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PubMed1979

[Mitotic regime of various spindle cell sarcomas and their differential diagnosis].

The mitotic regime was studied in 34 spindle-cell sarcomas of soft tissues, including 11 synovial, 13 low-differentiated fibrosarcomas, 5 leiomyosarcomas and 5 rhabdomyosarcomas. The compared neoplasms were found to differ in the degree of cell proliferation disorders (the mitotic activity, a preponderance of dividing cells at the stage of metaphase, the frequency of pathological mitoses and correlation of their different forms). It is shown that bridges are one of the features of the mitotic pathology for spindle-cell sarcomas, moreover myogenic sarcomas are characterized by a higher incidence of those mitotic disorders which occurrence is conditioned due to damaging of the mitotic apparatus (three group, multiple metaphases, c-mitoses, multipolar and monocentric mitoses).

Diagnosis, Differential↗
PubMed1991

Long-term risk of sarcoma following radiation treatment for breast cancer.

Between 1954 and 1983, 7620 patients were treated for breast carcinoma at Institut Gustave Roussy (France). Of these patients, 6919 were followed for at least 1 year. Out of these, 11 presented with sarcomas thought to be induced by irradiation, 2 of which were Steward-Treves Syndrome, and 9 of which were sarcomas within the irradiated fields. All histological slides were reviewed and a comparison with those of breast cancer was done. The sites of these sarcomas were: parietal wall, 1 case; second costal cartilage, 1 case; infraclavicular region, 1 case; supraclavicular region, 2 cases; internal third of the clavicle, 2 cases; axillary region 2 cases; and the internal side of the upper arm (Stewart-Treves syndrome), 2 cases. The median age of these 11 patients at the diagnosis of sarcomas was 65.8 (49-83). The mean latent period was 9.5 years (4-24). Three patients underwent radical mastectomy and nine modified radical mastectomy. Only one patient received chemotherapy. The radiation doses received at the site of the sarcoma were 45 Gy/18 fr. for 10 cases and 90-100 Gy for 1 case (due to overlapping between two fields). The histology was as follows: malignant fibrous histiocytoma, 5 cases; fibrosarcoma, 3 cases; lymphangiosarcoma, 2 cases; and osteochondrosarcoma, 1 case. The median survival following diagnosis of sarcoma was 2.4 years (4 months-9 years). Two patients are still alive: one with recurrence of her breast cancer, the other in complete remission, with 7 and 3 years follow-up, respectively. All other patients died from their sarcomas. The cumulative incidence of sarcoma following irradiation of breast cancer was 0.2% (0.09-0.47) at 10 years. The standardized incidence ratio (SIR) of sarcoma (observed n# of cases (Obs)/expected n# of cases (Exp) computed from the Danish Cancer Registry for the same period) was 1.81 (CI 0.91-3.23). This is significantly higher than one, with a p = 0.03 (One Tailed Exact Test). The mean annual excess (Obs-Exp)/100.000 person-years at risk during the same period/(100,000) was 9.92. This study suggests that patients treated by radiation for breast cancer have a risk of subsequent sarcomas that is higher than the general population. However, the benefit from adjuvant radiation therapy in the treatment of breast cancer exceeds the risk of second cancer; therefore, the potential of radiation-induced sarcomas should not be a factor in the selection of treatment for patients with breast cancer.

Adult↗
PubMed1980

[Dynamic telethermography in primary bone and soft tissue tumours (author's transl)].

Twelve cases of primative bone neoplasm and of soft tissues sarcomas have been thermographycally observed. All cases were positive and cutaneous hyper-thermic areas corresponding to the neoplasies under consideration were noticed. This hyper-thermic area was in all cases larger than the area of bone's disease radiographycally detectable. Five cases were controlled before during and after a conservative radio-chemotherapic treatment. Thermographic and clinic finding's variation were always according; precocious than radiography. The results are to emphasize the utility of thermography in the prognosis, in the diagnosis of neoplastic extension, in conservative treatment control and in the follow-up of treated patients.

Adolescent↗
PubMed1983

Isolation and characterization of DNA-binding proteins of Yoshida ascites tumour cells.

DNA-binding proteins from the cytosol and nuclei of Yoshida ascites sarcoma cells were isolated by affinity chromatography on native and denatured DNA-cellulose columns. The proteins that were retained in the columns were eluted by increasing concentrations of NaCl and analysed by electrophoresis in polyacrylamide gels. Two proteins with approximate molecular weights (MW) of 38 000 (38K) and 34 000 (34K) D showed high affinity for denatured DNA and eluted in large quantities from denatured DNA-cellulose columns. In contrast, only small amounts of 38 000 and 34 000 D proteins were found to be associated with native DNA and the native DNA-associated 38K and 34K proteins showed higher rate of phosphorylation than the corresponding denatured DNA-binding proteins. The 38 000 and 34 000 D DNA-binding proteins were present both in nuclei and cytoplasm. These two proteins together comprised over 70% of the total DNA-binding proteins present in the 0.4 M NaCl eluate of the cytoplasmic extracts. DNA-binding proteins of MW 38 000 and 34 000 D were also present in a methylcholanthrene-induced fibrosarcoma, although in smaller amounts.

Animals↗
PubMed1994

Soft tissue sarcoma of the breast after conservative surgery and irradiation for early mammary cancer.

At Istituto Tumori of Milano in a series of 3295 patients treated with conservative surgery and radiotherapy for breast cancer from 1973 to 1989 three cases of soft tissue sarcoma were observed in irradiated breasts. One patient developed a fibrosarcoma of the breast stroma, 16 months after irradiation. A grade II bulky angiosarcoma was diagnosed in the breast of a patient treated 59 months previously. The third was a grade II angiosarcoma detected 41 months after therapy. At present, the risk of a second primary in the irradiated breast seems too low to justify modification of our present policy of conservative therapy of breast cancer, but a careful and longer follow-up is needed.

Aged↗
PubMed1981

Incidence of pulmonary metastases for various neoplasms in BALB/cStCrlfC3H/Nctr female fed N-2-fluorenylacetamide.

Incidence of pulmonary metastases for a variety of neoplasms was studied in many inbred BALB/cStCrlfC3H/Nctr female mice fed 2-fluorenylacetamide. Bladder carcinomas and hepatocellular carcinomas appeared to be the only neoplasms that were dose related. Hepatocellular carcinomas metastasized to the lungs at an incidence of 4.8%, and bladder carcinomas metastasized at an incidence of 0.28%. Osteogenic sarcomas metastasized to the lungs at an incidence of 46.2%; renal adenocarcinomas, at 20%; fibrosarcomas, at 16.7%; mammary adenocarcinomas, at 9.8%; and myoepitheliomas, at 10.5%. Other malignant neoplasms, including leiomyosarcomas, granulosa cells tumors, adrenocortical carcinomas, angiosarcomas, squamous cell carcinomas, and harderian gland tumors, metastasized at an incidence of less than 5%.

2-Acetylaminofluorene↗
PubMedDate not supplied

Diagnosis, classification, and management of soft tissue sarcomas.

BACKGROUND: Soft tissue sarcomas are challenging to oncologists due to their unique character, the infrequency of their occurrence, and the difficulties in predicting outcomes. Advances in imaging, as well as improvements in surgical techniques and adjunctive treatment methods, have improved care for patients with these unusual disorders. METHODS: The various types of soft tissue tumors are defined, and the statistics for the Orthopaedic Oncology Group in relation to them are reviewed and compared with literature references. RESULTS: The overall survival rate for 1,220 tumors treated at our institute from June 1972 to June of 2001 was 72%, with a wide range. Patients with leiomyosarcomas, clear cell sarcomas, and malignant fibrous histiocytomas had a poorer survival rate, while those with fibrosarcomas, liposarcomas, and neurofibrosarcomas fared better. Outcome was affected by patient age, tumor anatomic site, tumor stage, and a history of recurrence. CONCLUSIONS: Competent imaging, predictive immunological and genetic studies, improved surgery, and newer methods of adjunctive and neoadjunctive treatment should result in improvements in outcomes for patients with these tumors.

Adolescent↗
PubMed1985

Ameloblastic sarcoma of the mandible.

Malignant ameloblastic odontogenic tumors have traditionally been classified as either ameloblastic fibrosarcomas, dentinosarcomas or odontosarcomas. This separation is based on the presence of either dentine or dentine and enamel in some lesions. To date, 28 cases of ameloblastic fibrosarcoma, one case of ameloblastic dentinosarcoma, and seven cases of ameloblastic odontosarcoma have been reported in the literature. An additional case of ameloblastic dentinosarcoma is reported in this paper together with a critical review of the clinicopathologic features of previously reported cases of malignant ameloblastic neoplasms. The presence of dental matrix material is not specific and is found in a wide variety of odontogenic tumors in variable amounts. This study supports the concept that the presence of dental matrix material does not alter the basic biologic characteristics of these neoplasms. Accordingly, to simplify a confusing nomenclature, we suggest that malignant tumors of this type be referred to collectively as ameloblastic sarcomas.

Adult↗