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PubMed1994

[The epidemiology of spondyloarthropathies among the native inhabitants of Chukotka. 2. The prevalence of HLA-B27 in the population and among spondyloarthropathy patients].

To establish the incidence of HLA-B27 among the indigenous population of Chukot Peninsula, a one-stage cross-sectional study was made of all the natives of the two settlements of eastern Chukot Peninsula (Sireniki and Novo-Chaplino). At the moment of examination altogether 640 natives lived in both settlements. Of these, 464 persons (72.5%) could be examined clinically; HLA typing could be performed in 439 persons (68.6%). Among the 439 natives examined, antigen B27 was identified in 141 cases (32.1%). Among Eskimos, the number of HLA-B27-positive individuals amounted to 39.7%, among Chukchi to 18.9% (p = 0.0005). Half-breeds occupied an intermediate position between the two groups. The frequency of NLA-B27-positive cases was 29.7% among them. 7 patients were diagnosed to have diseases belonging to the group of spondyloarthropathies. 2 persons presented with ankylosing spondyloarthritis, 2 with Reiter's syndrome, 2 with undifferentiated spondyloarthropathies and 1 with juvenile chronic arthritis. All the patients with ankylosing spondyloarthritis and Reiter's syndrome appeared HLA-B27-positive.

Arctic Regions↗

PubMed1976

[Sugar consumption and prenatal acceleration. I. Studies in the history of medicine on the coincidence and connection of these 2 secular phenomenon].

A comparative historic evaluation reveals an astonishing world-wide relationship between prenatal acceleration, i.e. secular changes of birth-weight and percentage of "large babies", of distinct population groups, and their sugar consumption. They seem to be "connected" as they are regularly "conjoined" (HUME [46]). A statistically highly significant correlation between these two phenomena was established for Switzerland and Germany. The assumption of a causal relationship was confirmed by the abrupt development of growth acceleration together with the rapid increase in the per capita sugar consumption observed in an experiment-like situation in certain Canadian Eskimo populations in recent years.

Birth Weight↗

PubMed1994

Epstein-Barr virus in exfoliated cells from the postnasal space. Viral detection by polymerase chain reaction is not a useful means of screening for nasopharyngeal carcinoma in high-risk populations.

There is a high incidence of undifferentiated nasopharyngeal carcinoma (NCP) in certain populations, including Greenland Eskimos. The cancer appears to have a causal association with Epstein-Barr virus (EBV), which is regularly found in NPC epithelial cells. With the aim of developing a method of screening or facilitating early diagnosis of NPC, we used the polymerase chain reaction to examine exfoliated nasopharyngeal cells for EBV in 54 Greenland and 17 white Danish subjects, none of whom was suspected of having NPC. EBV DNA was found in 81% of Greenland and 35% of Danish subjects. These findings support the concept of EBV infection leading in most cases to a chronic carrier state. It is concluded that EBV detection in nasopharyngeal cells is not at present a suitable method for identification of individuals at increased risk of developing NPC.

Base Sequence↗

PubMedDate not supplied

Epidemiology of cancer in Alaska Natives.

In contrast to many other Native American groups in the United States, cancer incidence data are available for the Alaska Native population from 1969 to present. These data support the fact that cancer patterns in this population differ from all other U.S. populations and are most similar to Eskimos (Inuit) of other circumpolar countries. The unique cancer patterns and the distribution of the population far from sophisticated medical centers strongly impact the cost/benefit ratios of recommended cancer screening procedures. Cost/benefits of cancer screening and data showing that more than one-third of cancer cases and cancer deaths are tobacco related, necessitate that cancer control efforts in this population should focus on eradication of tobacco.

Alaska↗

PubMed1994

Genetic characterization of the Cayapa Indians of Ecuador and their genetic relationships to other Native American populations.

One-hundred sixty-four Cayapa Indians living in the Esmeraldas Province (northwest Ecuador) were studied for several erythrocyte genetic markers (ACP1, ADA, AK1, CA2, ESD, GLO1, G6PD, PGD, PGM1 subtyping and thermostability, PGM2, SODA, and HB). The Cayapa show allele frequencies typical of those of South American Indians. The absence of the CA2*2, G6PD*A, G6PD*A-, HBB*S, and HBB*C alleles and the low PGM1*1A and PGM1*2A and high PGM1*1B allele frequencies indicate that very little (no more than 2%), if any, genetic admixture has occurred with the black community living in the same area. Correspondence analysis was used to study the genetic relationships between the Cayapa and other linguistically defined Amerind populations and between the Amerinds and the other two native American groups, the Na-Dene and Eskimo-Aleut. The results of this analysis, obtained on the basis of some erythrocyte and serum markers and some blood group systems, show (1) the close affinity between the Cayapa and other South American populations, (2) the absence in the Amerind group of a clear-cut correspondence between linguistic classification and genetic relatedness, and (3) the evident distinctiveness of the Amerinds from other native American people.

Adult↗

PubMedDate not supplied

A private sector view of health, surveillance, and communities of color.

The U.S. population is fast evolving into a patchwork of health behaviors, incomes, and ethnic backgrounds. Simple cultural labeling will not do. A growing number of Americans, now numbering about 10 million, cannot or will not describe their race in any one of the Census Bureau's standard categories--white, black, American Indian, Eskimo, Aleut, Asian Pacific, or Hispanic. They group themselves as a multicultural population rather than a single racial or ethnic category. To guide health interventions, the private sector now relies more on statistical clusters based on geography, lifestyle, behavior, financial status, and attitudes instead of on race. In marketing, the challenge is to reach diverse markets without stereotyping the product as one designed for only a certain ethnic group. The emphasis on athletics instead of on race is one example of how some marketers solve this problem of reaching minorities without giving the impression that specific products are only for blacks, or Hispanics, or Asians. Surveillance professionals can expand the way data are collected and publicized. Blacks, Hispanics, Asians, and Native Americans should not be categorized simply by race; other variables of health, such as income and age, should be given careful attention.

Commerce↗

PubMed1993

[Characteristics of tuberculosis in Japan compared with those in other developed countries].

To clarify the characteristics of the tuberculosis situation in Japan, it was analysed in comparison with those in other developed countries. The results are summarized as follows: 1. The tuberculosis epidemic peaked at the end of 1910s in Eastern Japan, and in the 1940s in Western Japan. It is estimated that the annual risk of tuberculosis infection was 4% or more until the end of the World War II. Tuberculosis has spread much later and was much more prevalent up through the 1940s in Japan than in other developed countries. 2. A modern tuberculosis control programme including active case-finding, isolation of infectious cases, charge free medication and BCG vaccination was launched in 1951, and in 1961 an effective case-holding system was established. Tuberculosis incidence decreased rapidly thereafter. As the rate of decrease was almost the same as that of the Inuit (Eskimo) (Fig. 1), one might say that Japan is one of the countries where tuberculosis incidence decreased most rapidly. 3. Incidence of tuberculosis in children is 2.1 per 100,000 in 1991 which is lower than that of the U.S.A. (3.1 per 100,000). 4. Incidence of tuberculosis among the aged is much higher than that of other developed countries as shown in Fig. 3. Of course, this is mainly caused by the fact that a higher percentage of Japanese aged 55 years or more was infected with tubercle bacilli in the past.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1993

[Deletion-insertion polymorphism in the V-region of mitochondrial DNA in ten Mongoloid populations of Siberia, Frequency of deletion correlates with the geographic coordinates of the locality].

Deletion-insertion polymorphism in the V-region of mitochondrial DNA was analysed in ten mongoloid populations of Siberia. Frequencies of 9-bp deletion and 4-bp insertion in the populations were: 7.7 and 1.5% in Buryats; 10.2 and 0.8% in north Altais: 1.4 and 0.0% in Nanays; 1.5 and 0.0% in eastern Evenks; no deletions and insertions of such type were revealed in western Evenks, and also in Mansi, Yakuts, Chukcha and Eskimos. Correlation analysis of the data about the populations from Siberia, foreign Asia and Oceania revealed a geographical gradient of the deletion frequency which increases towards the East. The azimuth of the deletion frequency geographical gradient direction is 170 degrees. The deletion frequency gradient (Z) within the limits from the subarctic regions of Siberia to the west regions of Oceania is described quite completely with the multiple regression equation: Z = 30.516 - 0.840 (latitude) + 0.145 (longitude). The part of geographical factor within the total variability of the deletion frequency is 64%. The regularity discovered does not extend to the indian population of America.

Asia↗

PubMed1993

Hemopexin: a unique genetic polymorphism in populations of African ancestry.

Using isoelectric focusing and immunoblotting techniques, we have screened 937 plasma or serum samples from Nigerian blacks (N = 380), Papua New Guineans (N = 110), Aleuts (N = 62), Mayans (N = 139), Dogrib Indians (N = 45), and Eskimos from Kodiak and St. Lawrence islands (N = 201) for the hemopexin (HPX) polymorphism. We compared these data with our previously published data for US whites (N = 267) and US blacks (N = 194). Except for Nigerian blacks and US blacks, HPX was found to be monomorphic for the common HPX*1 allele in all populations tested. In addition to the commonly occurring HPX*1 allele, two other less common alleles, HPX*2 and HPX*3, were observed with respective frequencies of 1.8% and 4.6% in US blacks and 1.7% and 9.0% in Nigerian blacks. These data strongly suggest that the HPX*2 and HPX*3 alleles are unique alleles restricted to the black gene pool and are of potential significance in microevolutionary studies and in defining African admixture in hybrid populations. In addition to their importance in anthropogenetic studies, these unique HPX mutations also have potential biological significance in hemolytic disorders.

Africa↗

PubMed1993

[Marine oils and prevention of cardiovascular diseases].

Observations done in Greenland Eskimos, and then confirmed in other populations, have led to the hypothesis that a diet rich in marine oils is associated with a low incidence of coronary heart disease. Marine oils are rich in n-3 polyunsaturated fatty acids which, if consumed in large amounts, influence plasma lipid concentrations (mainly by lowering triglycerides), and modify the synthesis of eicosanoids (leukotrienes and prostanoids) with effects on haemostasis, vasomotility and inflammation. Many experimental studies suggest that fish oils may exert and anti-atherosclerotic action. However, direct evidence (through prospective preventive trials) remains insufficient to establish that dietary supplements of marine oils prevent arterial diseases in humans efficiently. Aside from the treatment of hypertriglyceridaemia, no definitive recommendation can be made about the health benefits of marine oil supplement.

Cardiovascular Diseases↗

PubMed1995

Spindle cell malignant lymphoepithelial lesion of the parotid gland: clinical, light microscopic, ultrastructural, and in situ hybridization findings in one case.

Malignant lymphoepithelial lesions (MLEL) are rare tumors of the salivary glands that show high incidence in Inuit Canadians, Alaskans, and Greenland Eskimos. The tumors are usually anaplastic or poorly differentiated squamous cell carcinomas. Focal spindle cell elements have been rarely reported. The tumors have been epidemiologically linked to Epstein-Barr virus infection. We present a case of malignant lymphoepithelial lesion showing exclusive spindle cell morphology. The patient is a 44-year-old male Inuit Canadian who presented with a long-standing history of a left parotid mass. The mass did not show evidence of rapid growth or facial nerve involvement. Parotidectomy was performed. The tumor was histologically composed of spindle cells nodules in a background of lymphocytes. The spindle cells showed no evidence of cytologic atypia but were mitotically active. Immunohistochemical staining for low-molecular-weight cytokeratin was only focally positive. The differential diagnosis included a mesenchymal neoplasm and malignant lymphoepithelial lesion. Electron microscopic examination confirmed the squamous nature of the neoplasm. Intracytoplasmic viral particles were also identified ultrastructurally. In situ hybridization for Epstein-Barr virus mRNA using a 30-base oligonucleotide probe specific for the EBER-1 gene showed very high level of expression in the tumor cells. No expression was noted in the adjacent parotid gland tissue. Our findings confirm the squamous nature of malignant lymphoepithelial lesions despite the spindle cell morphology occasionally seen in these neoplasms. They also confirm the strong role of Epstein-Barr virus infection in the pathogenesis of these tumors. This may have further diagnostic and therapeutic implications.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1995

[Asymmetry of the human facial nerve].

Measurements of the right and left facial skull were carried out in 6 different series of skulls: two europeoid, Russian and Georgian; two mongoloid, Buryat and Eskimo; and two skulls of mixed origin, Khakass and Udmurt ones, in order to assess the bilateral asymmetry. The measurements included 18 signs characterizing the width, height, and length of the facial skull. Sums of all right-side and left-side signs were the integral parameters of the right and left halves of the facial skull. A compensatory type of asymmetry variations was revealed. All the components of the facial skull regarded individually demonstrate clear asymmetry, whereas the total summary size of both halves of the facial skull is similar. The cause of the symmetrical combination of whole parts in the presence of evident asymmetry of various elements of the facial skull is differently directed asymmetry of various extent. The results are discussed in the context of the evolution of human functions and the relevant transformation of the morphologic structure in the anthropogenesis.

Asian People↗

PubMed1995

HLA-B27 subtypes among the Chukotka Native groups.

The purpose of this study was to assess the relative frequency of the known HLA-B27 subtypes in HLA-B27 positive Chukotka natives, which have higher frequencies of HLA-B27 (to 40%) and spondyloarthropathies (to 2%) than the Russian Caucasian population. Using oligotyping of the polymerase-chain reaction amplified second and third exons of the HLA-B27 gene in 86 DNA samples from HLA-B27 positive individuals were successfully typed. All had HLA-B*2705, including 4 patients with Reiter's syndrome and 5 with ankylosing spondyloarthritis, except one Eskimo who had HLA-B*2702. None had HLA-B*2704, a frequent subtype in Orientals. With respect to HLA-B27 subtypes the indigenous populations from the eastern part of the Chukotka Peninsula are genetically more closely related to Caucasians than to Orientalis.

Alleles↗

PubMed1996

Origin and evolution of Native American mtDNA variation: a reappraisal.

The timing and number of prehistoric migrations involved in the settlement of the American continent is subject to intense debate. Here, we reanalyze Native American control region mtDNA data and demonstrate that only an appropriate phylogenetic analysis accompanied by an appreciation of demographic factors allows us to discern different migrations and to estimate their ages. Reappraising 574 mtDNA control region sequences from aboriginal Siberians and Native Americans, we confirm in agreement with linguistic, archaeological and climatic evidence that (i) the major wave of migration brought one population, ancestral to the Amerinds, from northeastern Siberia to America 20,000-25,000 years ago and (ii) a rapid expansion of a Beringian source population took place at the end of the Younger Dryas glacial phase approximately 11,300 years ago, ancestral to present Eskimo and Na-Dene populations.

Biological Evolution↗

PubMed1996

Obesity, central fat patterning, and their metabolic correlates among the inuit of the central Canadian Arctic.

I report on the occurrence and metabolic correlates of obesity among the Inuit (Eskimos) of the central Canadian Arctic using data from the Keewatin Health Assessment Study conducted during 1990 and 1991 in eight Inuit communities in the Northwest Territories (n = 434, adults aged 18 years and older). Data from the 1990 Manitoba Heart Health Survey among 2200 predominantly white residents of the province of Manitoba were used for comparison. Judging by body mass index and two skinfold thicknesses, obesity among the Inuit is as prevalent as it is in the general North American population. This is a new development over the past two or three decades, the result of rapidly changing physical activity, diet, and lifestyle. Obesity is more prevalent among women, among whom there is also a higher degree of central fat patterning based on the waist-to-hip ratio. When different categories of obesity are compared, blood pressure and one or more of the lipids show an increasing trend but glucose or insulin level shows no significant change. This observation distinguishes the Inuit from other populations. Even where a relationship exists, as with triglyceride and HDL cholesterol levels, the magnitude of the response is lower among the Inuit. The differential effect of obesity on glucose, blood pressure, and lipid levels in the Inuit compared with non-Inuit suggests a type of selective insulin resistance, the underlying mechanism of obesity and several chronic diseases. Inuit metabolism reflects their almost exclusive diet of fat and proteins traditionally. From the public health perspective it is important to monitor and ameliorate the impact of changing diet and physical activity on the prevalence of obesity and associated health effects.

Adolescent↗

PubMed1996

Alaska Native cancer update: incidence rates 1989-1993.

Five-year average annual age-adjusted cancer incidence rates for Alaska Natives (Eskimos, Indians, and Aleuts) for the most recent period (1989-1993) are compared to rates of 20 years earlier. Rates for all cancers combined increased 28 and 25% in men and women, respectively, during the 25-year interval. Increases were seen in men in cancers of the lung, prostate, and colon and in women for cancers of the lung, breast, and corpus uteri. Rates are also compared to data from the the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program for United States whites. Rates for all cancers combined in Alaska Native women are now similar to those of United States whites, whereas rates in Alaska Native men are lower than the United States, but only 10% lower. Significant site-specific differences previously reported between Alaska Natives and United States whites persist.

Alaska↗

PubMed1996

Aboriginal health.

OBJECTIVE: To inform health care workers about the health status of Canada's native people. DATA SOURCES: A MEDLINE search for articles published from Jan. 1, 1989, to Nov. 31, 1995, with the use of subject headings "Eskimos" and "Indians, North American," excluding specific subject headings related to genetics and history. Case reports were excluded. Material was also identified from a review of standard references and bibliographies and from consultation with experts. STUDY SELECTION: Review and research articles containing original data concerning epidemiologic aspects of native health. Studies of Canadian populations were preferred, but population-based studies of US native peoples were included if limited Canadian information was available. DATA EXTRACTION: Information about target population, methods and conclusions was extracted from each study. RESULTS: Mortality and morbidity rates are higher in the native population than in the general Canadian population. The infant mortality rates averaged for the years 1986 to 1990 were 13.8 per 1000 live births among Indian infants, 16.3 per 1000 among Inuit infants, and only 7.3 per 1000 among all Canadian infants. Age-standardized all-cause mortality rates among residents of reserves averaged for the years 1979 to 1983 were 561.0 per 100,000 population among men and 334.6 per 100,000 among women, compared with 340.2 per 100,000 among all Canadian men and 173.4 per 100,000 among all Canadian women. Compared with the general Canadian population, specific native populations have an increased risk of death from alcoholism, homicide, suicide and pneumonia. Of the aboriginal population of Canada 15 years of age and older, 31% have been informed that they have a chronic health problem. Diabetes mellitus affects 6% of aboriginal adults, compared with 2% of all Canadian adults. Social problems identified by aboriginal people as a concern in their community include substance abuse, suicide, unemployment and family violence. Subgroups of aboriginal people are at a greater-than-normal risk of infectious diseases, injuries, respiratory diseases, nutritional problems (including obesity) and substance abuse. Initial data suggest that, compared with the general population, some subgroups of the native population have a lower incidence of heart disease and certain types of cancer. However, knowledge about contributing factors to the health status of aboriginal people is limited, since the literature generally does not assess confounding factors such as poverty. CONCLUSIONS: Canadian aboriginal people die earlier than their fellow Canadians, on average, and sustain a disproportionate share of the burden of physical disease and mental illness. However, few studies have assessed poverty as a confounding factor. Future research priorities in native health are best determined by native people themselves.

Canada↗

PubMed1996

[The "Indian deletion" in the hypervariable segment II of mitochondrial DNA is absent in representatives of the native population of Northeastern Asia].

By means of MspI digestion analysis, a screening of the "Central American" deletion of six base pairs in the position 106-111 bp of the mtDNA control region in samples from native (Asian Eskimos, coastal Chukchi, Koryaks, and Evens) and migrant (Slavic group) inhabitants of northeastern Asia was performed. The absence of a 6-bp deletion in all the studied samples was demonstrated.

Base Composition↗