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Results for “CEREBRAL ARTERIOSCLEROSIS”

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PubMedDate not supplied

[Alkaline blood serum proteins in patients with the initial manifestations of cerebral arteriosclerosis and the late sequelae of mild closed craniocerebral trauma (comparative data)].

Alkaline proteins play their pathogenetic part in the course of cerebral atherosclerosis the development of which is accompanied by decline in their content. It has been ascertained that in patients with early cerebral atherosclerosis and remote sequelae of mild closed craniocerebral injury (RS MCCCI) the content of alkaline proteins is below the established norm. The absence of significant differences between the patients presenting with early manifestation of cerebral circulatory insufficiency and those with RS MCCCI may suggest similarity of mechanisms of development of vascular disorders of traumatic and atherosclerotic genesis.

Adult↗
PubMed1984

A new model of cerebral arteriosclerosis induced by intimal injury using a silicone rubber cylinder in rabbits.

We designed a new model for studies on atherogenesis in cerebrovascular systems. Myointimal thickening in the rabbit cerebral arteries was induced following intimal injury produced by a silicone rubber cylinder with nylon thread and which was injected from the bifurcation of the right external and internal carotid arteries to embolize either the intracranial internal carotid or middle cerebral artery. Fifteen minutes after the cylinder had been removed, there was a denudation of the endothelium, and platelets adhered to the exposed subendothelium at the site of embolization of the cylinder. Within 3 days, this denuded surface was completely covered by regenerated endothelial cells, and intimal thickening was not observed. After 7 and 28 days, there was a striking myointimal thickening composed of smooth muscle cells in the fibroelastic stroma in the injured region. Permeability of the regenerated endothelium to horseradish peroxidase continued to be enhanced through the intercellular junctions and by increase of vesicular transport after the regenerated endothelial cells had completely covered the denuded area. These findings suggest that enhancement of permeability of plasma constituents of the regenerated endothelium plays an important role in the atherogenesis of cerebral arteries.

Animals↗
PubMedDate not supplied

Effect of propentofylline and pentoxifylline on cerebral blood flow using 123I-IMP SPECT in patients with cerebral arteriosclerosis.

Propentofylline and pentoxifylline were administered to patients age 65 years or older who were suffering from chronic cerebrocirculatory insufficiency. Changes in clinical symptoms and the level of cerebral blood flow before and after drug administration were compared. 123I-IMP single photon emission computed tomography was used to compare cerebral blood flow before treatment with that 3 months after initiation of therapy. Focal regions of interest were established in the cerebellum, the frontal, temporal, parietal, and occipital lobes, and the thalamus. Comparisons were made between patients age 75 years or older (very old age group) (n = 5) and those age 65 to 74 years (old age group) (n = 7). Complaints of dizziness and slight headache disappeared by the eighth week after the start of therapy in both age groups. Two of the five patients in the very old age group showed elimination of memory disturbance symptoms at the 12th week of treatment. Six of the seven patients in the old age group had no memory disturbance symptoms by the eighth week of treatment, which indicates a high therapeutic effect in this group. In the cerebral blood flow studies, no increases in blood flow after drug administration were observed in the very old age group. This finding is probably related to the poor level of recovery achieved in disturbances in memory in this group. In contrast, improvements in blood flow were observed for all regions of the brain monitored in the old age group, which is consistent with the amelioration of clinical symptoms observed in these patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1984

[Physical exertion tolerance in patients with ischemic heart disease associated with cerebral arteriosclerosis].

The authors provide the results of a comparative study of exercise tolerance (bicycle ergometry test) in 64 patients with coronary heart disease (CHD) and in 68 patients with associated CHD and cerebral atherosclerosis. During the latter syndrome the working capacity was lowered as a result of less economical work of the circulatory apparatus. In particular, physical loading in such patients was accompanied by marked increment of the heart rate and blood pressure elevation. Increased heart oxygen requirement in the second group patients during exercise was accompanied by more frequent ischemic alterations in the myocardium attended by ST segment depression on the ECG. It is concluded that concomitant cerebral atherosclerosis aggravates the basic pathogenetic mechanisms of CHD, namely the disagreement between myocardium oxygen requirement and supply.

Adult↗
PubMed1980

[Comparison of the effectiveness of anginin and stugeron treatment of cerebral arteriosclerosis].

Using the method of double-blind trial the effectiveness of treatment with Anginin (pyrridinolcarbamate) and Stugeron (cinnarizine) was evaluated. The somatic and mental condition and the results of motor rehabilitation of the patients were estimated. In all the evaluated elements the results of Stugeron treatment were better. The results were assessed in two groups of 20 cases each of patients with cerebral atherosclerosis observed during two months.

Adult↗
PubMed2003

[Effect of tianlong xifeng granule on gan-yang-hua-feng zheng in cerebral arteriosclerosis].

OBJECTIVE: To investigate the efficacy of Tianlong Xifeng granule (TXG) in the treatment of ceroarterosclerosis (CAS) with Gan-yang-hua-feng Zheng(GYHFZ). METHODS: Patients with CAS were randomly divided into 2 groups: 122 patients in the treatment group were given TXG, while 60 patients in the control group were treated with Ginkgo Biloba capsule. Clinical symptom, blood lipid and transcranial doppler ultrasound were observed before and after the treatment. RESULTS: The symptom, elasticity of the cerebral blood vessel, and the speed of blood flow were significantly improved in the treatment group, and the efficacy of the treatment group was superior to that of the control group. Blood lipid was effectively reduced, and no toxic and side effects were found in both groups. CONCLUSION: TXG has ideal therapeutic effect on CAS patients with GYHFZ.

Aged↗