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At least 1,189 records · Page 66Linked to original sources
PubMed1993

Type X collagen degradation in long-term serum-free culture of the embryonic chick tibia following production of active collagenase and gelatinase.

Type X collagen has a very limited distribution during skeletal development in regions of hypertrophic cartilage destined for degradation. In solution assay, type X collagen is degraded to a 32-kDa cleavage product which is resistant to further degradation, suggesting this product may have a function in skeletal development. In this study, we have identified the 32-kDa cleavage product of type X collagen present in the conditioned media (CM) during incubation of isolated 12-day chick tibiae in the absence of serum. In this culture system, chondrocytes throughout the tibial cartilages hypertrophied and deposited type X collagen within their matrix. During culture, the cartilage matrix was degraded in two stages. First proteoglycan was lost followed by degradation of the collagenous components. Collagen degradation was accompanied by the release of active interstitial collagenase and gelatinase into the CM. Purified type X collagen incubated in this CM was cleaved to form a 32-kDa product which was resistant to further degradation. This cleavage product has the same electrophoretic mobility as the 32-kDa chain produced by purified human collagenase.

Animals↗
PubMed1991

Limb salvage for bone sarcoma of the proximal tibia.

We have treated 12 cases of high grade malignant bone tumours of the proximal tibia by various methods of limb salvage. Nine osteosarcomata and 3 malignant fibrous histiocytomata were included. Muscle flaps were needed in all cases except in the one arthrodesis, and reconstruction of the extensor mechanism was carried out. In nine cases an endoprosthesis was inserted. There were poor results due to loss of movement or failure to regain extension power. A two-stage method of reconstruction of the knee joint is described.

Adolescent↗
PubMed1990

Subchondral cysts of the tibia secondary to osteoarthritis of the knee.

Subchondral cysts of the tibia secondary to osteoarthritis of the knee are not usually seen on radiographs. When present, they are typically small and present no diagnostic difficulty. Two cases of unusually large subchondral lesions of the medial tibial plateau are presented. The lesions were well defined and lay adjacent to the medial tibial cortex with their long axes in the sagittal plane. Both were associated with moderate medial compartment osteoarthritis. Additional information obtained from computed tomography indicated that these lesions were subchondral cysts secondary to osteoarthritis rather than tumors or other tumor-like conditions.

Aged↗
PubMed1991

Vascularised osteocutaneous fibular transfer to the tibia.

We have reviewed 25 cases of vascularised osteocutaneous fibular transfers carried out between 1982 and 1988. The patients all had chronic osteomyelitis of the tibia, with extensive bone loss and associated soft tissue defects, following severely comminuted fractures. Union of the grafted bone could be seen in radiographs taken 3 to 4 months after operation. The results were generally satisfactory, but there were some complications.

Adult↗
PubMed1991

Case report 660: Adamantinoma of tibia.

An adamantinoma of the tibia is presented, for which the CT and MRI characteristics are described. Both imaging modalities were excellent in providing information as to the extent and invasiveness of the tumor, although MRI had the advantage of providing immediate high quality sagittal visualization. Comparison is made briefly between adamantinoma and both fibrous dysplasia and osteofibrous dysplasia.

Bone Neoplasms↗
PubMed1991

Case report 695: Cementifying fibroma of the proximal end of the tibia.

A case of a cementifying fibroma in the proximal end of the tibia in a 31-year-old woman is presented. The lesion was expanding but well-defined with amorphous central calcification. The unique, calcified, cementum-like particles in a fibrous stroma have been reported in only four previous cases in long bones. The histological and radiographic differences between a cementifying fibroma, bone cysts with cementum, and a true cementoma are discussed. The radiological differential diagnosis of fibrous dysplasia, giant cell tumor, and low grade central osteosarcoma was considered.

Adult↗
PubMed1990

Case report 592: Bone graft donor site of tibia.

A case is presented in which a donor site for a bone graft from the proximal end of the tibia caused diagnostic difficulty. The bony defect produced in such procedures is easily confused with a variety of neoplastic and neoplasm-like lesions. The clinical history, use of immediate postoperative films, and knowledge concerning the common sites for obtaining bone graft donor tissue are critical in offering the correct diagnosis.

Adult↗
PubMed1994

Case report 819: Periosteal Ewing's sarcoma of the tibia.

An exceptionally rare case of periosteal Ewing's sarcoma involving the mid shaft of the right tibia was reported. In this case, MRI was the technique that confirmed the integrity of the bone marrow. The clinical, radiographic, and histopathologic features of Ewing's sarcoma have been discussed, as has the differential diagnosis of the periosteal type of this tumor.

Adolescent↗
PubMed1991

Prevention of neurovascular complications in extension osteotomy of the tibia in poliomyelitis.

Extension osteotomy of the proximal tibia was carried out in patients with quadriceps weakness after poliomyelitis in order to obtain a stable knee during the stance phase. Blood flow in the anterior and posterior tibial arteries was measured by Doppler sonography before, during and after operation. It was found that there was a correlation between the degree of extension of the knee after operation and a diminished blood flow. This probably explains some of the neurovascular complications reported in the literature after this procedure. We recommend that blood flow is monitored sonographically in the postoperative phase and that optimum extension is obtained gradually over a period of time in a hinged plaster cast.

Female↗
PubMed1986

A three-dimensional ultrastructural study of osteoid-osteocytes in the tibia of chick embryos.

Morphology and ultrastructure of osteoid-osteocytes were studied in serial thin sections (700-800 A thick) of periosteal woven bone in tibiae of 15-day-old chick embryos. The three-dimensional shapes of 21 partially, and of one fully sectioned cell were reconstructed manually and by means of a computer-assisted image analyser. Osteoid-osteocytes are active cells engaged in organic matrix secretion and calcification. Like osteoblasts, their activity seems to be polarized towards the mineralization front, as shown by the presence of cytoplasmic processes on their mineral-facing side and by the position of the nucleus toward the vascular side of the cytoplasm. Cellular processes directed towards blood vessels appear only at a later stage, i.e. when the mineralization starts to spread all round the cell. The asynchrony in formation, together with the observed differences in morphology suggest the hypothesis that the cellular processes of the mineral-facing side are mainly involved in bone formation and those of the vascular side in cell nutrition.

Animals↗
PubMed1979

Resorption of uncalcified cartilage in the diaphysis of the chick embryo tibia.

The resorption of the uncalcified cartilage matrix of the middle third of the diaphysis in the chick embryo tibia has been studied using histological, histochemical and electron microscopic techniques. The first stage in the resorption process affects the periosteal bone, which is breached by osteoclasts at one or several points. Capillary vessels and clear, apparently undifferentiated cells penetrate through the holes so formed and reach the cartilage. The loss of acid proteoglycans to a depth of 10--20 micrometer into the matrix is the first sign of cartilage resorption; it is followed by the digestion of collagen fibrils, the opening of cell lacunae, chondrocyte degeneration and fragmentation and, lastly, the complete dissolution of the cartilage. This process is mediated by cells which probably derive from perivascular elements. Most of these cells have an undifferentiated appearance, but they have macrophagic properties, as is shown by phagocytotic activity along their plasma membrane, by the presence of lysosome-like bodies in their cytoplasm, and by their intense acid phosphatase activity. Resorption by giant cells of chondroclastic type only occurs at a late stage.

Animals↗
PubMed1981

The differential diagnosis of congenital pseudarthrosis of the tibia.

The key to the solution of this problem lies in the differential diagnosis. There are at least four dysplastic lesions of the congentially bowed tibia (with or without cysts) which have quite different behaviour patterns. There are also six different types of true congenital pseudarthrosis which exhibit similar differences in behaviour and response to treatment.

Child↗
PubMed1985

[Lamellar rotation osteotomy of the tibia in children].

The authors describe the technique and results obtained by a derotation osteotomy of the tibia in children. The method is simple, reliable and does not require internal fixation. It is suitable for dealing with deformity following poliomyelitis, and may also be used to treat tibial torsion which fails to correct with growth in children who are otherwise healthy.

Adolescent↗
PubMed1984

An adult form of Gaucher's disease with a huge tumour formation of the right tibia.

A case of adult, chronic or non-neuropathic, Gaucher's disease is presented. Severe bony changes, particularly involving the lower limbs developed after a splenectomy had been carried out. Our patient had all the orthopaedic complications of Gaucher's disease. Further, a huge tumour was present in the right tibia caused by the proliferation of Gaucher cells. This feature may be unique but pseudotumour should be listed in the possible orthopaedic complications of Gaucher's disease. The patient was bedridden, but was able to use a wheelchair after his leg was amputated.

Adult↗
PubMed1985

Aplasia of tibia with split-hand/split-foot deformity. Report of six families with 35 cases and considerations about variability and penetrance.

Six families with a total of 34 affected persons with the syndrome of tibial aplasia and ectrodactyly are reported. The spectrum of malformations is compared to that of 99 familial cases from the literature. The full-blown syndrome consists of bilateral aplasia of tibiae and split-hand/split-foot deformity. Additional malformations may be distal hypoplasia or bifurcation of femora, hypo- or aplasia of ulnae, and minor anomalies such as aplasia of patellae, hypoplastic big toes, postaxial and intermediate polydactyly in connection with split-hand deformity, and cup-shaped ears. The mildest visible manifestation may be hypoplastic big toes, the severest is tetramonodactyly or transverse hemimelia. This disorder is autosomal dominantly inherited. The penetrance is markedly reduced.

Abnormalities, Multiple↗
PubMed1984

Radiology of postnatal skeletal development. IX. Proximal tibia and fibula.

Ossification usually begins in the proximal tibia within the first three months following birth. The initial secondary ossification is centrally located and spherical. Expansion and maturation then changes the ossification center to a more elliptical shape. Variability in this expansion medially and laterally may create marginal irregularity in the first few years, followed by a smooth border by five to six years. Subsequently ossification extends into the tibial spines as a single conical mass which eventually divides into two separate extensions. The physis remains relatively transverse throughout development although contouring occurs under each tibial weight-bearing compartment. Peripheral lappet formation appears within a few months. Anteriorly there is an undulation at the site of the cartilaginous tibial tuberosity. The proximal fibular physis begins as a transverse contour, but changes to one with peripheral lappet formation and multiple undulations. Secondary ossification begins just above the physis and extends proximally into the rest of the physis. However, the fibular styloid, similar to the ulnar styloid, does not ossify until late in skeletal maturation. The proximal fibular physis usually is situated 5 to 10 mm distal to the tibial physis. The tibiofibular joint morphology has considerable morphologic variation, and the joint may communicate with the knee joint.

Adolescent↗