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At least 1,117 records · Page 62Linked to original sources
PubMed2005

Evaluation of the therapeutic activity of tulathromycin against swine respiratory disease on farms in Europe.

The clinical efficacy of tulathromycin in the treatment of natural outbreaks of swine respiratory disease (SRD) was evaluated at five European sites. Pigs (1 to 6 months of age) exhibiting clinical signs of SRD were treated intramuscularly with tulathromycin (n = 247) at 2.5 mg/kg on day 0 versus either tiamulin (n = 102) at 15 mg/kg on days 0, 1, and 2 (Germany, the Netherlands, and the United Kingdom) or florfenicol (n = 20) at 15 mg/kg on days 0 and 2 (France). Actinobacillus pleuropneumoniae, Pasteurella multocida, and Mycoplasma hyopneumoniae infections were the most frequently diagnosed pathogens. For both tulathromycin-treated animals and those treated with tiamulin or florfenicol, there were significant (P = .0001) reductions in mean rectal temperature and the severity of abnormal clinical signs on days 2 and 10 compared with day 0. There were no significant differences (P > .05) between treatments in average daily weight gain. Tulathromycin was found to be safe and highly effective in the treatment of natural outbreaks of SRD.

Animals↗
PubMed1979

[Bronchial abnormalities in a clinic for respiratory diseases (author's transl)].

The frequency in bronchial abnormalities is generally underestimated. In patients of a clinic for respiratory diseases however 3% were found in those having had a bronchoscopy, a figure which has up to now not been mentioned in the literature. After discussing originating theories and classifying possibilities the observations are tabulated, and some of them introduced as representative examples. In the discussion it is pointed out, that the abnormalities apparently represent a locus minoris resistentiae, since pathological changes are often found in these areas.

Adolescent↗
PubMedDate not supplied

[A systems analysis of the relationships between phenotypic traits and the clinical polymorphism of respiratory diseases in children].

Genetic phenotypic risk factors have been investigated in 1630 children with various forms of acute respiratory diseases and in control groups (314 children with bronchial asthma, 768 healthy children). Each of them was estimated by points using special elaborated prognostic tables. This allowed to distribute children into risk groups according to the development of disease from the moment of birth.

Acute Disease↗
PubMedDate not supplied

[The use of the nursing process in an acute respiratory disease service].

Due to the value of patient recovery and the development of nursing practices, 37 infants under 1 year of age are studied. These patients had been hospitalized in the Service of Acute Respiratory Diseases in Sur Teaching Children's Hospital in Santiago de Cuba during the months of March-April, 1987. This research work is based in the process of nursing care, and its aimed to determine the behavior and results of its application in a ward with a staff covering the current indicators. It was found that with the human resources available in this service it was feasible to carry out this process, which enabled a more rapid rehabilitation of these patients, according to the care plan carried out. The nurse-patient relationship became apparent in all of the patients studied, with prevalence of the 6-9 month-old age group.

Acute Disease↗
PubMed1976

[Present possibilities of antibiotic therapy in chronic non-specific respiratory diseases (author's transl)].

Due to the mainly infectious genesis drug-therapy with antibiotics is essential in chronic non-specific respiratory diseases. But they are only indicated when a bacterial infection is suspected. The broad spectrum antibiotics usually have a reliable efficacy. Bacteriological examination is no obligate supposition. But it is necessary if new drugs with limited effectiveness are intended to be given. In most cases of chronic bronchitis an intermittent application is sufficient. A continuous treatment is indicated only in a few cases. Some details of antibiotic therapy (kind of drugs, dosage, duration of treatment, side-effects etc.) are discussed. The possibility of antibiotic therapy in respiratory virus infections is inquired.

Ampicillin↗
PubMedDate not supplied

Inner-city housing and respiratory disease in children: a pilot study.

This cross-sectional pilot study, designed to examine problems and methodology of studies on the relationship of housing and health, focused on respiratory disease in inner-city black children in Baltimore. Public housing was contrasted to the older row private housing. History of illness, familial, and demographic characteristics were obtained by questionnaire, and a small subsample of children received physical examinations. The condition of the indoor environment was evaluated and measurements of indoor temperature, volume, relative humidity, and carbon monoxide were made. Children in public housing had higher illness rates than those in private housing. Evidence of self-selection into housing type was found. Carbon monoxide levels were found to be greater inside than outside the homes. Preliminary analysis suggests public housing-private-housing classification is less important than other variables, including socioeconomic variables.

Black or African American↗
PubMed2004

Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease.

A clinical trial was undertaken to investigate the efficacy of a single dose of carprofen (CPF) in the treatment of bovine respiratory disease in cattle. Tilmicosin was used as a basal treatment in all animals. Six hours after dosing, body temperature and respiratory rates in animals treated with CPF-tilmicosin had decreased and were significantly lower than in the animals treated with tilmicosin alone (P < 0.05). Over the period of clinical observation, CPF-tilmicosin treatment produced a clinical resolution of the pneumonia similar to treatment with tilmicosin alone. However, it is significant from an animal welfare perspective that over the period of the study after treatment, CPF-tilmicosin therapy produced significantly greater symptomatic improvement than tilmicosin.

Animals↗
PubMed1982

Antimicrobial resistance among Pasteurella spp recovered from Missouri and Iowa cattle with bovine respiratory disease complex.

A retrospective study was conducted to determine the prevalence of antimicrobial resistance among Pasteurella spp recovered from cattle with bovine respiratory disease complex. The study extended from January 1976 through May 1980, and included a review of the necropsy records of 386 beef cattle. Susceptibility or resistance of the Pasteurella isolants was determined by using the standard disk diffusion susceptibility test. Each isolant was tested for susceptibility with 15 different antimicrobial agents. A high prevalence of resistance (greater than 80%) was found when Pasteurella was tested with triple sulfonamides. For P haemolytica isolants, 57% to 70% were resistant to ampicillin (56/97), penicillin (58/101), and streptomycin (70/100); for unidentified Pasteurella spp isolants, 64% to 91% were resistant to ampicillin (83/129), penicillin (89/129), and streptomycin (118/129). For P haemolytica (21/100) and P multocida (34/146) isolants, 21% to 23% were resistant to tetracycline. Most of the P multocida isolants did not show marked antimicrobial resistance to 9 of the 15 drugs tested. However, 58% of the P multocida isolants (84/145) were resistant to streptomycin and 88% of them were resistant to three combined sulfonamides (126/144).

Animals↗
PubMed1999

Differential serologic response to Mycoplasma ovipneumoniae and Mycoplasma arginini in lambs affected with chronic respiratory disease.

An enzyme-linked immunoabsorbent assay (ELISA) was used to evaluate the levels of antibodies to Mycoplasma ovipneumoniae and M. arginini in lambs with chronic respiratory disease. Sera were obtained from lambs in several flocks at various stages of the clinical disease and tested with sodium dodecyl sulfate (SDS)-treated M. ovipneumoniae and M. arginini whole cells and a crude capsular extract of M. ovipneumoniae as the antigens. There were low levels of antibody to M. ovipneumoniae in flocks sampled at the early stages of infection, whereas increased levels of antibody were present in lambs from flocks that had apparently recovered from the clinical disease. Slowly rising titers of circulating antibodies to M. ovipneumoniae were confirmed by sequential bleeding of lambs during the course of the clinical disease. However, antibody levels of M. arginini were more likely to increase earlier in the disease process. There was significant cross-reactivity between the 2 SDS-treated antigens in both the ELISA test and western immunoblotting. In contrast, the crude capsular extract was specific for detecting antibodies to M. ovipneumoniae.

Animals↗
PubMed1999

Reemergence of adenovirus type 4 acute respiratory disease in military trainees: report of an outbreak during a lapse in vaccination.

From 23 April to 13 May 1995, an outbreak of acute respiratory disease (ARD) hospitalizations occurred in basic training soldiers at Fort Jackson, South Carolina. Weekly hospitalization rates for the most affected military unit reached 11.6%. Virus isolation and serologic studies from a sample of patients identified the agent as adenovirus type 4. Prior to starting vaccinations against adenovirus types 4 and 7 in 1971, these serotypes were the major causes of ARD in basic trainees. No outbreaks were reported when the vaccines were used. A logistical error temporarily interrupted vaccine production, and newly arriving trainees received no adenovirus vaccines from the summer of 1994 through late March 1995. This outbreak occurred in unvaccinated soldiers. The sole manufacturer has permanently stopped adenovirus vaccine production. All type 4 vaccine supplies are now depleted. This outbreak demonstrates continued susceptibility of military recruits to adenovirus type 4 and warns of future outbreaks.

Adenoviridae Infections↗
PubMed1999

Antireflux surgery in children suffering from reflux-associated respiratory diseases.

The aim of our study was to evaluate the success, complications, and morbidity following a modified Thal fundoplication in children with reflux-associated respiratory disease (RARD). We used a procedure consisting of retroesophageal hiatal plasty, wrapping the gastric fundus around the gastroesophageal junction 180 degrees, and fixation of the lesser curvature at the abdominal wall. Follow-up by questionnaire of 128 (77 male, 51 females) out of 196 antireflux procedures between 1992 and 1995 was achieved. Surgical therapy was considered justified whenever there was gastroesophageal reflux resulting in severe recurrent respiratory symptoms. Eleven percent of the children suffered from bronchiectasis. The diagnosis of RARD was based on a high index of suspicion, barium swallow with fluoroscopy, 24-hr two-level pH-monitoring, bronchoscopy, bronchoalveolar lavage and detection of lipid-laden alveolar macrophages, esophago-gastroscopy, and esophageal biopsy. Patients with bronchopulmonary diseases such as allergy, immunodeficiency, cystic fibrosis, primary ciliary dyskinesia, and malformation of the bronchial tree or vessels had been excluded. "Evident improvement" as a result of surgery was reported in 88%, "no change" in 10%, and a "change for the worse" in 2% of patients. Persistent mild difficulties in swallowing were observed in 11%. Paraesophageal hernia, gas-bloat syndrome, and dumping syndrome were not observed. Two children needed a second operation because of relapse. The use of emergency steroidal medication for acute respiratory distress decreased impressively (219 single doses/year before surgery vs. 30 single doses/year after surgery). The need for more than 4 times/year of antibiotic therapy before surgery was reduced from 52. 3% before to 14% after surgery. Most (90.6%) of the parents stated they would agree to have surgery done again if medically indicated. In conclusion, Thal fundoplication is sufficient, safe, and effective in the management of RARD. Complications of the procedure were minor and of little consequence to the patient.

Adolescent↗
PubMed2004

Experimental infectious respiratory disease in groups of calves: lobar distribution, variance, and sample-size requirements for vaccine evaluation.

The distribution and variance of respiratory disease produced with aerosols of bovine herpesvirus 1 (BHV-1) and Mannheimia haemolytica in control (183 calves in 44 experiments) and vaccinated calves were studied in experiments conducted at the Animal Diseases Research Institute, Lethbridge, Alberta, from 1975 to 1989. All calves had been born and raised at this institute and exposed similarly for 5 min by means of a face mask to viral and bacterial aerosols produced by a Collison atomizer (particles < 3 microm in diameter). We summarized the macroscopic pathological responses of pneumonia (main end point), tonsillitis, tracheitis, and other microbiologic and experimental variables. We also summarized the lobar distribution of pneumonia in 202 control and 192 vaccinated calves with this disease model and in calves similarly exposed to parainfluenza 3 virus/M. haemolytica or BHV-1/Pasteurella multocida. Pneumonia in control calves began in ventral tissues of all lobes, with lobar preferences, and progressed dorsally, the dorsal parts of both large caudal lobes being least affected. A high variance of pneumonia was evident within and among experiments. From the magnitude of variance observed in the control groups, the number of calves per group required in vaccine-challenge studies using this BHV-1/M. haemolytica disease model was estimated. Such estimates are required for any disease model used in vaccine-challenge studies.

Aerosols↗
PubMed1990

Effect of ascariasis and respiratory diseases on growth rates in swine.

Growth rates, measures of ascarid burden, and the levels of anteroventral pneumonia and atrophic rhinitis at slaughter were determined for 352 hogs born between March 8 and March 28, 1987 on 15 farms located in Prince Edward Island. Regression analyses were used to determine associations between average daily gain (ADG) and independent variables controlling for sex, farm, and litters nested within farm. The regression model accounted for 75.4% of the variation in ADG. The number of intestinal ascarids at slaughter did not affect ADG. However, the "life-time burden" (a composite measure based on fecal egg counts and duration of infection) was associated with ADG (p less than 0.05) in a quadratic manner. Although heavy ascarid burdens decreased the growth rate of swine, the magnitude of the effect was minimal. The maximum improvement one could expect from reducing the ascarid burden on heavily infected farms would be less than 1%. Severe atrophic rhinitis and the presence of anteroventral pneumonia each had a detrimental effect on ADG (p less than 0.001). The corresponding reductions in mean ADG were 7.7% and 2.8% respectively. There was significant interaction between the effects of atrophic rhinitis and anteroventral pneumonia on ADG (p less than 0.05). Hogs with both anteroventral pneumonia and severe atrophic rhinitis had a 17.6% lower ADG than hogs with neither disease. There is much greater potential for improvement in ADG through control of respiratory diseases than through control of ascariasis.

Animals↗
PubMed1986

[Atmospheric pollution and chronic respiratory diseases].

A national cooperative study was conducted from 1974 to 1976 in twenty-four areas located in six French cities, in order to investigate the relationships of air pollution to ventilatory function and the prevalence of respiratory symptoms. The concentrations of the following pollutants were daily measured: SO2, suspended particulates, NOx. The population included men and women, non manual workers, aged 25 to 59, and children, aged 6 to 10. The respiratory symptoms and other characteristics of the subjects were recorded and their ventilatory function was measured with a dry expirograph. The main results were as following: a) in adults of both sexes, the pollution in SO2 was associated with the prevalence of lower respiratory symptoms. b) in children, it was associated with the prevalence of upper respiratory symptoms. c) in both adults and children, the higher the SO2 concentration, the lower the FEV1. d) no other pollutant was related to respiratory diseases.

Adult↗
PubMedDate not supplied

[The biological properties of Haemophilus influenza isolated from healthy children and from patients with acute and chronic respiratory diseases].

The comparative study of the biological properties of H. influenzae strains isolated from healthy children and from patients with acute and chronic respiratory diseases has been made, taking into account the biochemical features (biotypes) and adhesive activity of these strains. Differences in various biotypes of H. influenzae strains isolated from patients with bronchopulmonary diseases and from healthy carriers have been established. H. influenzae strains isolated from various sources differ by their adhesive properties: strains isolated from patients with acute bronchopulmonary diseases have the highest adhesive activity, while strains isolated from healthy controls have the lowest adhesive activity. The data thus obtained indicate the possible dependence of the degree and duration of the colonization of the respiratory tract by H. influenzae on the biological properties of these microorganisms. The monitoring of the sensitivity of H. influenzae strains to antibiotics has demonstrated that these strains retain high sensitivity to ampicillin, chloramphenicol, gentamicin and exhibit a tendency towards an increase in resistance to penicillin and erythromycin.

Acute Disease↗