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PubMed2005

The heresy of African-centered psychology.

This paper contends that African-centered models of psychopathology represent a heretical challenge to orthodox North American Mental Health. Heresy is the defiant rejection of ideology from a smaller community within the orthodoxy. African-centered models of psychopathology use much of the same language and ideas about the diagnostic process as Western psychiatry and clinical psychology but explicitly reject the ideological foundations of illness definition. The nature of the heretical critique is discussed, and implications for the future of this school of thought are offered.

Black or African American↗
PubMed2006

How can information extraction ease formalizing treatment processes in clinical practice guidelines? A method and its evaluation.

OBJECTIVE: Formalizing clinical practice guidelines (CPGs) for a subsequent computer-supported processing is a challenging, but burdensome and time-consuming task. Existing methods and tools to support this task demand detailed medical knowledge, knowledge about the formal representations, and a manual modeling. Furthermore, formalized guideline documents mostly fall far short in terms of readability and understandability for the human domain modeler. METHODS AND MATERIAL: We propose a new multi-step approach using information extraction methods to support the human modeler by both automating parts of the modeling process and making the modeling process traceable and comprehensible. This paper addresses the first steps to obtain a representation containing processes which is independent of the final guideline representation language. RESULTS: We have developed and evaluated several heuristics without the need to apply natural language understanding and implemented them in a framework to apply them to several guidelines from the medical subject of otolaryngology. Findings in the evaluation indicate that using semi-automatic, step-wise information extraction methods are a valuable instrument to formalize CPGs. CONCLUSION: Our evaluation shows that a heuristic-based approach can achieve good results, especially for guidelines with a major portion of semi-structured text. It can be applied to guidelines irrespective to the final guideline representation format.

Artificial Intelligence↗
PubMed2006

Tracking the mind during reading: the influence of past, present, and future words on fixation durations.

Reading requires the orchestration of visual, attentional, language-related, and oculomotor processing constraints. This study replicates previous effects of frequency, predictability, and length of fixated words on fixation durations in natural reading and demonstrates new effects of these variables related to 144 sentences. Such evidence for distributed processing of words across fixation durations challenges psycholinguistic immediacy-of-processing and eye-mind assumptions. Most of the time the mind processes several words in parallel at different perceptual and cognitive levels. Eye movements can help to unravel these processes.

Adolescent↗
PubMed2006

Practical methods for the clinical assessment of information processing speed.

The rate at which individuals are capable of processing information is considered a sensitive indicator of brain dysfunction, particularly among clinical populations whose neurocognitive impairments generally are considered relatively mild in nature. Assessment of information processing speed often is confounded, however, by comorbid impairments in other constructs of neurocognition, including attentional capacity, visuospatial perception, language, immediate memory, and motor speed/coordination. This investigation examined the effect of controlling for various potential confounders on the strength of associations among several potential measures of information processing speed. Participants were 64 patients diagnosed with clinically definite multiple sclerosis. Analysis indicated consistent significant and positive associations among measures of processing speed, which generally persisted despite simultaneous statistical control of potential confounding factors. Results imply that examined confounding variables are similarly related to the measures of processing speed. Therefore, any of the measures of information processing speed considered in this study may be used as a proxy for the more direct measure of this construct derived from the Sternberg Memory Scanning Test.

Cognition↗
PubMed2001

Knowledge representation of signal transduction pathways.

MOTIVATIONS: Signal transduction is the common term used to define a diverse topic that encompasses a large body of knowledge about the biochemical mechanisms. Since most of the knowledge of signal transduction resides in scientific articles and is represented by texts in natural language or by diagrams, there is the need of a knowledge representation model for signal transduction pathways that can be as readily processed by a computer as it is easily understood by humans. RESULTS: A signal transduction pathway representation model is presented. It is based on a compound graph structure and is designed to handle the diversity and hierarchical structure of pathways. A prototype knowledge base was implemented on a deductive database and a number of biological queries are demonstrated on it.

Amino Acid Motifs↗
PubMed1984

Non-speech communication symbols and systems: where have we been and where are we going?

During the past quarter century, and especially during the past decade, we have seen the emergence of various non-speech communication symbols and systems as viable means of communication by and with severely handicapped individuals. A brief overview of the full range of both aided (static or graphic) and unaided (dynamic or manual) non-speech symbols and systems is presented. A hierarchy of difficulty, cognitive requisites, approximation to English (or other natural languages), abstraction, acceptance, etc. is considered. Advantages of non-speech communication are related to general input simplification, response production, receptive language/auditory processing, stimulus processing/stimulus association, and symbolic representation. The advantages of vocabulary limits and attentional facilitation for intervention with severely handicapped individuals are discussed. Major research issues are also explored.

Attention↗
PubMed2004

Disentangling the web: neologistic perseverative errors in jargon aphasia.

This article explores the relationship between the neologisms and perseverative errors produced by KVH, a man with severe neologistic jargon aphasia. Detailed examination of KVH's level of language processing breakdown revealed mild difficulties with phonological encoding and severe difficulties accessing the lexical form of the word. Many of KVH's neologisms contained phonemes perseverated from previous neologisms, suggesting an integral relationship between the production of neologisms and the perseveration of phonemes. Furthermore, KVH's patterns of whole word (total)and phonological (blended) perseverations reflected his proposed underlying language processing deficits, consistent with recent literature on perseveration (e.g.,Cohen and Dehaene, 1998). However, the simple binary distinction oftotalandblendedperseveration is proposed to be somewhat limited for understanding the underlying nature of KVH's complex neologistic errors. Possible explanations regarding the mechanisms underlying the production of KVH's neologistic and perseverative errors also are discussed.

Aged↗
PubMed2005

Testing the limits of the semantic illusion phenomenon: ERPs reveal temporary semantic change deafness in discourse comprehension.

In general, language comprehension is surprisingly reliable. Listeners very rapidly extract meaning from the unfolding speech signal, on a word-by-word basis, and usually successfully. Research on 'semantic illusions' however suggests that under certain conditions, people fail to notice that the linguistic input simply doesn't make sense. In the current event-related brain potentials (ERP) study, we examined whether listeners would, under such conditions, spontaneously detect an anomaly in which a human character central to the story at hand (e.g., "a tourist") was suddenly replaced by an inanimate object (e.g., "a suitcase"). Because this replacement introduced a very powerful coherence break, we expected listeners to immediately notice the anomaly and generate the standard ERP effect associated with incoherent language, the N400 effect. However, instead of the standard N400 effect, anomalous words elicited a positive ERP effect from about 500-600 ms onwards. The absence of an N400 effect suggests that subjects did not immediately notice the anomaly, and that for a few hundred milliseconds the comprehension system has converged on an apparently coherent but factually incorrect interpretation. The presence of the later ERP effect indicates that subjects were processing for comprehension and did ultimately detect the anomaly. Therefore, we take the absence of a regular N400 effect as the online manifestation of a temporary semantic illusion. Our results also show that even attentive listeners sometimes fail to notice a radical change in the nature of a story character, and therefore suggest a case of short-lived 'semantic change deafness' in language comprehension.

Adult↗
PubMed2003

The influence of language exposure on lexical and syntactic language processing.

Previous literature has argued that proficient bilingual speakers often demonstrate monolingual-equivalent structural processing of language (e.g., the processing of structural ambiguities; Frenck-Mestre, 2002). In this paper, we explore this thesis further via on-line examination of the processing of syntactically complex structures with three populations: those who classify as monolingual native English speaker (MNES), those who classify as non-native English speakers (NNES), and those who calssify as bilingual native English speakers (BNES). On-line measures of processing of object-relative constructions demonstrated that both NNES and BNES have different patterns of performance as compared to MNES. Further, NNES and BNES speakers perform differently from one another in such processing. The study also examines the activation of lexical information in biasing contexts, and suggests that different processes are at work in the different type of bilinguals examined here. The nature of these differences and the implications for developing sensitive models of on-line language comprehension are developed and discussed.

Humans↗
PubMed2001

Voices of the self in psychotherapy: a qualitative analysis.

Approaches that view the self as constituted by socio-cultural processes and as plural, consisting of a multiplicity of states, positions, functions, etc., have flourished in the last decades. This paper explores the multi-voiced nature of the self, drawing upon Lacan's theory of subjectivity and Bakhtin's concept of dialogism. Subjectivity is seen as constituted through language as expressed in the speech of the subject's important early others. The psychoanalytic concept of transference, understood as a semiotic process of enacting early interpersonal patterns in the subject's present relations, provides a link between the unfolding of subjectivity in the present and its historical continuity. The articulation of subjectivity is discussed through a micro-analysis of extracts from sessions of a long-term psychoanalytic psychotherapy. The analysis demonstrates the enactment of transferential dialogical positions at the beginning of the therapy and traces their recognition by the client through the gradual development of increasingly reflexive subject positions towards the end of therapy. It is argued that the aim of therapy should be the facilitation of a complex subjectivity, whereby the different subject positions can be fluently articulated within an overall reflexive frame.

Ego↗
PubMed2001

Voices of the self in psychotherapy: A qualitative analysis.

Approaches that view the self as constituted by socio-cultural processes and as plural, consisting of a multiplicity of states, positions, functions, etc., have flourished in the last decades. This paper explores the multi-voiced nature of the self, drawing upon Lacan's theory of subjectivity and Bakhtin's concept of dialogism. Subjectivity is seen as constituted through language as expressed in the speech of the subject's important early others. The psychoanalytic concept of transference, understood as a semiotic process of enacting early interpersonal patterns in the subject's present relations, provides a link between the unfolding of subjectivity in the present and its historical continuity. The articulation of subjectivity is discussed through a micro-analysis of extracts from sessions of a long-term psychoanalytic psychotherapy. The analysis demonstrates the enactment of transferential dialogical positions at the beginning of the therapy and traces their recognition by the client through the gradual development of increasingly reflexive subject positions towards the end of therapy. It is argued that the aim of therapy should be the facilitation of a complex subjectivity, whereby the different subject positions can be fluently articulated within an overall reflexive frame.

Journal Article↗
PubMed2004

The concept of 'developing the brain': a new natural science for learning and education.

From the viewpoint of biology, learning and education can be defined as the processes of forming neuronal connections in response to external environmental stimuli, and of controlling or adding appropriate stimuli, respectively. Learning and education can thus be studied as a new field of natural sciences with the entire human life span as its subject, thus including various problems such as fetal environment, childcare, language acquisition, general/special education, and rehabilitation. Non-invasive imaging of higher-order brain functions in humans will clarify the brain's developmental processes, and will provide various evidence for learning sciences. This new approach is called 'developing the brain' or 'brain science and education'. The origin of the concept and its present state are described and its future prospects are briefly analyzed.

Brain↗
PubMed1984

The nature and specificity of the language coding deficit in autistic children.

The subjects, 12 autistic, 12 retarded and 12 normal children, range-matched on digit span and mental age, were asked to learn and recall sequences of words. Four types of sequence were used: sequences were constructed to be either grammatically well formed or not and were constructed so that the elements had a high or low degree of semantic relatedness. Sequences were presented in an auditory-verbal serial recall task and performance was assessed with three measures: serial recall, cluster recall and free recall. In general, recall was better when the degree of semantic relatedness was high rather than low, and the improvement was similar for all groups. Similarly, recall was better for sequences which were grammatically well formed than for sequences which were not, but the improvement of normal children was significantly greater than that of autistic children. While contemporary theories view the linguistic deficit evidenced by autistics as a deficit in the processing of semantic information, these results show that autistics have a deficit in processing syntactic information. However, this study does not resolve the issue of whether the deficit is specific to autism or a more general, developmental deficit, for while autistics differed from matched normal children, they did not differ from matched retarded children. Methodological problems in the construction of natural language sequences which vary independently in semantic and syntactic features are discussed, and it is suggested that sequences with artificial syntactic and semantic (associational) structures should be used to resolve the question of whether autistics have a deficit in processing semantic information.

Adolescent↗
PubMedDate not supplied

Patients with medically unexplained symptoms: sources of patients' authority and implications for demands on medical care.

Lay and medical beliefs are not separate systems. The beliefs of somatizing patients, in particular, incorporate medical understanding and it has been argued that this increases the power that such patients exert in seeking treatment from doctors. To understand the nature and use of this power requires investigation of (i) how patients use medical ideas and language to explain their symptoms and (ii) how this process influences patients' expectations and evaluations of their doctors. We interviewed 68 patients, in whom no physical cause had been found for persistent physical symptoms. Their accounts of symptoms and of their experience of doctors were subjected to qualitative thematic analysis. As expected, patients used medical terms to explain their symptoms. However, these depicted explanatory themes which have long been familiar in traditional lay models: disease as a malign entity and imbalance between bodily forces. Patients' sense of authority over doctors derived, not from facility with medical language and ideas but from contrasting their own sensory, and therefore infallible, experience of symptoms with doctors' indirect and fallible knowledge. By providing explanations that questioned the reality of symptoms, doctors were perceived as incompetent and inexpert. Patients used their authority, not to seek treatment, but to secure naming of, and collaboration against, the disorder. Although these patients saw the doctors' role as limited and inexpert by comparison with their own, our analysis suggests ways in which doctors might more effectively engage with persistent somatizing patients.

Adult↗
PubMed1997

Genotypes with phenotypes: adventures in an RNA toy world.

Evolution has created the complexity of the animate world and deciphering the language of evolution is the key towards understanding nature. The dynamics of evolution is simplified by considering it as a superposition of three less sophisticated processes: population dynamics, population support dynamics, and genotype-phenotype mapping. Evolution of molecules in laboratory assays provides a sufficiently simple system for the quantitative analysis of the three phenomena. Coarse-grained notions of structures like RNA secondary structures are used as model phenotypes. They provide an excellent tool for a comprehensive analysis of the entire complex of molecular evolution. The mapping from RNA genotypes into secondary structures is highly redundant. In order to find at least one sequence for every common structures one need only search a (relatively) small part of sequence space. The existence of selectively neutral phenotypes plays an important role for the the success and the efficiency of evolutionary optimization. Molecular evolution found a highly promising technological application in the design of biomolecules with predefined properties.

Journal Article↗
PubMed2002

The cognitive functions of language.

This paper explores a variety of different versions of the thesis that natural language is involved in human thinking. It distinguishes amongst strong and weak forms of this thesis, dismissing some as implausibly strong and others as uninterestingly weak. Strong forms dismissed include the view that language is conceptually necessary for thought (endorsed by many philosophers) and the view that language is de facto the medium of all human conceptual thinking (endorsed by many philosophers and social scientists). Weak forms include the view that language is necessary for the acquisition of many human concepts and the view that language can serve to scaffold human thought processes. The paper also discusses the thesis that language may be the medium of conscious propositional thinking, but argues that this cannot be its most fundamental cognitive role. The idea is then proposed that natural language is the medium for nondomain-specific thinking, serving to integrate the outputs of a variety of domain-specific conceptual faculties (or central-cognitive "quasimodules"). Recent experimental evidence in support of this idea is reviewed and the implications of the idea are discussed, especially for our conception of the architecture of human cognition. Finally, some further kinds of evidence which might serve to corroborate or refute the hypothesis are mentioned. The overall goal of the paper is to review a wide variety of accounts of the cognitive function of natural language, integrating a number of different kinds of evidence and theoretical consideration in order to propose and elaborate the most plausible candidate.

Cognition↗
PubMed1997

In defence of patient/person human rights within national health care provision: implications for British nursing.

One cannot fail to be aware of the 'human rights' that are vividly thrust into our living rooms by the world's media; but, what are human rights and are they of relevance to British nursing practice? In a democratic state such as the UK, human rights infringements or violations are not typified as occurring in a health care system outwardly appearing to safeguard the interests of the patient/person. This paper examines some of the issues and concludes that the notion of human rights remains inconspicuous and peripheral to the 'real world' of clinical nursing practice. It challenges British nurses to reflect on their practice and outwardly demonstrate that nursing's contemporary language of human rights does not remain simply rhetorical in nature.

Dissent and Disputes↗
PubMed2006

Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing.

The advent of functional neuroimaging has allowed tremendous advances in our understanding of brain-language relationships, in addition to generating substantial empirical data on this subject in the form of thousands of activation peak coordinates reported in a decade of language studies. We performed a large-scale meta-analysis of this literature, aimed at defining the composition of the phonological, semantic, and sentence processing networks in the frontal, temporal, and inferior parietal regions of the left cerebral hemisphere. For each of these language components, activation peaks issued from relevant component-specific contrasts were submitted to a spatial clustering algorithm, which gathered activation peaks on the basis of their relative distance in the MNI space. From a sample of 730 activation peaks extracted from 129 scientific reports selected among 260, we isolated 30 activation clusters, defining the functional fields constituting three distributed networks of frontal and temporal areas and revealing the functional organization of the left hemisphere for language. The functional role of each activation cluster is discussed based on the nature of the tasks in which it was involved. This meta-analysis sheds light on several contemporary issues, notably on the fine-scale functional architecture of the inferior frontal gyrus for phonological and semantic processing, the evidence for an elementary audio-motor loop involved in both comprehension and production of syllables including the primary auditory areas and the motor mouth area, evidence of areas of overlap between phonological and semantic processing, in particular at the location of the selective human voice area that was the seat of partial overlap of the three language components, the evidence of a cortical area in the pars opercularis of the inferior frontal gyrus dedicated to syntactic processing and in the posterior part of the superior temporal gyrus a region selectively activated by sentence and text processing, and the hypothesis that different working memory perception-actions loops are identifiable for the different language components. These results argue for large-scale architecture networks rather than modular organization of language in the left hemisphere.

Brain Mapping↗