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At least 1,225 records · Page 68Linked to original sources
PubMed1994

Amino Acid analysis of intellan, a herbal product used in enhancing brain function.

Analysis of the drug "INTELLAN" and two reputed plants i.e. Centella asiatica and Herpestis monniera used in the preparation of the drug reveals that glutamic and aspartic acids are present in high concentration in the drug and are also required by brain in high concentration to keep itself in higher gears. Both these amino acids are used as neurotransmitters and also in stabilizing and stimulating the activities of brain, thus resulting in better performance.

Journal Article↗
PubMed1987

Verapamil enhances brain function tolerance against severe hypoxia without enhancing cerebral blood flow in the rat.

In spontaneously breathing, lightly anesthetized rats with chronically implanted epicortical electrodes, tolerance times were measured from onset of progressive hypoxia, anoxia or decapitation, until ultimate apnea and subsequent cessation of brain electrical activities. Arterial and cerebrovenous blood was collected initially and during progressive hypoxia, starting 5 min after intravenous verapamil or NaCl (controls). Verapamil induced significant hyperpnea, arterial alkalosis, slight bradycardia and brain venous acidosis. During progressive hypoxia, hyperpnea persisted and heart rate remained stable for a longer period than in controls. Tolerance times were significantly prolonged. Time courses of arterial PO2 and PCO2 and of cerebrovenous PO2 were hardly influenced. However, arterial alkalosis and brain venous acidosis became highly significant versus control courses. This raised the O2 saturation in arterial and O2 extraction in cerebral venous blood. Sinus sagittalis puncture needle outflow (as a measure of CBF) tended to be below the control rat courses throughout. This led to a higher O2 supply to the brain in verapamil rats only during severe hypoxia. Verapamil did not prolong tolerance times in anoxia or ischemia. It is concluded that the verapamil-induced increase of tolerance to hypoxia is primarily due to the acid-base (Bohr) effects observed in response to hyperpnea and prolonged cerebral metabolic activity.

Animals↗
PubMed1994

The role of mother's voice in the organization of brain function in the newborn.

Newborn infants prefer the sound of the maternal voice within the first two days after birth. This early preference may be based on prenatal experience. The mother's voice is reported to be the most intense acoustical signal measured in the amniotic environment. Data showing the ability of the newborn to demonstrate voice preferences are presented. We have also investigated the response of the perinatal autonomic nervous system to speech sound stimulation. Both the newborn and fetus show heart rate decelerations in response to speech sounds. This cardiorespiratory attentional response occurs during sleep when sensory stimulation is probably influencing perinatal brain development. Early experience with voice has both acute and enduring effects on the developing brain. These effects have ramifications for the development of the auditory system, as well as for later social and emotional development. Further speculation and discussion on the form, function and assessment of newborn responsiveness to voice will be offered.

Brain↗
PubMed1997

Amines and peptides in the brain of the American lobster: immunocytochemical localization patterns and implications for brain function.

The distributions of serotonin- (5HT-), substance P- (SP-), small cardioactive peptideb- (SCPb-), and histamine- (HA-) like immunoreactivities were examined in the adult lobster supraesophageal ganglion. Vibratome sections were labeled using avidin-biotin-peroxidase immunocytochemical methods. The localization patterns for each substance were assessed in 21 regions within the median protocerebrum, deutocerebrum, and tritocerebrum. Each immunoreactivity has a unique distribution within the brain; however, most regions are immunoreactive for more than one neurotransmitter. Of particular interest are SP-immunoreactive protocerebral neurons that contact olfactory projection neurons and appear homologous to those found in other crustaceans. Regional differences in immunolabeling within the deutocerebral olfactory and accessory lobes suggest that specific areas within individual olfactory lobe glomeruli serve distinct functions in olfactory processing, and that subpopulations of accessory lobe glomeruli are innervated by different groups of neurons. This detailed comparison of the labeling patterns also has allowed us to define the anatomical connectivity between several cell body clusters, fiber tracts, and neuropil areas in the lobster brain.

Amines↗
PubMed1996

Ligation of lateral carotid artery attenuates disturbance of brain function caused by subsequent cerebral ischemia in rabbits.

The effects of right carotid artery ligation on the subsequent cerebral ischemia, induced by iron particle injection, in rabbits, were evaluated by recording somatosensory evoked potentials (SEPs) and cerebral blood flow (CBF) using laser Doppler flowmetry. Iron particle injection decreased CBF over 120 min and delayed SEP onset latency in rabbits with no previous carotid artery ligation (control group). In rabbits with a carotid ligation 3 days before, iron particle injection induced the decrease of CBF, as in the control group, but did not prolong the latency of SEP. Injection of iron particles induced only a transient decrease of CBF (less than 10 min) followed by an abrupt recovery, and no prolongation of SEP latency was observed in rabbits with a carotid ligation 6 days before. These results suggest that carotid artery ligation induces a beneficial effect on cerebral function during the subsequent ischemia, which is independent on the CBF changes.

Animals↗
PubMed2002

Primary dystonia: is abnormal functional brain architecture linked to genotype?

The DYT1 dystonia mutation is associated with an abnormal metabolic brain network characterized by hypermetabolism of the basal ganglia, supplementary motor area, and the cerebellum. In this study, we quantified the activity of this network in carriers of other dystonia mutations to determine whether this functional abnormality is linked to genotype. The findings suggest that the DYT1 metabolic topography is not genotype specific and may be present in carriers of other dystonia mutations.

Adult↗
PubMed2004

Functional brain imaging in Sydenham's chorea and streptococcal tic disorders.

Group A streptococcal infections cause a wide range of neuropsychiatric disorders, such as Sydenham's chorea, tics, obsessive-compulsive disorders, and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). Structural (computed tomography and magnetic resonance imaging) and functional (positron emission tomography, single-photon emission computed tomography) imaging studies in patients with Sydenham's chorea have suggested reversible striatal abnormalities. The objective of this study was to investigate the cerebral perfusion patterns of the subcortical structures by using hexamethylpropylenamine oxime single-photon emission computed tomography (HMPAO-SPECT) in seven cases of Sydenham's chorea and two cases of streptococcal tic disorder. HMPAO-SPECT studies revealed a hyperperfusion pattern in two and a hypoperfusion pattern in five of the chorea patients and in two patients with tic disorder. The results are discussed in relation to the duration and severity of the symptoms and the response to therapy. Functional imaging findings can be variable in Sydenham's chorea, and hyperperfusion of the striatum and thalamus could be an indicator of the response to therapy and the severity of symptoms. However, the number of cases so far investigated by either SPECT or positron emission tomography is still too limited to draw any firm conclusions.

Adolescent↗