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At least 1,171 records · Page 65Linked to original sources
PubMed1994

Pattern of expression of five alternative transcripts of the lck gene in different hematopoietic malignancies: correlation of the level of lck messenger RNA I B with the immature phenotype of the malignancy.

The lck gene encodes a tyrosine protein kinase of the src family which is highly expressed in T-lymphocytes. Two widely separated promoters govern expression of the lck gene. We report in this study that alternative splicing between cryptic donor and acceptor sites in the 5' untranslated region of the transcripts initiated at the type I promoter give rise to three different type I lck mRNAs, I A, I B, and I C. Altogether with the types II A and II B reported previously, the lck transcription is thus characterized by five alternative transcripts. We further used the complementary DNA-polymerase chain reaction assay to describe the pattern of expression of these five lck transcripts in different hematopoietic cell lines and in blood or bone marrow samples from healthy donors and leukemic patients. We report that the transcript II A is by far the major transcript present both in human samples and in T-cell lines. The low lck expression in B-cell lines is characterized by the quite exclusive presence of the transcript I B. We show that hematopoietic diseases characterized by the presence of immature cells [acute myeloid leukemia (AML-0 and AML-1) and T- and B-cell acute lymphoid leukemia] exhibit a marked increase of the transcript I B. No significant difference from the normal pattern is observed in AML according to the differentiation stage (AML-2 to AML-5). A normal pattern of lck expression is restored in AML-0 and AML-1 patients at complete remission.

Adolescent↗
PubMed1993

[Polypoid malignant melanoma. An aggressive, seldom observed variant of nodular malignant melanoma].

We describe a 54-year-old man with a polypoid melanoma. The tumour had developed within 1 year. Physical examination showed an eroded pedunculated nodule approximately 2.5 x 3 cm in size. Histopathology revealed a pedunculated, sharply demarcated tumour with an eroded surface; it was composed of atypical melanocytes in sheets and nests. Physical examination 11 months after excision of the tumor with 3-cm safety margin disclosed no evidence for enlarged lymph nodes or cutaneous metastases. No metastases were seen on computer tomography. To our knowledge, this patient represents the first case of polypoid melanoma reported in the German literature.

Biopsy↗