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Interaction between facilitating and depolarizing drugs at the neuromyal junction of the cat.
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A radiometric microassay of acetylcholinesterase.
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Myasthenia gravis and pregnancy.
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[Therapy of myasthenia gravis in pregnancy].
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[Effect of reversible inhibitors on the reaction capacity of functional portions of the active center of acetylcholinesterase].
The effect of galanthamine, tacrine, and oxazyl (ambenomum) on human red cells acetylcholinesterase phosphorylation by armine and Gd-42 (o-ethyl-s-beta-ethylthioethyl ester of methylthiophosphinic acid) was studied. In the presence of galanthamine phosphororganic inhibitors interacted only with the active center of the enzyme, the anionic site of which was not occupied by the reversible inhibitor. Tacrine and oxazyl decreased the reactivity of the free enzyme and the rate of its phosphorylation.
[Paraneoplastic myasthenic syndrome].
We report a case of neuromuscular disease overlap between myasthenia gravis and Lambert-Eaton syndrome (LES). Clinical features were those of LES and occurred insidiously in this 68-year old man: proximal weakness predominant in the lower limbs, generalized areflexia, dryness of the mouth and partial right eye palsy. Investigations disclosed a small cell lung cancer. On the other hand, an electrophysiological study showed low amplitude of all motor evoked potentials, and significant decrement in the median nerve at repeated 3 Hz stimulation, but failed to disclose any increment of the motor evoked potential in abductor digiti minimi pedis muscle after both maximal voluntary contraction and repeated 20 Hz stimulation. In addition, the patient improved under anticholinesterase drugs, but failed to respond to guanidine. Titres for both anti-acetylcholine-receptor antibodies and calcium channel antibodies were negative. The relationship between our case and recently reported cases of co-existence of the Lambert-Eaton myasthenic syndrome and myasthenia gravis is discussed.
[Mitochondrial ocular myopathy sensitive to anticholinesterase agents].
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[Treatment of myasthenia gravis].
The authors discuss various therapeutical possibilities for myasthenia, such as drug therapy, immuno-suppression, radiological, and operative treatment. The indicatons of the different therapeutical methods are dealth with. Thymectomy was performed in 92 of our patients. Due to complex therapy the fate of patients with myasthenia is to be regarded as much more favourable than in the past.
Facilitation of neuromuscular transmission by anticholinesterase drugs.
A close correlation has been shown to exist between the in vitro anticholinesterase potencies of ambenonium, neostigmine, methoxyambenonium and edrophonium chloride and their abilities to increase muscle contractions produced by close-arterial injections of acetylcholine. No correlation was found between the anticholinesterase potencies of the drugs and their potentiations of the maximal twitch in response to electrical stimulation, or their antagonisms of tubocurarine. It is concluded that some action, in addition to inhibition of cholinesterase, contributed to their facilitation at the neuromuscular junction, and it is suggested that this action may be at the prejunctional site.