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Autonomic dysfunction in long-standing alcoholism.

Twenty-eight male alcoholics were studied for peripheral sensory-motor and autonomic neuropathy. The patients were examined neurologically and neurophysiologically after a period of withdrawal treatment in hospital. The function tests of the autonomic nervous system performed were: measurement of the variation of the heart rate at rest and during maximal breathing, Valsalva manoeuvre, postural pulse and blood pressure reactions, and isometric test. Slight abnormalities in the peripheral nervous system were observed in 8 patients, but a frank clinical polyneuropathy supported by neurophysiological findings could be diagnosed only in 2. All of the parameters which reflect the function of the parasympathetic division of the autonomic nervous system were lower in the alcoholics compared with the controls. The most sensitive variables were the heart rate variation at rest, and the postural pulse reaction. The functions mediated by the sympathetic nervous system were not abnormal among this group of alcoholics.

Adult

[Autonomic dysfunction in diabetics].

The authors examined 120 patients with diabetes mellitus of the first and second types. Vegetative dysfunction was revealed in 84 patients (70%) that was manifested in disorders of the vegetative tone, vegetative reactivity. Different tests for assessment of the vegetative status and method of treatment of vegetative dysfunction are described.

Adolescent

[The role of autonomic dysfunction in the pathogenesis of lipid and lipoprotein metabolic disorders in patients with metabolic-alimentary obesity].

Obesity is a "disease of civilization" that leads to the formation of vascular pathology. Vegetodystonia, a heterogeneous syndrome both as regards the type and clinical course, is a pronounced clinical manifestation of obesity. The role of vegetodystonia in the formation of atherogenic potential of obesity has not been studied yet. 77 patients with metabolic alimentary obesity were examined for blood lipidograms as compared to the vegetative status and anthropometric data. Based on a correlation analysis performed, a relationship was discovered between the changes in the parameters indicated. The character of the correlation was determined by the type of vegetodystonia. The leading part in the formation of atherogenic potential is played by sympathoadrenal influences which are most manifest is permanent vegetovascular dystonia of the vagoinsular type. The treatment of obesity should be carried out with regard to the concrete variety of vegetative dysfunction.

Adolescent