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PubMedDate not supplied

Association of early bilateral middle ear effusion with language at age 5 years.

OBJECTIVE: This study tested the hypothesis that children with early persistent middle ear effusion (MEE) are at risk for later language deficit. METHOD: We recruited 698 newborns and monitored them for MEE every 2 to 4 weeks at home until age 3 years. Language skills were assessed on 294 subjects at age 5, while controlling for 8 demographic and environmental factors. Language outcomes at age 5 years were studied as a function of duration of bilateral MEE from birth to age 3 years. RESULTS: A significant relation was found between duration of bilateral MEE and speech sound sensitivity (Carrow Elicited Language Inventory) and articulation (Goldman-Fristoe Articulation). Children's ability to discriminate speech sounds in a quiet environment (Carrow Auditory Visual Abilities Test) was less affected by early prolonged MEE in homes that provided more cognitive stimulation. CONCLUSIONS: These exploratory results indicate that prolonged early MEE may predispose children to language deficits at age 5 years. The language deficits are of small magnitude and may or may not be clinically significant. Language stimulation at home may protect against some of the effects of prolonged MEE.

Acoustic Impedance Tests↗

PubMed2002

The language of schizophrenia and the world of delusion.

The bizarre language of schizophrenics is nowadays generally believed to be the meaningless breakdown product of a neurobiological disorder. The psychological significance of hallucinations and delusions also remains mysterious. Verbatim vignettes are presented from an advanced stage of a psychoanalytically informed treatment to illustrate that schizophrenics speak a meaningful language that is syntactically and morphologically similar to ordinary language, but is qualitatively different in terms of semantics and pragmatics. From a semantic perspective the ordinary distinctions between words, things, body states and actions are absent, creating words and sentences that are not representational or symbolic. It is a language of equivalence, immediacy and action as contrasted with a language of self-awareness, thoughtfulness, reflection and communication. From a pragmatic standpoint, because the language of schizophrenia makes no distinction between mind and world, it enables and supports delusional thinking. In order for the psychoanalyst to comprehend what the patient means, and couch interpretations in such a way as to convey the meaning he/she intends, analyst and patient must become aware of their inability to comprehend one another's languages and find a way to bridge the communication barrier.

Adult↗

PubMed2001

Effects of intravenous secretin on language and behavior of children with autism and gastrointestinal symptoms: a single-blinded, open-label pilot study.

BACKGROUND: Autism is a severe developmental disorder with poorly understood etiology. A recently published case series describes 3 autistic children with gastrointestinal symptoms who underwent endoscopy and intravenous administration of secretin and were subsequently noted by their parents to demonstrate improved language skills over a 5-week period. This report sparked tremendous public interest, and investigators at several sites moved quickly to design controlled trials to test the efficacy of secretin as a therapy for autistic children. However, this is the first effort specifically designed to replicate the initial reported findings in terms of patient age, presenting symptoms, and drug administration. OBJECTIVE: To rigorously apply the scientific method by assessing the reproducibility of the reported effects of intravenous secretin on the language of young children with autism and gastrointestinal symptoms. METHODS: We performed a single-blinded, prospective, open-label trial by conducting formal language testing and blinded behavioral rating both before and repeatedly after a standardized infusion of secretin. We selected autistic children who were similar in age and profile to those described in the published retrospective case review. Inclusion criteria for study participation included age (3-6 years), confirmed diagnosis of autism, and reported gastrointestinal symptoms (16 had chronic diarrhea, 2 had gastroesophageal reflux, and 2 had chronic constipation). Twenty children (18 male) were admitted to the Pediatric Clinical Research Center at the University of California, San Francisco after administration of the Preschool Language Scale-3 (PLS-3). A 3 CU/kg dose of secretin (Secretin-Ferring) was administered intravenously (upper endoscopy was not performed). Behavioral ratings were derived using the Autism Observation Scale applied to a 30-minute time sample of the child's behavior consisting of a videotape of the PLS-3 (structured setting) and a second free play session with a standard set of developmentally appropriate toys. Participants then returned for follow-up evaluations, with readministrations of the PLS-3 at 1, 2, 3, and 5 weeks' postinfusion, and videotaping of each session for later blinded review by 2 independent observers using the Autism Observation Scale, uninformed about week of posttreatment. We also surveyed parents of our study children about their impressions of the effects of secretin using a 5-point Likert scale for parents to rate changes seen in their child. RESULTS: With a total study completion rate across all participants of 96%, repeated measures analyses of variance revealed no significant increases in children's language skills from baseline across all 5 study time periods after a single infusion of secretin. Similarly, neither significant decreases in atypical behaviors nor increases in prosocial behaviors and developmentally appropriate play skills emerged. Furthermore, no relationship was found between parental reports of change and observable improvement in the sample. Despite the objective lack of drug effect, 70% of parents in our study reported moderate to high change in their child's language and behavior. Furthermore, 85% of parents reported that they felt that their child would obtain at least some additional benefits from another infusion of secretin. CONCLUSIONS: The results of our pilot study indicate that intravenous secretin had no effects in a 5-week period on the language and behavior of 20 children with autism and gastrointestinal symptoms. The open-label, prospective design of our study with blinded reviews of patients both before and after secretin administration follows the scientific method by seeking to reproduce an observed phenomenon using validating and reliable outcome measures. Pilot studies remain a mandatory step for the design of future randomized, clinical trials investigating potential treatments for children with autism.

Analysis of Variance↗

PubMed2006

Clinical assessment of language development in children at age 3 years that were born preterm.

OBJECTIVE: To evaluate the influence of gestational age and birth weight on language development and neurodevelopmental outcome at age 3 years in children born preterm. METHOD: Cross sectional study including 69 children followed in our developmental outpatient clinic. Patients were consecutively included at the time of the 3 years of age appointment and stratified for birth weight (<1500 grams and between 1500-2500 grams). All patients were assessed for receptive and expressive language , Denver II and Bayley II tests and clinical neurological examination. For analysis patients were divided in two groups normal language acquisition (NLA) and delay in language acquisition (DLA). RESULTS: NLA children had higher scores on mental and psychomotor (p=<0.01, p=0.012) indexes of Bayley II. Newborns with less than 1500 grams had lower scores on all Bayley scale at age 36 months (p=0.002, p=0.007 and p<0.001). Multivariate analysis suggests an association between gestational age (p=0.032), abnormal behavior (p<0.001) and delay in language acquisition. Denver test at 12 and 24 months of age was a good predictor of delayed receptive and expressive language at three years of age (p=<0.01 and p=<0.01). CONCLUSION: Children born prematurely with low birth weight had an increased risk of language acquisition delay, and those had also lower cognitive and behavior scores when compared to NLA.

Child, Preschool↗

PubMed1982

Programming "loose training" as a strategy to facilitate language generalization.

This study investigated the generalization of spontaneous complex language behavior across a nontraining setting and the durability of generalization as a result of programming and "loose training" strategy. A within-subject, across-behaviors multiple-baseline design was used to examine the performance of two moderately retarded students in the use of is/are across three syntactic structures (i.e., "wh" questions, "yes/no" reversal questions, and statements). The language training procedure used in this study represented a functional example of programming "loose training." The procedure involved conducting concurrent language training within the context of an academic training task, and establishing a functional reduction in stimulus control by permitting the student to initiate a language response based on a wide array of naturally occurring stimulus events. Concurrent probes were conducted in the free play setting to assess the immediate generalization and the durability of the language behaviors. The results demonstrated that "loose training" was effective in establishing a specific set of language responses with the participants of this investigation. Further, both students demonstrated spontaneous use of the language behavior in the free play generalization setting and a trend was clearly evident for generalization to continue across time. Thus, the methods used appear to be successful for training the use of is/are in three syntactic structures.

Behavior Therapy↗

PubMed1997

Magnitude-estimation scaling of complex auditory stimuli: native and nonnative languages.

50 subjects used magnitude-estimation scaling to rate 11 languages on two subjective perceptual tasks. On Task 1, the subjects rated languages according to how similar they were to their native language (English). In Task 2, the subjects rated languages according to how much they like them. Analysis showed a high over-all correlation between how similar subjects felt the languages were to their native language and how much they liked them (Pearson product-correlation r = .86). The high correlation indicates consistency in subjects' scaling responses. This consistency may suggest that magnitude estimation is an appropriate method for scaling complex auditory stimuli represented by various attributes of native and nonnative languages.

Adolescent↗

PubMed1999

Relationships between anxiety and achievement at three stages of learning a foreign language.

Anxiety in foreign language courses has been conceptualized as occurring at each of three stages of input, processing, and output. Specifically, input anxiety refers to the learner's apprehension when receiving information in the foreign language; processing anxiety refers to the apprehension experienced by learners when learning and thinking in the foreign language; and output anxiety refers to the apprehension experienced when speaking or writing in the foreign language. The present purpose was to investigate the relationship between achievement and anxiety at each of these three stages of learning a foreign language. Participants were 224 college students from a variety of disciplinary backgrounds, enrolled in Spanish, French, or German classes. Small but significant negative associations were found between achievement in the foreign language and scores on the Input Scale, the Processing Scale, and the Output Scale. These indicate educators should consider more than just the output stage of learning in foreign language classes.

Achievement↗

PubMed2004

Random number generation in native and foreign languages.

The effects of different levels of language proficiency on random number generation were examined in this study. 16 healthy right-handed students (7 women, 9 men; aged 22 to 25 years, M=23.8, SD=.83) attempted to generate a random sequence of the digits 1 to 9 at pacing frequencies of 1, 1.5, and 2 Hz. Randomization was done in German (native language L1), English (first foreign language L2), and French (second foreign language L3). There was a pattern of redundancy and seriation tendencies, increasing with speed of generation for all languages (L1-L3). While using L2 and L3, responses slowed and the number of errors committed increased. Further, there was a peculiar pattern of dissociation in nonrandom performance with an increase of habitual counting in ones and a strong reduction of counting in twos. All effects were most pronounced when subjects used L3 and 2-Hz pacing rates. Slowing and nonrandomness was not correlated with self-assessment parameters regarding language proficiency. We suggest that in a task involving number activation in a nonnative language, lack of proficiency will interfere with random number generation, leading to interruptions and rule breaking, at least when reaching the limits of attentional capacity at higher pacing rates.

Adult↗

PubMed1997

Enhancement of expressive language in prelingually deaf children with cochlear implants.

Expressive language skills were assessed in two groups of prelingually-deafened children using the Reynell Developmental Language Scales (RDLS). Results from a group of 89 unimplanted subjects provided cross-sectional data which suggested that profoundly deaf children without implants, on average, could only be expected to make 5 months of expressive language growth in one year. Twenty-three children who received cochlear implants made up the second group of subjects and were administered the RDLS at three intervals: preimplant, 6-, and 12-months postimplant. The scores obtained at the post-implant intervals were then compared to scores that would be predicted on the basis of maturation alone, without the implant (these predictions were formulated based on the data obtained from the unimplanted subjects). At the 12-month postimplant interval, the observed mean language score was significantly higher than the predicted score. Although the mean group data were extremely encouraging, wide inter- subject variability was observed. Although the implant subjects, as a group, were substantially delayed compared with their normal hearing peers, their rate of language growth was found to match that of hearing peers, following implantation. Thus, the gap between chronological age and language age, which normally widens over time in deaf children, remained constant. Preliminary analyses over the first 2.5 years post-implant are consistent with this trend. These results suggest that early implantation (before age 3) might be beneficial to profoundly deaf children because the language delays at the time of implantation would be much smaller.

Age of Onset↗

PubMed1991

Mother-child interactions with language-impaired children and their siblings.

There are possible effects of language impairment on adult-child interaction. Previous research focused on (1) examining common features of adult-child interaction in different groups of atypical language learners and (2) examining differences between language-impaired parent-child dyads and normal control dyads. The present investigation studies language-impaired children and their mothers in comparison both to their own younger siblings of the same language stage and to normal controls of the same language stage. Consistencies within families but not across families were found. In addition, large individual differences were observed for different families. The implications of these findings for our understanding of interactive styles and language impairment are discussed.

Child, Preschool↗

PubMed1996

Management of speech and language disorders in a mental illness unit.

Few speech and language therapists work with psychiatric patients. This study investigates how the specific communication problems of this population are addressed by care staff. Following a survey to determine the prevalence of speech and language problems in a psychiatric population, subjects assessed as having moderate or severe difficulties were selected for further study in order to investigate how they were currently being managed by the people responsible for their care. Key workers or charge nurses were interviewed, and ward and department nursing care plans were examined for mentions of speech and language problems, for aims in connection with these problems and for strategies to achieve these aims. Speech and language problems were not mentioned in 40% of the nursing care plans inspected. Where speech and language problems were mentioned there were aims in connection with half of these and strategies to achieve the aims in only 10% of the sample. The reasons for failure to mention speech and language in nursing care plans and for discrepancies between the results of speech and language therapy assessment and assessments of ward and department staff are discussed.

Adolescent↗

PubMed1998

Preoperative predictors of anterior temporal language areas.

OBJECT: Although it is known that 5 to 10% of patients have language areas anterior to the rolandic cortex, many surgeons still perform standard anterior temporal lobectomies for epilepsy of mesial onset and report minimal long-term dysphasia. The authors examined the importance of language mapping before anterior temporal lobectomy. METHODS: The authors mapped naming, reading, and speech arrest in a series of 67 patients via stimulation of long-term implanted subdural grids before resective epilepsy surgery and correlated the presence of language areas in the anterior temporal lobe with preoperative demographic and neuropsychometric data. Naming (p < 0.03) and reading (p < 0.05) errors were more common than speech arrest in patients undergoing surgery in the anterior temporal lobe. In the approximate region of a standard anterior temporal lobectomy, including 2.5 cm of the superior temporal gyrus and 4.5 cm of both the middle and inferior temporal gyrus, the authors identified language areas in 14.5% of patients tested. Between 1.5 and 3.5 cm from the temporal tip, patients who had seizure onset before 6 years of age had more naming (p < 0.02) and reading (p < 0.01) areas than those in whom seizure onset occurred after age 6 years. Patients with a verbal intelligence quotient (IQ) lower than 90 had more naming (p < 0.05) and reading (p < 0.02) areas than those with an IQ higher than 90. Finally, patients who were either left handed or right hemisphere memory dominant had more naming (p < 0.05) and reading (p < 0.02) areas than right-handed patients with bilateral or left hemisphere memory lateralization. Postoperative neuropsychometric testing showed a trend toward a greater decline in naming ability in patients who were least likely to have anterior language areas, that is, those with higher verbal IQ and later seizure onset. CONCLUSIONS: Preoperative identification of markers of left hemisphere damage, such as early seizure onset, poor verbal IQ, left handedness, and right hemisphere memory dominance should alert neurosurgeons to the possibility of encountering essential language areas in the anterior temporal lobe (1.5-3.5 cm from the temporal tip). Naming and reading tasks are required to identify these areas. Whether removal of these areas necessarily induces long-term impairment in verbal abilities is unknown; however, in patients with a low verbal IQ and early seizure onset, these areas appear to be less critical for language processing.

Adolescent↗

PubMed2005

Language switching and the effects of orthographic specificity and response repetition.

In two experiments, Greek-English bilinguals alternated between performing a lexical decision task in Greek and in English. The cost to performance on switch trials interacted with response repetition, implying that a source of this "switch cost" is at the level of response mapping or initiation. Orthographic specificity also affected switch cost. Greek and English have partially overlapping alphabets, which enabled us to manipulate language specificity at the letter level, rather than only at the level of letter clusters. Language-nonspecific stimuli used only symbols common to both Greek and English, whereas language-specific stimuli contained letters unique to just one language. The switch cost was markedly reduced by such language-specific orthography, and this effect did not interact with the effect of response repetition, implying a separate, stimulus-sensitive source of switch costs. However, we argue that this second source is not within the word-recognition system, but at the level of task schemas, because the reduction of switch cost with language-specific stimuli was abolished when these stimuli were intermingled with language-nonspecific stimuli.

Adult↗

PubMed2004

Recognizing cognates and interlingual homographs: effects of code similarity in language-specific and generalized lexical decision.

In four experiments, we investigated how cross-linguistic overlap in semantics, orthography, and phonology affects bilingual word recognition in different variants of the lexical decision task. Dutch-English bilinguals performed a language-specific or a generalized lexical decision task including words that are spelled and/or pronounced the same in English and in Dutch and that matched one-language control words from both languages. In Experiments 1 and 3, "false friends" with different meanings in the two languages (e.g., spot) were presented, whereas in Experiments 2 and 4 cognates with the same meanings across languages (e.g., film) were presented. The language-specific Experiments 1 and 2 replicated and qualified an earlier study (Dijkstra, Grainger, & Van Heuven, 1999). In the generalized Experiment 3, participants reacted equally quickly on Dutch-English homographs and Dutch control words, indicating that their response was based primarily on the fastest available orthographic code (i.e., Dutch). In Experiment 4, cognates were recognized faster than English and Dutch controls, suggesting coactivation of the cognates' semantics. The nonword results indicate that the bilingual rejection procedure can, to some extent, be language specific. All results are discussed within the BIA+ (bilingual interactive activation) model for bilingual word recognition.

Adolescent↗

PubMed2000

[Rethinking the Sapir-Whorf hypothesis: role of language in shaping thought].

Traditionally, the issue of the relationship between language and thought has been framed as the Sapir-Whorf hypothesis, in which crosslinguistic-crosscultural universality or diversity of thought has been the center of the debate. The long-lasting debate revolving around the hypothesis has not yielded a clear, satisfactory conclusion. This unsatisfactory result seems to be largely attributed to the fact that (a) the term "thought" has been so vaguely defined, and that (b) the interpretation of the Sapir-Whorf hypothesis itself has been quite diverse among researchers. In this paper, I argue that the question we should ask is not whether thought is universal or different across different language groups. Instead, we should ask more specific (and realistic) questions, taking it for granted that our thought is constrained by innate language-independent cognitive faculties but at the same time a large part of our thought is shaped by language. The questions we should ask are: in what cognitive domains (e.g., spatial cognition, ontological knowledge, categorization of natural objects etc.), at what specific level (e.g., perception, memory, knowledge representation, on-line information processing) and in what degree (a) our thought is influenced by the specific structure of the given language (or is immune to it) and (b) our thought is shaped by language learning (or constrained by language-independent innate cognitive structure). In order to reevaluate the Sapir-Whorf hypothesis in this new perspective, I reviewed literature mainly focusing on three distinctive cognitive domains: ontological knowledge with respect to individuation, categorization of natural objects, and spatial cognition.

Cognition↗

PubMed2003

Localization of the human language cortex by magnetic source imaging.

OBJECTIVE: To localize the language cortex associated with Chinese word processing by magnetic source imaging (MSI). METHODS: Eight right-handed and one left-handed healthy native Chinese subjects were examined by magnetoencephalography (MEG) and a 1.5T magnetic resonance imaging (MRI) unit. All subjects were given pure tone stimuli 50 times, 150 pairs of Chinese words (meaning related or unrelated) auditory stimuli, and pure tone stimuli subsequently 50 times. Evoked response fields time locked to the pure tone and Chinese words were recorded using a whole-head neuromagnetometer in real-time. The acquired data were averaged by the acquisition computer according to the response to the pure tone, related pairs of words and unrelated pairs of words. The data obtained by MEG were superimposed on MRI, using a GE Signa 1.5T system. RESULTS: MEG, showed there were two obviously higher magnetic waves named M50 and M100, which were localized in the bilateral transverse temporal gyri in all subjects. The responses to the pairs of Chinese words (meaning related or unrelated) were similar in the same hemisphere of the same subjects. There was a higher peak during 300 - 600 ms in the right hemisphere of one left handed subject, but no peak in the left hemisphere, indicating that the language dominant hemisphere was localized in the right hemisphere. Superimposing the MEG data on MRI, the language area was localized in the Wernicke's areas. A 300 - 600 ms response peak was obsarved in each hemisphere (the amplitude of the 300 - 600 ms response peak in each hemisphere was almost the same) in two right-handed subjects, showing that the language area was localized in the 2 hemispheres in the two subjects. There was one peak in each hemisphere (300 - 600 ms response) in 6 subjects, but the amplitude of the wave in the left hemisphere in the 6 subjects was much higher than that in the right hemisphere. By choosing randomly from the later component (300 - 600 ms response) several time points and superimposing them on MRI, all time points were localized in the posterior part of the superior temporal gyri, which is the Wernicke's areas. CONCLUSIONS: Comparing with the later component of the bilateral hemispheres, the wave amplitude in the language dominant hemisphere was much higher than that in the non-language dominant hemisphere. The language areas could be identified by judging whether meanings of pairs of Chinese words were related or not.

Adolescent↗

PubMed2003

Autism and specific language impairment: categorical distinction or continuum?

Traditionally, autism and specific language impairment (SLI) are regarded as distinct disorders, with differential diagnosis hinging on two features. First, in SLI one sees isolated language impairments in the context of otherwise normal development, whereas in autism a triad of impairments is seen, affecting communication, social interaction and behavioural repertoire. Second, there are different communication problems in these two conditions. Children with SLI have particular difficulty with structural aspects of language (phonology and syntax). In contrast, abnormal use of language (pragmatics) is the most striking feature of autism. However, recently, this conventional view has been challenged on three counts. First, children with autism have structural language impairments similar to those in SLI. Second, some children have symptoms intermediate between autism and SLT. Third, there is a high rate of language impairments in relatives of people with autism, suggesting aetiological continuities between SLI and autism. One interpretation of these findings is to regard autism as 'SLI plus', i.e. to assume that the only factor differentiating the disorders is the presence of additional impairments in autism. It is suggested that a more plausible interpretation is to regard structural and pragmatic language impairments as correlated but separable consequences of common underlying risk factors.

Autistic Disorder↗

PubMed2004

Language preferences among callers to a regional Poison Center.

Providing service to non-English speaking populations is a common challenge facing Poison Centers (PC). Previous studies have identified that people who do not speak functional English are unlikely to call a PC. We developed a survey to determine the language preferences of poison center callers and to identify if we were failing to offer services in languages other than English to callers who felt they needed them. We surveyed 322 parents during routine callbacks about language spoken at home, first and second languages, country of birth, and satisfaction with language used by the PC. We found that 93% primarily spoke English, 5% spoke English and Spanish, and 5% spoke other languages at home in a region where approximately 10% of the population speak English poorly. The majority of respondents were born in the US and were comfortable using English when using the PC. There were 6 cases where callers would have preferred using a different language. Our study supports data suggesting that poison centers are underutilized by people that are recent immigrants and speak English poorly. Awareness programs and educational efforts should be directed toward this sub-population.

Communication Barriers↗