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At least 1,135 records · Page 63Linked to original sources

Characteristics of violent bars and bar patrons.

OBJECTIVE: The present analysis is an attempt to examine the characteristics of bars in which violence occurs while accounting for the personalities of the clientele that frequent the bar. It is proposed that an explanation of why violence occurs at certain bars requires examining the characteristics of the bars, the personalities of the clientele, and how these two types of variables act together in order to give rise to aggressive behavior. METHOD: We conducted interviews with frequent bar patrons (n = 327), assessing participants on a number of individual differences related to aggression and drinking behavior as well as on characteristics of the usual bar that they attend. Bars were categorized into violent bars (n = 256) or nonviolent bars (n = 71) based on participant responses. RESULTS: Participants' age, alcohol dependence and anger expression differentiated those who frequented violent bars from those who frequented nonviolent bars. The relationship of these individual differences to bar type was mediated by a number of characteristics of the bar itself, including noise, temperature, the presence of bouncers, the gender of the workers, the presence of billiards and illegal activities in the bar. CONCLUSIONS: The results indicate that individuals having certain personality characteristics are attracted to bar environments that promote antinormative behaviors such as violence. However, it seems to be the characteristics of the bars that are the strongest predictors of violence.

Adult↗

Behavioral Self-Control Program for Windows: results of a controlled clinical trial.

Forty nonalcoholic heavy drinkers were randomly assigned to receive a computer-based version of behavioral self-control training either immediately after pretreatment assessment or after a 10-week waiting period. Results at each of 3 follow-ups strongly support the study hypotheses. Participants in the immediate treatment group significantly reduced their drinking relative to their pretreatment levels and relative to those in the delayed treatment condition at the initial follow-up, 10 weeks after the pretreatment assessment. The delayed group did not change their drinking behaviors during this period of time. However, they significantly reduced their drinking by the second follow-up conducted after they received training. At the 12-month follow-up, participants maintained the gains they had achieved during treatment. There were no interactions involving participant ethnicity or gender. Although use of other drugs was not specifically addressed, such use did not increase, and there was some evidence of a decline.

Adult↗

Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples.

Basic information on the association between lifestyle factors and candidate genes is valuable for genetic-environmental study. We screened the association of habitual smoking or drinking with polymorphism in 40 candidate genes for a total of 153 single nucleotide polymorphisms (SNPs) using a sample of 339 middle-aged, randomly selected Japanese men. Smoking and drinking statuses were elicited during questionnaire-based interviews. Genes were selected based on their possible involvement in genetic-environmental, life-style interactions and constitute the genes expressing xenobiotic metabolism enzymes, DNA repair enzymes, and other stress-related proteins. The P values of odds ratios to habitual smoking for CYP17A1, ESR1, EPHX1, GSTT2, ALDH2, NOS2A, OGG1, and SLC6A4 and those of odds ratios to habitual drinking for CYP1B1, ESR1, HSD17B3, GSTM3, COMT, ADH1C, ALDH2, NOS3, and NUDT1 were under 0.05. These variables were included in a stepwise logistic analysis in order to develop a predictive model for smoking or drinking behavior. In the final model, the only significant variables selected for smoking were OGG1, SLC6A4, EPHX1, ESR1, and CYP17A1, and for drinking, ALDH2 and NUDT1. The findings of the present study suggest that polymorphism in associated candidate genes plays a role in the habitual use of tobacco and alcohol among Japanese men.

Adult↗

Angiotensin-induced thirst: effects of third ventricle obstruction and periventricular ablation.

The role of periventricular tissue surrounding the anteroventral third ventricle (AV3V) in mediating drinking behavior induced by angiotensin II was investigated rats. Electrolytic lesions which bilaterally destroyed preoptic-hypothalamic periventricular tissue surrounding AV3V abolished drinking responses normally elicited by intracerebral injections of angiotensin. In another experiment, ventricular obstruction in AV3V had no effect on drinking of a palatable sweet milk solution while the drinking responses induced by peripheral versus central administration of angiotensin were dissociated. Drinking normally induced by lateral preoptic injections of angiotensin was no longer observed when AV3V obstruction prevented drug distribution via cerebrospinal fluid circulation to AV3V periventricular tissue; the drinking response induced by subcutaneous injection of angiotensin was enhanced, however, after placement of the ventricular obstruction. These results, coupled with the earlier observation that AV3V lesions also abolish drinking induced by subcutaneous angiotensin injectin, suggest that, after central or peripheral administration, angiotensin acts on AV3V periventricular tissue to arouse drinking. In contrast to centrally injected angiotensin, peripherally administered angiotensin does not contact receptors by entry and spread in cerebrospinal fluid. After peripheral injection angiotensin may contact sensitive AV3V tissue directly from blood, perhaps via the organum vasculosum of the lamina terminalis, a highly vascularized circumventricular organ within the AV3V which lacks a blood-brain barrier.

Angiotensin II↗

Functional relationship of lateral hypothalamus and amygdala in control of eating.

Cannulas were stereotactically implanted in the lateral hypothalamus and the ipsilateral amygdaloid cortical nucleus of 7 male albino rats, Wistar strain. After functional checking of the accuracy of implants by adrenergic elicitation of increased food intake, the animals were injected with combinations of noradrenaline, phenoxybenzamine or tolazoline, or placebo under 6 treatment conditions, while food-and water satiated. The elicitation of increased food intake in the satiated rat by adrenergic stimulation of the lateral hypothalamus was confirmed, and it was further found that simultaneous adrenergic stimulation of the amygdaloid cortical nucleus augmented this increase. However, simultaneous anti-adrenergic blockade in the amygdaloid cortical nucleus reduced eating to control level. The lack of response of the amygdaloid cortical nucleus to adrenergic stimulation in the satiated rat, under simultaneous stimulation of the lateral hypothalamus with either placebo or an adrenergic blocker, was also demonstrated. It was concluded that the amygdaloid cortical nucleus has a modulatory influence on eating behavior, which is dependent on the level of activity in the lateral hypothalamus, and further that this modulatory influence is necessary to the behavioral output of the hypothalamic system. This is the same relationship between the hypothalamus and amygdala previously demonstrated in regard to drinking behavior and these results are seen as supporting the behavioral generality of the functional relationships reported.

Amygdala↗

Interactions between phencyclidine and central nervous system depressants evaluated in mice and rats.

The effects of phencyclidine (PCP) alone and in combination with the CNS depressants, pentobarbital (PB) or ethanol (ETOH), were determined in mice using the inverted screen test and in rats using disruption of milk drinking behavior. The effects of PB and ETOH alone, and in combination, were also determined so that the PCP combinations could be compared to this clinically relevant interaction. These homergic drug interactions were analyzed using the dose-addition model by isobolographic analyses. Most drug combinations resulted in shifts to the left of the dose-effect curves relative to the dose-effect curves for the drugs alone; in no cases were shifts to the right (antagonism) observed. In general, the interactions between PCP and ETOH or PB were quantitatively less (infra-additive) than the interaction between the CNS depressants (dose-additive) when studied in mice. In the rat studies, the interactions between PCP and ETOH or PB were, overall, quantitatively greater (dose-additive or supra-additive) than the ETOH-PB interactions (infra-additive). Since even infra-additive interactions may result in substantially enhanced effects, these results suggest that coabuse of PCP with CNS depressant drugs could produce marked behavioral toxicity.

Animals↗

Quantitative comparison of mu opioid receptor mRNA in selected CNS regions of alcohol naive rats selectively bred for high and low alcohol drinking.

We combined solution hybridization, ribonuclease protection and microdissection techniques to quantitatively compare the anatomical distribution of mu receptor mRNA in discrete brain regions of alcohol naive rats selectively bred for high and low alcohol drinking (HAD and LAD lines, respectively). The solution hybridization assay is highly sensitive and can detect mu opioid receptor mRNA in a 100-fold linear range from 4 to 421 amol. HAD and LAD rats exhibited a similar level of mu receptor mRNA in all central nervous system (CNS) regions examined except for the inferior colliculus. Our data suggest that the steady-state level of mu receptor mRNA is not associated with genetic differences in alcohol drinking behavior.

Alcohol Drinking↗

Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal axis and pituitary beta-endorphin as a function of alcohol intake, age, and gender.

BACKGROUND: Experimental evidence indicates that components of the hypothalamic-pituitary-adrenal (HPA) axis and of the endogenous opioid system, such as beta-endorphin (beta-END), influence alcohol consumption, whereas chronic alcohol abuse alters the activity of both systems. Furthermore, gender and age differences have been reported in the activity of the HPA axis under basal conditions, in response to stress and acute alcohol challenge. The objective of the present studies was to investigate the hypothesis that chronic alcohol consumption alters the activity of the HPA axis and pituitary beta-END as a function of severity of alcohol abuse, gender, and age. METHODS: Three age groups of each gender (18-29, 30-44, and 45-60 years old) were recruited. Each age and gender group included four subgroups: (a) nondrinkers, (b) light drinkers, (c) heavy drinkers, and (d) alcoholics in treatment. Demographic characteristics, alcohol consumption, and presence of alcohol dependence were recorded by using a structured interview. Blood samples were taken on the day of the interview. The levels of plasma adrenal corticotropic hormone (ACTH), cortisol, and beta-END were estimated as an index of the activity of the HPA-axis and pituitary beta-END. RESULTS: Plasma ACTH and beta-END levels were significantly lower in females than males of all age and drinking category groups. Plasma cortisol levels were higher in 18- to 29-year-old female subjects compared with the 18- to 29-year-old male subjects. The plasma ACTH and beta-END levels were lower whereas plasma cortisol levels were higher in heavy drinkers than nondrinkers. This decrease in plasma ACTH and beta-END levels with heavy drinking was more pronounced in female than male subjects of the 30-44 and 45-60 age groups. CONCLUSIONS: Chronic drinking, gender, and age influence the activity of the HPA-axis and pituitary beta-END, which in turn may influence drinking behavior.

Adolescent↗

Factors associated with alcohol consumption, problem drinking, and related consequences among high school students in Taiwan.

This research evaluated the risk factors associated with alcohol consumption, problem drinking, and related consequences among high school students in Taiwan. A total of 779 10th grade students from four randomly selected high schools in eastern Taiwan were included in the survey. Survey data were self-reported by students and analyzed using logistic regression methods. The results showed that alcohol consumption and problem drinking was 2.22-2.71-fold greater in male than in female adolescents. Parents and peer groups were the determinants influencing alcohol consumption, and these influences could be enhanced particularly by the drinking behaviors of fathers and peer groups, and the relationship of students with their peer groups. The probability of developing adolescent problem drinking was fourfold greater in students whose fathers had habits of drinking. Ethnicity had a notable impact on the risk of problem drinking. The occurrence of problem drinking among indigenous adolescents was 2.98-fold higher than among Hans, indicating a diversity of biological factors, social norms, and expectation for alcohol drinking between these two ethnic groups. This study suggests that a policy for preventing alcohol abuse among high school students should start by addressing the two major associated problems: a need to earn peer group recognition, and the lack of family support among at-risk students.

Adolescent↗

Psychophysiological effects of alcohol-related stimuli: II. Enhancement with alcohol availability.

This laboratory study examined methods of enhancing physiological and subjective responses of alcoholics to naturalistic alcohol-related stimuli by repeated exposures to a high-dose alcohol drink. Individual subjects participated in five successive daily sessions consisting of randomized-block presentations of gustatory and visual presentation of alcohol, pepper juice (as a control for stimulus taste intensity), or water stimuli. Following the stimulus trial series, all subjects ingested 1.5 oz of alcohol in a shot glass. Twelve subjects next received a 1.7 g/kg alcohol drink ("high dose alcohol group") on Days 1-4 and placebo on Day 5, and 12 subjects received a placebo drink on all study Days (1-5) ("placebo drink group"). On Day 1, alcohol stimuli generally elicited larger heart rate and skin conductance increases and skin temperature decreases than water or pepper juice stimuli. Alcohol stimuli also elicited greater subjective responses than either pepper juice or water. Alcohol availability within the taste trial markedly increased physiological and subjective reactivity to alcohol-related stimuli, perhaps due to the closer approximation to natural drinking behavior. A comparison with previous data from this laboratory suggests that prestudy deprivation from alcohol, instructions to expect alcohol, a conductive drink setting, and the opportunity to drink alcohol within the session may enhance reactivity to alcohol stimuli in alcoholics.

Adult↗

Do we learn from our mistakes? An examination of the impact of negative alcohol-related consequences on college students' drinking patterns and perceptions.

OBJECTIVE: Little research has examined antecedents of specific drinking consequences (vomiting, regretted sex, hangover, blackouts) among college students. This research examined how students' experiences of past consequences relate to their beliefs of experiencing similar consequences in the future and how these beliefs relate to current drinking patterns. METHOD: Self-reported past drinking behavior and resulting consequences associated with specific occasions were assessed among 303 (66% women) college students. Students also estimated number of drinks associated with risk of experiencing future similar consequences. RESULTS: Paired-samples t tests indicated that students significantly overestimated the number of drinks it would take to vomit, have unwanted sexual experiences, experience hangovers, and black out in comparison with the actual self-reported number of drinks consumed the last time identical consequences were experienced. In addition, a series of multiple-regression analyses revealed that greater misperceptions between the perceived and actual number of drinks associated with each type of consequence were consistently associated with heavier drinking. CONCLUSIONS: Results suggest that heavier-drinking students do not learn from their mistakes but instead overestimate the amount of alcohol they can consume without experiencing negative consequences. Clinical implications of these findings are discussed in terms of augmenting brief interventions aimed at heavy-drinking college students.

Adolescent↗

A multivariate analysis of excessive alcohol use involving labeling and self-constructs.

Previous studies have focused on predicting whether or not a person is likely to become a problem drinker, but have not employed concepts explaining the process whereby excessive alcohol use emerges. It is proposed that labeling concepts, in combination with a multidimensional conceptualization of the general self-concept, provide the components of a model capable of explaining this process. Automatic Interaction Detector permitted an assessment of the contingent relationships among the labeling and self variables. The findings indicated that the influence of the alcoholic labels of others on self-views and drinking behaviors hinged on self-esteem and self-complexity.

Alcohol Drinking↗

Gender and acculturation in relation to alcohol use among Hispanic (Latino) adults in two areas of the northeastern United States.

Telephone surveys were conducted in English or Spanish for 665 Hispanic adult residents of Long Island (New York) and Connecticut in 1992. Reported alcohol use was higher among men than women. In multivariate analyses using logistic regression, both gender and level of acculturation (positive association) were associated with drinking 1 day or more during the past month and with drinking at least 1 day per week. The association between drinking and acculturation was much stronger among women than men; thus, the gender difference in drinking declined with increasing level of acculturation. Studies are needed to delineate the processes whereby gender and acculturation influence the drinking behavior of Hispanics in different geographic areas.

Acculturation↗

Heavy drinking across the transition to college: predicting first-semester heavy drinking from precollege variables.

Parents, public health officials, college personnel, and society at-large continue to be concerned about the increase in heavy drinking that occurs across the transition to college, prompting alcohol researchers to continue the search for effective interventions. In this report we use data from a large (N=3720) prospective study to (1) estimate how predictable heavy drinking in the first semester of college is on the basis of information obtained prior to college and (2) identify precollege variables that are important predictors of heavy drinking in the first semester. We found that first-semester heavy drinking is highly predictable, primarily because of continuity from precollege heavy drinking, but also from precollege peer drinking norms, precollege other substance use (esp. tobacco use), and precollege party motivation for attending college. These findings have implications for both the timing and targets of interventions. Interventions timed to occur prior to college and/or in the early months of college may disrupt the momentum of previously established drinking behavior. Furthermore, interventions may be most effective if they target conjoint alcohol and tobacco use, college party motivation, and self-selection into heavy-drinking social environments.

Adolescent↗

Brain impairment in social drinkers? No cause for concern.

Correlations between measures of alcohol consumption and cognitive test scores have been interpreted to reflect a chronic toxic effect of ethanol on brain function in light to moderate social drinkers. However, the data indicate that there is little support across research groups for any specific relationship and, at best, the effect of alcohol consumption accounts for only a small proportion of variance. Consideration of test validity suggests that the principal measure of ability used in this research is not capable of elucidating cerebral deficit. Further, the pattern of observed correlations is not consistent with the assumption that the putative effects of social drinking involve deficits less severe but similar in type to those seen in chronic alcoholics. Instead, an association between innate ability, demographic variables, and drinking behavior in the general population is the most parsimonious explanation of all the data.

Age Factors↗

Conceptions of alcoholism among Koreans and Americans.

Ethnographic research has occasionally reported the presence (or absence) of the disease concept of alcoholism in non-Western cultures. But the problem of differences in the nature of the concept of alcoholism between cultures in which it exists has not been seriously investigated. This study contrasts beliefs about alcoholism among samples of Koreans and Americans at a university in the United States. The findings suggest that the concept of alcoholism is present in both cultures, but Koreans tend to restrict their disease to the physiological consequences of long-term alcohol use, while Americans accept a definition which is couched largely in social and behavioral terms. It thus appears that, in contrast to America, alcohol consumption in Korea is relatively high, but alcoholism is rare. The implications of these findings for drinking behaviors, and the diagnosis and treatment of alcoholism, are discussed.

Adult↗

Recent developments in alcoholism:the workplace.

We examine the results of recent research that considers the relationship of the work environment to drinking behavior and problems. We bring the concept of culture to the foreground in this discussion, and show that much of what alcohol researchers term as work-related risk factors are, in effect, best understood as aspects or dimensions of cultural processes which operate in complex organizations. We identify and review four perspectives on alcohol use in occupational contexts that highlight these cultural processes at work: (1) the development of organizational norms with respect to drinking, definitions of problem drinking, and mechanisms of social control; (2) working conditions that produce in some workers experiences of powerlessness, alienation, or stress which are in turn alleviated by drink; (3) the interaction of cultural factors external to the workplace--regional/national, community, ethnic, and religious--with organizational cultural norms which affect alcohol values, beliefs, and behaviors; and (4) processes that underlie the development of occupationally based drinking subcultures.

Alcohol Drinking↗

Construct validity evidence for the interpretation of drinking restraint as a response conflict.

A style of control over alcohol consumption, termed restrained drinking, has been identified as an important predictor of drinking behavior and a possible risk factor for more serious alcohol problems. This control style is hypothesized to involve a cyclical pattern of drinking in which the specific phase (restraint or binging) depends on the balance between opposing response tendencies. A survey study of 429 college students supported the important predictions that restrained drinkers experience more response conflict, as evidenced by stronger impulses to drink (cravings and preoccupation with alcohol) as well as stronger inhibitions against drinking (social commitment to drinking goals, self-esteem threat of excessive consumption, and negative expectancies) compared to unrestrained drinkers. Restrained drinkers additionally reported more cyclical and extreme patterns of drinking, more reduction of alcohol consumption below preferred levels, and more costs of drinking reduction compared to unrestrained drinkers. This pattern of results occurred after controlling for habitual levels of alcohol consumption. These findings support important theoretical predictions concerning a restrained drinking style and provide further evidence of its importance in the early identification of the development of alcohol problems.

Adolescent↗