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PubMed1975

[Does the weight of the brain depend on the body height?].

Brains of 1664 subjects (895 males and 769 females) aged from 20 to 89 years have been studied. The whole material being investigated was divided, within sex groups, into body-height classes and age classes. The class interval within the age classes was 10 years, that in height classes 5 cm. Mean arithmetics, standard deviations, standard error as well as coefficients of variation and correlation for respective classes have been calculated. It has been ascertained that the brain weight depends on the body height. In tall subjects no brains of extremely low absolute weight are encountered and, adversely, high brain weight is seldom met in short individuals. The body height also exerts certain influence upon the relative weight of the brain. More favourable proportion between the brain weight and the body length has been revealed in short subjects. Tall individuals are characterized by a low relative weight of the brain. It should be supposed that the spinal cord weight is higher in the latter subjects. The differences between the mean absolute weight of women's brains and that in men of the same age class are conditioned by the difference in the body length. A constant magnitude of difference in the mean brain weight in subjects of the same body height claims 100 g. The paper provides 2 enclosed tables representing obtained results for arithmetic mean of the absolute brain weight both in the age classes and body height classes. The differences between the mean weights of brains in women as well as in men are not significant. The coefficient of correlation between the brain weight and the body height is for men r male1 = 0.2008 for women r female1 = 0.2630, wherease the coefficient of regression for the brain weight is r male2 = 3.67 and r female2 = 3.906 respectively.

Adult↗
PubMed1987

Some secular changes in body height and proportion of Japanese medical students.

Anthropometric dimensions of 738 medical students at Kyushu University in Japan were analyzed to determine secular changes of height and body proportions during a 20-year period. Since 1961, means of standing height, leg length, and ratio of leg length to standing height have increased, although the rate of increase from 1971 to 1981 has been rather slow. On the contrary, the mean sitting height X 100/standing height has declined during this same period. Compared with data on the Japanese general population, the medical students were considerably taller, but the difference has decreased.

Adult↗
PubMed1999

Body height and weight of patients with childhood onset and adult onset thyrotoxicosis.

The present study has compared body height and weight of thyrotoxic female patients of childhood onset and adult onset. The body height of 141 out of 143 (99%) adult-onset thyrotoxic patients was within the range of mean +/- 2SD for the age-matched general Japanese female population. On the other hand, in 42 patients with childhood-onset thyrotoxicosis, 6 (14%) had their height being greater than the mean + 2SD of general population, and 34 (81%) were taller than the mean value. In 86 patients with siblings, 42 (49%) were at least 2 cm taller than their sisters, and 26 (30%) were more than 2 cm shorter than their sisters. The body weight of 27 out of 42 (68%) patients younger than 20 years was not decreased but was even greater than the mean value for the age-matched general population. The results indicate that excessive thyroid hormone in vivo enhances body height in humans. The increased body weight in some young patients suggests that enhanced dietary intake due to increased appetite in hyperthyroidism has overcome the energy loss with increased metabolism.

Adolescent↗
PubMed2003

The association between body height and coronary heart disease among Finnish twins and singletons.

OBJECTIVE: An inverse association between body height and the incidence of coronary heart disease (CHD) has been observed. However, the mechanisms behind this association are still largely unknown. We will examine the role of genetic and familial factors behind the association in a large twin data set. DESIGN AND SETTING: The data were derived from the Finnish Twin cohort including 2438 singletons, 4073 monozygotic (MZ) twins, and 9202 dizygotic (DZ) twins aged 25-69 years at baseline in 1976. Incident CHD cases were derived from hospital discharge data and cause of death data between 1977 and 1995. Cox regression analysis and conditional logistic regression analysis were used. RESULTS: In population-level analyses no differences in the general risk of CHD between zygosity groups were found. The association between body height and CHD was similar between sexes and zygosity groups. When men and women in all zygosity groups were studied together an increased risk of CHD was found only among the shortest quartile (hazard ratio [HR] = 1.34, 95% CI: 1.14-1.57). Among the twin pairs discordant for CHD a suggestive increased risk for the shorter twin was seen among DZ twins (odds ratio [OR] = 1.19, 95% CI: 0.95-1.48) when men and women were studied together. CONCLUSION: An inverse association between body height and CHD was broadly similar between sexes and twin zygosity groups and was associated with short stature. Among discordant twin pairs we found a weak association among DZ twins but not MZ twins. This may suggest the role of genetic liability behind the association between body height and CHD.

Adult↗
PubMedDate not supplied

Relation between body height and self-reported myocardial infarction in Germany.

BACKGROUND: Several studies have reported an association between body height and the incidence of myocardial infarction. METHODS: We analyzed data from regional and national health surveys that were conducted from 1984-1992 within the framework of the German Cardiovascular Prevention Study. Eligible survey candidates were males and females with German nationality in the age group 25-69 years. The total number of subjects in our study comprised 12,447 males and 13,355 females. The assessment of whether a respondent had ever undergone a myocardial infarction was based on self-reporting by the subject. Multiple logistic regression analyses, controlling for several confounding factors, were carried to calculate odds ratios to estimate th effect of body height on the prevalence of self-reported myocardial infarction, comparing each body-height quintile with the shortest group, which served as the reference group. RESULTS: Without adjusting for confounding variables, a strong association between body height and self-reported myocardial infarction was found in both genders (trend test: p < 0.001), with an unadjusted odds ratio (OR) of 0.41 for males and 0.33 for females. After adjusting for age, the ORs increased to 0.67 (p < 0.05) in males and 0.58 (p < 0.05) in females for quintile 5 (tallest) compared with quintile 1 (shortest). After an additional adjustment for community size, region, social class, and number of CVD risk factors, the ORs of myocardial infarction for quintile 5 (males OR = 0.78, females OR = 0.68) were higher than those for quintile 1, but the results were no longer statistically significant. CONCLUSIONS: Despite the lack of statistical significance, we suggest that the differences in the prevalence of myocardial infarction for the five height quintiles cannot be explained by confounding factors alone. The underlying causes for such height-specific differences remain unknown.

Adult↗
PubMedDate not supplied

Cortical somatosensory potentials evoked by magnetic stimulation: effect of body height, age, and stimulus intensity.

Cortical somatosensory evoked potentials elicited by non-invasive magnetic stimulation at Th10, Th12, and L5 vertebral levels and at mid-gluteus and ankle were studied in 45 normal controls varying in body height and age. Peak latencies of P2 evoked by ankle, mid-gluteus and L5 stimulation were correlated with body height. However, P2 latencies evoked by Th10 and Th12 stimulation were independent of body height. In contrast, all N2 latencies evoked by Th10, Th12, L5, mid-gluteus and ankle were correlated with body height. There were no correlations between latencies of P3 and N3 and body height. No peak latencies of cortical components were affected by age within the age group studied (15-67 years). In the intensity study, N2 showed double peaks when low to moderate stimulus intensities were applied to Th12 vertebra. Furthermore, in 2 patients with mild somatosensory dysfunction of lumbar roots or cord, N2 evoked by L5 stimulation revealed double peaks with prolonged interpeak latencies between the first peak of N2 and P3, which might be related to the temporal dispersion of the afferent fibers. These data suggest that the N2 component is induced by both fast and slow afferent fibers.

Adolescent↗
PubMed1995

Reduced variance of latencies in pudendal evoked potentials after normalization for body height.

The value of the Somatosensory Evoked Potentials (SEP) in the assessment and detection of neurological disorders could be considerably enhanced if the normative standards of (SEP) characteristic parameters were normalized taking into account all other systematic sources of variance. The present study examines the influence of body height on the peak and interpeak latencies of the pudendal somatosensory evoked potentials. We examined the peak latency (L1) of the evoked potential recorded at the L1 vertebra and the onset latency (ONc) of the cortical evoked potentials, after stimulation of the pudendal nerve, as a function of body height in 40 normal male subjects (age 20-40 years). Significant positive correlation was found between both (ONc) latency and ONc-L1 interpeak latency and body height (H). Assuming that the latter is proportional to the length of the neural pathways, the experimental data were fitted using a theoretical model representing the conduction in the sensory neuraxis as a function of body height. Using the estimated fitting functions, we normalized our data with regard to a typical value of body height. The normalized values of the aforementioned latencies reveal a significantly reduced variance, as compared to the original ones, and consequently their diagnostic importance is significantly increased. Similar procedures applied to the L1 (spinal) latencies and the latencies of the bulbocavernosus reflex (BCR) reveal no correlation with body height and this is discussed on the basis of neuroanatomical considerations.

Adult↗
PubMed1992

Prospective study of height, body mass index and risk of breast cancer.

The associations of breast cancer risk with height and body mass index have been examined in 291 cases of breast cancer that occurred among 25,967 Norwegian women during a mean follow-up of approximately 14 years (range 12-16 years). There was an overall increased risk of breast cancer with increasing body height, and the relative risk of women in the fourth quartile of height (mean = 170 cm) was 1.43 (95% confidence limits, 1.18-1.73) compared to women in the lowest quartile (mean = 155 cm), after adjusting for age, parity, age at first birth, and county of residence. Simultaneously, there was an overall inverse relation between body mass index (BMI) and breast cancer risk, which, however, was confined to women 50 years or younger. After adjustment for age, parity, age at first birth, and county of residence, the relative risk of women (less than or equal to 50 years) in the highest quartile of BMI (mean Quetelet = 30) was 0.63 (95% confidence limits, 0.48-0.82), compared to women in the lowest (mean Quetelet = 21). We propose that the lower breast cancer risk in shorter women may reflect caloric restriction during the pre- and peripubertal period, which may affect hyperplastic growth, and lead to a reduced number of breast tissue cells. The negative association with BMI may be related to a lower rate of cell division of breast tissue among obese premenopausal women.

Age Factors↗
PubMedDate not supplied

[Determining body height by the femur and femoral fragments].

Using a forensic series of human specimens, the reliability of frequently-cited formulas applied to estimate body height on the basis of the femur was examined with regard to their accuracy. Very few proved reliable enough to render accurate results. In most cases, less than half of the actual body heights were found to have predicted within the single estimation interval. The method to be used for such estimations must therefore be selected with great care. Even with partial femur measures, it is possible to estimate reliably body height. In particular, the circumference of the diaphysis centre correlates well with body height. The regression equations calculated in the present study, however, reveal greater errors in estimates than the formulas worked out using the total femur length.

Adolescent↗
PubMed2007

Vitamin D receptor gene haplotype is associated with body height and bone size.

CONTEXT: Adult stature is a complex genetic trait. The vitamin D endocrine system has pleiotropic effects on several physiological processes, especially on skeletal metabolism. We recently identified promoter and 3'-untranslated region (UTR) haplotype alleles that influence vitamin D receptor (VDR) mRNA expression. OBJECTIVE: We studied whether VDR gene variants contribute to the genetic variation in height. DESIGN AND SUBJECTS: We studied VDR haplotype alleles and body height in two independent populations (n=7187). In a meta-analysis (n=14,157 from 27 studies and our current data), we evaluated the effect of the Bsm I polymorphism. RESULTS: Haplotypes of the linkage disequilibrium block 3 and block 5 were associated with body height differences with evidence for additive effects in the Rotterdam Study (P=0.00002) and the Longitudinal Aging Study Amsterdam study (P=0.001). Height differences between the extreme genotypes were 1.4 and 2.7 cm, respectively. The relationship was independent of age, gender, presence of vertebral fractures, and age-related height loss. In the Rotterdam population, we found the combined genotype to be associated with decreased vertebral area (P=0.03) and femoral narrow neck width (P=0.002). In the meta-analysis, subjects with the "BB" genotype were 0.6 cm (95% confidence interval, 0.2-1.1 cm) taller than those with the "bb" genotype (P=0.006). CONCLUSION: VDR gene variants are associated with differences in body height as evidenced by our study and by a meta-analysis. It remains for further studies to confirm whether the underlying mechanism of the association involves lower VDR expression in cells important for determining bone size.

Analysis of Variance↗
PubMed1983

Postural and time-dependent effects on body height and scoliosis angle in adolescent idiopathic scoliosis.

Changes in body height and scoliosis angle under the influence of gravity were studied in 40 patients with adolescent scoliosis. The average decrease in body height was 1% during a day. There were no significant changes in the mean angles of the scoliosis curves during the day. The patients were grouped according to age, standing and sitting heights, weight and skeletal maturation. A decrease in the scoliosis angles occurred in younger, more skeletally immature and lighter individuals, while an increase occurred in older, more skeletally mature and heavier individuals. The difference between the scoliosis angles measured from standing and supine views was also analyzed. The correction of the scoliosis angle in the supine position was on average 19%. No correlation was found between the change in angle and any of the growth factors studied. There was also no correlation between the change in angle and the degree of curvature.

Adolescent↗
PubMed1998

Influence of body height on pulsatile arterial hemodynamic data.

OBJECTIVES: This study sought to present evidence that short stature is a hemodynamic liability, which could explain in part the inverse relation between body height and cardiovascular risk. BACKGROUND: Other explanations for the association of short stature with increased cardiovascular risk include advancing age, reduced pulmonary function, genetic factors, poor childhood nutrition and small-caliber coronary arteries. This study adds another factor-the physiologic effects of reduced body height on the arterial tree, which increase left ventricular work and jeopardize myocardial perfusion. METHODS: Four hundred two subjects were studied: 149 with end-stage renal disease and 253 with normal renal function. Measurements included blood pressure, body height, cardiac cycle length, carotid to femoral artery pulse wave velocity, carotid artery pulse waves (by applanation tonometry) and the arrival time of reflected waves. Calculations included the carotid augmentation index, carotid artery compliance and the diastolic to systolic pressure-time ratio (an index of myocardial supply and demand). RESULTS: On linear and stepwise multiple regression, body height correlated with all variables except mean blood pressure. CONCLUSIONS: The early systolic arrival of reflected waves in short people in this group acts to stiffen the aorta and increase the pulsatile effort of the left ventricle, even at the same mean blood pressures. Short stature also induces a faster heart rate, which increases cardiac minute work and shorten diastole. Stiffening lowers the aortic diastolic pressure and, coupled with a shortened diastole, could adversely influence myocardial supply. Although indirect, this evidence supports a physiologic hypothesis for the body height-cardiovascular risk association.

Adolescent↗
PubMed1993

CSF/plasma ratio of 10-hydroxynortriptyline is influenced by sex and body height.

The CSF/plasma ratios of nortriptyline (NT) and its major metabolite 10-hydroxy-NT (10-OH-NT) were investigated retrospectively in 25 depressed patients. For 10-OH-NT (but not NT), a significant influence of sex and body height was found, most conspicuously in males, in whom the ratio related to body height curvilinearly (N = 8; R = 0.93; P < 0.01). In males, the NT/10-OH-NT ratio in plasma correlated with body height (N = 8; r = 0.80; P < 0.05). Hypothetically, CSF circulation is partly influenced by body height, which accounts for a steeper gradient of 10-OH-NT across the blood-brain barrier in taller persons. From the lumbar site, the more polar 10-OH-NT is assumed to be eliminated by bulk flow via the villi, while the less polar NT exits by diffusion in the choroid plexus. Prospective studies are urgently needed to further evaluate the distribution of antidepressants in the CSF.

Adult↗
PubMed1992

The relation of body height to handedness in male and female right- and left-handed human subjects.

The association between body size and the degree of hand preference was studied in male and female right- and left-handed human subjects. Hand preference was assessed by the Edinburgh Handedness Inventory. In left-handers (total sample), there was a significant, negative linear correlation between the degree of left-hand preference and body height. There was no significant correlation between these parameters if the males and females were considered separately. In right-handers (total sample), body height was found to be significantly and negatively linearly correlated with the degree of right-hand preference. A similar correlation was observed in males without familial sinistrality (FS-) and in FS+ females. There was no significant correlation between these parameters in FS+ right-handed males and FS- right-handed females. It was suggested that hormones affecting body height and brain size such as human growth hormone and testosterone would also contribute to the development of cerebral lateralization.

Adult↗
PubMed1999

[Studies on standard growth curve chart on body height of Chinese adolescent for orthodontic diagnosis].

OBJECTIVE: To make a standard growth curve chart on the body height of Chinese adolescent. METHODS: Statistical data were surveyed in 1995, which were obtained from subjects consisting of 32,524 students aged from seven to nineteen years in the province of Sichuan. RESULTS: Mean values of the annual increment of body height and the ages of the pubertal growth periods were analyzed. CONCLUSION: The new standard growth curve chart on the body height of adolescent chinese were applied for better understanding the growth pattern of chinese orthodontic patients.

Adolescent↗
PubMed1999

Standard growth curve chart for body height of Chinese adolescent for orthodontic diagnosis.

OBJECTIVE: To make a standard growth curve chart on the body height of Chinese adolescents. METHODS: Statistical data from 32,524 Sichuan students aged 7 to 19 years were surveyed in 1995. Mean values of the annual increment of body height and the ages of the pubertal growth periods were analyzed. RESULTS: During the period between 9 and 13 years of age, females grow faster than their male peers. After age 13 years, males surpass females, and the difference in physical growth and development becomes more pronounced. CONCLUSIONS: The new standard growth curve chart on the body height of Chinese adolescent may be applied to better understand the growth pattern of Chinese orthodontic patients.

Adolescent↗
PubMed1990

[Variations in body height within the course of a working day].

Variation of body height during the day has been analyzed considering the influence of various occupations (standing, sitting, mixed) on the posture. In addition to this the following variables have been recorded on the 302 individuals under study: Sex, age, working time, time of getting up in the morning, kind of occupation, physique, sporting activities in the leisure-time, presence of defects of the spinal column, possibility of changes of the carriage at the working place and extensibility of the spinal column. The statistical analysis showed that with the exception of pathological alterations of the spinal column all these variables are influencing the variation of body height during the day. It could also be shown that the extensibility of the spinal column does not vary during the day. The author is discussing also ergonomical rules concerning the organization of working places for standing and sitting occupations. Finally some recommendations for the future organization of such places are given.

Adult↗