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At least 127 records · Page 7Linked to original sources
PubMed1983

Enhancing effect of vitamin E on murine intestinal tumorigenesis by 1,2-dimethylhydrazine dihydrochloride.

The effect of the antioxidant vitamin E on the tumor-inducing ability of 1,2-dimethylhydrazine dihydrochloride (1,2-DMH) was investigated in randomly bred Swiss mice. Three groups of mice that were 6 weeks of age at the beginning of the experiment received the following treatments: a) vitamin E acetate [DL-alpha-tocopheryl acetate (TA)] at a 4% dose level in a powdered diet for life; b) 1,2-DMH, 10 weekly sc injections at 20 micrograms/g body weight; c) combination of a and b treatments. The administration of TA enhanced the tumorigenicity of 1,2-DMH, as evidenced by statistically significant incidences of tumors in the duodenum, cecum, colon, rectum, and anus. The present finding apparently is in contrast with the reported inhibitory effect of TA on colon carcinogenesis by 1,2-DMH.

1,2-Dimethylhydrazine↗
PubMed1978

Ileocecal masses discovered unexpectedly at surgery for appendicitis.

During the past five years we have encountered 15 patients who were found to have an ileocecal mass of undetermined etiology when explored through a right lower quadrant incision for presumed appendicitis. Diverticulitis of the ileocecal region accounted for almost one-half of these lesions. There are many possible etiologies for mass lesions in this location, but beacuse malignancy cannot be excluded at operation, a right hemicolectomy is advised. We found that this procedure could be done with relative safety in unprepared bowel under emergency conditions.

Adolescent↗