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Intravitreal triamcinolone in the treatment of serous retinal detachment in Vogt-Koyanagi-Harada syndrome.

PURPOSE: To report the use of intravitreal injection of triamcinolone acetonide during the acute phase of Vogt-Koyanagi-Harada disease. DESIGN: Prospective interventional case series. METHODS: Three eyes from two patients at the acute phase of Vogt-Koyanagi-Harada disease with serous retinal detachments were treated with a 4-mg intravitreal injection of triamcinolone acetonide. The following variables were evaluated: visual acuity, intraocular pressure, and height of the serous retinal detachment using optical coherence tomography. RESULTS: The optical coherence tomography images showed a marked decrease in the retinal detachment in the first week after the injection with subsequent return to normal retinal thickness in all eyes. CONCLUSIONS: Intravitreal triamcinolone acetonide provides short-term improvement in visual acuity and serous retinal detachments associated with Vogt-Koyanagi-Harada disease. These findings should be followed by future studies to evaluate long-term effects.

Acute Disease↗

Primary vitrectomy for rhegmatogenous retinal detachment.

One hundred and twenty-four eyes with a rhegmatogenous retinal detachment, considered to be at high risk of failure if treated conventionally, underwent vitrectomy and internal tamponade, with or without scleral buckling, as the primary procedure. The retina was reattached in 64.5% of eyes after one operation, 75.0% after two, and in 83% of eyes after more than two operations, with no difference in the success rate between those eyes which underwent vitrectomy alone, and those that received adjunctive scleral buckling; duration of surgery was significantly shorter, however, in the former group. Twenty percent of eyes redetached in association with proliferative vitreoretinopathy, and 20% of phakic eyes developed posterior subcapsular lens opacities after surgery. Vitrectomy is now an established method in the management of selected cases of rhegmatogenous retinal detachments.

Adolescent↗

Prognosis of cystoid macular edema after retinal detachment repair.

Twenty eyes of 20 patients who had undergone successful retinal detachment repair by means of microsurgery had cystoid macular edema (CME) disclosed by fluorescein angiography 10-12 weeks postoperatively. Clinical evaluation war repeated at 6-month intervals for a period of 12-30 months. Sixteen eyes were followed for at least 18 months. CME spontaneously cleared or dramatically decreased in 12 of the 16 eyes (75%), which were followed for at least 18 months. CME had spontaneously cleared in 50% of the eyes by the end of 1 year after surgery. For those eyes with transient CME, the mean visual acuity improved from 0.3 at 3 months postoperatively to 0.6 at the end of the follow-up period. The final visual acuity was 0.4 or better in 83.3% of the eyes with transient CME. None of the eyes with persistent CME developed premacular fibrosis or cystoid macular degeneration during the follow-up period. No prognostic factor for angiographic CME after repair of retinal detachment could be determined in the present series of patients.

Fluorescein Angiography↗

Late recurrence of retinal detachment.

We reviewed 1,136 cases of retinal detachment in 1,073 patients. Late recurrence was defined as the reappearance of subretinal fluid after at least 6 months of clear, total reattachment. Fifty-one patients (4.75%) had a late recurrence. New or reopened peripheral breaks were either definitely observed or presumed to be present in 40 eyes (78.5%), and none were definite peripheral holes or retinal dialyses. Three macular holes reopened after having initially been managed by vitrectomy. One additional macular hole occurred as a new break. Late severe proliferative vitreoretinopathy occurred in the last 7 cases. Only vitrectomy for initial detachment and lens extraction after reattachment correlated with late recurrence. Vitrectomy was still a significant risk factor when macular holes were excluded.

Aged↗

Pneumatic buckle for the repair of primary rhegmatogenous retinal detachment.

OBJECTIVES: This prospective study examines the effectiveness of the pneumatic buckle procedure (nondrainage scleral buckle with pneumatic retinopexy) for repair of primary rhegmatogenous retinal detachments. METHODS: We studied 58 consecutive patients with primary rhegmatogenous retinal detachments who underwent a pneumatic buckle with air or SF6. The procedures were performed at 2 centers. Retinal reattachment and visual acuity were examined. RESULTS: The single operation reattachment rate for patients undergoing a pneumatic buckle procedure was 95%. Eighty eight percent of patients with macula-on detachment had unchanged or improved final visual acuity. Sixty seven percent of patients with macula-off detachments had a final visual acuity between 20/20 and 20/50. Twenty nine percent had final visual acuity between 20/60 and 20/200. Two patients developed a new retinal hole postoperatively. CONCLUSION: Pneumatic buckle is an effective technique for repair of primary rhegmatogenous retinal detachments caused by breaks in the superior 8 o'clock segment. This technique avoids the complications associated with the drainage portion of the traditional scleral buckle operation and results in a high rate of retinal reattachment and stable or improved visual acuity. The rate of new retinal hole formation in this study is much lower than those reported for pneumatic retinopexy.

Adult↗

Vitrectomy with internal limiting membrane peeling for macular retinoschisis and retinal detachment without macular hole in highly myopic eyes.

PURPOSE: To report anatomic and visual improvement following vitrectomy with internal limiting membrane (ILM) peeling for two highly myopic patients with retinoschisis and/or retinal detachment without a macular hole. DESIGN: Two interventional case reports. METHODS: Two highly myopic patients who had retinoschisis and/or retinal detachment without a full-thickness macular hole underwent vitrectomy, internal limiting membrane peeling, and long-acting gas injection. Main outcome measures included best-corrected visual acuity, biomicroscopic appearance, and optical coherent tomography finding. RESULTS: Vitrectomy with ILM peeling results in biomicroscopic, functional, and tomographic improvement in both patients, for follow-up periods of 12 months and 8 months, respectively. CONCLUSIONS: Vitrectomy with ILM peeling and gas tamponade is an effective method for retinoschisis and/or retinal detachment without a macular hole in highly myopic patients.

Aged↗

Unilateral atypical retinal pigment epitheliopathy associated with serous retinal detachment.

We treated a young patient with unilateral gray-yellow subretinal lesions associated with bullous retinal detachment in the posterior pole. Angiography revealed the presence of multiple areas of subretinal pigment epithelial pooling of the dye. It is rare to find an association between acute inflammation of the retinal pigment epithelium and sensory retinal detachment.

Adult↗

Preoperative peribulbar block in patients undergoing retinal detachment surgery under general anesthesia: a randomized double-blind study.

Retinal detachment surgery is frequently associated with significant postoperative pain and emesis in adults. In this randomized, double-blind, controlled study we sought to demonstrate that 1% ropivacaine peribulbar (PB) block in conjunction with general anesthesia (GA) improves operative conditions and postoperative analgesia compared with GA combined with subcutaneous normal saline injection into the inferior eyelid. Thirty-one patients were included in each group. Anesthesia was performed with target-controlled infusion propofol and continuous remifentanil infusion adjusted to maintain bispectral index values between 40 and 50. Postoperative analgesia included fixed-dose IV infusion of propacetamol and IV injection of nefopam via a patient-controlled analgesia device. Tramadol was infused IV as rescue medication. Demographic data were comparable between the groups and bispectral index values were maintained at the objective target. In the PB group, fewer patients presented an oculocardiac reflex (6 versus 17; P < 0.01); bleeding interfering with the surgical field was reduced (1 versus 11 patients; P < 0.01); mean time to first nefopam request was longer (148 +/- 99 versus 46 +/- 58 min; P < 0.01); mean nefopam consumption was diminished during the first 6 h after tracheal extubation (18.9 +/- 13.9 versus 28.5 +/- 14.7 mg; P < 0.05); immediate postoperative pain scores were lower; and fewer patients required rescue medication (5 versus 23; P < 0.01). The two groups were similar with respect to the incidence of postoperative nausea and vomiting. Overall, PB block combined with GA improved operating conditions and postoperative analgesia in retinal detachment surgery.

Adult↗

[Blue-yellow perimetry in rhegmatogenous retinal detachment. Studies before and after therapy in comparison with white-white perimetry].

INTRODUCTION: Disturbance of the blue light perceptance in rhegmatogenous retinal detachment was demonstrated by Köllner 1907 with the help of colour-perimetries. We examined the blue- and white-function after retinal reattachment by blue-on-yellow-perimetry compared with white-on-white-perimetry. PATIENTS AND METHODS: 10 Patients with rhegmatogenous retinal detachment and a visual acuity > or = 0.1 were examined preoperatively, 4 days and 6 weeks after successful buckling procedure. We performed a white-on-white-perimetry as also perimetries with blue stimuli on a yellow luminance background (program 30-2 of the Humphrey Field Analyzer 750). RESULTS: Four days after surgery the increase in sensitivity was significantly less for the blue-function compared with the white-function. Preoperatively and 6 weeks postoperatively the sensitivities were not significantly different. Between these time-points function recovered in average for both methods from MD -15 dB to MD -5 dB. CONCLUSION: After successful retinal detachment surgery the blue- and white-function increased. Blue-on-yellow-perimetry showed more retinal sensitivity loss than white-on-white-perimetry immediately after surgery. Blue-on-yellow-perimetry measured the same retinal sensitivity loss as white-on-white-perimetry preoperatively and 6 weeks postoperatively.

Adult↗

[Treatment by internal tamponade of retinal detachment with a macular hole].

The authors analyse the operative results of 92 cases of retinal detachment with macular hole, treated by internal tamponade, since 1976. Three technics were used: vitrectomy + silicone oil injection (75 cases), vitrectomy + SF6 gas injection (9 cases), intra-ocular liquid suction + SF6 gas injection (8 cases). Silicone vitrectomy is particularly advisable in the case of large, old retinal detachment with proliferative vitreoretinopathy. This form of treatment is imperative when there is no hope of a satisfactory postoperative positioning, or after an unsuccessful gas treatment due to epiretinal macular membrane. Suction gas is a new and simple technique which is recommended when the macular hole is isolated and without epiretinal membranes. A lattice pattern argon-laser retinopexy is performed, by means of a series of laser impacts at the posterior pole, up to the edge of the macular hole. Treatment of isolated macular holes in a flexible retina by silicone vitrectomy achieved a 78.5% success rate; suction + gas achieved a similar success rate; this last method appears to be the ideal first choice for most of the cases, i-c the two failures which were subsequently turned into successes by silicone vitrectomy.

Evaluation Studies as Topic↗

Nonrhegmatogenous retinal detachment in Goodpasture's syndrome: a case report and discussion of the clinicopathologic entity.

BACKGROUND: Goodpasture's syndrome is a rare, rapidly fatal disease that consists of glomerulonephritis and pulmonary hemorrhage. Although not common, the ophthalmic manifestations of this disease include hemorrhagic and/or exudative retinopathy and infrequently, nonrhegmatogenous retinal detachment. METHODS: A 25-year-old white male was examined with a complaint of bilateral intermittent blurring of vision. His medical history revealed a diagnosis of Goodpasture's syndrome with subsequent renal failure and associated complications. Ophthalmoscopy and visual field testing demonstrated bilateral, inferior nonrhegmatogenous retinal detachments. RESULTS: Optimum control of both blood pressure and metabolic processes were recommended to increase the chance of resolution of the nonrhegmatogenous retinal detachments. CONCLUSIONS: Although infrequently seen in Goodpasture's syndrome, nonrhegmatogenous retinal detachment may have a good prognosis for recovery when diagnosed early and with treatment of the underlying disease and its metabolic derangements.

Adult↗

Retinal detachment following extracapsular cataract extraction and posterior chamber intraocular lens implantation.

Fourteen cases of primary retinal detachment after extracapsular cataract extraction and posterior chamber intraocular lens implantation were treated by scleral buckling surgery. Retinal reattachment was achieved in 100% of the cases. All eyes had a postoperative visual acuity of 6/30 or better; in six eyes the visual acuity was 6/12 or better. We attributed our high anatomical success rate to early detection of the retinal detachment, good visibility of the retinal breaks, lack of inflammatory reaction in the vitreous body, and preoperative absence of fixed retinal folds and preretinal membranes.

Aged↗

Fluid dynamics in eyes with rhegmatogenous retinal detachments.

Inward and outward permeabilities to sodium fluorescein at the blood-retinal barrier were measured by kinetic vitreous fluorophotometry in ten eyes with rhegmatogenous retinal detachments. Fellow eyes were used as controls. Inward permeability of eyes with detachments was significantly larger than that of controls (P less than .005), suggesting damage to the blood-retinal barrier in eyes with detachments. Outward permeability of eyes with detachment and retinal holes was slightly less than that of controls, but the difference was not statistically significant. However, outward permeability of eyes with detachments and with retinal tears was significantly larger than that of controls (P less than .05). This increased outward permeability may be attributed to the increased fluid flow posteriorly through the break across the retinal pigment epithelium.

Adolescent↗

Surgical approaches to retinal detachment in retinopathy of prematurity.

Outlined in this chapter are surgical approaches to retinal detachment in ROP. Technical details of the vitrectomy approach to stage V ROP are covered extensively in the chapters by Machemer and Charles. Late-onset retinal detachment is a rare complication. Two types of detachment, those associated with traction and those associated with retinal breaks or tears (rhegmatogenous), generally respond well to standard buckling procedures. The incidences of these complications provide reason for continued long-term follow-up of eyes with ROP.

Adolescent↗

Serous retinal detachment in a patient with rhino-orbital mucormycosis.

BACKGROUND: Rhino-orbital mucormycosis is a difficult disease to treat. We report one case of rhino-orbital mucormycosis, complicated by serous retinal detachment, that responded to aggressive treatment. CASE: A 38-year-old man with diabetic ketoacidosis was referred to the emergency department of our hospital with fever, proptotic right eye, and complaint of lethargy. OBSERVATIONS: Fundus examination showed serous retinal detachment and focal lesions of retinitis with exudate at the inferior portion coincident with the position of opacification in the orbit on MRI. Fluorescein angiography showed pooling of dye in the detached retina and leakage from focal lesions of retinitis. We thoroughly removed the large necrotic materials in the orbit and sinus through the lower conjunctiva without enucleation or exenteration. Microscopic examination and culture of the necrotic materials that were removed from the orbit proved that the patient had mucormycosis. The serous retinal detachment improved 10 days after orbital debridement combined with intravenous and local (intraorbital) amphotericin B treatment. Visual acuity recovered to 20/50. CONCLUSION: We propose that inflammation of the sclera in close contact with necrotic fungi materials may cause serous retinal detachment.

Adult↗

Exudative retinal detachment occurring in a patient with pyogenic liver abscess.

This is a report of a rare case of bilateral exudative retinal detachment occurring in a young Nigerian male with pyogenic liver abscess. Detailed ocular and clinical examination with biochemical, haematological and microbiological studies of the blood and liver aspirate were done. Ocular and abdominal scan plus surgical drainage of abscess were also done. The main features were febrile illness with hepatomegaly and sudden loss of eyesight. Visual acuity was light perception in both eyes. The cardiovascular and renal systems were normal. Ocular scan showed bilateral bullous retinal detachment while abdominal ultrasound revealed multiple liver abscess cavities. HIV and HBsAg tests were negative. Pyogenic liver abscess should be regarded as possible cause of exudative retinal detachment and has a potential blinding complication.

Adult↗

[Retinal detachment caused by giant tears: recent clinical results].

We perform surgery on ten eyes of ten patients of retinal Detachment with giant retinal tear. The surgical procedure induced lensectomy, vitrectomy, retinal incarceration, circumferential scleral buckling on 360 degrees, retinal tamponade with gaz (C3F8) and post-operative photocoagulation of the giant tear. Although most of cases was associated with massive proliferation vitreo-retinopathy, total retinal reattachment was achieved in five eyes.

Follow-Up Studies↗

[Colobomatous pits of the optic nerve papilla associated with serous retinal detachment. The clinical and pathogenic aspects].

The present study is about a number of 19 cases (19 eyes), the patients having a congenital pit of the optic papilla (CPP) complicated with serous retinal detachment (SRD). The cases were selected, from a group of 41 patients with CPP. Average age of the cases was 37(31-54) years. The serous retinal detachment appeared under two different clinical appearances: the detachment of the internal retinal layers (DIRL) or retinal schisis, 10 cases, located between the papillae and macula, and involving the optic disc; the detachment of the external retinal layers (DERL), 9 cases, located within the macular area, without involvement of the optic disc. A number of 8 cases (42%) developed a macular hole, located within the external retinal layers. The cases with DIRL had better visual acuity, compared to those with DERL. This study proves the bilamellate character, of the serous retinal detachment. The disease starts with DIRL (retinal schisis), due to fluid passing at the level of the CPP and then DERL develops as a complication, following the degenerescence of the retinal layers within this area.

Adult↗