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Results for “Models, Theoretical”

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PubMed2003

Readiness for anger management: clinical and theoretical issues.

Anger management methods are a common and successful feature of contemporary cognitive behavioral therapy. Meta-analyses and narrative reviews of the outcome of anger management have been broadly supportive of the view that it is an effective approach. We argue in this paper that an important impediment to the future success of anger management is the failure to fully address the issue of treatment readiness. We discuss distinctive features of anger that make readiness a more important issue than it is for other problem emotions and affects. Relevant theoretical models of readiness are discussed and we review the components of a lack of readiness, including difficulties in establishing a therapeutic alliance. Progress in this area requires greater attention to the measurement and analysis of readiness, to its inclusion as an independent variable in outcome studies and to its clinical modification when readiness is low.

Affect↗

PubMed2003

Untying a Lancastrian bundle: valuing ecosystems and ecosystem services for wetland mitigation.

A utility-theoretic model indicates that mitigation prices for wetland ecosystems depend on preferences and technical knowledge. Empirical analysis found gaps in respondents' knowledge about such ecosystems. Valuing wetland types requires dealing with respondents' possible misinformation, by developing tools for informing respondents or by combining service-based valuations with valid technical data.

Conservation of Natural Resources↗

PubMed2001

Quantification of flow rates using harmonic grey-scale imaging and an ultrasound contrast agent: an in vitro and in vivo study.

It is unclear if the dye-dilution theory and its corresponding parameters are capable of measuring brain perfusion using harmonic grey-scale imaging. We performed a study on a flow phantom using a SONOS 5500 (1.8--3.6-MHz harmonic imaging) and Levovist as the ultrasound (US) contrast agent (UCA). We applied the UCA in six different doses (0.1 to 3.0 mL) and used eight different flow-rates (180 to 540 mL/min). Additionally, we performed a study on dog brain using Levovist boluses of 1.5 mL and 3 mL. We evaluated the influence of dose and flow-rate on the parameters of the time-intensity curve: peak signal intensity (PSI), area under the curve (AUC) and mean transit time (MTT). Along with an increase of the Levovist dose, the AUC and the PSI increased only in the dose range between 0.1 and 0.5 mL Levovist; further increase led to no change of parameters. Flow-rate showed no influence on AUC, MTT or PSI. The dye-dilution theory is not a useful theoretical model for the analysis of perfusion using harmonic grey-scale imaging. A possible explanation for this effect is the bubble saturation.

Analysis of Variance↗

PubMed1998

In situ measurements of Doppler power vs. flow turbulence intensity in red cell suspensions.

Whereas previous studies have shown that ultrasonic backscatter and Doppler power from blood are affected by flow turbulence, turbulence level has only been inferred from the flow Reynolds number and not directly measured. In this study, both ultrasonic Doppler power and flow turbulence intensity were measured in situ to quantify the relationship between Doppler power and flow turbulence. Three grid meshes of different geometries were used in a steady-flow mock loop to generate controlled levels of flow turbulence in porcine red blood cell saline suspensions. Doppler power was measured by a 10-MHz PW Doppler flowmeter, and the turbulence intensity by using constant-temperature hot film anemometry. We showed that Doppler power is affected by turbulence and hematocrit in a complex way. At a fixed hematocrit, Doppler power increases nonlinearly with turbulence intensity and, at fixed turbulence intensity, Doppler power peaks at an optimal hematocrit level that increases with turbulence level. The shape factor, introduced by Lucas and Twersky (1987) to take into account effects of shape and orientation of the scatterers in a dense distribution of small and tenuous scatterers, was estimated by fitting the experimental data to the theoretical model. The results indicate that shape factor decreases with increasing turbulence intensity.

Animals↗

PubMed1998

Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics.

Shear wave elasticity imaging (SWEI) is a new approach to imaging and characterizing tissue structures based on the use of shear acoustic waves remotely induced by the radiation force of a focused ultrasonic beam. SWEI provides the physician with a virtual "finger" to probe the elasticity of the internal regions of the body. In SWEI, compared to other approaches in elasticity imaging, the induced strain in the tissue can be highly localized, because the remotely induced shear waves are attenuated fully within a very limited area of tissue in the vicinity of the focal point of a focused ultrasound beam. SWEI may add a new quality to conventional ultrasonic imaging or magnetic resonance imaging. Adding shear elasticity data ("palpation information") by superimposing color-coded elasticity data over ultrasonic or magnetic resonance images may enable better differentiation of tissues and further enhance diagnosis. This article presents a physical and mathematical basis of SWEI with some experimental results of pilot studies proving feasibility of this new ultrasonic technology. A theoretical model of shear oscillations in soft biological tissue remotely induced by the radiation force of focused ultrasound is described. Experimental studies based on optical and magnetic resonance imaging detection of these shear waves are presented. Recorded spatial and temporal profiles of propagating shear waves fully confirm the results of mathematical modeling. Finally, the safety of the SWEI method is discussed, and it is shown that typical ultrasonic exposure of SWEI is significantly below the threshold of damaging effects of focused ultrasound.

Acoustics↗

PubMed1997

Internal regulation of a modular system: the different faces of internal control.

The living cell houses a multitude of molecular processes that operate simultaneously in a mutually consistent fashion. A certain degree of organization stands out, e.g. in terms of the various metabolic pathways, transcription versus translation, signal transduction versus metabolism. This paper shows that by taking one of the aforementioned organizational principles into account, the complexity of understanding cell function quantitatively may be reduced significantly. To this aim the definition of the corresponding type of organization is refined and the conceptual tools used in the analysis of the control of cell function are adjusted. The approach is elaborated for a theoretical model of cell function, in which the latter depends on a constellation of interdependent but unconnected modules. The organization of a system is reduced to global control within a limited set of partaking modules and the links between them. Information about the systems total internal control and regulability is then drastically reduced to the information specifying global control and the regulability of the pathways that constitute the system. It is shown quantitatively how control at a lower level of organization bears on the control of the cell as a whole. The approach centers on writing the product of control (matrix) and elasticity (matrix) at a number of different levels of aggregation; these products equalling the identity (matrix) under different conditions. We demonstrate that there are at least three ways in which control and regulability of a system can be matched. In one, the true control within and between the modules of the systems is the inverse of the primary regulability (i.e. elasticity plus stoichiometry). In a second, the control internal to a module (but partly determined through the other modules) is matched by the inverse of newly defined 'global' regulabilities for each module separately, which comprise the regulatory impact of the remainder of the system. In the third, the regulabilities are the ones intrinsic to the module and the control is taken equal to the control that would reign in the absence of the regulatory interactions between the units. In making these distinctions, it becomes transparent how much control stems from control within the organizational modules, and how much derives from the regulatory interactions between them. Control through other modules turns out to be equivalent, at steady state, to control within a module. The implications of this type of cellular organization for the location of the steady-state operating point is discussed.

Animals↗

PubMedDate not supplied

On the temperature dependence of the electric characteristics and mass spectra of liquid metal alloy ion sources.

This paper reports on an extensive study of the characteristics of AuGeSi and CoNd liquid metal alloy ion sources (Focused Ion Beams From Liquid Metal Ion Sources, Research Studies Press, Taunton, Somerset, UK, 1991). Such characteristics include current-voltage curves and ion beam mass spectra. A careful investigation has been undertaken where the emitter temperature is the main variable experimental parameter. Theoretical models, or theoretical attempts in certain cases, tend to support the experimental results. The experimental results, in conjunction with existing theories, suggest that simply for reasons of self-consistency two mechanisms must be operative for the production of doubly-charged ions from the AuGeSi source: direct field-evaporation and post-ionisation.

Journal Article↗

PubMed2003

Food allergy diagnosis: are there any missing factors? A theoretical approach.

Actual diagnostic criteria in food allergy frequently show a group of subjects with uncertain diagnosis, i.e., subjects with only occasional reactions to an offending food. These subjects are probably under- or misdiagnosed. It is possible that food itself may be only one of the factors involved in the allergic food reaction, at least in these subjects. In these cases, several factors besides food could modify either the allergenic potential of food or the absorption of allergens and may be relevant for a clinical response to occur. In order to investigate the possible relevance of missing factors, a theoretical model is elaborated by modifying the equation that represents the classical food allergy model: xAg+(IgE(*)-cell)--> clinical response (mediators release em leader ). In this classical model, it is assumed that if there is specific IgE against a food (IgE*-cell), the only limiting factor will be x (total amount of allergen ingested), being Ag, the allergen supposed to elicit a clinically relevant response. Always that x>/=a (threshold quantity of allergen that elicits a reaction) a reaction should occur. The possible existence of missing factors, i.e., the presence of 'modified allergens' (Ag('),Ag("), em leader,Ag(n)) induced by modification of the allergenic potential of food, are not considered in the equation, but these factors may have clinical relevance, and these relevance could be related to x(1),x(2), em leader,x(n) (relative quantities of 'modified allergens'). So, a modified formula is proposed:(x-Sigma(x(1),x(2), . . . x(n)]Ag+Sigma(x(1)Ag('),x(1)Ag("), . . . x(n)Ag(n)]+IgE(*)-cell)-->clinical response. In this formula, depending of the relative amount of the limiting factors: x(1),x(2), . . . x(n) and the relevant allergen (Ag,Ag('),Ag(") . . . or Ag(n)) to which the subject is sensitized an allergic reaction could or could not be elicited. So, factors other that the food itself and the threshold of sensitivity may be missed in the diagnosis of food allergy. When there are not any factors modifying Ag, the allergic response will depend only on the amount of x ('classical equation'). But when there is some kind of modification the response will depend on the relevance of the modified allergens and on the relative amount of them. If the factors modifying the allergenicity cannot be controlled, the amount of the clinically relevant allergen cannot be estimated, and the clinical response may be only occasional, explaining the inconsistent findings of some subjects.

Food Hypersensitivity↗

PubMed2000

Water uptake and relaxation processes in mixed unlimited swelling hydrogels.

The rheological oscillatory test parameters have been observed for highly concentrated hydroxypropylmethyl cellulose (HPMC), carboxymethylcellulose-sodium (NaCMC) and mixed HPMC/NaCMC hydrogels obtained by swelling of matrix tablets in 0.1 mol cm(-3) HCl and pH 6.8 phosphate buffer. The mechanical spectra of the gels have been analysed using theoretical models, i.e. a generalised Maxwell model and an adapted Maxwell model, both based on Ferry and Williams approximations. The relaxation time spectra as well as the parameters characteristic of linear viscoelastic behaviour have been calculated: zero shear viscosity (eta(0)), plateau moduli (G(N)(0), G(0)' and G(0)"), zero-relaxation time (tau(0)) and mean relaxation time (θ). The mechanical spectra of mixed HPMC/NaCMC hydrogels differ considerably from those of the pure ones, the type of the spectrum depending on the two polymers' ratios. In both media, the rheological models applied define the HPMC gels as homogeneous entangled networks, and those of NaCMC and mixed HPMC/NaCMC as heterogeneous physical gels. The relationship between the kinetic constants of water penetration and the mean relaxation times suggests that the molecular relaxation controls the water uptake velocity. With all the systems tested irrespective of pH of the aqueous phase, an inversely proportional dependence between the viscosity and the water penetration velocity has been noted. Since the degree of hydration is one of the factors determining the degree and velocity of drug release from the hydrogel matrices, the relation between the kinetic parameters of water penetration and the viscosity is a characteristic indicator for the gel structure, the degree of swelling and the drug release rate.

Absorption↗

PubMed2001

Magnetic resonance imaging of alternating electric currents.

Electric Current Density Imaging (CDI) is a new modality of magnetic resonance imaging that enables electric current distribution imaging in conductive samples containing water. So far, two CDI techniques have been in use: DC-CDI operating at zero frequency and RF-CDI operating at the RF Larmor frequency. In this paper we present a new CDI technique, which extends the CDI frequency range to alternating electric currents (AC-CDI). First, a theoretical model for the electric current response to the alternating voltage is presented. Later, this model is used for the frequency analysis of the AC-CDI sequence. Additionally, the effect of off-resonance spins and imperfect refocusing RF pulses on the stability of the AC-CDI sequence and the echo formation is studied. The new theory is verified by experiments on a model system and compared to the other two methods: DC-CDI and RF-CDI. Finally, an application of the AC-CDI sequence to biological systems is demonstrated by an experiment on a wood twig in which an increase of approximately 30% was obtained at AC as compared to DC electric current.

Electricity↗

PubMedDate not supplied

Slow dynamics in colloidal glasses and porous media as probed by NMR relaxometry: assessment of solvent levy statistics in the strong adsorption regime.

Mesoscopic media such as porous materials or colloidal pastes develop large specific surface area which strongly influence the dynamics of the embedded fluid. This fluid confinement can be used either to probe the interfacial geometry (frozen porous media) or the particle dynamics (paste and colloidal glass). In the strong adsorption regime, it was recently proposed that the effective surface diffusion on flat surface is anomalous and exhibits long time pathology (Lévy walks). This phenomena is directly related to the time and space properties of loop trajectories appearing in the bulk between a desorption and a readsorption step. The Lévy statistics extends the time domain of the embedded fluid dynamics toward the low frequency regime. An interesting way to probe such a slow interfacial process is to use field cycling NMR relaxometry. In the first part of this paper, we propose a simple theoretical model of NMR dispersion which only involves elementary time steps of the solvent dynamics near an interface (loops, trains, tails in relation with the confining geometry). In the second part, field cycling NMR relaxometry is used to probe the slow solvent dynamics in two type of interfacial systems: (i) a colloidal glass made of thin and flat particles (ii) two fully saturated porous media, the Vycor glass and MCM48 respectively. Experimental results are critically compared to closed-form analytical expressions and numerical simulations.

Adsorption↗

PubMed1999

Partial volume effects in MRI studies of multiple sclerosis.

We have estimated the accuracy of volume measurements of multiple sclerosis (MS) lesions made using magnetic resonance imaging (MRI) for lesions of comparable diameter to the image slice thickness. We used a phantom containing objects of known volume and obtained images using a range of slice thicknesses. Measurements on the phantom were used to assess a theoretical model, which was then employed to investigate the effects of image dimensions and geometry upon volume measurement accuracy. We observed measured volume to be dependent upon slice thickness. Thin slices gave the most accurate estimate of volume. As slice thickness increased relative to object diameter, the error in the volume measurement increased (to as much as 100%), the volume measured being dependent on the position of the object relative to the slice center. Using a signal intensity threshold value of 50% to outline objects gave results closest to the actual volume. As expected, a lower threshold value tended to give higher volume estimates (up to 100% larger), as did a semi-automated local edge detection technique. For accurate volume measurement, the slice thickness should be no more than a fifth of anticipated object diameter. For typical MS lesions (7 mm in diameter), this implies using a 1.5-mm slice thickness. For serial studies, a repositioning error of 1 mm could lead to differences in the volume measurement of individual lesions of up to 12% between studies for lesions of typical MS size and 5-mm slice thickness. These results emphasize the need for accurate patient repositioning, relatively thin slices, for regular quality assurance checks to ensure that pixel size and slice position are correct and stable over time, and that lesion outlining is performed in a consistent fashion. We would recommend the use of a 3D sequence with 1 mm cubic voxels for accurate measurements of MS lesions.

Humans↗

PubMed1991

Optical performance of an aspheric multifocal intraocular lens.

A five zone, centrosymmetric, multifocal intraocular lens has been developed using a design analysis approach which assumes that the optical image strength (intensity) achieved by an optical zone is linearly proportional to its aperture. The advantages of including an aspheric zone are discussed, and the optical performance of this IOL is characterized interferometrically. Optical resolution data have been obtained according to the ANSI procedure, using standard Air Force targets. These experimental data are compared with theoretical models of optical performance of diffraction-limited circular, annular, and compound circular-annular lenses.

Lenses, Intraocular↗

PubMed1998

The effect of second-order couple on the application of torque.

Complex combinations of linear forces, moments, and couples are developed by the arch wire during orthodontic treatment. For instance, application of torque to a canine during distal driving may create force interactions if the tooth tips distally toward the extraction site. This investigation studied the effect of second-order couples and bracket angulations on the application of torque to a single tooth. By using a test apparatus to simulate application of torque to a single tooth, 0.016 x 0.022 inch stainless steel wires were tested in longitudinal torsion simultaneous to fixed amounts of second-order couples or fixed degrees of second-order bracket angulation. Application of a second-order couple through a bracket to a longitudinally twisted arch wire produces a third-order couple, since the bracket slot walls exert forces on the wire, tending to detwist it. This third-order couple will usually be small as the distance between the two couple members is short. Nevertheless, it may have a restraining effect on the third-order wire-bracket interaction. The results show that application of second-order couples or bracket angulations lead to an increase in exerted torque for angles of twist below 22 degrees. Because of torsional play, a wire twisted 18 degrees in a 0.018-inch bracket slot did not exert any torque unless it was subjected to a second-order couple. Thus, in an in vivo situation where forces interact, the actual torsional play may be substantially less than predicted from theoretical models only regarding third-order mechanics. The restraining effect of second-order couples tapered when the torque created by longitudinal twisting became much larger than the torque exerted by the second-order couple. Second-order couples of biologically acceptable magnitudes had little effect on the level of torque after the third-order clearance had been eliminated.

Cuspid↗

PubMed2002

Effect of surface roughness on liquid property measurements using mechanically oscillating sensors.

The resonant frequency and quality factor Q of a liquid immersed magnetoelastic sensor are shown to shift linearly with the liquid viscosity and density product. Measurements using different grade oils, organic chemicals, and glycerol-water mixtures show that the surface roughness of the sensor in combination with the molecular size of the liquid play important roles in determining measurement sensitivity, which can be controlled through adjusting the surface roughness of the sensor surface. A theoretical model describing the sensor resonant frequency and quality factor Q as a function of liquid properties is developed using a novel equivalent circuit approach. Experimental results are in agreement with theory when the liquid molecule size is larger than the average surface roughness. However, when the molecular size of the liquid is small relative to the surface roughness features molecules are trapped, and the trapped molecules act both as a mass load and viscous load; the result is higher viscous damping of the sensor than expected.

Biosensing Techniques↗

PubMed2002

Tracking the harmonic response of magnetically-soft sensors for wireless temperature, stress, and corrosive monitoring.

This paper describes the application of magnetically-soft ribbon-like sensors for measurement of temperature and stress, as well as corrosive monitoring, based upon changes in the amplitudes of the higher-order harmonics generated by the sensors in response to a magnetic interrogation signal. The sensors operate independently of mass loading, and so can be placed or rigidly embedded inside nonmetallic, opaque structures such as concrete or plastic. The passive harmonic-based sensor is remotely monitored through a single coplanar interrogation and detection coil. Effects due to the relative location of the sensor are eliminated by tracking harmonic amplitude ratios, thereby, enabling wide area monitoring. The wireless, passive, mass loading independent nature of the described sensor platform makes it ideally suited for long-term structural monitoring applications, such as measurement of temperature and stress inside concrete structures. A theoretical model is presented to explain the origin and behavior of the higher-order harmonics in response to temperature and stress.

Corrosion↗

PubMed1997

Stresses from flexure in composite helical implantable leads.

This study presents a theoretical model of the general stress state found in helical implantable leads in bending. The model accurately predicts stress in large filarity coils made from clad wire. The stress is predicted using flexural rigidity of the coil and is developed to include the effects of coil pitch and the relative amounts and composition of the coil materials. The results is verified using finite element models of coils made from MP35N wire and MP35N clad silver wire. The resulting model will be especially useful for the fatigue analysis and engineering design of implantable leads which are built in this manner.

Computer Simulation↗

PubMed1999

The behavioral side of information technology.

Exposure to technologies is becoming more prevalent in healthcare technologies. Few strategies have been developed that work reliably to successfully implement information technologies. Information technology enables, but does not guarantee organizational change. A theoretical model has been developed identifying several areas that have been found important in information technology implementation. The information technology adoption model is described, and provides a framework for implementors of information technologies. It provides a structure to categorize areas that may benefit from the development of implementation strategies and the development of evaluation techniques. Implementation and evaluation strategies are discussed as they pertain to end-user fit, user perceptions of innovation usefulness and ease of use, and adoption and utilization.

Attitude to Computers↗