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We have shown that skin-types I/II are much more susceptible to UVR-induced suppression of the induction phase of contact hypersensitivity than skin-types III/IV. Studies with a UVB sunscreen have provided indirect evidence that UVA is more immunosuppressive than it is erythemogenic. Overall, our studies show a lack of direct correlation between erythema and immunosuppression.
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An association between fertility and longevity has been known for many years, and considerable research has been focused on the mechanisms of ageing that ultimately determine longevity, which has remained essentially unchanged despite a near doubling of human life expectancy in the past 200 years. In this paper, the authors present evidence that the Sun determines the limits of longevity for the longest-living complex organisms. The Sun is a dynamical system and although solar cycles occur every 8-14 years (averaging approximately 11.1 years), the authors show that 28% of these cycles exhibit chaotic features and irregularly release up to 300% more ultraviolet radiation than usual. These chaotic solar cycles create an environment mutagenic to DNA that must be largely avoided in order to pass uncorrupted genes to the next generation. This requirement determines the limits of fertility, e.g., menarche and menopause in humans, and sets longevity to approximately 100 years.
A telestimulator has been constructed which is suitable for mounting on the heads of medium-sized Macaca mulatta or larger primates. It differs from previous units in that the battery supply is continuously recharged from ambient light by means of solar cells. The system features remote control of all stimulus parameters, constant current output, and remote selection of any of 11 electrodes. If additional transmitters are employed, simultaneous and independent stimulation of a number of primates in the same group is possible. A shielded room with a terminated antenna system is used to produce a homogeneous radio-frequency field for laboratory use.
BACKGROUND: The idiopathic photodermatoses have been reported to be rarer in tropical Singapore than in countries of higher latitude, with photoaggravated dermatoses and systemic phototoxicity making up most of the photodermatoses seen here. This study aims to reassess the spectrum of photodermatoses seen at the National Skin Centre, Singapore, compared with almost a decade ago, and analyse the clinical and photobiological characteristics, as compared with other countries. MATERIALS AND METHODS: We reviewed the clinical data of 141 patients phototested from January 2000 to December 2001, and analysed the epidemiological, clinical and photobiological features. RESULTS: Photosensitive dermatoses were diagnosed in 88% (124/141) of patients phototested. In those diagnosed with photodermatoses, polymorphic light eruption (PMLE) (28%) was the most common diagnosis, followed by photoaggravated dermatoses (26%), chronic actinic dermatitis (CAD) (15%), systemic phototoxicity (15%), solar urticaria (SU) (7%), actinic prurigo (AP) (5%) and photoallergic contact dermatitis (4%). Ethnic Indians appeared to be more predisposed to PMLE; AP was diagnosed only in ethnic Chinese. The other photodermatoses occurred proportionally in all racial groups. AP differed from that found in Caucasians, being of adult onset and persistent. Abnormal phototest results were obtained in all patients with CAD, SU and AP, but only in 56% and 49% of systemic phototoxicity and PMLE, respectively. CONCLUSION: Idiopathic photodermatoses are more commonly diagnosed in Singapore than a decade ago, while the incidence of systemic phototoxicity has remained stable. The spectrum of photodermatoses in our Asian population now approximates that seen in Caucasian cohorts.
Recent major advances in x-ray imaging and spectroscopy of clusters have allowed the determination of their mass and mass profile out to approximately 1/2 the virial radius. In rich clusters, most of the baryonic mass is in the gas phase, and the ratio of mass in gas/stars varies by a factor of 2-4. The baryonic fractions vary by a factor of approximately 3 from cluster to cluster and almost always exceed 0.09 h50-[3/2] and thus are in fundamental conflict with the assumption of Omega = 1 and the results of big bang nucleosynthesis. The derived Fe abundances are 0.2-0.45 solar, and the abundances of O and Si for low redshift systems are 0.6-1.0 solar. This distribution is consistent with an origin in pure type II supernova. The amount of light and energy produced by these supernovae is very large, indicating their importance in influencing the formation of clusters and galaxies. The lack of evolution of Fe to a redshift of z approximately 0.4 argues for very early enrichment of the cluster gas. Groups show a wide range of abundances, 0.1-0.5 solar. The results of an x-ray survey indicate that the contribution of groups to the mass density of the universe is likely to be larger than 0.1 h50-2. Many of the very poor groups have large x-ray halos and are filled with small galaxies whose velocity dispersion is a good match to the x-ray temperatures.
The European Light Dosimeter Network (ELDONET) project has been designed with the purpose of establishing an efficient system to monitor solar radiation in Europe, in as many as possible locations. This paper describes the structure of the server that collects and processes the data acquired by the different stations belonging to the network, and makes them freely available on the Internet to the scientific community. The server is able to receive data either via FTP from the Internet or via modem and to process them looking for errors or inconsistencies. Moreover, it automatically generates graphs, Web-pages and FTP archives. The server has been active for some years in testing mode and is now fully operative.
While advances in protein design have made possible the construction of protein architectures with nativelike properties and predictable structures and function, there are as of yet no examples of functional, protein-based, solar energy conversion systems. This communication describes the design and characterization of an artificial reaction center (RC) protein that closely resembles the function of the natural photosynthetic RC. The synthetic protein, designed by the protein design program CORE, participates in multiple reduction/oxidation cycles with exogenous acceptors/donors following photoexcitation. The designed metalloprotein, aRC, consists of a tetrahelical bundle functionalized with two bis-histidine bound metal cofactors: a Ru(bpy)2 moiety and a heme group. Two distinct bis-histidine binding sites were engineered for each of these metal centers. Photoexcitation of aRC results in rapid ET from the RuII complex to the heme group (kET >/= 5 x 1010 s-1) yielding a long-lived (70 ns) charge-separated state (CSS), RuIII/FeII. This long-lived CSS participates in subsequent ET reactions with exogenous donors and acceptors in multiple photocycles, thus mimicking the basic function of native photosynthetic RCs. This study illustrates the successful design and construction of a protein-based functional charge separation device using a combination of automated computational protein design and knowledge of the engineering principles of biological electron tunneling extracted from natural electron-transfer systems. To our knowledge, this represents the first example of a functional protein-based artificial reaction center.
In terms of resistance to extreme environmental stresses, the bacterial spore represents a pinnacle of evolution. Spores are highly resistant to a wide variety of physical stresses such as: wet and dry heat, UV and gamma radiation, oxidizing agents, chemicals, and extremes of both vacuum and ultrahigh hydrostatic pressure. Some of the molecular mechanisms underlying spore resistance properties have been elucidated in the laboratory, and involve both: (i) protection of vital spore macromolecules during dormancy, and (ii) repair of damaged macromolecules during germination. Our group has recently become interested in testing if the laboratory model of spore UV resistance is relevant to spore persistence in the environment. We have constructed a number of Bacillus subtilis strains which are defective in various DNA repair systems and spore structural components. Using spores of these strains, we have been exploring: (i) the types of damage induced in DNA by the UV-B and UV-A components of sunlight; (ii) the relative contribution of the major spore DNA repair systems to spore solar radiation resistance; and (iii) the role of spore structural components such as the spore coats and dipicolinic acid (DPA) in attenuation of the lethal and mutagenic effects of solar UV. The current data are reviewed with the ultimate goal of obtaining a complete model describing spore persistence and longevity in the terrestrial solar UV radiation environment.
We present an analytic solution of the complete set of jump relations at the rotational discontinuity and the slow-mode shock in a two-and-half-dimensional (2 1/2D) symmetric reconnection model. The solution is used for analyzing the outflow jet characteristics in dependence on the speed and the incidence angle of the inflowing plasma, for a given shear of the inflow magnetic field. It is found that the magnetosonic Mach number of the outflow depends significantly on the incidence angle, the effect being more prominent at larger reconnection rates. The compression increases weakly with increasing reconnection rate. Dynamical changes in the flow/field geometry are found in the transition to the 2D regime: In the region between the rotational discontinuity and the slow-mode shock the direction of flow and the magnetic field become extremely sensitive to the degree of the magnetic field shear in the inflow. Implications for evolutionary systems such as solar flares are discussed.
Since the Cassini spacecraft reached Saturn's orbit in 2004, its instruments have been sending back a wealth of data on the planet's magnetosphere (the region dominated by the magnetic field of the planet). In this Viewpoint, we discuss some of these results, which are reported in a collection of reports in this issue. The magnetosphere is shown to be highly variable and influenced by the planet's rotation, sources of plasma within the planetary system, and the solar wind. New insights are also gained into the chemical composition of the magnetosphere, with surprising results. These early results from Cassini's first orbit around Saturn bode well for the future as the spacecraft continues to orbit the planet.
A second-generation solar disinfection (SODIS) system (pouch) was constructed from food-grade, commercially available packaging materials selected to fully transmit and amplify the antimicrobial properties of sunlight. Depending upon the season, water source, and challenge organism, culturable bacteria were reduced between 3.5 and 5.5 log cycles. The system was also capable of reducing the background presumptive coliform population in nonsterile river water below the level of detection. Similar experiments conducted with a model virus, the F-specific RNA bacteriophage MS2, indicated that the pouch was slightly less efficient, reducing viable plaques by 3.5 log units in comparison to a 5.0 log reduction of enterotoxigenic Escherichia coli O18:H11 within the same time period. These results suggest that water of poor microbiological quality can be improved by using a freely available resource (sunlight) and a specifically designed plastic pouch constructed of food-grade packaging materials.
Although it is well known that radiation causes mutational damage, little is known about the biological effects of long-term exposure to radiation in space. Exposure to radiation can result in serious heritable defects in experimental animals, and in humans, susceptibility to cancer, radiation-sickness, and death at high dosages. It is possible to do ground controlled studies of different types of radiation on experimental animals and to physically measure radiation on the space station or on space probes. However, the actual biological affects of long-term exposure to the full range of space radiation have not been studied, and little information is available about the biological consequences of solar flares. Biological systems are not simply passive recording instruments. They respond differently under different conditions, and thus it is important to be able to collect data from a living animal. There are technical difficulties that restrict the placement of an experimental organism in a space environment for long periods of time, in a manner that allows for the recovery of genetic data. Use of the self-fertilizing hermaphroditic nematode, Caenorhabditis elegans offers potential for the design of a biological dosimeter. In this paper, we describe the advantages of this model system and review the literature of C. elegans in space.
Sodium is used as the heat transfer medium in several new energy technologies such as liquid-metal fast-breeder reactors and solar-thermal collection systems. Because sodium burns in air and reacts violently with water, the potential exists for an airborne release of sodium combustion products and subsequent human exposure. To help evaluate the potential short-term hazard from an accidental sodium fire, male juvenile or adult Wistar rats were exposed to sodium aerosols for 2 hours to determine the dose at which 50 percent of the animals were affected (ED50) for each age group. The estimated ED50 of 510 microgram/l for adults was not significantly different from the estimated ED50 of 489 microgram/l for juveniles. The incidence of acute laryngitis, attributed to exposure, was three times higher for juvenile rats than for adults, and the degree of severity of this lesion was significantly (P less than 0.05) higher for juveniles.
Introduction of dicyanovinyl groups on a triphenylamine-based conjugated system leads to an intramolecular charge transfer which extends the spectral response and raises the open-circuit voltage of the resulting hetero-junction solar cells.
Is there life beyond planet Earth? This is one of the grand enigmas which humankind tries to solve through scientific research. Recent progress in astronomical measurement techniques has confirmed the existence of a multitude of extra-solar planets. On the other hand, enormous efforts are being made to assess the possibility of life on Mars. All these activities have stimulated several investigations about the habitability of cosmic bodies. The habitable zone (HZ) around a given central star is defined as the region within which an Earth-like planet might enjoy the moderate surface temperatures required for advanced life forms. At present, there are several models determining the HZ. One class of models utilises climate constraints for the existence of liquid water on a planetary surface. Another approach is based on an integrated Earth system analysis that relates the boundaries of the HZ to the limits of photosynthetic processes. Within the latter approach, the evolution of the HZ for our solar system over geological time scales is calculated straightforwardly, and a convenient filter can be constructed that picks the candidates for photosynthesis-based life from all the extra-solar planets discovered by novel observational methods. These results can then be used to determine the average number of planets per planetary system that are within the HZ. With the help of a segment of the Drake equation, the number of "Gaias" (i.e. extra-solar terrestrial planets with a globally acting biosphere) is estimated. This leads to the thoroughly educated guess that there should exist half a million Gaias in the Milky Way.
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