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At least 1,207 records · Page 67Linked to original sources
PubMed1976

Muscle spindle control during locomotor movements generated by the deafferented spinal cord.

In acute spinalized (Th 12) cats, treated with DOPA, curarized or with all lumbosacral dorsal roots transected, stepping patterns were elicited in the hindlimbs by continuous electrical stimulation of the dorsal roots. Single primary endings in dorsal root filaments or single gamma and alpha efferents in muscle nerve filaments from flexors and extensors were recorded together with the efferent nerve activity to various hindlimb muscles. The experiments showed a clear coactivation of the intra- and extrafusal system to the same muscle. The alpha efferent discharges typically started with a very short first interspike interval. It is concluded that there exists a central spinal alpha-gamma-linkage for locomotion in the hindlimbs.

Animals↗
PubMed1977

Quantitative evaluation of the blood-brain barrier capacity to form dopamine from circulating L-DOPA.

The ability of the blood-brain barrier to form dopamine from increasing doses of systemically administered L-DOPA has been studied in rats by a combination of chemical determination of dopamine, and histochemical and cytofluorometric measurements of L-DOPA and dopamine. The break-through of L-DOPA from the circulation into the brain parenchyma via the enzymatic blood-brain barrier was estimated by comparing the amount of newly formed dopamine in the caudate nucleus-putamen and in the cerebellum. The capillaries were found to efficiently trap L-DOPA in their walls, and an upper limit was reached (at an administered i.p. dose of 100 mg/kg of L-DOPA). It could be estimated that approximately 3% of the total dose of L-DOPA given was decarboxylated by the blood-brain barrier. The possible influence by the regional differences in perfusion of the two regions seen after administration of L-DOPA was ruled out in measurements of local cerebral blood flow using the 14C-ethanol technique.

Animals↗
PubMed1986

Catecholamines of endoneurial laryngeal paraganglia in the rat.

The catecholamines in the recurrent and superior laryngeal nerves of the rat were assayed by high performance liquid chromatography. The nerves were shown to contain high levels of dopamine (1.9 +/- 0.6 and 2.3 +/- 0.4 pmol, respectively) and noradrenaline (1.3 +/- 0.3 and 0.9 +/- 0.2 pmol, respectively). No adrenaline could be detected in any of the nerves. Reserpine markedly depleted the stores of these amines in both nerves. A significant increase in dopamine level was seen in the superior laryngeal nerve after treatment with a monoaminoxidase inhibitor, but not in the recurrent laryngeal nerve. The high levels of dopamine detected are presumably derived from endoneurial paraganglia which were demonstrated by glyoxylic acid-induced fluorescence. The source of noradrenaline is less evident, but noradrenaline is probably stored in both endoneurial paraganglia and in sympathetic nerve endings.

Animals↗