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PubMedDate not supplied

[Experiences with the intracutaneous Mendel-Mantoux tuberculin test in routine screening in a public health office].

The intracutaneous tuberculin test according to Mendel-Mantoux is internationally recognised as a standard testing method in all countries of the globe. In routine everyday working of the Public Health Office of the German provincial capital Stuttgart the Mendel-Mantoux tuberculin test was examined in respect of practicability, acceptance and economy and was compared against the multipuncture-stamp test. 2,710 persons for whom the tuberculin test was prescribed according to the German infectious diseases law were tested for tuberculosis by the Stuttgart Public Health Office between August 1995 and February 1996, using the Mendel-Mantoux test with Behring 5 TE GT. Of these, 154 persons did not return for checking the result. Checking was effected on 2,556 persons. The tested persons were 28.4 years old on the average, the majority being female (59.5% against 40.5% males) and of German nationality (60.7% against 39.3% other nationals). A positive reaction was seen in 37% (induration > 6 mm), in 23.3% Germans against 57.5% other nationals. In 65% of the positive results the indurations had a diameter of more than 10 mm, in 29.2% more than 15 mm. 80 probands, i.e. 2.5% of all tested persons, had an excessive reaction; firmation of blisters with local necrosis. The intracutaneous test according to Mendel-Mantoux can be routinely performed by Public Health offices, is well accepted by the persons concerned, and is also economic if 3 tests are conducted per bottle. The proportion of positive findings is similar to that obtained with the multipuncture-stamp test, whereas the significance of the results is more differentiated. The indication should be in accordance with the objective.

Adolescent↗

PubMed1989

Ca2+-activated K+ conductance of the human red cell membrane: voltage-dependent Na+ block of outward-going currents.

Human red cells were prepared with various cellular Na+ and K+ concentrations at a constant sum of 156 mM. At maximal activation of the K+ conductance. gK(Ca). the net efflux of K+ was determined as a function of the cellular Na+ and K+ concentrations and the membrane potential. Vm, at a fixed [K+]ex of approximately 3.5 mM. Vm was only varied from (Vm-EK) approximately equal to 25 mV and upwards, that is, outside the range of potentials with a steep inward rectifying voltage dependence (Stampe & Vestergaard-Bogind, 1988). gK(Ca) as a function of cellular Na+ and K+ concentrations at Vm = -40.0 and 40 mV indicated a competitive, voltage-dependent block of the outward current conductance by cellular Na+. Since the present Ca2+-activated K+ channels have been shown to be of the multi-ion type, the experimental data from each set of Na+ and K+ concentrations were fitted separately to a Boltzmann-type equation, assuming that the outward current conductance in the absence of cellular Na+ is independent of voltage. The equivalent valence determined in this way was a function of the cellular Na+ concentration increasing from 0.5 to 1.5 as this concentration increased from 11 to 101 mM. Data from a previous study of voltage dependence as a function of the degree of Ca2+ activation of the channel could be accounted for in this way as well. It is therefore suggested that the voltage dependence of gK(Ca) for outward currents at (Vm-Ek) greater than 25 mV reflects a voltage-dependent Na+ block of the Ca2+-activated K+ channels.

Calcium↗

PubMed1988

Ca2+-activated K+ conductance of human red cell membranes exhibits two different types of voltage dependence.

The voltage dependence for outward-going current of the Ca-activated K+ conductance (gK(Ca] of the human red cell membrane has been examined over a wide range of membrane potentials (Vm at constant values of [K+]ex, [K+]c and pHc, the intact cells being preloaded to different concentrations of ionized calcium. Outward-current conductances were calculated from initial net effluxes of K+ and the corresponding (Vm - EK) values. The basic conductance, defined as the outward-current conductance at (Vm - EK) greater than or equal to 20 mV and [K+]ex greater than or equal to 3 mM (B. Vestergaard-Bogind, P. Stampe and P. Christophersen, J. Membrane Biol. 95:121-130, 1987) was found to be a function of cellular ionized Ca. At all degrees of Ca activation gK(Ca) was an apparently linear function of voltage (Vm range -40 to +70 mV), the absolute level as well as the slope decreasing with decreasing activation. In a simple two-state model the constant voltage dependence can, at the different degrees of Ca activation, be accounted for by a Boltzmann-type equilibrium function with an equivalent valence of approximately 0.4, assuming chemical equilibrium at Vm = 0 mV. Alternatively, the phenomenon might be explained by a voltage-dependent block of the outward current by an intracellular ion. Superimposed upon the basic conductance is the apparently independent inward-rectifying steep voltage function with an equivalent valence of approximately 5 and chemical equilibrium at the given EK value.

Calcium↗

PubMed1988

The effect of ATP, intracellular calcium and the anion exchange inhibitor DIDS on conductive anion fluxes across the human red cell membrane.

The influence of ATP depletion, the intracellular ionized Ca-concentration, anion substitution and DIDS on the conductive anion fluxes across the human red cell membrane has been examined. Under physiological or near physiological conditions it is not possible to observe conductive anion fluxes across the erythrocyte membrane in that anions totally dominate the membrane conductance. Consequently anions are at electro-chemical equilibrium and the netflux is zero. However, conductive anion fluxes can be induced by raising the potassium conductance, either by addition of valinomycin, or by triggering the native calcium activated potassium channel by addition of the Ca2+ ionophore A23187 to cells suspended in a calcium containing medium. The interpretation of data from experiments with valinomycin induced netfluxes has normally been done according to a constant field model, and the results have consequently been given as permeabilities. Since it has been demonstrated recently, that these cation pathways do not conform to a constant field scheme (Bennekou, P. and Christophersen, P. (1986) J. Membr. Biol. 93, 221-227 and Vestergaard-Bogind, B., Stampe, P. and Christophersen, P. (1985) J. Membr. Biol. 88, 67-75), it has been chosen, instead of permeabilities, to calculate the ion conductances from net efflux data, using an independent estimate of the membrane potential. The main result reported, is that only one component is found for the conductive anion fluxes in the presence of DIDS using the latter theoretical framework, whereas a sizeable DIDS-insensitive component is found when the constant field analysis is used. Furthermore it is found that ATP and intracellular calcium do not influence the anion conductances.

4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid↗

PubMed2026

Clinical Performance of Bulk-Fill Versus Incremental Composite Placement Approaches in Vital Posterior Teeth: A 24 Months Randomized Controlled Trial.

BACKGROUND: Composite resin placement technique may influence marginal integrity, polymerization stress distribution, and long-term clinical performance of posterior restorations. This randomized controlled clinical trial evaluated the 24-month clinical performance of four different placement techniques in Class I posterior composite restorations. METHODS: Fifty patients aged 20-35 years presenting with four occlusal carious lesions each were enrolled, resulting in 200 restorations. Cavities (4-5 mm depth) were prepared according to caries extension. Restorations were randomly allocated into four equal groups (n = 50) according to placement technique: stamp technique, snowplow technique, modified incremental "pizza" technique, and bulk-fill technique. All materials were applied following manufacturers' instructions. Clinical evaluation was performed at baseline and after 6, 12, and 24 months using FDI criteria. Functional (fracture/retention, marginal adaptation), esthetic (marginal staining, anatomical form), and biological (postoperative sensitivity, secondary caries) properties were assessed by two calibrated evaluators. Statistical analysis was performed at a significance level of α = 0.05. RESULTS: Thirty-eight patients with a total of 152 restorations were evaluated at the end of the 24 months in line with FDI at the end of the study with 76% recall rates. No statistically significant differences were observed among groups regarding fracture/retention or secondary caries (p > 0.05). Marginal adaptation and marginal staining demonstrated minor deterioration over time across all groups, with statistically significant intergroup differences found (p < 0.05). Postoperative sensitivity was minimal and transient in all groups with no significant difference (p = 0.181). CONCLUSIONS: Within the limitations of this 24-month follow-up, the four placement techniques demonstrated comparable clinical performance in Class I posterior composite restorations. Selection of technique may therefore be guided by clinical preference and procedural efficiency rather than differences in short-term clinical outcomes. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT07415317.

Humans↗

PubMed2005

Sunscreen use related to UV exposure, age, sex, and occupation based on personal dosimeter readings and sun-exposure behavior diaries.

OBJECTIVES: To examine during what behaviors people apply sunscreen and to assess the relationship to UV exposure monitored by personal dosimetry and diaries. DESIGN: Open prospective observational study. SETTING: University hospital. PARTICIPANTS: A convenience sample of 340 Danish volunteers: children, adolescents, indoor workers, sun worshippers, golfers, and gardeners (age range, 4-68 years). Intervention Subjects recorded sunscreen use and sun-exposure behavior in diaries and carried personal, electronic UV dosimeters, measuring time-stamped UV doses continuously, during a median of 119 days covering 346 sun-years (1 sun-year equals 1 subject participating during 1 summer season). MAIN OUTCOME MEASURES: Associations between sunscreen use and age, sex, skin type, occupation, sunburn, UV exposure doses, and behavior; and adequate application density and sun protection factor required to prevent sunburn. RESULTS: There were great variations in sunscreen use, which was highly correlated with risk behavior (sunbathing or exposing the upper body) (r = 0.39; P<.001). Sunscreens were used on a median of 5 days per sun-year (range, 1 day for gardeners to 16 days for sun worshippers). Ten percent of females and 41% of males never used sunscreens. Females used sunscreens more but also had more unprotected risk behavior than males (8 days vs 4 days; P<.001). Sunscreen use was not correlated with age, and children had as much unprotected risk behavior as adults. Sunscreens were used on 86% of the days with risk behavior in southern Europe vs 20% in northern Europe (P<.001). The UV doses were significantly higher on days with sunscreen (P< or = .03) and on sunburn days (P<.001). The median sun protection factor was 10.5. The sun-protecting effect corresponded to an application density of 0.5 mg/cm2. CONCLUSION: Days with sunscreen correlated not with days without risk behavior, but with days "sunbathing with the intention to tan," indicating that sunscreens were used as tanning aids to avoid sunburn.

Adolescent↗

PubMed2001

Significance of airborne transmission of methicillin-resistant Staphylococcus aureus in an otolaryngology-head and neck surgery unit.

OBJECTIVES: To quantitatively investigate the existence of airborne methicillin-resistant Staphylococcus aureus (MRSA) in a hospital environment and to perform phenotyping and genotyping of MRSA isolates to study MRSA epidemiology. DESIGN: Prospective surveillance of patients with MRSA infections or colonizations was performed, as was an observational study of environmental airAirborne samples were taken by an air sampler; samples were obtained from object surfaces by stamping or swabbing. Epidemiological study of MRSA isolates was performed with an antibiotic susceptibility test, coagulase typing, and pulsed-field gel electrophoresis. SETTING: Three single-patient rooms in a 37-bed otolaryngology-head and neck surgery unit. PATIENTS: Three patients with squamous cell head and neck cancer were observed to have been colonized or infected with MRSA after surgery. RESULTS: The MRSA samples were collected from the air in single-patient rooms during both a period of rest and when bedsheets were being changed. Isolates of MRSA were detected in all stages (from stage 1 [>7 microm] to stage 6 [0.65-1.1 microm]). About 20% of the MRSA particles were within a respirable range of less than 4 microm. Methicillin-resistant S aureus was also isolated from inanimate environments, such as sinks, floors, and bedsheets, in the rooms of the patients with MRSA infections as well as from the patients' hands. An epidemiological study demonstrated that clinical isolates of MRSA in our ward were of one origin and that the isolates from the air and from inanimate environments were identical to the MRSA strains that caused infection or colonization in the inpatients. CONCLUSIONS: Methicillin-resistant S aureus was recirculated among the patients, the air, and the inamimate environments, especially when there was movement in the rooms. Airborne MRSA may play a role in MRSA colonization in the nasal cavity or in respiratory tract MRSA infections. Measures should be taken to prevent the spread of airborne MRSA to control nosocomial MRSA infection in hospitals.

Carcinoma, Squamous Cell↗

PubMed1998

Hunger in midwestern inner-city young children.

OBJECTIVE: To determine the characteristics of hunger in young children who attend ambulatory pediatric clinics in a midwestern city. DESIGN: Consecutive sample. SETTING: Ambulatory pediatric clinics of an inner-city teaching hospital. PARTICIPANTS: English-speaking caregivers of 2578 children younger than 5 years. MAIN OUTCOME MEASURE: Structured survey measures of hunger, family characteristics, assistance program use, child feeding practices, and anthropometrics. RESULTS: In this population, 171 (6.6%) were hungry, and 842 (32.7%) were at risk for hunger. Hunger status was associated with increased age (P<.001), decreased maternal education level (P=.013), maternal nonwhite race (P<.002), a history of homelessness (P<.001), and parental unemployment (P<.001). Hunger status was associated with use of Aid to Families with Dependent Children (P<.001) and food stamps (P<.001) but not with participation in The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). Results of anthropometrics indicated that mean growth percentiles were no different between hunger categories. CONCLUSIONS: Housing, dietary, and family characteristics are identifiable risk factors for early childhood hunger. Hunger cannot be identified, however, using anthropometrics. It is disconcerting that fewer hungry children and children at risk for hunger participate in WIC compared with other programs. These data suggest the potential for more aggressive identification and intervention at the primary care and social service levels to benefit hungry children.

Anthropometry↗

PubMed2001

Removing the pediatric cervical collar: current practice patterns.

OBJECTIVES: To identify the current practice patterns of emergency medicine practitioners and the typical criteria used in discontinuing cervical spine immobilization (CSI) in the pediatric patient. DESIGN: Mail-in survey. PARTICIPANTS: All physicians on the mailing list of the American Academy of Pediatrics Section of Emergency Medicine and an equal number of randomly chosen members of the American College of Emergency Physicians. The total number of participants was 1360. METHODS: The survey consisted of a case scenario describing a 3-year-old child brought to the emergency department with CSI. The approach to such a scenario was assessed. Surveys were mailed with self-addressed stamped envelopes; repeat mailings were sent at 4 and 8 weeks after the first mailing. Those not currently in active practice or not involved in the decision to discontinue CSI were excluded from the study. RESULTS: The response rate was 55%. Most respondents were younger than 44 years (71%), in practice less than 10 years (56%), and practiced in an urban setting (68%). Nearly two thirds (62.6%) had completed residency training in pediatrics, 24% in emergency medicine and 36% a pediatric emergency medicine fellowship. Most (63%) would discontinue CSI without obtaining radiographs. Factors associated with removal were residency training in pediatrics and being in practice for less than 10 years. The most common criteria for discontinuing CSI were normal neurological (96%) and cervical spine (98%) examinations, normal mental status (92%), and absence of neck pain (93%). CONCLUSIONS: Discontinuing CSI without obtaining radiographs is common, especially among those with residency training in pediatrics and those in practice for less than 10 years. Knowledge of current practice is essential to future development of guidelines for managing pediatric trauma patients for whom cervical spine injury is a consideration.

Adult↗

PubMed2003

Lower risk of overweight in school-aged food insecure girls who participate in food assistance: results from the panel study of income dynamics child development supplement.

BACKGROUND: A quarter of US children are at increased risk of obesity-related health problems because of excess weight. The few national studies of child overweight and inadequate household resources available to purchase healthy foods, or food insecurity, have shown inconsistent results. We hypothesized that the inconsistency in these results may be attributed to a differential effect of participation in food assistance programs in food secure and food insecure households. METHODS: Using the 1997 Panel Study of Income Dynamics Child Development Supplement, we compared the risk of a child aged 5 to 12 years being at or above the 85th percentile of body mass index for age in food insecure and food secure, low-income households when controlling for participation in the Food Stamp Program and the national school lunch and breakfast programs as well as other covariates. RESULTS: We found that food insecure girls who participated in all 3 programs had a 68% reduced odds (odds ratio, 0.32; 95% confidence interval, 0.12-0.77) of being at risk of overweight when compared with food insecure girls in nonparticipating households and controlling for other factors. Girls in food secure households generally had no greater or less risk of overweight if they participated in any or all programs. Boys in both food insecure and food secure households had no greater or less risk of overweight by if they participated in any or all of the programs. CONCLUSIONS: These results support our hypothesis that food assistance programs play a protective role for low-income children's health, particularly in girls in food insecure households.

Body Mass Index↗

PubMed1977

Nutritional benefits from federal food assistance: a survey of preschool black children from low-income families in Memphis.

Approximately 4,000 preschool black children from low-income families in South Memphis participated for three years in a supplementary food program sponsored by the US Department of Agriculture. Part of this group received additional benefit from food stamps, day-care centers, and an infant-feeding program. We evaluated the effects of this participation in 250 children selected randomly from the enrollment list of the supplemetary program. Each child was examined for height, weight, head circumference, and levels of hemoglobin, serum iron, and vitamins A and C. The data were then compared with those from a similar survey in the same area conducted three years before. The results of this comparison indicate considerable improvements in height and weight and a reduction in the incidence of anemia and in the numbers of children with low plasma vitamin A levels. In the absence of other recognizable intervening factors, we conclude that federal food assistance programs were primarily responsible for the observed nutritional improvements.

Body Height↗

PubMed1995

Nephrogenic diabetes insipidus. A personal perspective.

To summarize these ideas that all center around time and variations, we might think of the genes as constituting a biological memory that serves at once to connect individuals with other people and with the past. The genes also provide a plan to construct and maintain an individual homeostatic memory that mediates experiences in the context of an ontogenetic memory that preserves individuality through time and change to set on health and disease a personal stamp. It is the mission of medicine to understand the individuality of these memories and of the elements that constitute them and, where necessary, to adjust the environment to homeostatic limitation. It is my hope that this account of this often colorful but hapless and stricken family might give substance to these thoughts.

Diabetes Insipidus, Nephrogenic↗

PubMed1998

Acute traumatic injuries in automotive manufacturing.

Motor vehicle manufacturing, with its varied tasks, challenging work environment, and diverse worker populations, presents many hazards to employees. This study examined routinely collected surveillance data from a major motor vehicle manufacturer to identify injury types, high-risk workers, causes of injury, and factors associated with work loss. Injury and personnel data were used to calculate injury rates. Injury data were from the routinely collected medical and safety surveillance system on occupational injuries. The number of persons working in the plants was estimated using year-end personnel reports. Key word searches supplementing the analyses provided insight into the specific circumstances of injury. The most common injuries were sprains/strains (39% of the total), lacerations (22%), and contusions (15%). Forty-nine percent of the injuries resulted in one or more lost or restricted workdays; 25% resulted in 7 or more lost or restricted workdays. The injuries most likely to result in work loss were amputations, hernias and fractures. Sprains/strains accounted for 65% of all lost workdays. Injury rates ranged from 13.8 per 100 person-years at stamping plants to 28.7 at parts depots. Even within similar types of plants, injury rates varied widely, with a twofold difference among the individual assembly plants in overall injury rates. Injury surveillance systems with descriptive data on injury events shed light on the circumstances under which certain types of injuries occur and can provide the basis for preventive interventions. Sources of variation and potential biases are discussed, providing guidance for those interested in designing and using surveillance systems for occupational injuries.

Accidents, Occupational↗

PubMed1996

Neural network modeling of the hippocampal formation spatial signals and their possible role in navigation: a modular approach.

Cells throughout the hippocampal formation show striking spatial firing correlates as a rat navigates through space. These cells are thought to play a critical role in orchestrating the navigational abilities of the animals, since damage to the hippocampal formation causes spatial learning deficits. Here, we present a theoretical framework aimed at explaining how the different spatial signals are generated, as well as how they may help guide navigational behavior. Earlier work from our laboratory has presented a simple model for how the location-related signals exhibited by hippocampal place cells could be generated, based on convergent sensory information. Here, the results of this work are combined with two more recent models, to provide a more comprehensive theoretical framework. Specifically, we present 1) A neural network model of head direction cells, based on the idea that the directional signals are generated using a path integration mechanism. Cells which combine directional and angular head velocity information project onto the head direction cells, to "update" the current directional signal. This model reproduces the basic phenomenon of direction-specific firing, as well as the anticipatory nature of this firing, reported for some head direction cells. 2) A network simulation of how the hippocampal spatial signals could be used to orchestrate instrumental learning. Here, place and directional signals converge onto motor cells, each of which are thus driven to fire to specific combinations of location and directional heading. Each active motor cell generates a small leftward or rightward "step" of the simulated animal. When the simulated goal is encountered, recently active synapses are strengthened, so that goal-directed trajectories are "stamped in". We have found these models useful in helping to clarify our thinking about the proposed theoretical principles, as well as in generating testable predictions.

Animals↗

PubMed1997

Philatelic introduction to the history of anatomy.

Representative postage stamps reproduced here provide an idea of the scope available for introducing the history of human anatomy. Included are ancient Greek pioneers, the reformer of human anatomy (Vesalius), the discoverer of the circulation of the blood (Harvey), the compound microscope, and well-known names in histology, neurohistology, and topographical anatomy.

Anatomy↗

PubMed1999

Dire straits: the divisive legacy of the 1898 Cambridge anthropological expedition.

Bartlett's claim that the Cambridge anthropological expedition of 1898 to the Torres Strait "put a social and ethnological stamp upon Cambridge psychology" does not bear close examination. Rivers pursued his interests in both anthropology and psychology but came to regard them as largely independent pursuits. Myers, through the influence of Rivers, came to identify himself primarily as a psychologist. McDougall was very quickly marginalized. There were two occasions when the promise of the Torres Strait began to be fulfilled: first, the reunion of Rivers, Myers, McDougall, and Seligman, all medically trained, at Maghull Hospital to help in the treatment of shell-shocked soldiers; second, Bartlett's attempt, early in his career, to establish a sociocultural psychology. However, the remarkable "academy" at Maghull was disbanded at the end of the war, and Bartlett, in his attempt to promote the "upstart subject" of psychology at Cambridge, increasingly came to distance his department from social and ethnological concerns. There is a neglected legacy of the Torres Strait expedition, the curious belief that the methods of experimental psychology, and indeed psychophysics, could (somehow) be foundational to the human sciences. This legacy has served both to suggest that psychology must have something to do with anthropology, while perpetually deferring any actual integration between the two disciplines.

Anthropology↗

PubMed2000

Integration of Layered Redox Proteins and Conductive Supports for Bioelectronic Applications.

Integration of redox enzymes with an electrode support and formation of an electrical contact between the biocatalysts and the electrode is the fundamental subject of bioelectronics and optobioelectronics. This review addresses the recent advances and the scientific progress in electrically contacted, layered enzyme electrodes, and discusses the future applications of the systems in various bioelectronic devices, for example, amperometric biosensors, sensoric arrays, logic gates, and optical memories. This review presents the methods for the immobilization of redox enzymes on electrodes and discusses the covalent linkage of proteins, the use of supramolecular affinity complexes, and the reconstitution of apo-redox enzymes for the nanoengineering of electrodes with protein monolayers of electrodes with protein monolayers and multilayers. Electrical contact in the layered enzyme electrode is achieved by the application of diffusional electron mediators, such as ferrocene derivatives, ferricyanide, quinones, and bipyridinium salts. Covalent tethering of electron relay units to layered enzyme electrodes, the cross-linking of affinity complexes formed between redox proteins and electrodes functionalized with relay-cofactor units, or surface reconstitution of apo-enzymes on relay-cofactor-functionalized electrodes yield bioelectrocatalytic electrodes. The application of the functionalized electrodes as biosensor devices is addressed and further application of electrically "wired" enzymes as catalytic interfaces in biofuel cells is discussed. The organization of sensor arrays, self-calibrated biosensors, or gated bioelectronic devices requires the microstructuring of biomaterials on solid supports in the form of ordered micro-patterns. For example, light-sensitive layers composed of azides, benzophenone, or diazine derivatives associated with solid supports can be irradiated through masks to enable the patterned covalent linkage of biomaterials to surfaces. Alternatively, patterning of biomaterials can be accomplished by noncovalent interactions (such as in affinity complexes between avidin and a photolabeled biotin, or between an antibody and a photoisomerizable antigen layer) to provide a means of organizing protein microstructures on surfaces. The organization of patterned hydrophilic/hydrophobic domains on surfaces, by using photolithography, stamping, or micromachining methods, allows the selective patterning of surfaces by hydrophobic, noncovalent interactions. Photoactivated layered enzyme electrodes act as light-switchable optobioelectronic systems for the amperometric transduction of recorded photonic information. These systems can act as optical memories, biomolecular amplifiers, or logic gates. The photoswitchable enzyme electrodes are generated by the tethering of photoisomerizable groups to the protein, the reconstitution of apo-enzymes with semisynthetic photoisomerizable cofactor units, or the coupling of photoisomerizable electron relay units.

Journal Article↗

PubMed2001

Real-time multiple linear regression for fMRI supported by time-aware acquisition and processing.

Real-time parametric statistical analysis of functional MRI (fMRI) data would potentially enlarge the scope of experimentation and facilitate its application to clinical populations. A system is described that addresses the need for rapid analysis of fMRI data and lays the foundation for dealing with problems that impede the application of fMRI to clinical populations. The system, I/OWA (Input/Output time-aWare Architecture), combines a general architecture for sampling and time-stamping relevant information channels in fMRI (image acquisition, stimulation, subject responses, cardiac and respiratory monitors, etc.) and an efficient approach to manipulating these data, featuring incremental subsecond multiple linear regression. The advantages of the system are the simplification of event timing and efficient and unified data formatting. Substantial parametric analysis can be performed and displayed in real-time. Immediate (replay) and delayed off-line analysis can also be performed with the same interface. The capabilities of the system are demonstrated in normal subjects using a polar visual angle phase mapping paradigm. The system provides a time-accounting infrastructure that readily supports standard and innovative approaches to fMRI. Magn Reson Med 45:289-298, 2001.

Adult↗