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PubMed2006

The full bibliography of Ernst Ludwig Wynder.

The chronology of lifetime publications authored and/or co-authored by Dr. Ernst L. Wynder spans a rich assortment of topics relating to the etiology and prevention of chronic diseases. Dr. Wynder's interdisciplinary approach to research in cancer and heart disease embraces the disciplines of epidemiology, biology, pathology, chemistry, biochemistry, tobacco sciences, and nutrition as well as health behavior, and health education. His works reflect his attention to diverse subjects from methodology in scientific endeavors, to mechanisms in carcinogenesis, brain development, alternative medicine, principles of disease prevention, history of medicine, and societal issues, as well as philosophy, and religion. In 1972 Dr. Wynder created the journal Preventive Medicine as an international forum for the exchange of ideas that address the promotion of health and prevention of disease in our time. Many of his ideas were developed and nurtured in the symposia and workshops the Journal has published.

Epidemiology↗
PubMed2001

Cartilage regeneration using principles of tissue engineering.

It is well known that articular cartilage in adults has a limited ability for self-repair. Numerous methods have been devised to augment its natural healing response, but these methods generally lead to filling of the defect with fibrous tissue or fibrocartilage, which lacks the mechanical characteristics of articular cartilage and fails with time. Recently, tissue engineering has emerged as a new discipline that amalgamates aspects from biology, engineering, materials science, and surgery and that has as a goal the fabrication of functional new tissues to replace damaged tissues. The emergence of tissue engineering has facilitated the generation of new concepts and the revival of old ideas all of which has allowed a fresh approach to the repair or regeneration of tissues such as cartilage. The collaborations between scientists with different backgrounds and expertise has allowed the identification of some key principles that serve as the basis for the development of therapeutic approaches that now are less empiric and more hypothesis-driven than ever before. The current authors review some of the considerations regarding the various models used to test and validate the above repair methods and to address different aspects of the cartilage repair paradigm. Also, some key principles identified from past and current research, the need for the development of new biomaterials, and considerations in scale-up of cell-biomaterial constructs are summarized.

Age Factors↗
PubMed2007

Gastrointestinal tissue engineering.

Tissue engineering is an emerging discipline that combines engineering principles and the biological sciences toward the development of functional replacement tissue. Virtually every tissue in the body has been investigated and tremendous advances have been made in many areas. This article focuses on the gastrointestinal tract and reviews the current status of bioengineering gastrointestinal tissues, including the esophagus, stomach, small intestine and colon. Although progress has been achieved, there continues to be significant challenges that need to be addressed.

Biocompatible Materials↗
PubMed2006

The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome.

Chronic fatigue syndrome (CFS) is a debilitating illness characterized by multiple unexplained symptoms including fatigue, cognitive impairment and pain. People with CFS have no characteristic physical signs or diagnostic laboratory abnormalities, and the etiology and pathophysiology remain unknown. CFS represents a complex illness that includes alterations in homeostatic systems, involves multiple body systems and results from the combined action of many genes, environmental factors and risk-conferring behavior. In order to achieve understanding of complex illnesses, such as CFS, studies must collect relevant epidemiological, clinical and laboratory data and then integrate, analyze and interpret the information so as to obtain meaningful clinical and biological insight. This issue of Pharmacogenomics represents such an approach to CFS. Data was collected during a 2-day in-hospital study of persons with CFS, other medically and psychiatrically unexplained fatiguing illnesses and nonfatigued controls identified from the general population of Wichita, KS, USA. While in the hospital, the participants' psychiatric status, sleep characteristics and cognitive functioning was evaluated, and biological samples were collected to measure neuroendocrine status, autonomic nervous system function, systemic cytokines and peripheral blood gene expression. The data generated from these assessments was made available to a multidisciplinary group of 20 investigators from around the world who were challenged with revealing new insight and algorithms for integration of this complex, high-content data and, if possible, identifying molecular markers and elucidating pathophysiology of chronic fatigue. The group was divided into four teams with representation from the disciplines of medicine, mathematics, biology, engineering and computer science. The papers in this issue are the culmination of this 6-month challenge, and demonstrate that data integration and multidisciplinary collaboration can indeed yield novel approaches for handling large, complex datasets, and reveal new insight and relevance to a complex illness such as CFS.

Adult↗
PubMed2002

Implementation of a monitoring system to measure impact of stormwater runoff infiltration.

Stormwater infiltration is a drainage mode, which is more and more used in urban areas in France. Given the characteristics of urban surfaces, and especially the loads of various pollutants contained in stormwater, it is important to assess the impact of stormwater infiltration systems on soil and groundwater by carrying out field experiments. The main difficulty is due to the complexity of the system observed and the need of multidisciplinary approaches. Another difficulty is that measurements are carried out in situ, in an uncontrolled environment submitted to quantitatively and qualitatively highly variable interferences. Very long term monitoring is needed to get representative results. In order to contribute to solve these problems, the OTHU project has recently been launched in Lyon (France). One of its key action concerns a long-term (10 years) experiment on an infiltration basin specifically rehabilitated for measurements and operational drainage issues. This paper presents the experimental site, the objectives of the project and the way the monitoring process has been built according to the various disciplines involved (biology, ecology, hydrology, chemistry and soil sciences) and to the will of assessing all the uncertainties in the measurement process.

Cities↗
PubMedDate not supplied

History of biochemistry.

Biochemistry in broad terms is the study of the chemical composition of the living matter and the biochemical processes that underlie life activities during growth and maintenance. This article is an attempt to explore the metamorphosis of biochemistry from a pupa entwined in its own cocoon to a vibrantly colored phenomenon. Studies pertaining to this discipline of science began with Biochemistry interfaces with biology and chemistry even before nineteenth century with studies concerned with the chemical processes that take place within living cells. Modern biochemistry developed out of and largely came to replace what in the nineteenth and early twentieth centuries was called physiological chemistry, which dealt more with extra cellular chemistry, such as the chemistry of digestion and of body fluids. The name Biochemistry was coined in 1903 by a German chemist named Carl Neuber. However, work in this very living, aspect of chemistry had started much earlier. Claude Bernard is accredited with the Sirehood of Biochemistry. During the later part of the nineteenth century eminent scientists contributed a great deal to the elucidation of the chemistry of fats, proteins and carbohydrates. At this period some very fundamental aspects of enzymology were under close scrutiny. Study of nucleic acid is central to the knowledge of life but its fusion with biochemistry started with works of Fredrick Sanger and Har Gobind Khurana. Their experiments involved a subtle bland of enzymology and chemistry that few would have thought possible to combine. The scientists were busy removing the mist that was mitigating the light of knowledge but they still lacked an insight into the cell. In 1990's research turned to finding the structural details of cell. The field of molecular biochemistry was also progressing at an almost unstoppable speed having expanded its horizons beyond human imagination with the introduction of PCR, creating waves of appreciation from every field of medicine and then coming out of the lab to help establish better therapies for various diseases by introduction of gene therapy. Biochemistry has promises to the world of science in development of new path-breaking research and coming times would surely prove these promises to be fulfilled.

Biochemistry↗
PubMed1990

[The cell theory--history, present state and prospects (on the 150th anniversary of the development of the cell theory)].

The main stages of history of this most important biological conception are presented and the state of the modern cell theory and its future prospects are considered. Since 1839, when T. Schwann expounded his conception of the cell, a long pathway in cognition of the cell function and organization has been covered. From the original picture of the complex organism as a "cellular state", made up of relatively independent "elementary organisms", i.e. cells the modern biology has come to the idea of the cell as an integral system either being a part of a complex organism, or living free in the nature (protists). The cell represents certain qualitatively peculiar level in a complex evolutionary established hierarchy of biological systems. Some particular tight relations, existing between cytology, as a fundamental biological science and molecular biology, genetics, ecology and other biological disciplines are considered. The importance of the cell conception is ascertained for practical aims, especially in medicine.

Animals↗
PubMed1994

Bulk isolation and identification of fish genes by cDNA clone tagging.

The fish has long been a popular research model for various disciplines in the life sciences, but its molecular biology remains largely unexplored, and the number of fish genes identified at present is still limited. To increase the repertoire of fish genes to facilitate further research, we have embarked on cDNA clone tagging studies in several teleosts. The basic procedure is partial sequencing of randomly selected cDNA clones by a single sequencing reaction to obtain nucleotide sequences of about 200 to 300 bp for each clone. These partial DNA sequences can be used as tags to identify fish homologous genes by searching for sequence similarity in DNA databases. By this method, we have sequenced a total of 265 clones from pituitary and liver cDNA libraries from five species of fish and identified 83 clones encoding 55 different genes. These 55 genes are described for the first time in their species, and 37 of them are described for the first time in fish. These preliminary data indicate that cDNA clone tagging is useful for rapidly increasing the number and availability of genes in teleosts. Several applications of these tagged random clones are discussed.

Animals↗
PubMed1994

There must be a prokaryote somewhere: microbiology's search for itself.

While early microbiologists showed considerable interest in the problem of the natural (evolutionary) relationships among prokaryotes, by the middle of this century that problem had largely been discarded as being unsolvable. In other words, the science of microbiology developed without an evolutionary framework, the lack of which kept it a weak discipline, defined largely by external forces. Modern technology has allowed microbiology finally to develop the needed evolutionary framework, and with this comes a sense of coherence, a sense of identity. Not only is this development radically changing microbiology itself, but also it will change microbiology's relationship to the other biological disciplines. Microbiology of the future will become the primary biological science, the base upon which our future understanding of the living world rests, and the font from which new understanding of it flows.

Archaea↗
PubMed2006

Standardization of biological medicines: the first hundred years, 1900-2000.

The use of materials of biological origin in medicine has a long history. These materials, including tissue, organ and microbial extracts, blood and its derivatives, antibodies and hormones, share the feature that for much of the last century the ability to characterize and quantify the active substance was limited. Quantification of these substances depends on biological standardization, a discipline that was refined to a science by the Medical Research Council from the 1920s onwards, and which, with contributions from several prominent Fellows of the Royal Society, including principally Sir Henry Dale, the UK has led the world to the present date.

Biological Products↗
PubMed1994

[Apropos of Swiss research in psychogeriatrics. A critical analysis].

Psychogeriatrics is the general psychiatry of old age. It is closely related with the biological and human fundamental sciences and with the medical disciplines concerned with the care of old patients. Its issues are ubiquitous and also interest non psychiatrists, particularly geriatricians, internists, neurologists and psychologists. Therefore there is a risk for research to be spread out. As a medicine of synthesis, it must assert itself as a convergence point for the related branches. Its very vast field of research is confronted with particular methodological problems, like the chronological and biological age, the heterogeneity of the population, the polymorbidity. Psychogeriatrics is young and still requires an important involvement in the clinical tasks, in the medico-social coordination and in the teaching to medical and paramedical circles. Rare are centers having the critical mass for developing good research with complete peace of mind, Switzerland is an example of this. An analysis of the 1992 international literature shows a certain scattering of the psychogeriatric themes with a 50% predominance of papers devoted to dementias. In the future, psychogeriatrics must well limit its territory, particularly by developing services where care, teaching and research are harmonized.

Aged↗
PubMed1998

13th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies and conceptual issues.

Substantial world-wide resources are being committed to develop improved toxicological testing methods that will contribute to better protection of human health and the environment. The development of new methods is intrinsically driven by new knowledge emanating from fundamental research in toxicology, carcinogenesis, molecular biology, biochemistry, computer sciences, and a host of other disciplines. Critical evaluations and strong scientific consensus are essential to facilitate adoption of alternative methods for use in the safety assessment of drugs, chemicals, and other environmental factors. Recommendations to hasten the development of new alternative methods included increasing emphasis on the development of mechanism-based methods, increasing fundamental toxicological research, increasing training on the use of alternative methods, integrating accepted alternative methods into toxicity assessment, internationally harmonizating chemical toxicity classification schemes, and increasing international cooperation to develop, validate, and gain acceptance of alternative methods.

Animal Testing Alternatives↗
PubMed2005

A user's guide to animal welfare science.

Here, I provide a guide for those new to the burgeoning field of animal welfare science as to what this comprehensive, relatively young discipline is all about. Drawing on all branches of biology, including behavioural ecology and neuroscience, the science of animal welfare asks three big questions: Are animals conscious? How can we assess good and bad welfare in animals? How can we use science to improve animal welfare in practice? I also provide guidelines for an evidence-based approach to welfare issues for policy makers and other users of animal welfare research.

Animal Husbandry↗
PubMed1994

Ancient DNA: using molecular biology to explore the past.

Ancient DNA has been discovered in many types of preserved biological material, including bones, mummies, museum skins, insects in amber and plant fossils, and has become an important research tool in disciplines as diverse as archaeology, conservation biology and forensic science. In archaeology, ancient DNA can contribute both to the interpretation of individual sites and to the development of hypotheses about past populations. Site interpretation is aided by DNA-based sex typing of fragmentary human bones, and by the use of genetic techniques to assess the degree of kinship between the remains of different individuals. On a broader scale, population migrations can be traced by studying genetic markers in ancient DNA, as in recent studies of the colonisation of the Pacific islands, while ancient DNA in preserved plant remains can provide information on the development of agriculture.

Agriculture↗
PubMedDate not supplied

Ca2+ imaging in single living cells: theoretical and practical issues.

The measurement of intracellular calcium ion concentrations [( Ca2+]i) in single living cells using quantitative fluorescence microscopy draws from a diverse set of disciplines, including cellular biology, optical physics, statistics and computer science. Over the last few years, we have devised and built a number of systems for measuring [Ca2+]i with Fura-2, and have applied them in the exploration of a wide range of biological processes controlled by Ca2+. In this report we discuss these systems and their advantages and limitations. We also describe the theoretical and practical problems associated with using Fura-2 to measure [Ca2+]i, and the solutions that we, and others, have developed to overcome them. The approaches described should provide useful guidance for others interested in imaging [Ca2+] distribution in living cells. The factors that limit current methods are discussed, and areas for future development are highlighted.

Animals↗
PubMed2001

Whole-cell biocomputing.

The ability to manipulate systems on the molecular scale naturally leads to speculation about the rational design of molecular-scale machines. Cells might be the ultimate molecular-scale machines and our ability to engineer them is relatively advanced when compared with our ability to control the synthesis and direct the assembly of man-made materials. Indeed, engineered whole cells deployed in biosensors can be considered one of the practical successes of molecular-scale devices. However, these devices explore only a small portion of cellular functionality. Individual cells or self-organized groups of cells perform extremely complex functions that include sensing, communication, navigation, cooperation and even fabrication of synthetic nanoscopic materials. In natural systems, these capabilities are controlled by complex genetic regulatory circuits, which are only partially understood and not readily accessible for use in engineered systems. Here, we focus on efforts to mimic the functionality of man-made information-processing systems within whole cells.

Computational Biology↗
PubMed2006

The inorganic side of chemical biology.

Bioinorganic chemistry remains a vibrant discipline at the interface of chemistry and the biological sciences. Metal ions function in numerous metalloenzymes, are incorporated into pharmaceuticals and imaging agents, and inspire the synthesis of catalysts used to achieve many chemical transformations.

Biochemical Phenomena↗