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At least 1,153 records · Page 64Linked to original sources
PubMed1992

Oral changes in interleukin-2 treated patients: a preliminary report.

Immunotherapy with high doses of interleukin-2 (IL-2) in patients with metastatic cancer is accompanied by multiorgan side effects. To determine the effect of this treatment on oral tissues, 5 cancer patients receiving a course of recombinant IL-2 (rIL-2) were followed. Oral pathology and subjective oral complaints were noted. Whole saliva parameters and routine blood and urine values were recorded daily before, during and after treatment. Mucositis and diminution of salivary flow occurred in all patients. Concomitantly, salivary sodium and protein were elevated.

Adult↗
PubMed2005

Eating disorders and oral health: a review of the literature.

This article is a review of the recent literature pertaining to the oral sequelae of eating disorders (EDs). Dentists are recognized as being some of the first health care professionals to whom a previously undiagnosed eating disorder patient (EDP) may present. However, despite the prevalence (up to 4 per cent) of such conditions in teenage girls and young adult females, there is relatively little published in the recent literature regarding the oral sequelae of EDs. This compares unfavourably with the attention given recently in the dental literature to conditions such as diabetes mellitus, which have a similar prevalence in the adult population. The incidence of EDs is increasing and it would be expected that dentists who treat patients in the affected age groups would encounter more individuals exhibiting EDs. Most of the reports in the literature concentrate on the obvious clinical features of dental destruction (perimolysis), parotid swelling and biochemical abnormalities particularly related to salivary and pancreatic amylase. However, there is no consistency in explanation of the oral phenomena and epiphenomena seen in EDs. Many EDPs are nutritionally challenged; there is a relative lack of information pertaining to non-dental, oral lesions associated with nutritional deficiencies.

Adolescent↗
PubMed2001

Sialometry and sialochemistry: diagnostic tools for Sjögren's syndrome.

BACKGROUND: The common occurrence of xerostomia in Sjögren's syndrome (SS) as well as the easy accessibility of saliva supports the use of sialometry and sialochemistry in the diagnosis of SS. Collection and analysis of whole saliva (oral fluid) is currently the routine technique for sialometry, despite the fact that it is rather inaccurate and impure. OBJECTIVE: To assess the value of glandular sialometry and sialochemistry as diagnostic instruments in SS. METHODS: In a group of 100 consecutive patients referred for diagnosis of SS, glandular secretory flow rates and a spectrum of salivary components (sodium, potassium, chloride, calcium, phosphate, urea, amylase, total protein) were assessed. The patients were classified as positive or negative for SS according to the revised European classification criteria. RESULTS: Patients with SS differed clearly from those who tested negative for SS, showing lower submandibular/sublingual (SM/SL) flow rates and an appreciably changed salivary composition of parotid and SM/SL saliva. Besides changes in salivary flow rate and composition, distinct sialometric profiles were observed, characteristic of either early or late salivary manifestation of SS, or of the xerogenic side effects of medication. CONCLUSIONS: Glandular sialometry and sialochemistry are not only useful tools for differentiating SS from other salivary gland disease in clinical practice, but they also have great potential as diagnostic criteria for SS, showing distinct sialometric and sialochemical changes as well as profiles. Being simple, safe (non-invasive), and sensitive (early disease detection), they have three major advantages over other oral tests for SS.

Adult↗
PubMed1981

Manifestations of parotid gland enlargement: radiographic, pathologic, and clinical correlations. Part I: The autoimmune pseudosialectasias.

Histologic, clinical, and radiographic presentations of the autoimmune salivary gland diseases are reviewed. The punctate and globular sialographic changes observed actually reflect penetration of contrast material through the uniquely diseased glandular ducts and not sialectasis, as was previously thought. "Pseudosialectasis" is suggested as a more accurate term. The progressive cavitary and destructive patterns seen on sialography appear to reflect complications of secondary infection rather than the specific pathology of these diseases. Conditions causing recurrent enlargement of the parotid gland or development of a multinodular gland include chronic sialadenitis, the sialoses, the granulomatous diseases, primary neoplasms, and metastatic tumors. Although they appear similar clinically, many of these diseases can be differentiated sialographically, and such a radiographic approach is presented.

Autoimmune Diseases↗
PubMed1980

Infectious sialodacryoadenitis and rat breeding.

The littering rate of female rats was significantly lowered when they had been exposed to sialodacryoadenitis early in pregnancy. Rats of 8 weeks or more of age were highly susceptible to contact infection, showing marked decrease in bodyweight gain, whereas those of 5-6 weeks of age were resistant.

Animals↗
PubMed1991

Saliva and salivary gland alterations in HIV infection.

HIV-1 infection may involve saliva and the salivary glands. The virus may be recovered from the mouth and anti-viral antibodies are found in saliva. Salivary dysfunction after infection ranges from xerostomia to a Sjogren's syndrome-like condition with persistent glandular enlargement and marked secretory hypofunction.

Acquired Immunodeficiency Syndrome↗
PubMed1995

The impact of gene therapy on dentistry.

To the casual observer, gene therapy--an emerging science--appears likely to have little impact on dentistry. However, even in these early research stages, it is clear that gene therapy will have a broad effect on dentistry. This article is designed to provide the practitioner with a general understanding of gene therapy, as well as several examples of how it is being used today in efforts to manage dental and oral problems better.

Animals↗
PubMed2001

Dental management considerations for the patient with diabetes mellitus.

BACKGROUND: The prevalence of diabetes mellitus, or DM, in the United States is increasing steadily. The increasing longevity of the American population and more effective diagnostic protocols mean that the dental practitioner will be treating an increasing number of patients with the disease. METHODS: The authors present relevant information about DM, including a recently revised nomenclature system, pathophysiology, complications, new diagnostic criteria, medical and dental management considerations, and associated oral conditions. CONCLUSIONS: There are many important medical and dental management issues that dentists should consider when treating patients with DM. CLINICAL IMPLICATIONS: The information presented in this report should help general dentists deliver optimum treatment to patients with DM.

Burning Mouth Syndrome↗
PubMed1978

Some clinical and epizootological observations of infectious sialoadenitis in rats.

Epizootological and clinical observation was made of infectious sialoadenitis ocurring at a rat facility. The disease occurred mostly among animals 8 to 64 weeks of age without specific relevance with sex and age, and clinical signs disappeared within 5 days after the onset. Morbidity rates and duration of epizootics ranged from 13 to 100% and from 5 to 32 days, respectively. Most rats having severe clinical signs of sialoadenitis showed decrease in food uptake, body weight loss and remarkable disorders of estrous cycles.

Animals↗
PubMed2000

[Ultrasonography in the diagnosis of post-pubertal epidemic parotitis and its complications].

PURPOSE: To assess the yield of US in the study of salivary glands and other organs involved in post-pubertal mumps. PATIENTS AND METHODS: We examined 68 patients with serologically proven post-pubertal mumps (age range 14-34 years). All patients were symptomatic, with fever and salivary gland swelling in 25 cases, marked hyperamylasemia in 32, epigastric pain in 9, unilateral scrotal swelling and/or pain in 19 cases and acute bronchitis in 1 case. All patients underwent US of salivary glands, neck lymph nodes, abdomen and scrotum with 48 hours of admission. RESULTS: Salivary glands: Parotid and submandibular glands showed normal echotexture in all patients. The parotid glands also showed multiple hypeoechoic intraparenchymal lymph nodes which were, ovoid or rounded, with smooth margins and a central hyperechoic area, with diameter ranging 3-14 mm (mean 5.4). No intraparenchymal lymph nodes were observed in submandibular glands. Neck: All patients had enlarged submandibular lymph nodes (maximum diameter ranging 5-22 mm; mean 11 mm); swelling was always bilateral and it was symmetric in 19/68 patients (30%) versus asymmetric because of prevailing right side involvement (more numerous and bigger nodes) in the other 47/68 cases (70%). All lymph nodes showed a benign pattern, with an ovoid or elongated shape, homogeneous hypoechoic echotexture and a hyperechoic hilum. Abdomen: The pancreas showed normal volume and normal parenchymal echotexture in all patients. Liver and spleen were always normal. Testes: US showed mild unilateral hydrocele in 10 cases, hydrocele and unilateral swelling of epidymis in 5 cases, hydrocele and swelling of both epidymis and didymis with inhomogeneous echotexture because of intraparenchymal hypeoechoic areas in 2 cases. There were no US changes in 2 cases. CONCLUSIONS: US of the salivary glands shows a specific pattern in post-pubertal mumps which has never been reported for other salivary gland diseases. In contrast US signs in other organs are not specific.

Adolescent↗