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Influence of muscle strength and total work on exercise-induced plasma growth hormone isoforms in women.

The purpose of this investigation was to determine the influence of physical strength and the ability to do more total work on human growth hormone (GH) variants to a heavy resistance exercise protocol in untrained women. From a distribution of 100 healthy, untrained women, the strongest 10 women (S) and the weakest 10 women (W) were compared for GH responses pre- and post an acute heavy resistance exercise test (AHRET, 6 sets of 10 RM squats, 2 minutes rest between sets). Blood samples were obtained pre-exercise and immediately post-exercise and subsequently analysed in total as well as fractionated by Sephacryl S-100R column chromatography into three molecular weight size classes: fraction A: > 60 kD, fraction B: 30-60 kD, fraction C: < 30 kD. For each total sample as well as each fraction, immunoreactive GH was measured via the Nichols IRMA, while bioactive GH was measured via the hypox rat tibial line bioassay and Diagnostic Systems Laboratory's immunofunctional GH ELISA. No exercise-induced changes or differences between groups were observed in the tibial line bioassay. However, the S group displayed a significantly higher pre-exercise resting value in the total fraction than the W group. Conversely, the W group exhibited a significantly higher pre-exercise value in the smaller molecular weight fraction C. With regards to the immunofunctional and immunoreactive assays, the total fraction, fraction A, and fraction B demonstrated significant (P < or = 0.05) exercise-induced increases in both the S and W group despite no group differences. For the Nichols and immunofunctional assays significant exercise-induced changes were observed in the smaller molecular weight C fraction in the W group but not the S group. However, the S group displayed a significantly higher pre-exercise value in fraction C relative to the W group. These data demonstrate for the first time that differences exist in the GH molecular weight variants between strong and weak untrained women, with the lower molecular weight variants seemingly less responsive to greater amounts of exercise in stronger women, thus suggesting differential regulation of GH molecular weight variants during resistance exercise due to pre-existing physical parameters.

Animals↗

Muscle strength and aerobic capacity in a representative sample of employees with and without repetitive monotonous work.

OBJECTIVES: The purpose of the study was to determine a possible association between the type of work individuals perform and his or her physical capacity. There was focus on whether workers performing repetitive monotonous work differ from workers with varied work tasks with respect to the physical capacity. METHODS: Maximal backward extension and forward flexion torques of the trunk, maximal shoulder elevation and abduction torques, handgrip strength and aerobic capacity were measured on 423 (213 male and 210 female) Danish employees with a mean age of 40 years. Half of the group had varied work and the other half had repetitive monotonous work. RESULTS: The main finding was that there is no difference in the measured physical capacities between employees with repetitive monotonous work and those compared with workers with varied work tasks. CONCLUSIONS: No difference in the physical capacities measured in the two groups of employees was found. Reasons for this are discussed.

Adult↗

[Muscle strength and functional results after surgical repair of Achilles tendon rupture with fibrin gluing].

Treatment of Achilles tendon rupture is discussed controversially. Some trauma centers prefer a conservative therapy. Because of the tendency to a higher rate of reruptures and worse functional results following conservative treatment, operation is the standard therapy of fresh ruptures of the Achilles tendon in Germany. Concerning the functional postoperative outcome, only few studies with uncomparable results were published. To evaluate the functional outcome after Achilles tendon ruptures treated by fibrin gluing, we realized reactive force measurements and motion analysis of 30 patients and 25 healthy test persons. We could observe significant limitations of active range of motion in the ankle joint and a significant deficiency of maximum- and rapid-force. Force deficiency was only detected by the sensitive technical examinations. In daily routine 26 of 30 patients had no limitations. The detected force- and motion-deficiencies were completely compensated. Therefore fibrin gluing of fresh ruptures of the Achilles tendon usually allows postoperatively the same leisure sports activity level as preoperatively. In competitive sporting athletes postoperative loss of performance must be expected.

Achilles Tendon↗

Muscle strength and mobility as predictors of survival in 75-84-year-old people.

The purpose of the study was to examine the association of physical capacity, as determined on the basis of self-report and physical measurements, with survival in three groups of elderly people aged 75, 80 and 75-84 years. The main aspects of physical capacity were mobility, walking speed, hand grip strength and knee extension strength. Although 1142 persons participated in mobility interview, of whom 466 also took part in the walking speed test, and 463 in the strength tests. The follow-up periods ranged from 48 to 58 months. Risk of death was significantly related to difficulties in indoor mobility among the 75-84-year-olds (odds ratio = 1.99, 95% confidence interval = 1.27-3.13) and 75- and 80- year-olds (OR = 1.60, CI = 1.07-2.38) and outdoor mobility among the 75-84-year-olds (OR = 2.44, CI = 1.63-3.67) and 75- and 80-year-olds (OR =2.75, CI = 1.72-4.40). The odds ratios for hand grip strength (OR = 1.86, CI=1.13-3.07), knee extension strength (OR =2.52, CI = 1.50-4.42) and walking time over 10 meters (OR = 1.98, CI = 1.18-3.34) for the 75- and 80-year-olds were also significant. Since these variables can be easily measured and provide valuable information about functional capacity and risk of death they merit inclusion in medical examination of elderly clients.

Aged↗

Evaluation of shoulder internal rotator muscle strength in baseball players with physical signs of glenohumeral joint instability.

OBJECTIVES: To identify whether subjects with glenohumeral translational instability present with a strength deficit in their internal rotator musculature, and therefore to determine if general strengthening exercises are warranted for the management of this condition. METHODS: Eighteen male baseball players were allocated to two groups on the basis of expert clinical evaluation of the presence (n=8) or absence (n=10) of shoulder translational instability. A strain gauge was used to calculate the force generated during maximal isometric internal rotation contractions in neutral shoulder rotation and 30 degrees of internal rotation. RESULTS: The Mann-Whitney test identified no significant difference in force production during the maximum contractions in neutral rotation between the two subject groups. In the position of 30 degrees shoulder internal rotation, subjects with glenohumeral translational instability produced significantly greater force than the control group (p<0.05). CONCLUSIONS: High load strength testing cannot be used as a diagnostic tool to identify people with glenohumeral instability. Similarly, heavy resistance strengthening exercises for the internal rotator musculature are not warranted during rehabilitation.

Adolescent↗

Associations of muscle strength and fitness with metabolic syndrome in men.

PURPOSE: To examine the associations for muscular strength and cardiorespiratory fitness with the prevalence of metabolic syndrome among men. METHODS: Participants were 8570 men (20-75 yr) for whom an age-specific muscular strength score was computed by combining the body weight adjusted one-repetition maximum measures for the leg press and the bench press. Cardiorespiratory fitness was quantified by age-specific maximal treadmill exercise test time. RESULTS: Separate age and smoking adjusted logistic regression models revealed a graded inverse association for metabolic syndrome prevalence with muscular strength (beta = -0.37, P < 0.0001) and cardiorespiratory fitness (beta = -1.2, P < 0.0001). The association between strength and metabolic syndrome was attenuated (beta = -0.08, P < 0.01) when further adjusted for cardiorespiratory fitness. The association between cardiorespiratory fitness and metabolic syndrome was unchanged (beta = -1.2, P < 0.0001) after adjusting for strength. Muscular strength added to the protective effect of fitness among men with low (P trend = 0.0002) and moderate (P trend < 0.0001) fitness levels. Among normal weight (BMI < 25), overweight (BMI 25-30), and obese (BMI >or= 30) men, respectively, being strong and fit was associated with lower odds (73%, 69%, and 62% respectively, P < 0.0001) of having prevalent metabolic syndrome. CONCLUSIONS: Muscular strength and cardiorespiratory fitness have independent and joint inverse associations with metabolic syndrome prevalence.

Adult↗

Balance and muscle strength as predictors of frailty among older adults.

The term frailty is increasingly used in gerontological literature and in practice. However, indicators differentiating frail from nonfrail are not well delineated. Identifying factors discriminating between frail and nonfrail older community-residing adults may lead to more comprehensive clinical assessments and targeted interventions to minimize or prevent frailty. Eighty-four adults, ages 60 to 88 (mean = 74) living independently in the community completed a functional performance questionnaire and a perceived health questionnaire that were combined as measures of frailty. Predictor variables of frailty included four measures of balance and three measures of lower leg strength. Discriminant analysis revealed that one balance score and dorsiflexion correctly classified 65% of group membership, with better prediction of the nonfrail than frail group. This study clarifies that the predictors of frailty include the combination of dorsiflexion strength and balance, specifically the contribution of vision to balance when the support surface is compliant. Recommendations are proposed for conceptualizing and operationalizing frailty and adding variables to enhance discrimination between frailty and nonfrailty. Nursing implications include adding clinical assessments of specific components of balance and ankle strength to develop a more comprehensive evaluation of frailty.

Activities of Daily Living↗

Normative data for muscle strength in relation to age, knee angle and velocity.

Standardized normal values are necessary to assess the performance with respect to the momentary functional state as well as a documentation of a training or rehabilitation program. The isokinetic extension strength of the right and left knee was investigated in 147 healthy male subjects between 17 and 70 years who were divided into 6 age groups. Normative data are given in dependence on age, knee angle and various velocities and regression equation in relation to the knee angle and for the peak torque in relation to the angular velocity. We found a significant decrease in maximum torque with increasing angle acceleration (p < 0.001) and a correlation between strength and body mass (p < 0.05). The highest values were found in the group of 20- to 29-year olds, while the strength was lower up to age 20. The decrease in force between 25 to 70 years ranges up to 37% at a velocity of 10 degrees/s, up to 41% at a velocity of 60 degrees/s and up to 50% at a velocity of 180 degrees/s.

Adolescent↗