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Results for “parameter optimization”

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At least 1,243 records · Page 69Linked to original sources
PubMed1987

[Neurophysiological and mathematical optimization of the parameters for electrostimulation of the muscles with sinusoidal modulated currents in patients with poststroke paralysis].

Patients with poststroke pareses exposed to different frequencies of stimulating current (sinusoidal modulated currents--SMC) were studied for changes in the H-reflex amplitude (by the H max/M max index). The authors identified a number of clinical signs of stroke predisposing to a definite regimen of electrostimulation. Mathematical processing of the clinical findings has helped to develop a technique of the differential use of muscle electrostimulation by SMC in patients with poststroke hemipareses.

Adult↗
PubMed1987

Clinical parameters related to optimal tumor localization of indium-111-labeled mouse antimelanoma monoclonal antibody ZME-018.

Radioimmunolocalization of an 111In-labeled mouse antimelanoma monoclonal antibody (MoAb), ZME-018, was examined in 21 patients with metastatic malignant melanoma. Each patient received a single. i.v. infusion of MoAb at concentrations ranging from 1 mg to 20 mg, coupled to 5 mCi 111In by the chelating agent DPTA. No toxicity was observed in any patient. Total-body and regions of interest scans performed at 4, 24, and 72 hr following MoAb administration revealed uptake in 63 out of 105 previously diagnosed metastases for an overall sensitivity of 60%. Uptake was consistently observed in liver/spleen, and less frequently in bowel, testes, axillae and bone. Sensitivity of detection increased significantly at doses of MoAb above 2.5 mg, with 74% of lesions imaging at 20 mg/5 mCi compared with 29% at 2.5 mg/5 mCi (p less than 0.005). A significant correlation was observed between tumor uptake of 111In-MoAb conjugate and increasing tumor size. Soft-tissue lesions such as skin and lymph node metastases were imaged to a greater extent (76%) than visceral metastases (19%). In five of six patients, biopsies obtained from 3 days to 14 days after MoAb administration showed antibody present on tumor cells as demonstrated by flow cytometry and/or radioimmunoassay. Human anti-murine immunoglobulin responses were observed in seven of 17 patients studied. Mean plasma clearance of ZME-018 was prolonged with a T1/2 of 24.7 hr and increased slightly with increasing MoAb dose. Urinary excretion of 111In averaged 12.4% of the injected dose over 48 hours. Radioimmunolocalization of melanoma with 111In-labeled ZME-018 appears feasible. The sensitivity of the technique was related to dose, tumor size, and disease site.

Antibodies, Monoclonal↗
PubMedDate not supplied

Optimized search for parameters useful in the interpretation of fetal heart rate data.

A comprehensive computerized perinatal data management system was used to acquire and process FHR data and to link this information to a set of control and outcome variable for 1000 deliveries. Multivariate correlation analyses and stepwise linear regression techniques were used to study the interrelationships between risk factors of pregnancy and labor, monitored data, obstetric interventions, and outcome. It was found that while some FHR characteristics, such as moderate-to-severe bradycardia, lack of beat-to-beat variability, and severe variable decelerations were significantly associated with poor outcome, others, such as accelerations, early decelerations, mild bradycardia, and mild-to-moderate tachycardia, were positively correlated with good outcome. Several statistical models for outcome prediction were developed using FHR data alone and also in conjunction with small subsets of control variables.

Arrhythmias, Cardiac↗
PubMedDate not supplied

[Analysis and optimization of major parameters of air sterilizers].

The investigation of the process proceeding in the chamber of an air sterilizer has shown that its design and testing should be performed with the loaded chamber. Petri dishes are advisable to be used as a loading simulator. Thermophysic parameters of sterilizers may be improved through the use of a blower with the blade angle of 40 degrees and the rate of 2400 revs/min.

Air↗
PubMed1995

Helical CT during arterial portography: optimization of contrast enhancement and scanning parameters.

PURPOSE: To determine the optimal scanning parameters for helical computed tomography during arterial portography (CTAP) of the liver. MATERIALS AND METHODS: Single- and double-helix CTAP were performed in 11 and 20 adult patients, respectively, with 200 mL of contrast material (300 mg of iodine per milliliter) injected at a rate of 3 mL/sec via the superior mesenteric artery. Scanning delays were adjusted for single-helix CTAP so the last scan was obtained at 66 seconds. Delays were adjusted for double-helix CTAP so the last scan during the first helix (CTAP-1) was obtained 10 seconds before the end of the injection at 56 seconds and the first scan during the second helix (CTAP-2) was obtained at the end of the injection at 66 seconds. RESULTS: Single-helix CTAP scans were of poor quality owing to multiple perfusion abnormalities. Lesion detection for double-helix CTAP-1 was 93.2% and was 100% for CTAP-2, and CTAP-2 scans had significantly fewer perfusion abnormalities. CONCLUSION: A scanning delay of 60-66 seconds appears to be optimal. The CTAP-1 scans showed no useful information and need not be acquired.

Carcinoma, Hepatocellular↗
PubMed2006

[Optimization of three-dimensional triple IR fast spoiled gradient recalled acquisition in the steady state (FSPGR) to decrease vascular artifact at 3.0 Tesla].

The purpose of this study was to decrease vascular artifacts caused by the in-flow effect in three-dimensional inversion recovery prepared fast spoiled gradient recalled acquisition in the steady state (3D IR FSPGR) at 3.0 Tesla. We developed 3D triple IR (3IR) FSPGR and examined the signal characteristics of the new sequence. We have optimized scan parameters based on simulation, phantom, and in-vivo studies. As a result, optimized parameters (1st TI=600 ms, 3rd TI=500 ms) successfully have produced the vessel signal at more than 40% reduction, while gray-white matter contrast was preserved. Moreover, the reduced artifact was also confirmed by visual inspection of the in-vivo images for which this condition was used. Thus, 3D 3IR FSPGR was a useful sequence for the acquisition of T1-weighted images at 3.0 Tesla.

Adult↗
PubMed2006

[Optimization of biological and physical parameters for biolistic genetic transformation of common wheat (Triticum aestivum L.) using a particle inflow gun].

The parameters for delivery of expression cassettes to cells of wheat morphogenic callus induced from immature embryos were optimized. Three systems (gradation, delayed, and regeneration) for in vitro selection of transgenic wheat tissue using the bar gene, providing resistance to the herbicide phosphinothricin (PPT), were compared. The efficiency of gene delivery to the cells competent for plant regeneration was assessed by comparing the number of spots transiently expressing uidA gene (encoding beta-glucuronidase) per unit surface of the morphogenic calluses treated under various conditions. The selection systems in question were evaluated by comparing the transformation efficiency frequencies. The optimal parameters for wheat biolistic transformation using a particle inflow gun were determined, namely, the distance between the particle source and the target tissue (12 cm) and helium pressure during the shot (6 atm). The optimal time of callus tissue development on the medium inducing callus formation was determined (10-14 days). Comparison of the three selection variants demonstrated that the regeneration system was the most efficient for producing true transgenic plants of common wheat.

Aminobutyrates↗