in the diagnosis and management of periodontal disease although opinions as to the most appropriate form of assessment vary. It is important to recognize the limitations of each technique in terms of resolution, repeatability and accuracy so that radiographs can be correctly interpreted to the benefit of the patient. The value of intra-oral and panoramic radiography is reviewed, with particular reference to articles published over the past five years, followed by a consideration of developing computer-aided techniques which may, in time, prove of value to the dental practitioner in the diagnosis and management of periodontal disease.

Alveolar Bone Loss↗

PubMed1991

Factors in virulence expression and their role in periodontal disease pathogenesis.

The classic progression of the development of periodontitis with its associated formation of an inflammatory lesion is characterized by a highly reproducible microbiological progression of a Gram-positive microbiota to a highly pathogenic Gram-negative one. While this Gram-negative microbiota is estimated to consist of at least 300 different microbial species, it appears to consist of a very limited number of microbial species that are involved in the destruction of periodontal diseases. Among these "putative periodontopathic species" are members of the genera Porphyromonas, Bacteroides, Fusobacterium, Wolinella, Actinobacillus, Capnocytophaga, and Eikenella. While members of the genera Actinomyces and Streptococcus may not be directly involved in the microbial progression, these species do appear to be essential to the construction of the network of microbial species that comprise both the subgingival plaque matrix. The temporal fluctuation (emergence/disappearance) of members of this microbiota from the developing lesion appears to depend upon the physical interaction of the periodontal pocket inhabitants, as well as the utilization of the metabolic end-products of the respective species intimately involved in the disease progression. A concerted action of the end-products of prokaryotic metabolism and the destruction of host tissues through the action of a large number of excreted proteolytic enzymes from several of these periodontopathogens contribute directly to the periodontal disease process.(ABSTRACT TRUNCATED AT 250 WORDS)

Gram-Negative Bacteria↗

PubMed1995

Modulation of host matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases.

OBJECTIVE: Bacterial pathogens involved in periodontal diseases exert a part of their destructive effect by triggering and inducing host cells to elevate their secretion of matrix metalloproteinases (MMPs). Pathogen-secreted phospholipase (PLC) is one bacterial product that may trigger this host response. The roles of exogenous PLC leading to the release, secretion and expression of MMPs by peripheral blood neutrophils (PMNs), cultured epithelial cells of human gingiva and porcine periodontal ligament were investigated. Also the activities of PLC in the diseased and healthy gingival sulcular fluid (crevicular fluid, GCF) and molecular forms of gelatinases present in dental plaque were investigated. MATERIALS AND METHODS: GCF, salivary and dental plaque samples were analyzed for PLC and proteinase activities. The abilities of PLC to induce PMNs and oral epithelial cells to release and express their MMPs were examined by specific functional, immunological and molecular biology means. RESULTS: PMN-derived MMPs were found to predominate in periodontitis GCF and plaque, and PLC activities were higher in GCF of adult periodontitis patients than in healthy controls. Purified bacterial PLC (1 mU ml(-1)) efficiently induced PMN degranulation. PLC also induced MMP expression in the cultured epithelial cells. The strongest response was seen in MMP-9 and less in MMP-2. The induction was dose-dependent in the range of 0.0-1.0 U ml(-1) PI-PLC, and quiescent cultures were more responsive than proliferating ones. PLC induction of MMPs was polar, with increased levels of MMP-9 in the apical region and increased MMP-2 levels secreted in the basal direction. Northern analysis showed a strong increase in mRNA levels of MMP-9 and a smaller increase for MMP-2 and MMP-1. In the second part of the study we investigated the molecular forms of the released MMPs during periodontitis. In bacterial plaque of periodontitis patients the MMP-9 were found to be converted into lower molecular weight forms. Isolated proteinase from Porphyromonas gingivalis (ATCC 33277) was able to convert human proMMPs to their active forms. CONCLUSION: Bacterial PLC may induce degranulation of PMN MMPs and increase MMP expression in oral epithelial cells. The released proteases can be converted into active form by the proteases of plaque bacteria. Thereby, the pathogenic oral bacteria may indirectly participate in the destruction of periodontal tissues.

Adult↗

PubMed2003

Effect of variable moderate chronic stress on ligature-induced periodontal disease in Wistar rats.

The aim of this investigation was to study the impact of stress on ligature-induced periodontal disease in rats by means of a variable moderate chronic stress model. Thirty male Wistar rats were randomly assigned to six groups. Control groups received only ligatures around the second maxillary molars, while experimental groups were exposed to stress in additional. Stress was imposed by means of flashing light, isolation, rat blood smelling, new environment exposure, immobilization in cold temperature and immobilization at room temperature. Stress was applied randomly, thereby diminishing adaptation of the animals to the model. The animals were killed after 29, 43, and 57 days. The distance between the cementum-enamel junction and the alveolar bone (CEJ-AB) was measured. Alveolar bone loss was statistically different between stressed and control animals, whereas differences were not observed between experimental periods. The mean CEJ-AB distance in animals exposed to stress was 154.50 microm smaller than the corresponding distance in the controls. It might be concluded that variable moderate chronic stress decreased alveolar bone loss in a ligature-induced periodontal disease model.

Alveolar Bone Loss↗

PubMed1990

A 10-year retrospective study of periodontal disease progression. Clinical characteristics of subjects with pronounced and minimal disease development.

The present study reports on some characteristics of 2 groups of subjects, chosen from a sample of 191 dentate individuals who had been exposed to full-mouth intraoral radiographic examinations in 1975 and 1985. The 1st group, which comprised 14 subjects, had experienced pronounced loss of periodontal bone support during a 10-year period (mean longitudinal bone loss of 4.13 mm (S.D. 1.4]. The 2nd group of 14 subjects had suffered no or minimal periodontal disease progression (mean longitudinal bone gain of 0.35 mm (S.D. 0.7]. A clinical examination was performed in conjunction with the radiographic examination in 1985 and included assessment of plaque, gingivitis, bleeding on probing from the base of the pocket, probing depth and probing attachment loss. Information regarding the oral hygiene habits of the subjects as well as the amount of dental and periodontal therapy received between 1975 and 1985 was obtained through a questionnaire. The results revealed that the 14 subjects who had experienced pronounced progression of periodontal disease had more plaque and gingivitis, deeper pockets and more attachment loss than the 14 subjects with minimal periodontal disease progression. Over the 10-year period, subjects in the "high rate" group had lost a mean of 6.8 teeth (S.D. 5.0) as compared to 4.1 teeth (S.D. 4.4) in the "low rate" group. The radiographic assessments of alveolar bone loss were strongly correlated with the assessments of probing attachment loss (r = 0.80, p = 0.0001). In 92% of the tooth sites examined, the difference between the radiographic and the clinical assessment was within 2 mm.(ABSTRACT TRUNCATED AT 250 WORDS)

Alveolar Process↗

PubMed2003

The prevalence of periodontal disease measures in elderly adults, aged 79 and older.

From 1996-98, we examined 449 adults (mean age 85 years) from the 1982 Iowa 65+ Rural Health Study, in the field using headlight, mirror, and periodontal probe. Ninety-six of the 342 dentate subjects were excluded from the follow-up examination due to contraindications to probing, and 10 could not be assessed due to refusals, fatigue or other reasons. For all remaining subjects (n=236), attachment loss, defined as recession plus probing depth, was determined at four sites per tooth. Ninety-one percent of the subjects had at least one site with 4+ mm of attachment loss, 45% had one or more sites with attachment loss of 6+ mm, and 15% had 8+ mm of attachment loss. Moderate periodontal disease is prevalent among very old dentate adults while advanced periodontal disease is much less prevalent, suggesting that most periodontal treatment needed by this age group can be provided by general dentists and dental hygienists rather than periodontists.

Aged↗

PubMed1993

Site-specific CPITN score and periodontal disease activity assessed by the paper BANA assay.

The purpose of this study was to examine the association between site-specific periodontal conditions assessed by CPITN and BANA test results. A total of 161 Japanese company employees aged 18-59 were examined for their periodontal conditions at mesio-buccal and mid-lingual sites of the maxillary right and mandibular left first molars using CPITN. Code 2 (calculus) was divided into Code 2+ and Code 2- by the presence or absence of bleeding. Plaque samples were collected from the examined sites with a scaler and placed on BANA reagent cards. The results indicated a close relationship between site-specific CPITN Codes and the BANA test results except at sites designated Code 2-. The proportion of sites with strong-positive reactions were 19.0% for Code 0, 21.4% for Code 2-, 29.9% for Code 1, 37.0% for Code 2+ and 50.0% for Code 3. These data indicated that the teeth given higher CPITN Codes tend to have higher risks for periodontal disease. From these results, it was concluded that the site-specific CPITN score is a good indicator of periodontal disease activity and that a higher priority for treatment should be given to the sites with pocket formation (Code 3 and Code 4) and/or gingival bleeding (Code 1 and Code 2+).

Adolescent↗

PubMed2001

Tooth and periodontal disease: a review for the primary-care physician.

Dental diseases are widespread and are often underrecognized and treated. Caries and periodontal disease are common dental conditions that cause the majority of tooth loss. Although these conditions are preventable, many persons do not receive regular dental care and have acute problems when seen by their physician. Dental diseases frequently affect patients with multiple systemic disorders, including autoimmune disorders, diabetes, and human immunodeficiency virus (HIV) infection. The presence of dental disease may trigger inflammatory responses and have systemic consequences. Since dental disease affects almost all individuals, physicians should be able to recognize common conditions such as caries, periodontal disease, pulpitis, and dental abscess. In addition to initiating treatment and appropriate dental referrals, physicians should be familiar with the management of antibiotics and medications in the perioperative period. Another important role for physicians is to help reduce the societal and economic impact of these diseases through patient education and prevention.

Humans↗