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PubMed1998

Quantitative morphometry of renal biopsies prior to cyclosporine in nephrotic syndrome.

Use of cyclosporine (CsA) in the management of children with steroid-resistant (SRNS) and steroid-dependent (SDNS) nephrotic syndrome has become increasingly popular in recent years. Although most children receive a renal biopsy prior to initiation of CsA, the relationship between initial renal histology and the subsequent clinical response to CsA is not known. We analyzed the correlation between pre-CsA segmental and global glomerular scarring and interstitial fibrosis and the subsequent response to CsA in 23 children (5.6+/-1.0 years, Mean+/-SEM) with SDNS (n=8) and SRNS (n=15) treated with CsA for 24.2+/-3.8 months and followed for 28.0+/-4.1 months. Complete remission was obtained in 78% of patients within 67.6+/-16 days, while 18% had a partial response and 4% no response. Quantitative histological analysis revealed a trend toward partial rather than complete response with increasing segmental glomerular (P=0.13), global glomerular (P=0.05), and interstitial (P=0.08) scarring, and among patients with minimal change nephrotic syndrome versus IgM nephropathy versus focal segmental glomerulosclerosis. Among complete responders, linear regression analyses revealed no correlation between time to response and pre-CsA glomerular or interstitial scarring. We conclude that increased glomerular or interstitial scarring on a pre-CsA renal biopsy tends to correlate with a partial, rather than complete, response to CsA in childhood nephrotic syndrome.

Adolescent↗
PubMed2001

Morphometry of the lower lumbar vertebrae in patients with and without low back pain.

UNLABELLED: The authors made several measurements in the lower lumbar vertebrae of patients with and without low back pain. Our objective was to determine the allometric relationships between different dimensions of the lumbar canal, the effects on these from degenerative disease, and differences between the symptomatic and asymptomatic populations. We compared 119 patients suffering from low back and sciatic pain and 39 subjects without lumbar symptoms as determined by computed tomography (CT). The following measurements were made: sagittal diameter of the canal, interpedicular distance, interarticular distance, and anteroposterior diameter of lateral recess and foramen. With respect to the patients with lumbar pain, the asymptomatic group proved to have wider foramina from L3 to L5 and wider sagittal diameters in S1. The patients with canal stenosis revealed lower figures for all diameters of the central canal, lateral recess of L4, and foramina of L4 and L5. Patients with lumbarization showed smaller diameters of the central canal. CONCLUSION: There is an allometric relationship between the dimensions of the central canals. This relationship is less evident with lateral canals. The patients without lumbar symptoms had wider foramina and sagittal diameters in S1 than those with lumbar symptoms. Of these, patients who developed symptoms of canal stenosis demonstrated smaller diameters in central and lateral canals. Of the developmental anomalies, lumbarization proved to be associated with canal stenosis due to smaller diameters of the central canals.

Adult↗
PubMed2002

Magnetic resonance imaging-based morphometry and landmark correlation of basal ganglia nuclei.

The two principle targets for deep brain stimulation or lesioning in patients with Parkinson's disease, the subthalamic nucleus (STN) and the globus pallidus internus (GPi), reveal a high degree of individual variability which is relevant to the planning of stereotactic operations. Both nuclei can clearly be delineated in T2WI spin echo MRI which was acquired under stereotactic conditions in general anesthesia before surgery. Such images of 35 patients served for retrospective morphometric analysis of different basal ganglia nuclei (STN, GP, red nucleus, and substantia nigra) and several anatomical landmarks (anterior and posterior commissure, maximum width of third ventricle, brain length and width). The average AC-PC distance was 25.74 mm (range 21 to 29 mm) and is in agreement with previous studies. On average, the center of the STN was located 12.65 mm (+/-1.3) lateral from the midline as determined 3 mm ventral to the intercommissural plane. The average width of the third ventricle was 7.05 mm (+/-2.41). The width of the third ventricle correlated with the laterality of the STN (r(right)=.78; r(left)=.83) and GP (r(right)=.76; r(left)=.68). Although to a lesser extent, significant correlations were also observed between the laterality of the STN and brain width, improving prediction of STN laterality by multiple linear regression analysis (r(right)=.82; r(left)=.87). Similarly, the laterality of GP correlated with brain width. In addition, gender-specific differences were detected. The STN and GP was located farther lateral in males which may be due to overall brain anatomy as gender-specific differences were also observed for brain width and length and AC-PC distance. MRI-based in vivo-localization of different basal ganglia nuclei extend statistical information from common histological brain atlases which are based on a limited number of brains. The correlations observed between different basal ganglia nuclei, i.e. the STN and GPi, and anatomical landmarks may be useful for surgical planning.

Adult↗
PubMed2004

Morphometry of the lumbar zygapophyseal facet capsule and cartilage with special reference to degenerative osteoarthritic changes: an anatomical study using fresh cadavers of elderly Japanese and Korean subjects.

Morphometric data were obtained from fresh cadaver dissections, and observations of degenerative changes in the joint cartilage (DCs) were analyzed to determine whether the morphometric parameters of the lumbar zygapophyseal joint capsule varied according to the presence and severity of DCs. There have been no previous morphometric studies of the facet capsule that describe age-related DCs. Using 23 fresh osteoligamentous lumbar spines from donated cadavers, we performed morphometric investigations of the surface areas of the joints and their capsules and measured the capsular thickness. We hypothesized that the ratio of the inner capsular area to the joint surface area for each facet (the capsule/facet index) could serve as an index showing a functional aspect of a large or small capsule. Our results showed that the joint surface area increased significantly with increasing severity of DCs, according to Grogan's classification. Facets with advanced DCs tended to have a small inner capsular surface. The capsule/facet index generally correlated positively with capsular thickness, especially the dorsal portion; however, this was not true for the ventral portion. The index also correlated negatively with DC progression. Thus, lumbar facet DCs were strongly linked to reconstructive alterations in capsular size, thickness, and looseness. The occurrence and progression of DCs narrowed the joint capsule, especially the dorsal portion, and this seemed to decrease the potential looseness of the joint. Conversely, these capsular alterations seemed to accelerate DC progression. A negative adaptation cycle seemed to occur.

Age Factors↗
PubMed2026

CT-Derived pelvic morphometry for preoperative risk assessment of recurrent unilateral inguinal hernia.

BACKGROUND: Recurrent inguinal hernia remains a significant challenge in abdominal wall surgery despite advances in mesh-based repair techniques and minimally invasive approaches. Although pelvic skeletal morphology has been implicated in inguinal hernia development, its association with recurrent disease remains incompletely understood. This study aimed to evaluate computed tomography (CT)-derived pelvic morphometric parameters and investigate their potential value in preoperative recurrence risk assessment. METHODS: This retrospective study included 251 male patients with preoperative abdominal CT examinations and complete clinical records who underwent elective inguinal hernia repair at a tertiary referral center. After applying the predefined eligibility criteria, 188 patients with unilateral inguinal hernias constituted the primary study cohort, including 162 primary and 26 recurrent unilateral hernias. The Radoievitch angle and Ami's line were measured independently by two blinded radiology residents using a standardized CT-based pelvic morphometric measurement protocol, and the mean values were used for analysis. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were performed to evaluate the association between pelvic morphometric parameters and recurrent inguinal hernia. RESULTS: Patients with recurrent unilateral inguinal hernias demonstrated significantly greater affected-side Ami's line measurements (8.27 ± 0.63 vs. 7.90 ± 0.71 cm, p = 0.014) and larger Radoievitch angles (40.68 ± 4.02° vs. 38.80 ± 3.68°, p = 0.018) than patients with primary unilateral hernias. Both the Radoievitch angle (OR 1.14, 95% CI 1.01-1.28, p = 0.033) and Ami's line (OR 2.26, 95% CI 1.14-4.49, p = 0.020) remained independently associated with recurrent inguinal hernia after adjustment for age and body mass index. ROC analysis demonstrated modest discriminatory performance (AUC 0.634 for the Radoievitch angle and 0.633 for Ami's line), while the multivariable model incorporating age, body mass index, and Ami's line showed slightly improved discrimination (AUC 0.655). CONCLUSION: CT-derived pelvic morphometric parameters were independently associated with recurrent unilateral inguinal hernia. Although their individual discriminatory performance was modest, standardized CT-based pelvimetry may serve as an objective adjunctive tool for individualized preoperative recurrence risk assessment in patients who already undergo CT imaging for unrelated clinical indications. Prospective multicenter studies are warranted to validate these findings and determine their clinical applicability.

Humans↗
PubMed2006

Vertebral morphometry reference data by X-ray absorptiometry (MXA) in Iranian women.

The anterior, medial, and posterior heights and the A/P and M/P ratios of the spine (T5-L4) in 41 normal premenopausal Iranian women were determined using an imaging densitometer (Expert XL) and dual energy X-ray absorptiometry (DXA) method. All the women were healthy (age 20-39 years, and height 149-171 cm), without any signs of vertebral fractures, and with normal bone mineral density (BMD) of the spine and femoral neck (T-score>-1.5). The vertebral heights were normalized using the Expert XL software, and the average vertebral height for the L2-L4 vertebrae was taken to minimize the effect of variation of body size among the subjects. The Z-score for all vertebral heights (T5-L4) averaged -0.68, with the A/P and M/P ratios coming to +0.34 and +0.49, respectively. It showed the normalization procedure not to correct the differences of vertebral heights in Iranian women. The average of the three heights (H (avg)) correlated fairly well with the stature of the subject (r=0.47, p<0.05), but no correlation was found between H (avg) and subject age (p>0.05). The lower vertebral heights in older women in comparison with the younger women (0.4 mm) obtained in our study can be attributed to the relatively shorter stature of older women (mean 154 vs 159 cm for younger women, p<0.05). It was concluded that the normalization procedure used in the software does not equally apply to Iranian women due to their having different heights than those of American and northern European women, from whom the reference data for the Expert XL software have been gathered. The reference values thus obtained are therefore not accurate for our population group and a separate study with a bigger and more varied sample group is needed for obtaining more definitive results.

Absorptiometry, Photon↗
PubMed2003

Morphometry of the anterior third ventricle region as a guide for the subfrontal (translaminaterminalis) approach.

The anterior third ventricle region acquires clinical significance in benign and malignant tumors and cyst formations, of which craniopharyngiomas and gliomas are the most common. The subfrontal approach is one of the most preferred approaches for removing these tumors. In this study, the microsurgical anatomy of 81 Turkish, adult cadaveric hemispheres was examined to provide morphometric data of the region. These measurements from the anterior third ventricle region serve as a guide for neurosurgeons during surgical approach for removing anterior third ventricle tumors.

Adult↗
PubMed1987

Growth direction in the mandibular condyle of pre-pubertal and pubertal monkeys (Macaca fascicularis) studied by morphometry and radioautography.

Eight male monkeys with prepubertal or pubertal skeletal maturity were used to assess age-related changes in anterior-posterior gradients of parameters which characterize growth velocity. The animals received single intravenous doses of 1 mCi/kg body weight of [3H]-proline at 24 h, and of 0.5 mCi/kg body weight [3H]-thymidine, 3 h before death. Four perichondral and chondral layers, and the subchondral zone of erosion of each condyle, were analysed morphometrically and radioautographically at 12 sampling sites distributed systematically over the joint surface. Values for cell density, cell proliferation, extracellular cartilaginous matrix production, cartilage resorption and subchondral bone formation produced characteristic curves which generally peaked in the central joint region. These peaks did not shift, either in relation to age or growth velocity, suggesting a uniform posterior-superior growth direction. Individual variability in both shape and prominence of the curves usually prevailed over the group effects attributable to skeletal maturity or growth velocity. Thus the gradual age-dependent shift in human condylar growth direction may be revealed only in longitudinal studies and would be masked by pronounced individual variation in cross-sectional studies of small samples.

Animals↗
PubMed1975

The morphometry of the branching pattern in dendrites of the visual cortex pyramidal cells.

An analysis has been made of the three-dimensional branching structure for the basal and apical dendrites of cortical neurons in an adult rabbit. The real branching angles of basal dendrites and apical oblique branches are in the same range, but differ from those of the apical main shaft. Therefore, several different parts of the apical dendrite have to be distinguished on anatomical grounds, coincident with the presynaptic areas distinguished in the literature. The bifurcations of basal dendrites are essentially symmetrical. The mode of outgrowth, however, is non-symmetrical. Redirection of dendrites will, therefore, occur. This redirection is often not complete, so that a large variability of branching angles results. The possible significance of the observed symmetry is discussed.

Animals↗
PubMed1986

Hippocampal sympathetic ingrowth in rats and guinea pigs: quantitative morphometry and topographical differences.

Sympathetic ingrowth is an unusual neural rearrangement in response to damage of the septohippocampal pathway in which peripheral noradrenergic nerves grow into the hippocampal formation. Hippocampal ingrowth has been extensively studied in rats and has been suggested to be regulated by the mossy fibers of the dentate granule cells, hippocampal interneurons, or glial cells. Sympathetic ingrowth was found to occur in both rats and guinea pigs; however, a discrepancy between the species was observed in the topographical distribution of sympathetic ingrowth. Ingrowth fibers were found in the dentate hilus and area CA3 of guinea pigs and rats. However, in the guinea pig fibers extended into area CA1. Quantitative estimates of fiber number confirmed these observations and identified significant differences between the species in the intrahippocampal lamellar distribution of ingrowth fibers. The topographical differences in sympathetic ingrowth could not be explained by differences in the distribution of the mossy fibers (Timms stain), cholinergic septal afferents (anterograde HRP), or in hippocampal interneurons (GAD-immunoreactive neurons). These species differences are challenging to current theories concerning the regulation of sympathetic ingrowth and may provide a useful model for testing further hypotheses about axonal guidance and target selection.

Animals↗
PubMed1986

The effect of electrical stimulation on reinnervation of rat muscle: contractile properties and endplate morphometry.

Denervated extensor digitorum longus muscles of Wistar rats were electrically stimulated in vivo for 4 days (2h per day) after peroneal nerve crush 1 cm from the muscle. Isometric contractile properties and endplate ultrastructure were measured on days 11 and 18. On day 11, the time to peak (116% of control) and 1/2-relaxation time (136% of control) for the twitch tensions of stimulated muscles measured in vivo were significantly less than those (127% and 157% of controls, respectively) of non-stimulated muscles. Peak twitch and tetanic tensions were not significantly different. The postsynaptic area of endplates for stimulated muscles were closer in size to controls than those for the non-stimulated ones. On day 18, no difference was found in the contractile responses between stimulated and non-stimulated groups. Similarly, the postsynaptic areas were the same for both groups. These results demonstrate that denervated muscle stimulated electrically for 4 days prior to reinnervation can preserve the structure of the endplate as well as accelerate recovery of normal function in reinnervated muscle fibers after 11 days of denervation.

Animals↗
PubMed1987

Morphometry of individual capillary beds in the hypothalamo-neurohypophysial system of rats.

Unusually high capillary densities, volumes, and surface areas were revealed by morphometric analysis of the hypothalamic paraventricular nuclei (magnocellular and parvocellular divisions), supraoptic nuclei, and pituitary neural lobe of Long-Evans and Brattleboro rats. Capillaries of the magnocellular division of the paraventricular nucleus were greater in number, but smaller in diameter, than those in the parvocellular division. Expressed per unit area or volume, capillary dimensions in the hypothalamo-neurohypophysial system of Brattleboro rats were the same as in Long-Evans rats.

Animals↗
PubMed1989

Is the supply of axoplasmic proteins a burden for the cell body? Morphometry of sensory neurons and amino acid incorporation into their cell bodies.

Since the perikaryon is considered to be the source of all axoplasmic proteins, we estimated the amount of protein synthesized in cell bodies and axoplasmic volumes of sensory neurons of two anuran species (Xenopus and Caudiverbera) to detect a correlation between these variables. The range of cell body volumes was 1:28 and 1:38 in Xenopus and Caudiverbera, respectively, while that of axoplasmic volumes was 1:5000-6000. The protein synthesis in glial and neuronal cell bodies was assessed with pulses of labeled amino acids followed by radioautography. No obvious correlation was found between axoplasmic volume and either rate or amount of amino acid incorporated into cell bodies. The rate of amino acid incorporation into glial and neuronal cell bodies was of the same order of magnitude. Results suggest that the maintenance of the axoplasm does not seem to be a burden for the perikaryon.

Amino Acids↗
PubMed1992

Morphometry of spinal motor neurons in amyotrophic lateral sclerosis with special reference to chromatolysis and intracytoplasmic inclusion bodies.

Lewy body-like hyaline inclusions (LBI), Bunina bodies (BB) and central chromatolysis are characteristic neuropathological features of spinal motor neurons in amyotrophic lateral sclerosis (ALS). Using histometric methods, we studied the spinal motor neurons of 4 patients with sporadic ALS and 3 neurological control patients to determine the possible relationship between these neuropathological features and cytoplasmic, nuclear and nucleolar size. In an ALS patient with a very rapid clinical course, many neurons with LBI were observed. Enlargement of nucleolar size and the nucleolar/nuclear ratio of neurons with LBI or BB were the only histometric difference compared to those of normal-appearing neurons. In ALS patients with an average clinical course, the number of neurons with LBI was lower, the number of neurons with BB was higher, and the nuclear and nucleolar sizes were smaller than those of normal-appearing neurons, particularly in chromatolytic neurons without LBI or BB. These data raise the possibility that motor neurons with LBI may represent an early stage in the neurodegenerative process, when the rate of protein synthesis is elevated as evidenced by their larger nucleolar size. Thus, the causative agent(s) of ALS may initially stimulate protein synthesis while in turn leading to down regulation of certain luxury function genes, culminating in neuronal dysfunction and death.

Amyotrophic Lateral Sclerosis↗