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At least 1,171 records · Page 65Linked to original sources
PubMed2004

Derivation and analysis of basic computational operations of thalamocortical circuits.

Shared anatomical and physiological features of primary, secondary, tertiary, polysensory, and associational neocortical areas are used to formulate a novel extended hypothesis of thalamocortical circuit operation. A simplified anatomically based model of topographically and nontopographically projecting ("core" and "matrix") thalamic nuclei, and their differential connections with superficial, middle, and deep neocortical laminae, is described. Synapses in the model are activated and potentiated according to physiologically based rules. Features incorporated into the models include differential time courses of excitatory versus inhibitory postsynaptic potentials, differential axonal arborization of pyramidal cells versus interneurons, and different laminar afferent and projection patterns. Observation of the model's responses to static and time-varying inputs indicates that topographic "core" circuits operate to organize stored memories into natural similarity-based hierarchies, whereas diffuse "matrix" circuits give rise to efficient storage of time-varying input into retrievable sequence chains. Examination of these operations shows their relationships with well-studied algorithms for related functions, including categorization via hierarchical clustering, and sequential storage via hash- or scatter-storage. Analysis demonstrates that the derived thalamocortical algorithms exhibit desirable efficiency, scaling, and space and time cost characteristics. Implications of the hypotheses for central issues of perceptual reaction times and memory capacity are discussed. It is conjectured that the derived functions are fundamental building blocks recurrent throughout the neocortex, which, through combination, gives rise to powerful perceptual, motor, and cognitive mechanisms.

Algorithms↗
PubMed2001

The potential impacts of climate variability and change on health impacts of extreme weather events in the United States.

Extreme weather events such as precipitation extremes and severe storms cause hundreds of deaths and injuries annually in the United States. Climate change may alter the frequency, timing, intensity, and duration of these events. Increases in heavy precipitation have occurred over the past century. Future climate scenarios show likely increases in the frequency of extreme precipitation events, including precipitation during hurricanes, raising the risk of floods. Frequencies of tornadoes and hurricanes cannot reliably be projected. Injury and death are the direct health impacts most often associated with natural disasters. Secondary effects, mediated by changes in ecologic systems and public health infrastructure, also occur. The health impacts of extreme weather events hinge on the vulnerabilities and recovery capacities of the natural environment and the local population. Relevant variables include building codes, warning systems, disaster policies, evacuation plans, and relief efforts. There are many federal, state, and local government agencies and nongovernmental organizations involved in planning for and responding to natural disasters in the United States. Future research on health impacts of extreme weather events should focus on improving climate models to project any trends in regional extreme events and as a result improve public health preparedness and mitigation. Epidemiologic studies of health effects beyond the direct impacts of disaster will provide a more accurate measure of the full health impacts and will assist in planning and resource allocation.

Climate↗
PubMed2002

Development and characterisation of a ceramic HF-resonator for the MR-tomography.

Future trends in magnetic resonance imaging (MRI) lead to higher magnetic field strengths of the static magnetic fields and as an implication of that to much higher frequencies. Nowadays a common model of a send-receive coil is the birdcage resonator. However it is very difficult to find an optimal L/C-relation for the capacities and inductivities at frequencies above 300 MHz. The idea is to build a completely new send-receive resonator without discrete network elements. The solution presented in this work is the development of a fully ceramic resonator with a high dielectric constant (between 30-100) and a low loss factor (tan delta approximately 10(3)). This approach has shown to produce a stable transversal magnetic field at the desired MR-frequencies above 300 MHz.

Artifacts↗
PubMed2006

[Diversity of oviposition containers and buildings where Aedes albopictus and Aedes aegypti can be found].

OBJECTIVE: To assess the diversity of oviposition containers and buildings where females of Aedes albopictus and Aedes aegypti can be found. METHODS: A study was carried out in the city of Rio de Janeiro, Southern Brazil, between 2002 and 2003. Larvae in different types of buildings were investigated, and immature forms found were then sent to the laboratory for identification. The larval frequency for both mosquitoes was estimated in the oviposition containers available. The Breteau index and the building infestation index were calculated and differences were tested using the Chi-square test. RESULTS: The types of buildings that were positive for Aedes albopictus and Aedes aegypti were: dwellings (83.9%); churches, schools, clubs (6.8%); vacant land (6.4%); and businesses (2.8%). Of 9,153 larvae collected, 12.0% were Aedes albopictus and 88.0% were Aedes aegypti. Aedes albopictus were mostly found in drains (25.4%); cans, bottles, empty bottles (23.9%); and plant vases (16.2%). Aedes aegypti was much more frequently found than Aedes albopictus (chi(2)=145.067; p<0.001). Both species were significantly more frequent in artificial than in natural oviposition containers (chi(2)=31.46; p<0.001). The building infestation index and Breteau index for Aedes albopictus were 0.3% and 0.28% in 2002 and 0.4% and 0.5 in 2003, respectively. For Aedes aegypti, they were 1.0%, 1.16 in 2002 and 3.5% and 4.35 in 2003, respectively. CONCLUSIONS: The present study assessed the frequencies of Aedes albopictus and Aedes aegypti females in various types of oviposition containers and types of buildings. The abundant availability of artificial containers in dwellings, associated with the capacity of Ae. albopictus to be also found in natural oviposition containers, has greatly contributed for their gradual adaptation to human environment.

Aedes↗
PubMed1978

Reconstruction of auricular defect with perichondrial graft: a new technique. Case report.

A new technique is introduced to reconstruct defects of the auricle. The neochondrogenic capacity in a free graft of the auricular perichondrium is used to build the cartilaginous framework in the missing part of the auricle. By using local flaps and skin grafts for coverage of the newly formed cartilage the missing part of the auricle is satisfactorily reconstructed.

Adolescent↗
PubMed2003

Gravity and spatial orientation in virtual 3D-mazes.

In order to bring new insights into the processing of 3D spatial information, we conducted experiments on the capacity of human subjects to memorize 3D-structured environments, such as buildings with several floors or the potentially complex 3D structure of an orbital space station. We had subjects move passively in one of two different exploration modes, through a visual virtual environment that consisted of a series of connected tunnels. In upright displacement, self-rotation when going around corners in the tunnels was limited to yaw rotations. For horizontal translations, subjects faced forward in the direction of motion. When moving up or down through vertical segments of the 3D tunnels, however, subjects facing the tunnel wall, remaining upright as if moving up and down in a glass elevator. In the unconstrained displacement mode, subjects would appear to climb or dive face-forward when moving vertically; thus, in this mode subjects could experience visual flow consistent with rotations about any of the 3 canonical axes. In a previous experiment, subjects were asked to determine whether a static, outside view of a test tunnel corresponded or not to the tunnel through which they had just passed. Results showed that performance was better on this task for the upright than for the unconstrained displacement mode; i.e. when subjects remained "upright" with respect to the virtual environment as defined by subject's posture in the first segment. This effect suggests that gravity may provide a key reference frame used in the shift between egocentric and allocentric representations of the 3D virtual world. To check whether it is the polarizing effects of gravity that leads to the favoring of the upright displacement mode, the experimental paradigm was adapted for orbital flight and performed by cosmonauts onboard the International Space Station. For these flight experiments the previous recognition task was replaced by a computerized reconstruction task, which proved to be more efficient in terms of the time required to achieve reliable results. Suppressing gravity did not immediately affect relative performance between the two modes, indicating that on-line graviceptor information is not directly responsible for this differential effect. Trends in the evolution of responses over the course of a 10-day mission, however, suggest that human subjects might adapt their ability to represent internally complex 3D displacements.

Gravitation↗
PubMedDate not supplied

The emerging functionality of endogenous lectins: A primer to the concept and a case study on galectins including medical implications.

Biochemistry textbooks commonly make it appear that it is a foregone conclusion that the hardware of biological information storage and transfer is confined to nucleotides and amino acids, the letters of the genetic code. However, the remarkable talents of a third class of biomolecules are often overlooked. For example, one of them far surpasses the building blocks of nucleic acids and proteins in terms of theoretical coding capacity by oligomer formation. Although often exclusively assigned to duties in energy metabolism, carbohydrates as part of cellular glycoconjugates (glycoproteins, proteoglycans, glycolipids) have, in fact, other important tasks. Currently, they are increasingly gaining recognition as an operative high-density information coding system. An elaborate enzymatic machinery enables cells to be versatile enough to produce a glycan profile (glycome) that is as characteristic as a fingerprint. Moreover, swift modifications during dynamic processes, such as differentiation or malignant transformation, are readily possible. The translation of the information presented in oligosaccharide determinants to biological responses is carried out by lectins. Recognition of foreign glycosignatures in innate immunity, regulation of cell-cell/matrix interactions, cell migration or growth, and intra- and intercellular glycan routing etc represent physiologically far-reaching lectin-carbohydrate functionality. The classification of endogenous lectins is guided by sequence alignments and conservation of distinct structural traits. For example, a jelly-roll-like folding pattern and maintenance of key residue positioning involved in stacking and C-H/pi-interactions as well as directional hydrogen bonds to the 1-galactoside ligands are common denominators among galectins. Biochemical and biophysical studies are beginning to unravel the intricacies of the selection of a limited set of endogenous ligands, such as certain integrins or ganglioside GM1, and combined with biological cell experiments, its relevance for cell sociology, e.g. in growth regulation and tumor cell invasion or activated T cell apoptosis. Histopathological monitoring accompanies the biological cell investigations, linking expression of certain family members to tumor progression or suppression. Further insights into the functional consequences of the sugar code's translation are thus expected to have notable repercussions for diagnostic and therapeutic procedures.

Amino Acid Sequence↗
PubMed1996

HIV risk correlates among non-injection cocaine dependent men in treatment.

Guided by the AIDS Risk Reduction Model (ARRM), psychosocial correlates of HIV risk behavior were examined among noninjection cocaine dependent, heterosexual men (NI-CD-HM) in treatment. Subjects (N = 111) completed a structured interview to measure ARRM mediating variables and HIV risk behaviors. The results indicated that greater perceived susceptibility to contracting HIV, lower sexual self-efficacy, higher lifetime incidence of sexually transmitted diseases, and being under the influence of alcohol or other drugs during sex predicted having more sexual partners in the month prior to admission. Despite adequate knowledge of safer sex guidelines, subjects remained misinformed regarding certain aspects of HIV transmission. Men who perceived that their partners viewed condoms more positively and who exchanged drugs for sex were more likely to use condoms, yet condom use skills were typically inadequate to ensure effective prevention. These results suggest that HIV prevention interventions among NI-CD-HM should focus on improving knowledge, enhancing beliefs in the capacity to enact safer sex behaviors for preventing HIV and other STDs, building relevant skills (e.g., condom use, open sexual communication between partners), and emphasizing psychoactive substance abstinence. Couple interventions, in which partners actually rehearse safer sex negotiations, may be particularly effective in this regard.

Acquired Immunodeficiency Syndrome↗