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PubMed1993

Attitudinal and behavioral characteristics of older Floridians with tooth loss.

In this cross-sectional study of Floridians aged 65 yr or older, 600 persons were interviewed to identify the characteristics of individuals who survived into old age with an intact or nearly intact dentition. Persons with total or partial tooth loss reported less frequent dental care, less ability to pay dental care fees, less frequent dental hygiene, and were more likely to have been smokers or diabetic. Persons with tooth loss also had less positive attitudes toward dentists and dental care. These cross-sectional findings are consistent with tooth loss being the result of disease-, behavior-, and attitude-related causes, and/or their interactions. Tobacco use, diabetes, and infrequent oral hygiene and dental care may increase risk for dental disease; decreased ability to pay for dental treatment may impair utilization of non-extraction treatment options, and negative attitudes toward dental treatment may influence the desire for non-extraction treatment options. Research targeted toward modifying attitudes toward dental treatment may be useful in preventing or delaying tooth loss, and measurement of attitudes may be a useful way to identify individuals at the greatest risk for tooth loss for intervention studies.

Aged↗

PubMed1996

Salivary flow and risk of tooth loss in an elderly population.

To investigate the relationship between salivary flow and tooth loss, 818 randomly selected dentate people aged 65 and older and living in North Carolina were administered a dental health interview and examination. A single paraffin-stimulated whole saliva sample of 3 ml was collected and flow rate was calculated. Three years later, 490 people were re-examined and tooth loss was determined. Thirty-five percent of the participants had salivary flow rates of 1.0 ml/min or less at baseline and 41% lost at least one tooth over the 3-yr follow-up. A logistic regression model controlling for marital status, race, and socioeconomic status showed that those with low salivary flow were more likely to lose at least one tooth during the 3-yr study period than were those with normal flow (odds ratio = 1.52, 95% CI = 1.02-2.24). Results from this representative study of community-dwelling older adults support the concept that compromised salivary flow is related to tooth loss. This finding should be considered in the management and prevention of oral diseases.

Age Factors↗

PubMed1989

Patterns of expression of intermediate filaments in ameloblastoma and human fetal tooth germ.

Monoclonal antibodies (Mab) were used to study the expression of cytokeratins and vimentin in various histological types of ameloblastoma and in human fetal tooth germ. The ameloblastoma and the tooth germ epithelia showed characteristics of both simple glandular and stratified squamous epithelial cells. Cytokeratin No. 18 was detected focally in most ameloblastomas studied but not in fetal odontogenic epithelia. Cytokeratins Nos. 8 and 19 were expressed in all epithelial elements of ameloblastomas and tooth germs. Only two tumors showed focally characteristics of keratinizing epithelia also seen in dental lamina but not in the enamel organ. All tumors except the granular cell ameloblastoma showed a variable coexpression of vimentin and cytokeratins in their neoplastic epithelia. A similar coexpression was detected in the stellate reticulum cells of the developing tooth. Ameloblastoma and human tooth germ epithelia share complex pattern of cytokeratin polypeptides together with coexpression of vimentin. The results strongly support the theory that ameloblastomas are of odontogenic origin and not direct derivatives of basal cells of oral epithelium or epidermis.

Adolescent↗

PubMed1984

Histology, innervation and radiographic appearance of fetal rat tooth germs developing in oculo.

Rat molar and incisor tooth germs from gestational days 18-21 were homologously grafted to the anterior eye chamber of adult recipients. The fetal tooth transplants survived and grew considerably in the eye, attached to and vascularized from the anterior surface of the host iris. Grafts were examined histologically and compared with in situ controls after up to 6 months in oculo. Radiographic examinations of the grafts showed a normal rate of mineralization and a distinct enamel/dentin border after intraocular development. The size of the tooth grafts was somewhat smaller than in situ but the grafted teeth attained a form much resembling in situ incisors and molars. Light microscopy revealed a regular dentin and predentin, a distinct dentin/enamel border and a well innervated and vascularized pulp. No degenerative changes in dentin or enamel layers could be found in long-term grafts (6 months). Thus, intraocular tooth grafts in rats develop many histologic and anatomic features typical of normal teeth, emphasizing the importance of intrinsic regulatory mechanisms in tooth development.

Animals↗

PubMed1997

Erosive tooth wear: prevalence and severity in Swedish winetasters.

Full-time Swedish winetasters test on average 20-50 different wines, nearly 5 days a week. As the pH of wines ranges from 3.0 to 3.6, there is a potential risk for tooth erosion. The aims of this study were to document the prevalence and severity of tooth erosion in qualified winetasters in relation to number of years of winetasting, salivary flow rate, and buffer capacity. The subjects comprised all 19 qualified winetasters (7 women and 12 men, aged 29-64 years employed in Stockholm by Vin & Sprit AB, the state-owned company marketing wines and spirits. At intraoral examination, tooth surface loss was registered and documented by photography. Salivary flow rate and buffer capacity of unstimulated and stimulated saliva were measured. Data on occupational background and dental and medical histories were collected. Fourteen subjects had tooth erosion, the severity varying from mild to extreme, mainly on the labio-cervical surfaces of maxillary incisors and canines. The severity of the erosion tended to increase with years of occupational exposure. Caries activity in all subjects was low. 14 subjects had low unstimulated salivary flow rates. It was concluded that full-time winetasting is an occupation associated with increased risk for tooth erosion.

Adult↗

PubMed2006

Immunohistochemical localization of transcription factor Sp3 during dental enamel development in rat tooth germ.

Sp3, a member of the Sp family of transcription factors, has previously been thought to be ubiquitously expressed, and its expression pattern in tooth development is not clear. This study was carried out to investigate the immunolocalization of Sp3 during the development of rat tooth germs. Sprague-Dawley rats at ages of 1, 3, 7, 10, and 14 d were used to represent different stages of tooth development. First mandibular molar tooth germs were sectioned and studied by immunohistochemistry. Sp3 was found to be localized within the nuclei of cells in developing tooth germs; however, ameloblast nuclei showed variable intensities at different developmental stages. At the same time, the positive signals in odontoblast nuclei remained stable. The results suggest that Sp3 may play a role in the development of teeth, specifically in the transcription of enamel-specific genes.

Ameloblasts↗

PubMed2006

Effects of aging on RANKL and OPG levels in gingival crevicular fluid during orthodontic tooth movement.

OBJECTIVES: To compare the levels of the receptor activator of NFkB ligand (RANKL) and osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) during orthodontic tooth movement in juvenile and adult patients. DESIGN: Fifteen juveniles and 15 adults served as subjects. GCF was collected from the distal cervical margins of the experimental and control teeth at 0, 1, 24, and 168 h after application of a retracting force. Enzyme-linked immunosorbent assay kits were used to determine RANKL and OPG levels in the GCF samples. RESULTS: The amount of tooth movement for juveniles was larger than for adults after 168 h. Further, after 24 h RANKL levels were increased and those of OPG decreased in GCF samples from the compression side during orthodontic tooth movement in both juveniles and adults. The RANKL/OPG ratio in GCF from adult patients was lower than that in the juvenile patient samples. CONCLUSION: Our results suggest that the age-related decrease in amount of tooth movement may be related to a decrease in RANKL/OPG ratio in GCF during the early stages of orthodontic tooth movement.

Adolescent↗

PubMed2005

Managing congenitally missing lateral incisors. Part III: single-tooth implants.

UNLABELLED: Three treatment options exist for the replacement of congenitally missing lateral incisors. They include canine substitution, a tooth-supported restoration, and a single-tooth implant. Selecting the appropriate treatment option depends on the malocclusion, anterior relationship, specific space requirements, and condition of the adjacent teeth. The ideal treatment is the most conservative option that satisfies individual esthetic and functional requirements. Today, the single-tooth implant has become one of the most common treatment alternatives for the replacement of missing teeth. This article closely examines the many interdisciplinary issues that arise when treatment planning the placement of single-tooth implants in patients with congenitally missing lateral incisors. The specific criteria that must be evaluated illustrate the importance of an interdisciplinary treatment approach to achieve optimal esthetics and long-term predictability. This is the final article of a three-part series discussing the three treatment alternatives for replacing congenitally missing lateral incisors. CLINICAL SIGNIFICANCE: When treatment planning single-tooth implants to replace congenitally missing lateral incisors, an interdisciplinary approach is necessary to provide the most predictable treatment outcome.

Age Factors↗

PubMed2005

Age and perception of dental appearance and tooth colour.

OBJECTIVES: To determine the prevalence of satisfaction with dental appearance and own tooth colour in the UK and investigate the impact of ageing on these perceptions. METHODS: Data about ageing and satisfaction with dental appearance and tooth colour was gathered by means of a questionnaire completed at face-to-face interview. The questionnaire was first tested and then used by the Office of National Statistics (ONS) in a stratified random sample of adults drawn from the UK. A total of 3384 adults were interviewed. RESULTS: Three quarters of the population were satisfied with their own dental appearance and two-thirds were satisfied with their tooth colour. Subjects over the age of 55 were significantly more likely to be satisfied with their dental appearance and tooth colour (p < 0.05) compared with younger age groups. CONCLUSIONS: Ageing is not necessarily associated with negative self-perception of dental appearance or tooth colour. Greater dissatisfaction with dental appearance or colour in younger ages may suggest that perceived appearance is linked to cognitive factors other than social or cultural ones.

Adolescent↗

PubMed1982

The influence of vascular beta-adrenoceptors on the position and mobility of the rabbit incisor tooth.

The influence of vascular beta-adrenoceptors on the tooth-supporting functions of the periodontal ligament were studied in 30 anesthetized rabbits. Propranolol and the beta 2-adrenoceptor antagonists ICI 118,551 and H 35/25 induced a marked extrusion of the incisor, probably due to reduced vasodilator tone in periodontal postcapillary blood vessels. Isoprenaline reversed the movement. beta 1- and beta 2-receptor antagonists decreased the intrusive responses to sympathetic nerve stimulation in teeth close to control position, but had no effect on responses in fully extruded teeth. Intrusive mobility, as tested by intermittent loading with 5-10 g, remained unaffected by beta-adrenoceptor blockade. The results suggest that vascular beta 2-adrenoceptors are important in the regulation of tooth position by their control of periodontal postcapillary resistance. Prejunctional beta-receptors enhancing the vasoconstrictor--and intrusive--responses to sympathetic nerve stimulation are probably a mixture of beta 1- and beta 2-receptors. It would seem that the periodontal vasculature is important for the position of the rabbit tooth but, due to rapid adaptive mechanisms of the tooth-supporting tissues, the vasculature contributes little to the resistance against load-induced intrusive movements of the tooth.

Adrenergic beta-Antagonists↗

PubMedDate not supplied

Prevalence and demographic correlates of tooth loss among the elderly in the United States.

The aging of the United States population and the contribution of tooth loss to oral health make it important to describe tooth loss among the elderly in this country. Data from the National Survey of Oral Health in US Employed Adults and Seniors: 1985-1986, conducted by the National Institute of Dental Research, were analyzed to examine the prevalence and demographic correlates of tooth loss among the elderly. Results show that there were important differences in tooth loss among subgroups of the elderly sample (overall n = 5,649 persons aged 65+ years attending senior centers). The oldest seniors and those with the least education or income were the most likely to be edentulous. The oldest dentulous seniors, blacks, those with the least education or income, and those who lived in New England or the Northeast had the fewest number of teeth present. These findings suggest that efforts to reduce tooth loss among the elderly should target those with the least education and income.

Age Distribution↗

PubMed1999

New horizons in understanding early tooth development.

Information on the mechanism that governs tooth shape, size, and location in the developing jaw is sparse. One hypothesis holds that exogenous signals from the ectomesenchyme and epithelium of the embryonic jaw induce a specific pattern of cellular development that leads to tooth formation. A second hypothesis is that a specific tooth type develops from select clones of cells. The objective of this review is to consider these ideas in light of recent studies on genes that regulate embryonic patterning. Special attention is directed at the notion that there is restricted expression of specialized genes. These genes are expressed in overlapping domains along the jaw axis. Genes expressed within a region provide a unique homeobox code that serves to specify a tooth type and ultimately determines tooth form and position in the developing jaw. Expression of this genetic 'bar code' is carefully controlled by the dental epithelium, neural crest-derived cells, and growth factors. The latter agents also probably serve as epithelial signals that activate events that lead to odontogenic differentiation and morphogenesis.

Animals↗

PubMed2003

An advanced approach for computer modeling and prototyping of the human tooth.

This paper presents a systematic and practical method for constructing accurate computer and physical models that can be employed for the study of human tooth mechanics. The proposed method starts with a histological section preparation of a human tooth. Through tracing outlines of the tooth on the sections, discrete points are obtained and are employed to construct B-spline curves that represent the exterior contours and dentino-enamel junction (DEJ) of the tooth using a least square curve fitting technique. The surface skinning technique is then employed to quilt the B-spline curves to create a smooth boundary and DEJ of the tooth using B-spline surfaces. These surfaces are respectively imported into SolidWorks via its application protocol interface to create solid models. The solid models are then imported into Pro/MECHANICA Structure for finite element analysis (FEA). The major advantage of the proposed method is that it first generates smooth solid models, instead of finite element models in discretized form. As a result, a more advanced p-FEA can be employed for structural analysis, which usually provides superior results to traditional h-FEA. In addition, the solid model constructed is smooth and can be fabricated with various scales using the solid freeform fabrication technology. This method is especially useful in supporting bioengineering applications, where the shape of the object is usually complicated. A human maxillary second molar is presented to illustrate and demonstrate the proposed method. Note that both the solid and p-FEA models of the molar are presented. However, comparison between p- and h-FEA models is out of the scope of the paper.

Anatomy, Cross-Sectional↗

PubMed2004

Encoding of amplitude and rate of tooth loads by human periodontal afferents from premolar and molar teeth.

Microneurographic recordings were obtained from 20 periodontal mechanoreceptive afferents in the inferior alveolar nerve while force profiles of different amplitudes and rates were applied to a premolar or the first molar in the most sensitive direction. The majority of afferents (17/20) showed a hyperbolic relationship between the steady-state discharge rate and the amplitude of the stimulating force, featuring a pronounced saturation tendency. These afferents were also characterized by a similar decline in dynamic sensitivity with increasing amplitude of background force. However, a few afferents (3/20) showed nearly linear stimulus-response relationships and a small decline in dynamic sensitivity with increasing tooth load. Quantitative models developed for all afferents successfully predicted the afferent discharge rates for novel force stimulations. Application of the transfer function to chewing forces predicted that the discharge rates of periodontal afferents rapidly increased at initial tooth contact and continued to discharge as long as the tooth was loaded. However, due to the marked saturation tendencies at higher forces, most periodontal afferents poorly encoded the magnitude of the strong chewing forces. In addition, the discharge rates of a minority of afferents continued to reflect the force profile during high chewing forces. The results revealed that periodontal afferents of posterior teeth were less sensitive at low tooth loads compared with afferents of anterior teeth. During each chewing cycle, periodontal afferents may provide information about the mechanical properties of food shortly after tooth contact that can be used to scale the muscle commands of the upcoming power phase.

Action Potentials↗

PubMedDate not supplied

A caries susceptibility classification of tooth surfaces by survival time.

Individual tooth surfaces have vastly different susceptibilities to caries and this susceptibility also varies over time. The aim of this study was to develop a method of grouping tooth surfaces into a caries susceptibility classification based on their survival experience. The data used in the study were from a 3-year caries clinical trial. The definition of survival time was taken to be the time from the start of the trial to when a surface is recorded as decayed or filled. Cluster analysis was used to divide the tooth surfaces into groups in such a way that surfaces in the same group have similar survival time distributions. The 13 groups identified were ordered from 1 to 13 starting with the group with the shortest survival time, i.e. the occlusal surfaces of the four first molars. Approximately 80% of symmetrical pairs of tooth surfaces were in the same group. The groups obtained using cluster analysis were compared to groups defined using dental/anatomical criteria. It is concluded that the cluster analysis method developed for grouping the tooth surfaces cn provide a useful descriptive measure of caries susceptibility which can be applied to data from any longitudinal study of caries.

Child↗

PubMed1996

Salivary factors in vomiting bulimics with and without pathological tooth wear.

The increased occurrence of dental erosion from self-induced vomiting in bulimia nervosa is not linearly associated with the frequency or the duration of vomiting. Possible changes in the buffering and lubricating role of saliva in bulimia nervosa and their relationship to erosion have not been previously investigated. Chewing-gum-stimulated salivary flow rate, pH, bicarbonate concentration and viscosity were compared between two groups of vomiting bulimics and with 10 healthy controls. One bulimic group (n = 9) had pathological tooth wear present according to the criteria of the Tooth Wear Index and the other bulimic group (n = 10) did not. The influence of salivary pellicle on enamel acid dissolution by perchloric acid was also assessed by an enamel biopsy method. Bicarbonate was measured in a Natelson microgasometer. Both the bulimic groups had mean initial 3-min flow rates and overall 9-min flow rates significantly lower (p < 0.01) than the healthy subjects. The mean pH values were not significantly different between the two bulimic groups or the control group. However, the mean bicarbonate concentration in both bulimic groups was significantly less (p < 0.01) than in the control group. The mean salivary viscosity of 7.4 centipoise (cP), measured by a DV1 Brookfield viscometer, was significantly greater (p < 0.05) in the pathological tooth-wear-present group than in the tooth-wear-absent group (4.5 cP) and the control group (4.1 cP). Slightly more calcium was released from the pellicle-free surface in both groups but this was not statistically significant, whilst the dissolved calcium in enamel biopsies was significantly lower (p < 0.05) in the tooth-wear-present group.

Adult↗

PubMed2004

Gender differences in the relationship between periodontal disease, tooth loss, and atherosclerosis.

BACKGROUND AND PURPOSE: Males carry a disproportionate burden of cardiovascular disease. Because males also bear a higher burden of periodontal disease, we investigated the existence of gender differences in the postulated relationship between periodontal infections, tooth loss, and subclinical atherosclerosis. METHODS: A total of 1710 randomly enrolled participants between the ages of 45 and 75 with no history of myocardial infarction or stroke received a clinical periodontal examination, carotid scan using high-resolution B-mode ultrasound, and extensive measurements for conventional cardiovascular risk factors (age, education, smoking, alcohol, body mass index, diabetes, systolic blood pressure, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, and triglycerides) as well as markers of healthy lifestyle and social network. RESULTS: In both genders, measures of current and long-term periodontitis worsened as tooth loss increased. In males but not females, an approximately 10% difference in carotid artery plaque prevalence was observed between the lowest and highest tertiles of tooth loss (P<0.05) and long-term periodontitis (P=0.05) after multivariate adjustment. Similar patterns were observed for intima-media thickness. The influence of gender on carotid artery plaque prevalence was most evident among the younger age group (<59 years). Between genders, carotid plaque prevalence differed by 10%, 15%, and 25% across increasing levels of tooth loss, and by 5%, 15%, and 25% across increasing levels of long-term periodontitis. CONCLUSIONS: Our data suggest that tooth loss and long-term periodontitis are related to subclinical atherosclerosis in men but not women. Gender variations in cardiovascular morbidity or mortality may be explained partly by the differential contributions of novel risk factors across genders.

Aged↗

PubMed2000

Inhibition of Wnt signaling by exogenous Mfrzb1 protein affects molar tooth size.

Wnt extracellular signaling molecules have essential roles as regulators of cell proliferation, migration, differentiation, and in epithelial-mesenchymal interactions involved in tissue morphogenesis. Frizzled integral membrane proteins have been shown to function as receptors for Wnt signaling molecules. Vertebrates also produce secreted proteins related to Frizzled receptors, Frizzled-related proteins (FRPs), which contain the cysteine-rich domain of Frizzleds and appear to function as Wnt antagonists. Tooth development is regulated by a reciprocal series of epithelial-mesenchymal interactions, and many Wnt signaling pathway genes are expressed in the developing tooth at these sites. Here we report the expression of one FRP gene, Mfrzb1, in the rostral mesenchyme of the mandibular primordium. Using explant cultures, we show that expression of Mfrzb1 in the mandibular mesenchyme is under the control of signals derived from the overlying epithelium. Bead implantation experiments in vitro show that FGF8 induces Mfrzb1 expression, whereas BMP4 and SHH proteins have no effect. We studied the effect of ectopic MFrzb1 protein on the developing tooth germs by transplanting explants treated with Mfrzb1 protein into renal capsules, and found it to retard tooth development. This suggests that Wnt signaling is required early in tooth germ formation and that interference with signaling via addition of an antagonist results in retarded development and formation of smaller teeth.

Animals↗