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Postural compensation after intratympanic gentamicin treatment of Menière's disease.

We have treated 93 patients with severe Menière's disease with gentamicin (GM) applied with 1 to 4 or intratympanic injections in a prospective study. The patients were tested at frequent intervals and followed up for two years. Postural stability was evaluated on posturography. Unsteadiness and gait between attacks, working capacity and vertigo were scored. Before commencing the treatment 47 of the patients complained from moderate to severe postural instability. After treatment moderate to severe postural instability was met in 19 patients. Initially the sway velocity was 27 mm/s on average being significantly worse than in referents. Two weeks after treatment the sway velocity increased to 33 mm/s. Thereafter the sway velocity slowly started to decline to 31 mm/s after two years. Patients with severe attacks of rotatory vertigo had a good postural outcome with GM treatment. In logistic regression analysis the most significant risk factor for poor recovery after GM treatment was severely reduced gait before commencing the treatment with odds ratio of 2.0. Subjectively, after two years, the patients rated their postural stability significantly improved when compared to pretreatment values. The good subjective rating of postural stability is related to postural training program where in the absence of attacks, the patients have learned to cope with daily tasks.

Adult↗

[Influence of knee replacement arthroplasty on modalities of weight transfer during the lateral step].

INTRODUCTION: The aim of this work was to study the relations between equilibrium and movement in patients after total knee arthroplasty. A previous study, conducted in patients with unilateral knee osteoarthritis, had shown that the timing of the events occurring during a side-step was modified in an asymmetrical way according to the supporting leg with respect to the affected one. METHOD: A kinetic and kinematic analysis was performed in a population of 9 patients before and after total knee arthroplasty and in 11 control subjects, using an ELITE system and two AMTI force-plates. The different phases (i.e. postural, monopodal, landing and stabilization) of a side step were studied. RESULTS AND DISCUSSION: Before surgery, the postural phase was longer and the monopodal phase was shorter in knee arthritis patients when the affected leg was the supporting one than when the sound leg was supporting. Total step duration and landing-stabilization phase duration were longer in patients no matter which leg was supporting than in control subjects. After total knee arthroplasty, the postural phase remained longer when the operated leg was supporting than when the sound leg was supporting. Altered proprioception can provide an explanation for this result. However, the duration of the postural phase decreased significantly when the operated leg was supporting as compared to when the affected leg was supporting before surgery. The duration of the monopodal phase was the same when the operated leg was supporting than when the sound limb was supporting and increased significantly as compared to when the affected leg was supporting before surgery. This result can be related to the decrease of pain which was observed in all patients after surgery. The duration of the landing-stabilization phase and the total movement duration remained longer in patients after surgery no matter which leg was supporting than in control subjects. CONCLUSION: This study shows that relations between equilibrium and movement tend to become symmetrical with respect to the leg used as supporting one in patients after undergoing total knee arthroplasty but remain different from those of control subjects. This movement analysis method enables to determine and to quantify differences in patients before and after undergoing total knee arthroplasty and thus provides additional information for the functional evaluation of patients with total knee prosthesis.

Aged↗

Disruption of postural readaptation by inertial stimuli following space flight.

Postural instability (relative to pre-flight) has been observed in all shuttle astronauts studied upon return from orbital missions. Postural stability was more closely examined in four shuttle astronaut subjects before and after an 8 day orbital mission. Results of the pre- and post-flight postural stability studies were compared with a larger (n = 34) study of astronauts returning from shuttle missions of similar duration. Results from both studies indicated that inadequate vestibular feedback was the most significant sensory deficit contributing to the postural instability observed post flight. For two of the four IML-1 astronauts, post-flight postural instability and rate of recovery toward their earth-normal performance matched the performance of the larger sample. However, post-flight postural control in one returning astronaut was substantially below mean performance. This individual, who was within normal limits with respect to postural control before the mission, indicated that recovery to pre-flight postural stability was also interrupted by a post-flight pitch plane rotation test. A similar, though less extreme departure from the mean recovery trajectory was present in another astronaut following the same post-flight rotation test. The pitch plane rotation stimuli included otolith stimuli in the form of both transient tangential and constant centripetal linear acceleration components. We inferred from these findings that adaptation on orbit and re-adaptation on earth involved a change in sensorimotor integration of vestibular signals most likely from the otolith organs.

Adaptation, Physiological↗

Head stability in walking in children with cerebral palsy and in children and adults without neurological impairment.

BACKGROUND AND PURPOSE: The location of several sensory systems in the head implies that maintenance of head stability may be a potentially important part of locomotor activity. A limited amount of research, however, has been conducted to measure stability or to compare head stability among different groups. The purpose of this study was to determine whether a method for measuring head stability during walking could differentiate among 3 groups: (1) children with cerebral palsy, (2) children without neurological impairment, and (3) adults without neurological impairment. SUBJECTS: Eight adults without known neurological impairment, 6 children without known neurological impairment, and 6 children with cerebral palsy and mild spastic hemiplegia were compared. METHODS: Subjects walked on a treadmill at their preferred speed at a number of frequencies. Head stability was characterized by fluctuations in period and amplitude of head motion in the sagittal plane across walking cycles. RESULTS: Mean period fluctuation was lower for the adults than for the children, and it was lower for the children without neurological impairments than for the children with cerebral palsy. CONCLUSION AND DISCUSSION: The method can be used to differentiate head stability among different groups during functional activities.

Adult↗

Postural activity of constrained subject in response to disturbance in sagittal plane.

The study examines postural activity of a constrained subject in response to various disturbances in the sagittal plane. Three different initial standing postures were examined. Each response to a perturbation was divided into three consecutive phases according to the intensity of the muscular activity. The relation of the ankle joint torque versus the ankle joint angle was studied. A linear relationship, resulting in constant ankle stiffness, was observed in each phase of the response. Only negligible differences in the stiffness values were observed among different phases. The results indicate an ankle stiffness value of 10 N m/o for the majority of initial stance postures and perturbation intensities.

Adult↗

[The role of risk factors in developmental diagnosis].

Cerebral Palsy (CP) is a chronic disorder of motion and postural balance caused by defect or damage of immature brain. Possibility of primary prevention of CP is not big, the most important is early diagnosis. 120 newborns admitted to the Developmental department of Pediatric Clinic as "child at risk" were investigated. The average gestational age was 37.18 weeks, average birth weight was 2820.09 g. In the group of prematurely born children CP has developed in 15 out of 50 children (30%), in the group of term children it was present in 17 out of 57 children (29.83%). 32 children (29.92%) had birth weight below 2500 g. Among them there were 7 cases of CP (21.88%). Children with birth weight of over 2500 g (75 children, 70.09%) had CP in 25 cases (33.33%). There was no statistically significant difference between boys and girls, and between healthy and children with CP. There was high rate of correlation between gestational age, birth weight and score of neonatal optimality, as well as score of pregnancy optimality, score of delivery optimality and neonatal optimality. The important correlation appeared between score of delivery optimality and score of neonatal optimality. There was high correlation between score of perinatal optimality and all three of its components. Diagnosis of "child at risk" made only on the basis of risk factors during pregnancy, delivery and neonatal period is out of discussion, it is not pointing out the developmental outcome. Evaluation by the methods of clinical examination is necessary for prediction of neurological development.

Birth Weight↗

The Timed Get-up-and-Go test revisited: measurement of the component tasks.

The "Timed Get-up-and-Go" (TGUG) test measures the overall time to complete a series of functionally important tasks. In the "Expanded Timed Get-up-and-Go" (ETGUG) test, times for the component tasks are measured using a multimemory stopwatch. Results from the ETGUG test were compared to those from the TGUG test on three groups of subjects: nonimpaired young, nonimpaired elderly, and elderly subjects at risk of falling. Significant differences were found between the two control groups and the at-risk group for all components of the test. Walking speed was the only measurement found to be significantly different between the young and elderly controls. The ETGUG test is a sensitive and objective assessment of function that requires minimal equipment, training, or expense. It better isolates functional deficits, thereby aiding the clinician in devising prevention strategies and guiding both treatment and further testing.

Adult↗

[Sagittal equilibrium of the pelvis: analysis of the inclination of the ischio-pubic ramus from the horizontal].

PURPOSE OF THE STUDY: The sagittal equilibrium of the spine and pelvis has been examined in numerous studies looking for the origin of certain posture disorders of the spine and the cause of lower back pain. Sagittal x-rays of the pelvis provide an analysis of the degree of inclination of the pelvis from the horizontal and the bi-coxo-femoral axis and information on the form of the sacrum. There is no radiographic parameter however which analyzes the transition between the pelvis-sacrum component and the femoral component, i.e. the periacetabular region. In the sagittal plane, a line tangent to the ischio-pubic ramus would appear to best reflect the orientation of the periacetabular region and the muscular forces applied to this region. The purpose of this work was to analyze the inclination of the ischio-pubic ramus from the horizontal and its relations with other sagittal radiographic parameters in a population of growing children with spinal disorders. MATERIALS AND METHOD: The study population included 100 children with spinal disorders who underwent a teleradiographic series with lateral view in the upright position. Most of the children had scoliosis (80 cases), 7 had kyphoscoliosis, 4 isthmic spondylolysis with spondylolisthesis, 1 spondylodiscitis and 4 lower back pain. Mean age was 13 years (range 2.5-22 years). We measured 7 radiographic parameters: lumbo-sacral angle, slope of the sacrum, pelvic version, incidence, thickness, overhang, and inclination of the ischio-pubic ramus from the horizontal. Data were analyzed to search for correlations between radiographic parameters and between radiographic parameters and clinical features. RESULTS: Mean inclination of the ischio-pubic ramus from the horizontal was 33.9 degrees (SD =5.9 degrees ). The only positive statistical correlation between the inclination of the ischio-pubic ramus and the clinical data was a relationship with the position of the arms compared with the horizontal (p =0.04). There was no correlation with age, sex, ethnic background, etiology. There was no correlation between the inclination of the ischio-pubic ramus and the other radiographic parameters (coefficient r ranging from 0.06 to 0.43). DISCUSSION: The interdependence of sagittal radiographic parameters of the pelvis and the spine have been largely demonstrated. Certain pathological situations (isthmic spondylolysis with spondylolisthesis, lower back pain, etc.) can be explained by the value of these parameters, particularly incidence. The inclination of the ischio-pubic ramus from the horizontal reflects the periacetabular region. When analyzed in the sagittal plane, it was found to be a more stable parameter, independent of most clinical criteria (particularly age, and etiology) and of the other radiographic parameters studied. The only determining factor appears to be acquisition of the upright position. The consistency of this parameter constrasts with the variability of the other radiographic parameters of the pelvis and the spine, particularly incidence, although the inclination of the ischio-pubis ramus is an expression of a region different than the pelvis. This study suggests that the periacetabular region plays a key role in acquisition of the upright position in humans. The periacetabular region would be a fixed point around which the lower limbs and spine describe varying orientations.

Adaptation, Biological↗

The direction of apparent movement during transient pressure vertigo.

Pressure vertigo or alternobaric vertigo is the type of vertigo normally associated with relative overpressure in the middle ear. As with other types of vertigo, it should occur only if there is unequal stimulation of the left and right vestibular systems: there should be a lawful relation between the orientation of the head, the side of the overpressured ear, and the direction of apparent movement. Few published accounts give information on all these aspects. This paper reports some old and new cases which suggests that, when the head is upright during the ascent, overpressure in the right ear causes apparent bodily and visual movement to the right (clockwise), while overpressure in the left ear has the opposite effect. Horizontal orientation of the head probably reduces the vertigo. There are no detailed and unequivocal reports of pressure vertigo during descent, or with the head inverted. Some reports exist of tumbling sensations and of tilting of the visual scene, but the exact circumstances are unclear.

Diving↗

[Deficit of learning of posture voluntary control in patients with cortical lesions of various locations: cortical mechanisms of posture regulation].

Forty two hemiparetic patients after cerebrovascular accidents were trained to change the position of the center of pressure according to a target on the screen with the visual feedback control. The learning was substantially impaired in comparison with the group of healthy subjects. Patients with the right-hemispheric lesions showed somewhat greater learning deficit than patients with lesions in the left hemisphere. Lesion localization also affected the process of learning. The learning was disturbed to a greater extent in patients with lesions involving not only motor but also premotor and parietal cortical areas. In patients with parieto-temporal lesions the learning reached a very low level after three initial days of training, possibly, because of the deficit of sensory integration and of body scheme in the extra-personal space. Patients with combined lesions of the motor, premotor, and parietal areas showed the lowest results. The learning was shown to depend on the deficit of proprioception and extent of postural disturbances (asymmetry of body weight distribution and amplitude of the center of pressure oscillations) rather than on the extent of motor deficit (paresis and spasticity). However, the learning itself improved some motor disturbances.

Biofeedback, Psychology↗

The effects of scopolamine and cyclizine on visual-vestibular interaction in humans.

The aim of the present study was to investigate the effects of scopolamine (1.5 mg, transdermal patch) and cyclizine (50 mg tablet), at the doses usually used for the relief of motion sickness, on postural sway, optokinetic nystagmus (OKN) and circularvection (CV) in humans, using a within-subjects, double-blind, placebo-controlled design. Scopolamine and cyclizine were found to have no significant suppressive effect on these aspects of visual-vestibular interaction. Postural sway and CV were not significantly affected by either drug treatment; OKN SPV was significantly increased (p < 0.05), although OKN amplitude and frequency were unaffected. These results suggest that scopolamine and cyclizine, at doses used for the relief of motion sickness, may have minimal suppressive effects on these aspects of visual-vestibular interaction.

Administration, Cutaneous↗