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Case management programs in primary care.

To review the impact of case management programs on health care resource use; their impact on patient satisfaction, quality of life, and functional status (patient-centered outcomes); and their cost-effectiveness, we reviewed the English language literature utilizing the following MEDLINE and HealthSTAR headings: case management, patient care planning, patient-centered care, disease management, care management, and managed care programs. Bibliographies of relevant articles were also reviewed. Only randomized controlled trials were included. Data were extracted manually from relevant publications and are presented descriptively because formal, quantitative methods were not applicable. Nine studies met our inclusion criteria. Of the seven studies examining case management's impact on health resource use, only two found a positive effect. Both successful programs targeted patients with specified disease conditions and care was supervised by a medical subspecialist. None of the programs targeting general disease conditions or supervised by generalists reported a positive effect. All six studies examining patient-centered outcomes reported a positive impact. These effects were unrelated to the patient's conditions or the study personnel. Both studies examining clinical parameters found a positive impact. Only three studies examined costs; all reported nonsignificant cost savings. While case management programs offer theoretical benefits, few examples of successful programs were found. Positive effect was related to disease condition and specialty training of study personnel. Patient-centered outcomes were often improved upon but at unknown cost. Further multisite clinical trials are needed to define case management's role in our future health care system.

Case Management↗

Magnetic resonance angiography for the diagnosis of renal artery stenosis: a meta-analysis.

AIM: To review the published literature comparing the diagnostic accuracy of magnetic resonance angiography (MRA) with and without gadolinium in diagnosing renal artery stenosis, using catheter angiography as reference. MATERIALS AND METHODS: A meta-analysis was performed of English language articles identified by computer search using PubMed/MEDLINE, followed by extensive bibliography review from 1985 to May 2001. Inclusion criteria were: (1) blinded comparison with catheter angiography; (2)indication for MRA stated; (3) clear descriptions of imaging techniques; and (4) interval between MRA and catheter angiography < 3 months and only the largest of all studies from one centre was selected in the analysis. RESULTS: A total of 39 studies were identified, of which 25 met the inclusion criteria. The number of patients included in the meta-analysis was 998: 499 with non-enhanced MRA and 499 with gadolinium-enhanced MRA. The sensitivity and specificity of non-enhanced MRA were 94% (95% CI: 90-97%) and 85% (95% CI: 82-87%), respectively. For gadolinium-enhanced MRA sensitivity was 97% (95% CI: 93-98%) and specificity was 93% (95% CI: 91-95%). Thus, specificity and positive predictive value were significantly better for gadolinium-enhanced MRA (P < 0.001). Accessory renal arteries were depicted better by gadolinium-enhanced MRA (82%; 95% CI: 75-87%) than non-gadolinium MRA (49%; 95% CI: 42-60%) (P < 0.001). CONCLUSIONS: Gadolinium-enhanced MRA may replace arteriography in most patients with suspected renal artery stenosis, and has major advantages in that it is non-invasive, avoids ionizing radiation and uses a non-nephrotoxic contrast agent.

Contrast Media↗

[Psychopharmaceuticals in primary care: prescription quality].

OBJECTIVE: Using criteria based on the bibliography, to assess drugs prescription in a Health Centre, in order to put forward corrective measures in line with the defects identified. DESIGN: Descriptive and retrospective study. SETTING: Santa Maria de Benquerancia Health Centre (Toledo). PARTICIPANTS: A sample of 40% of the clinical records of patients over 14 produced records of patients treated with drugs for psychic disorders between October 1990 and October 1991. MEASUREMENTS AND MAIN RESULTS: 248 prescriptions for these drugs were found. The most common diagnoses were: neurotic depression (33.1%), anxiety (25.8%) and insomnia (10.1%). Benzodiazepines made up 78.2% of the prescriptions. Of 8 quality criteria assessed, the compliance level was acceptable by WHO standards except in the recording in the notes of the diagnosis or problem for which the drug was prescribed (74.2% non-compliance); Alprazolam and Triazolam were not considered first-choice benzodiazepines (31.3% non-compliance); and there was 44.5% non-compliance by Primary Care physicians with the non-prescription of anti-psychotic or stimulant MAO inhibitor antidepressants. CONCLUSIONS: Quality-control studies, such as this one, in order to identify problems, to take corrective measures and subsequently assess them, are useful in improving care procedures.

Drug Prescriptions↗

Diethylstilbestrol revisited: a review of the long-term health effects.

PURPOSE: To review the literature on the long-term health effects of exposure to diethylstilbestrol (DES) among women prescribed DES during pregnancy (DES mothers), among their children exposed inutero to the drug (DES sons and daughters) and among the progeny of these exposed sons and daughters (DES grandchildren). DATA SOURCES: English-language articles were identified through MEDLINE and CANCERLIT searches and through review of the bibliographies of identified articles. STUDY SELECTION: All human studies relevant to long-term health effects of exposure to DES were reviewed. DATA EXTRACTION: Descriptive data on existing DES cohorts were extracted from early publications. Risk estimates for health effects were extracted from published reports. DATA SYNTHESIS: An estimated 5 to 10 million Americans received DES during pregnancy or were exposed to the drug in utero. Exposure to DES has been associated with an increased risk for breast cancer in DES mothers (relative risk, < 2.0) and with a lifetime risk of clear-cell cervicovaginal cancer in DES daughters of 1/1000 to 1/10,000. The association between DES exposure and testicular cancer in DES sons remains controversial. Exposure to DES has also been linked to reproductive tract abnormalities in DES sons and daughters that consist of immune system disorders and psychosexual effects. No evidence for transgenerational effects currently exists. Recommendations for screening persons exposed to DES are reviewed. CONCLUSIONS: Further research is needed to define long-term health effects related to DES exposure. Such research would provide a basis for counseling persons exposed to DES and would further understanding of environmental and pharmacologic compounds similar to DES.

Animals↗

Library use of public health materials: description and anaylsis.

A method is described for optimizing the efficiency of a journal collection. The method is employed to determine an optimal journal collection in public health. A citation analysis of 3,456 citations from the bibliographies of forty-four master's and doctoral dissertations from five different universities is performed. It is verified that the distribution of references to journal titles is approximately logarithmic (Bradford's Law) and that the distribution of references by year is exponential. These two parameters are combined to formulate an equation which may be used to specify a journal collection satisfying the greatest possible percent of demand. In public health, for example, a 1,500-volume library containing sixty titles could satisfy 73% of the demand for references in health related areas and 48% of the total demand for references for this particular, diverse research group. Other desirable aspects of a public health collection are also described as determined from the data.

Libraries, Medical↗

Distraction manipulation of the lumbar spine: a review of the literature.

OBJECTIVE: The purpose of this study is to review the literature concerning distraction manipulation of the lumbar spine, particularly regarding physiological effects, clinical efficacy, and safety. DATA SOURCES: A search of the English language literature was conducted using the MEDLINE, Embase, CINAHL, Chiropractic Research Archives Collection, and Manual, Alternative, and Natural Therapies Information System databases. A secondary hand search of bibliographies was completed to identify older or nonindexed literature. DATA SELECTION AND EXTRACTION: Articles were identified, which described the characteristics of distraction manipulation beyond a simple description or the results of treatment with distraction manipulation. Data were extracted on the basis of relevance to the stated objective. DATA SYNTHESIS AND RESULTS: Thirty articles were identified. Three were uncontrolled or pilot studies, 3 were basic science studies, and 6 were case series. Most were case reports. Lumbar distraction manipulation is a nonthrust mechanically assisted manual medicine technique with characteristics of manipulation, mobilization, and traction. It is used for a variety of lumbar conditions and chronic pelvic pain. The primary rationale for its use is on the basis of the biomechanical effects of axial spinal distraction. Little data are available describing the in vivo effect of distraction when used in combination with flexion or other motions. CONCLUSIONS: Despite widespread use, the efficacy of distraction manipulation is not well established. Further research is needed to establish the efficacy and safety of distraction manipulation and to explore biomechanical, neurological, and biochemical events that may be altered by this treatment.

Biomechanical Phenomena↗

Cocaine: pathophysiology and clinical toxicology.

PURPOSE: To review the medical complications of cocaine abuse and the mechanisms of action of cocaine that contribute to medical complications. DATA SOURCES: Pertinent articles identified through a MEDLINE search of the English-language literature from 1985 to 1996 and through a manual search of bibliographies of all identified articles. STUDY SELECTION: All articles describing complications of cocaine use including case reports, small reported series, and review articles. DATA SYNTHESIS: A qualitative description of reported complications. RESULTS: Since the introduction of freebase and crack cocaine, multiple medical complications have been observed, and all major body organ systems have been affected. Cocaine can cause acute strokes, myocardial infarction, cardiac dysrhythmias, pulmonary edema, rhabdomyolysis, and acute renal failure. CONCLUSION: Adverse reactions to cocaine should be considered in the differential diagnosis of acute ischemic events that occur in young adults. General awareness of the significant complications of cocaine will facilitate early diagnosis and prompt treatment.

Adult↗

Adrenocorticotrophic hormone and related peptides.

This chapter describes how adrenocorticotropin (ACTH) can be measured in biological fluids. The principle can be applied to similar peptide hormones. Following an introduction of the principle of the method, details are given on sample collection and storage, and materials required. Detailed descriptions are given for the methodology with a "Notes" section that gives practical tips on the more complex or difficult steps in the analytical process. A brief bibliography lists peer reviewed articles relevant to the development and application of this method.

Adrenocorticotropic Hormone↗

[A new case of Cohen's syndrome].

We report a detailed description of ocular alterations, especially uveal coloboma, as shown in a patient with Cohen's syndrome. We also report new lesions, not previously described in the revised bibliography: lens and optic head colobomas, hyaloid artery and anterior "vasculosa lentis" tunica vestige. The most characteristic ocular alterations previously described in the bibliography are eyelid antimongoloid fissures, strabismus and myopia.

Abnormalities, Multiple↗

Aquatic therapy in pediatrics: annotated bibliography.

"Aquatic therapy" refers to therapeutic intervention taking place in water. The purpose of this review is to summarize the published articles in the rehabilitation literature from 1979 through 1999 that relate to the use of aquatic therapy as an intervention for children and adolescents with neuromuscular and musculoskeletal diagnoses. Despite the trend toward evidence-based practice, a paucity of literature exists related to aquatic therapy for children. Most of the available articles are case reports and other descriptions of clinical practice. The research reports are limited in design and scope, and subjects had a wide variety of ages and diagnoses.

Exercise Therapy↗

A comprehensive bibliography database using a microcomputer.

A system was implemented using a commercial database management program and a microcomputer for computerising references from journals and other sources. In addition to the citation, the user can enter the address of the institution where the study was carried out, a description of the article and of the work, key words, and an abstract. References are added, edited, searched for, displayed on screen, typed on paper, or sent to a text file, using selection criteria entered by the user. When a search is performed the printout will include the abstract of each paper, similar to that obtained from larger bibliographic services. The computer also writes requests for reprints. This program now holds over 30 000 references and has been in use for over three years. Such a system is beneficial for personal study, for writing books, articles, and theses, and for use by institutions, departments, and small libraries.

Bibliographies as Topic↗

Problem and pathological gambling in North American Aboriginal populations: a review of the empirical literature.

This literature review attempts to: estimate Aboriginal population prevalence rates for problem and pathological gambling and compare these rates to the general population; determine factors associated with the Aboriginal population problem gambling behaviour; and identify other salient findings and issues. Materials used in the review were drawn from available research literature and bibliographies. There were no time restrictions or study design criteria included in the review. Key words used: Aboriginal, Indians, First Nations, Native, lotteries, gambling, casinos, and gaming. Eleven descriptive studies were identified. Gambling appears to be problematic among Aboriginal people. Aboriginal adolescents have higher rates of problem gambling, as do Aboriginal adults for both problem and pathological gambling than their non-Aboriginal counterparts. The odds ratios indicate that the Aboriginal population has a problem gambling behaviour rate 2.2 to 15.69 times higher than the non-Aboriginal population. A number of factors associated with Aboriginal population problem and pathological gambling were identified. Gambling literature specific to the Aboriginal population is limited and there is extensive variation in estimates of their increased risk. Several associated factors were identified but whether these are specific to the Aboriginal population or to all problem and pathological gamblers needs to be determined. More research, particularly qualitative, into these factors is warranted.

Adolescent↗

Current status of prevention, diagnosis, and management of coronary artery disease in patients with kidney failure.

BACKGROUND: Patients with kidney failure have a heavy burden of coronary artery disease. The results of preventive, diagnostic, and therapeutic measures developed in nonuremic populations cannot automatically be extrapolated to this unique group of patients. METHODS AND RESULTS: Articles were reviewed if they contained English language text or an abstract identified by MEDLINE search from 1980 to 1999, supplemented by manual review of bibliographies of published articles and abstract issues of national cardiology meetings, studies on diagnostic techniques, risk modification measures, pharmacologic agents, and coronary revascularization procedures in patients with uremia. Descriptive and quantitative data as appropriate were extracted. Lipid-lowering agents may be safely administered to uremic patients. Direct evidence of lipid lowering in this population is not available and is not likely to be forthcoming. Erythropoietin therapy is effective in reversing the cardiovascular perturbations of uremic anemia, but an approach of normalizing the hematocrit cannot be recommended. Glycoprotein IIb/IIIa inhibitors used in acute coronary syndromes require downward dose adjustment or are contraindicated. Thrombolytic agents are underutilized in the management of myocardial infarction. Noninvasive testing is less accurate than in nonuremic populations. Coronary revascularization offers relative clinical advantages over medical therapy similar to non-kidney failure populations, even though the results in uremic patients is significantly less favorable than for nonuremic patients. Stenting is the preferred revascularization approach, and conventional balloon percutaneous transluminal coronary angioplasty the least favorable. CONCLUSIONS: Many but not all of the benefits of therapies developed in nonuremic patients extend to patients with kidney failure. Physicians should be familiar with the advantages and limitations of each of these modalities in this population.

Coronary Angiography↗

Gallery of medical devices.

This article provides an overview of the multitude of medical devices used in patients from head to toe. Simple line drawings show a wide assortment of medical devices. These drawings and the accompanying short descriptions are to be used for quick reference to identify some of the more common medical devices that are certain to appear on everyday radiographs. There is an extensive bibliography for the reader to obtain more detailed information about a particular device or medical apparatus. Knowing the specific name of a device is nearly impossible and is really not necessary, in particular, the eponyms attached to all manner of orthopedic apparatus. Many device names have evolved from their original meaning. What is important is the device's function and the recognition of its presence, as well as an understanding of its use and potential complications.

Bone and Bones↗

An overview of treatment in paranoia/delusional disorder.

OBJECTIVE: To examine delusional disorder (formerly paranoia) which has re-emerged as an important diagnosis in psychiatry and familiarize present-generation psychiatrists with this disorder and its treatment. To benefit other researchers, a bibliography is appended. METHOD: Approximately 1,000 articles on paranoia/delusional disorder were analyzed in detail. These articles date from 1961 with the greater majority dating from 1980 onward. Case descriptions were often vague and only cases identifiable by DSM-IV diagnostic criteria were accepted. Eventually 257 cases were accumulated, but it was only possible to report on treatment aspects of 209 of these, due to lack of detail. RESULTS: Because the data are so disparate, and the literature is confusing in therapeutics aspects, only the broadest conclusions can be drawn. However, it does appear that when adequately treated, delusional disorder is an illness with a reasonably good prognosis. Cases respond equally well to treatment, whatever the specific delusional content, and pimozide currently appears to be the neuroleptic which produces the best results. CONCLUSIONS: There is an urgent need to raise standards in the study of delusional disorder and its treatment.

Antipsychotic Agents↗

[Surgical treatment of Wilm's tumours in children (author's transl)].

Introductory data on nephroblastoma occurence in children is followed by a general discussion on the methods of procedure used in treatment of these tumours in the last century. Then the author gives definite indices how to treat the disease surgically. In the description all groups of clinical advancement (promotion) of the neoplasm and the age of children are mentioned. The paper is supplemented by 20 Polish as well as foreign works (bibliographies).

Age Factors↗

[Adolpho Lutz and the history of tropical medicine in Brazil].

This text presents an evaluation of the activities of the Adolpho Lutz project and a history of tropical medicine in Brazil: progress in the preparation of texts and Lutz's correspondence for publication, the description and treatment of components of his papers, which are found at the National Museum. Appendices include a list of posts, titles, awards and decorations received by Adolpho Lutz, his bibliography and a selection of letters received by him.

Brazil↗

Sarcoidosis--the beginning: historical highlights of personalities and their accomplishments during the early years.

Sarcoidosis, an affliction of mankind named only as recently as this century, was first described by Hutchinson in 1878, and noted in a second patient, one Mrs. Mortimer, in 1898. In 1889, Besnier described lupus pernio.Boeck obtained skin biopsies in 1899. Kreibich described punched-out bone lesions in 1904. Darier and Roussy described subcutaneous nodules in 1906, and Heerfordt described uveoparotid fever in 1909. Schaumann synthesized the many diverse syndromes of sarcoidosis into a single disease in a prizewinning essay in 1914. Kveim biopsied the sarcoid skin test-site and established a diagnostic test in 1941.Lofgren described the bilateral hilar lymphadenopathy-erythema nodosum syndrome in 1946. In 1954, Israel and Sones helped establish sarcoidosis as an immunologic disorder. In 1963 Cummings compiled a bibliography on sarcoidosis, and in 1966 Siltzbach conducted his renowned international Kveim test trial.At Howard University, Harden ignited an interest in sarcoidosis. In 1944 Johnson and Jason contributed to a description of cardiac involvement, while Cowan studied ocular involvement in sarcoidosis.

History, 19th Century↗