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PubMedDate not supplied

Annotation: care of children in hospital. The European Association for Children in Hospitals.

The Charter for Children in Hospitals, drawn up by professional and women's groups from a number of European countries at the First Conference for the Care of Children in Hospital (Netherlands 1988) presents many fine guidelines for protecting the rights of children and their parents before, during and after hospitalization. The development of these guidelines, their current acceptance in Europe and the psychological principles underlying them, are outlined here.

Child↗
PubMed2006

Nuclear receptors of the honey bee: annotation and expression in the adult brain.

The Drosophila genome encodes 18 canonical nuclear receptors. All of the Drosophila nuclear receptors are here shown to be present in the genome of the honey bee (Apis mellifera). Given that the time since divergence of the Drosophila and Apis lineages is measured in hundreds of millions of years, the identification of matched orthologous nuclear receptors in the two genomes reveals the fundamental set of nuclear receptors required to 'make' an endopterygote insect. The single novelty is the presence in the A. mellifera genome of a third insect gene similar to vertebrate photoreceptor-specific nuclear receptor (PNR). Phylogenetic analysis indicates that this novel gene, which we have named AmPNR-like, is a new member of the NR2 subfamily not found in the Drosophila or human genomes. This gene is expressed in the developing compound eye of the honey bee. Like their vertebrate counterparts, arthropod nuclear receptors play key roles in embryonic and postembryonic development. Studies in Drosophila have focused primarily on the role of these transcription factors in embryogenesis and metamorphosis. Examination of an expressed sequence tag library developed from the adult bee brain and analysis of transcript expression in brain using in situ hybridization and quantitative RT-PCR revealed that several members of the nuclear receptor family (AmSVP, AmUSP, AmERR, AmHr46, AmFtz-F1, and AmHnf-4) are expressed in the brain of the adult bee. Further analysis of the expression of AmUSP and AmSVP in the mushroom bodies, the major insect brain centre for learning and memory, revealed changes in transcript abundance and, in the case of AmUSP, changes in transcript localization, during the development of foraging behaviour in the adult. Study of the honey bee therefore provides a model for understanding nuclear receptor function in the adult brain.

Amino Acid Sequence↗
PubMed2006

Genes of the antioxidant system of the honey bee: annotation and phylogeny.

Antioxidant enzymes perform a variety of vital functions including the reduction of life-shortening oxidative damage. We used the honey bee genome sequence to identify the major components of the honey bee antioxidant system. A comparative analysis of honey bee with Drosophila melanogaster and Anopheles gambiae shows that although the basic components of the antioxidant system are conserved, there are important species differences in the number of paralogs. These include the duplication of thioredoxin reductase and the expansion of the thioredoxin family in fly; lack of expansion of the Theta, Delta and Omega GST classes in bee and no expansion of the Sigma class in dipteran species. The differential expansion of antioxidant gene families among honey bees and dipteran species might reflect the marked differences in life history and ecological niches between social and solitary species.

Amino Acid Sequence↗
PubMedDate not supplied

Annotation. Recent biochemical and immunological observations in multiple sclerosis.

As there is evidence of early biochemical and histological changes in the normal-appearing white matter in MS, which appear to be independent of or precede demyelination, the formation of plaques may be incidental to a more primary lesion. The finding of persistently increased levels of IgG in the CSF of patients with MS points to an ongoing immune reaction in the CNS, possible against an infective agent; but virus-specific antibodies account for only a small proportion of IgG in the CSF. Furthermore, in vitro assays of T cell function suggest that there may be a regulator T cell defect in MS. Salk and colleagues (1980) have postulated that MS may be a disorder, attributable to multiple inducing agents, which is potentiated through deregulation of lymphocyte function.

Animals↗
PubMedDate not supplied

Annotation. Action of pyrethroid insecticides on the vertebrate nervous system.

The neurotoxic action of the synthetic pyrethroid insecticides has received much interest in recent years, as the number of available pyrethroids and their practical applications have greatly increased. Although the majority of pyrethroids have a low oral toxicity to mammals, they may cause severe neurotoxic symptoms whenever they reach the nervous system in sufficient amount. The principal effect of pyrethroids in the vertebrate nervous system is to induce repetitive activity, particularly in the sensory nervous system. This repetitive activity originates from a prolongation of the transient increase in sodium permeability of the nerve membrane associated with excitation. Available evidence indicates that pyrethroids primarily interfere with the sodium channels in the nerve membrane. All active pyrethroids affect sodium channel gating in a similar manner, but marked differences in neurotoxic activity exist between the various pyrethroids, especially between alpha-cyano and non-cyano compounds.

Animals↗
PubMed1990

Annotation: recent life events and psychiatric disorder in school age children.

Life events research in school age children using semi-structured interview techniques has only just begun. The advantages, however, for investigating the role of events and difficulties in children's lives outweigh the problems of data collection and training involved in the technique. Improving the collection of information also improves sensitivity at the level of measurement through a consideration of the personal meaning of social experiences. It is already apparent that recent undesirable life events effects of some importance in the genesis of anxious and depressive disorders in school age children. Investigating the social origins of emotional and behavioural disorders, and determining the role of recent social factors in the course and outcome of these conditions, will be substantially advanced by the application of these techniques in future studies.

Adolescent↗
PubMed1991

Annotation: trichotillomania.

In spite of intriguing new information about trichotillomania, the most basic information about its prevalence, natural history, and treatment is lacking. While there is evidence that trichotillomania is more common than expected, epidemiological data are needed to establish the true frequency and pattern of associated disorders, and cross-cultural work would also be of great interest. The natural history of the disorder remains uncertain, although there are apparently both chronic and remitting forms, which may differ in age of onset and sex distribution. Finally (as with obsessive compulsive disorder), the relative effectiveness, and long-term benefits, of behavioral and drug treatments are not established. Child psychologists, psychiatrists and pediatricians need to be more aware of this disorder, as the misery from trichotillomania has been greatly under-recognized, and continued research could extend our understanding of developmental psychopathology.

Child↗